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Q9R0M8 (S35A2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 103. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
UDP-galactose translocator
Alternative name(s):
Solute carrier family 35 member A2
UDP-galactose transporter
Short name=UDP-Gal-Tr
Short name=UGT
Short name=mUGT1
Gene names
Name:Slc35a2
Synonyms:Ugt1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length390 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Transports nucleotide sugars from the cytosol into Golgi vesicles where glycosyltransferases function.

Subunit structure

Interacts with SLC35A3 By similarity.

Subcellular location

Golgi apparatus membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 390390UDP-galactose translocator
PRO_0000213354

Regions

Transmembrane3 – 2321Helical; Potential
Transmembrane37 – 5721Helical; Potential
Transmembrane65 – 8521Helical; Potential
Transmembrane97 – 11721Helical; Potential
Transmembrane140 – 16021Helical; Potential
Transmembrane169 – 18921Helical; Potential
Transmembrane200 – 22021Helical; Potential
Transmembrane238 – 25821Helical; Potential
Transmembrane269 – 28921Helical; Potential
Transmembrane315 – 33521Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q9R0M8 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: F7CD57C5C0D401B8

FASTA39040,766
        10         20         30         40         50         60 
MAAVGVGGST AAAGAGAVSS GALEPGSTTA AHRRLKYISL AVLVVQNASL ILSIRYARTL 

        70         80         90        100        110        120 
PGDRFFATTA VVMAEVLKGL TCLLLLFAQK RGNVKHLVLF LHEAVLVQYV DTLKLAVPSL 

       130        140        150        160        170        180 
IYTLQNNLQY VAISNLPAAT FQVTYQLKIL TTALFSVLML NRSLSRLQWA SLLLLFTGVA 

       190        200        210        220        230        240 
IVQAQQAGGS GPRPLDQNPG AGLAAVVASC LSSGFAGVYF EKILKGSSGS VWLRNLQLGL 

       250        260        270        280        290        300 
FGTALGLVGL WWAEGTAVAS QGFFFGYTPA VWGVVLNQAF GGLLVAVVVK YADNILKGFA 

       310        320        330        340        350        360 
TSLSIVLSTV ASIRLFGFHL DPLFALGAGL VIGAVYLYSL PRGAVKAIAS ASASGPCIHQ 

       370        380        390 
QPPGQPPPPQ LSSRGDLTTE PFLPKSVLVK 

« Hide

References

« Hide 'large scale' references
[1]"Indispensability of transmembrane domains of Golgi UDP-galactose transporter as revealed by analysis of genetic defects in UDP-galactose transporter-deficient murine had-1 mutant cell lines and construction of deletion mutants."
Ishida N., Yoshioka S., Iida M., Sudo K., Miura N., Aoki K., Kawakita M.
J. Biochem. 126:1107-1117(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: BALB/c.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Salivary gland.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB027147 mRNA. Translation: BAA86885.1.
BC037701 mRNA. Translation: AAH37701.1.
CCDSCCDS52987.1.
PIRJC7162.
RefSeqNP_001077406.1. NM_001083937.1.
UniGeneMm.214976.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000111327.

Protein family/group databases

TCDB2.A.7.12.8. the drug/metabolite transporter (dmt) superfamily.

PTM databases

PhosphoSiteQ9R0M8.

Proteomic databases

PaxDbQ9R0M8.
PRIDEQ9R0M8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000115660; ENSMUSP00000111324; ENSMUSG00000031156.
GeneID22232.
KEGGmmu:22232.
UCSCuc009sna.1. mouse.

Organism-specific databases

CTD7355.
MGIMGI:1345297. Slc35a2.

Phylogenomic databases

eggNOGCOG0697.
GeneTreeENSGT00550000074563.
HOVERGENHBG054025.
KOK15272.
OrthoDBEOG7NCV4D.

Gene expression databases

ArrayExpressQ9R0M8.
BgeeQ9R0M8.
GenevestigatorQ9R0M8.

Family and domain databases

InterProIPR007271. Nuc_sug_transpt.
IPR021189. UDP/CMP-sugar_transptr.
IPR004689. UDPgal_transpt.
[Graphical view]
PANTHERPTHR10231. PTHR10231. 1 hit.
PfamPF04142. Nuc_sug_transp. 1 hit.
[Graphical view]
PIRSFPIRSF005799. UDP-gal_transpt. 1 hit.
TIGRFAMsTIGR00803. nst. 1 hit.
ProtoNetSearch...

Other

NextBio302275.
PROQ9R0M8.
SOURCESearch...

Entry information

Entry nameS35A2_MOUSE
AccessionPrimary (citable) accession number: Q9R0M8
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: July 9, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot