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Q9R0M8

- S35A2_MOUSE

UniProt

Q9R0M8 - S35A2_MOUSE

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Protein
UDP-galactose translocator
Gene
Slc35a2, Ugt1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Transports nucleotide sugars from the cytosol into Golgi vesicles where glycosyltransferases function.

GO - Molecular functioni

  1. UDP-galactose transmembrane transporter activity Source: MGI
  2. sugar:proton symporter activity Source: InterPro

GO - Biological processi

  1. UDP-galactose transmembrane transport Source: GOC
  2. carbohydrate transport Source: MGI
  3. transport Source: MGI
Complete GO annotation...

Keywords - Biological processi

Sugar transport, Transport

Enzyme and pathway databases

ReactomeiREACT_203051. Transport of nucleotide sugars.

Protein family/group databases

TCDBi2.A.7.12.8. the drug/metabolite transporter (dmt) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-galactose translocator
Alternative name(s):
Solute carrier family 35 member A2
UDP-galactose transporter
Short name:
UDP-Gal-Tr
Short name:
UGT
Short name:
mUGT1
Gene namesi
Name:Slc35a2
Synonyms:Ugt1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome X

Organism-specific databases

MGIiMGI:1345297. Slc35a2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei3 – 2321Helical; Reviewed prediction
Add
BLAST
Transmembranei37 – 5721Helical; Reviewed prediction
Add
BLAST
Transmembranei65 – 8521Helical; Reviewed prediction
Add
BLAST
Transmembranei97 – 11721Helical; Reviewed prediction
Add
BLAST
Transmembranei140 – 16021Helical; Reviewed prediction
Add
BLAST
Transmembranei169 – 18921Helical; Reviewed prediction
Add
BLAST
Transmembranei200 – 22021Helical; Reviewed prediction
Add
BLAST
Transmembranei238 – 25821Helical; Reviewed prediction
Add
BLAST
Transmembranei269 – 28921Helical; Reviewed prediction
Add
BLAST
Transmembranei315 – 33521Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. Golgi membrane Source: MGI
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 390390UDP-galactose translocator
PRO_0000213354Add
BLAST

Proteomic databases

PaxDbiQ9R0M8.
PRIDEiQ9R0M8.

PTM databases

PhosphoSiteiQ9R0M8.

Expressioni

Gene expression databases

ArrayExpressiQ9R0M8.
BgeeiQ9R0M8.
GenevestigatoriQ9R0M8.

Interactioni

Subunit structurei

Interacts with SLC35A3 By similarity.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000111327.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0697.
GeneTreeiENSGT00550000074563.
HOVERGENiHBG054025.
KOiK15272.
OrthoDBiEOG7NCV4D.

Family and domain databases

InterProiIPR007271. Nuc_sug_transpt.
IPR021189. UDP/CMP-sugar_transptr.
IPR004689. UDPgal_transpt.
[Graphical view]
PANTHERiPTHR10231. PTHR10231. 1 hit.
PfamiPF04142. Nuc_sug_transp. 1 hit.
[Graphical view]
PIRSFiPIRSF005799. UDP-gal_transpt. 1 hit.
TIGRFAMsiTIGR00803. nst. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9R0M8-1 [UniParc]FASTAAdd to Basket

« Hide

MAAVGVGGST AAAGAGAVSS GALEPGSTTA AHRRLKYISL AVLVVQNASL    50
ILSIRYARTL PGDRFFATTA VVMAEVLKGL TCLLLLFAQK RGNVKHLVLF 100
LHEAVLVQYV DTLKLAVPSL IYTLQNNLQY VAISNLPAAT FQVTYQLKIL 150
TTALFSVLML NRSLSRLQWA SLLLLFTGVA IVQAQQAGGS GPRPLDQNPG 200
AGLAAVVASC LSSGFAGVYF EKILKGSSGS VWLRNLQLGL FGTALGLVGL 250
WWAEGTAVAS QGFFFGYTPA VWGVVLNQAF GGLLVAVVVK YADNILKGFA 300
TSLSIVLSTV ASIRLFGFHL DPLFALGAGL VIGAVYLYSL PRGAVKAIAS 350
ASASGPCIHQ QPPGQPPPPQ LSSRGDLTTE PFLPKSVLVK 390
Length:390
Mass (Da):40,766
Last modified:May 1, 2000 - v1
Checksum:iF7CD57C5C0D401B8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB027147 mRNA. Translation: BAA86885.1.
BC037701 mRNA. Translation: AAH37701.1.
CCDSiCCDS52987.1.
PIRiJC7162.
RefSeqiNP_001077406.1. NM_001083937.1.
UniGeneiMm.214976.

Genome annotation databases

EnsembliENSMUST00000115660; ENSMUSP00000111324; ENSMUSG00000031156.
GeneIDi22232.
KEGGimmu:22232.
UCSCiuc009sna.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB027147 mRNA. Translation: BAA86885.1 .
BC037701 mRNA. Translation: AAH37701.1 .
CCDSi CCDS52987.1.
PIRi JC7162.
RefSeqi NP_001077406.1. NM_001083937.1.
UniGenei Mm.214976.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000111327.

Protein family/group databases

TCDBi 2.A.7.12.8. the drug/metabolite transporter (dmt) superfamily.

PTM databases

PhosphoSitei Q9R0M8.

Proteomic databases

PaxDbi Q9R0M8.
PRIDEi Q9R0M8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000115660 ; ENSMUSP00000111324 ; ENSMUSG00000031156 .
GeneIDi 22232.
KEGGi mmu:22232.
UCSCi uc009sna.1. mouse.

Organism-specific databases

CTDi 7355.
MGIi MGI:1345297. Slc35a2.

Phylogenomic databases

eggNOGi COG0697.
GeneTreei ENSGT00550000074563.
HOVERGENi HBG054025.
KOi K15272.
OrthoDBi EOG7NCV4D.

Enzyme and pathway databases

Reactomei REACT_203051. Transport of nucleotide sugars.

Miscellaneous databases

NextBioi 302275.
PROi Q9R0M8.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9R0M8.
Bgeei Q9R0M8.
Genevestigatori Q9R0M8.

Family and domain databases

InterProi IPR007271. Nuc_sug_transpt.
IPR021189. UDP/CMP-sugar_transptr.
IPR004689. UDPgal_transpt.
[Graphical view ]
PANTHERi PTHR10231. PTHR10231. 1 hit.
Pfami PF04142. Nuc_sug_transp. 1 hit.
[Graphical view ]
PIRSFi PIRSF005799. UDP-gal_transpt. 1 hit.
TIGRFAMsi TIGR00803. nst. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Indispensability of transmembrane domains of Golgi UDP-galactose transporter as revealed by analysis of genetic defects in UDP-galactose transporter-deficient murine had-1 mutant cell lines and construction of deletion mutants."
    Ishida N., Yoshioka S., Iida M., Sudo K., Miura N., Aoki K., Kawakita M.
    J. Biochem. 126:1107-1117(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Salivary gland.

Entry informationi

Entry nameiS35A2_MOUSE
AccessioniPrimary (citable) accession number: Q9R0M8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: September 3, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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