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Q9R0M8

- S35A2_MOUSE

UniProt

Q9R0M8 - S35A2_MOUSE

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Protein

UDP-galactose translocator

Gene

Slc35a2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Transports nucleotide sugars from the cytosol into Golgi vesicles where glycosyltransferases function.

GO - Molecular functioni

  1. sugar:proton symporter activity Source: InterPro
  2. UDP-galactose transmembrane transporter activity Source: MGI

GO - Biological processi

  1. carbohydrate transport Source: MGI
  2. transport Source: MGI
  3. UDP-galactose transmembrane transport Source: GOC
Complete GO annotation...

Keywords - Biological processi

Sugar transport, Transport

Enzyme and pathway databases

ReactomeiREACT_203051. Transport of nucleotide sugars.

Protein family/group databases

TCDBi2.A.7.12.8. the drug/metabolite transporter (dmt) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-galactose translocator
Alternative name(s):
Solute carrier family 35 member A2
UDP-galactose transporter
Short name:
UDP-Gal-Tr
Short name:
UGT
Short name:
mUGT1
Gene namesi
Name:Slc35a2
Synonyms:Ugt1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome X

Organism-specific databases

MGIiMGI:1345297. Slc35a2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei3 – 2321HelicalSequence AnalysisAdd
BLAST
Transmembranei37 – 5721HelicalSequence AnalysisAdd
BLAST
Transmembranei65 – 8521HelicalSequence AnalysisAdd
BLAST
Transmembranei97 – 11721HelicalSequence AnalysisAdd
BLAST
Transmembranei140 – 16021HelicalSequence AnalysisAdd
BLAST
Transmembranei169 – 18921HelicalSequence AnalysisAdd
BLAST
Transmembranei200 – 22021HelicalSequence AnalysisAdd
BLAST
Transmembranei238 – 25821HelicalSequence AnalysisAdd
BLAST
Transmembranei269 – 28921HelicalSequence AnalysisAdd
BLAST
Transmembranei315 – 33521HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. Golgi membrane Source: MGI
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 390390UDP-galactose translocatorPRO_0000213354Add
BLAST

Proteomic databases

MaxQBiQ9R0M8.
PaxDbiQ9R0M8.
PRIDEiQ9R0M8.

PTM databases

PhosphoSiteiQ9R0M8.

Expressioni

Gene expression databases

BgeeiQ9R0M8.
ExpressionAtlasiQ9R0M8. baseline and differential.
GenevestigatoriQ9R0M8.

Interactioni

Subunit structurei

Interacts with SLC35A3.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000111327.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0697.
GeneTreeiENSGT00550000074563.
HOVERGENiHBG054025.
InParanoidiQ9R0M8.
KOiK15272.
OrthoDBiEOG7NCV4D.

Family and domain databases

InterProiIPR007271. Nuc_sug_transpt.
IPR021189. UDP/CMP-sugar_transptr.
IPR004689. UDPgal_transpt.
[Graphical view]
PANTHERiPTHR10231. PTHR10231. 1 hit.
PfamiPF04142. Nuc_sug_transp. 1 hit.
[Graphical view]
PIRSFiPIRSF005799. UDP-gal_transpt. 1 hit.
TIGRFAMsiTIGR00803. nst. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9R0M8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAAVGVGGST AAAGAGAVSS GALEPGSTTA AHRRLKYISL AVLVVQNASL
60 70 80 90 100
ILSIRYARTL PGDRFFATTA VVMAEVLKGL TCLLLLFAQK RGNVKHLVLF
110 120 130 140 150
LHEAVLVQYV DTLKLAVPSL IYTLQNNLQY VAISNLPAAT FQVTYQLKIL
160 170 180 190 200
TTALFSVLML NRSLSRLQWA SLLLLFTGVA IVQAQQAGGS GPRPLDQNPG
210 220 230 240 250
AGLAAVVASC LSSGFAGVYF EKILKGSSGS VWLRNLQLGL FGTALGLVGL
260 270 280 290 300
WWAEGTAVAS QGFFFGYTPA VWGVVLNQAF GGLLVAVVVK YADNILKGFA
310 320 330 340 350
TSLSIVLSTV ASIRLFGFHL DPLFALGAGL VIGAVYLYSL PRGAVKAIAS
360 370 380 390
ASASGPCIHQ QPPGQPPPPQ LSSRGDLTTE PFLPKSVLVK
Length:390
Mass (Da):40,766
Last modified:May 1, 2000 - v1
Checksum:iF7CD57C5C0D401B8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB027147 mRNA. Translation: BAA86885.1.
BC037701 mRNA. Translation: AAH37701.1.
CCDSiCCDS52987.1.
PIRiJC7162.
RefSeqiNP_001077406.1. NM_001083937.1.
UniGeneiMm.214976.

Genome annotation databases

EnsembliENSMUST00000115660; ENSMUSP00000111324; ENSMUSG00000031156.
GeneIDi22232.
KEGGimmu:22232.
UCSCiuc009sna.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB027147 mRNA. Translation: BAA86885.1 .
BC037701 mRNA. Translation: AAH37701.1 .
CCDSi CCDS52987.1.
PIRi JC7162.
RefSeqi NP_001077406.1. NM_001083937.1.
UniGenei Mm.214976.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000111327.

Protein family/group databases

TCDBi 2.A.7.12.8. the drug/metabolite transporter (dmt) superfamily.

PTM databases

PhosphoSitei Q9R0M8.

Proteomic databases

MaxQBi Q9R0M8.
PaxDbi Q9R0M8.
PRIDEi Q9R0M8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000115660 ; ENSMUSP00000111324 ; ENSMUSG00000031156 .
GeneIDi 22232.
KEGGi mmu:22232.
UCSCi uc009sna.1. mouse.

Organism-specific databases

CTDi 7355.
MGIi MGI:1345297. Slc35a2.

Phylogenomic databases

eggNOGi COG0697.
GeneTreei ENSGT00550000074563.
HOVERGENi HBG054025.
InParanoidi Q9R0M8.
KOi K15272.
OrthoDBi EOG7NCV4D.

Enzyme and pathway databases

Reactomei REACT_203051. Transport of nucleotide sugars.

Miscellaneous databases

NextBioi 302275.
PROi Q9R0M8.
SOURCEi Search...

Gene expression databases

Bgeei Q9R0M8.
ExpressionAtlasi Q9R0M8. baseline and differential.
Genevestigatori Q9R0M8.

Family and domain databases

InterProi IPR007271. Nuc_sug_transpt.
IPR021189. UDP/CMP-sugar_transptr.
IPR004689. UDPgal_transpt.
[Graphical view ]
PANTHERi PTHR10231. PTHR10231. 1 hit.
Pfami PF04142. Nuc_sug_transp. 1 hit.
[Graphical view ]
PIRSFi PIRSF005799. UDP-gal_transpt. 1 hit.
TIGRFAMsi TIGR00803. nst. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Indispensability of transmembrane domains of Golgi UDP-galactose transporter as revealed by analysis of genetic defects in UDP-galactose transporter-deficient murine had-1 mutant cell lines and construction of deletion mutants."
    Ishida N., Yoshioka S., Iida M., Sudo K., Miura N., Aoki K., Kawakita M.
    J. Biochem. 126:1107-1117(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Salivary gland.

Entry informationi

Entry nameiS35A2_MOUSE
AccessioniPrimary (citable) accession number: Q9R0M8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: October 29, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3