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Protein

UDP-galactose translocator

Gene

Slc35a2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Transports nucleotide sugars from the cytosol into Golgi vesicles where glycosyltransferases function.

GO - Molecular functioni

GO - Biological processi

  • carbohydrate transport Source: MGI
  • transport Source: MGI
Complete GO annotation...

Keywords - Biological processi

Sugar transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-727802. Transport of nucleotide sugars.

Protein family/group databases

TCDBi2.A.7.12.8. the drug/metabolite transporter (dmt) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-galactose translocator
Alternative name(s):
Solute carrier family 35 member A2
UDP-galactose transporter
Short name:
UDP-Gal-Tr
Short name:
UGT
Short name:
mUGT1
Gene namesi
Name:Slc35a2
Synonyms:Ugt1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:1345297. Slc35a2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei3 – 23HelicalSequence analysisAdd BLAST21
Transmembranei37 – 57HelicalSequence analysisAdd BLAST21
Transmembranei65 – 85HelicalSequence analysisAdd BLAST21
Transmembranei97 – 117HelicalSequence analysisAdd BLAST21
Transmembranei140 – 160HelicalSequence analysisAdd BLAST21
Transmembranei169 – 189HelicalSequence analysisAdd BLAST21
Transmembranei200 – 220HelicalSequence analysisAdd BLAST21
Transmembranei238 – 258HelicalSequence analysisAdd BLAST21
Transmembranei269 – 289HelicalSequence analysisAdd BLAST21
Transmembranei315 – 335HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • Golgi membrane Source: MGI
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002133541 – 390UDP-galactose translocatorAdd BLAST390

Proteomic databases

MaxQBiQ9R0M8.
PaxDbiQ9R0M8.
PRIDEiQ9R0M8.

PTM databases

iPTMnetiQ9R0M8.
PhosphoSitePlusiQ9R0M8.

Expressioni

Gene expression databases

BgeeiENSMUSG00000031156.
ExpressionAtlasiQ9R0M8. baseline and differential.
GenevisibleiQ9R0M8. MM.

Interactioni

Subunit structurei

Interacts with SLC35A3.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000111327.

Structurei

3D structure databases

ProteinModelPortaliQ9R0M8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2234. Eukaryota.
COG0697. LUCA.
GeneTreeiENSGT00550000074563.
HOVERGENiHBG054025.
InParanoidiQ9R0M8.
KOiK15272.

Family and domain databases

InterProiIPR007271. Nuc_sug_transpt.
[Graphical view]
PANTHERiPTHR10231. PTHR10231. 1 hit.
PfamiPF04142. Nuc_sug_transp. 1 hit.
[Graphical view]
PIRSFiPIRSF005799. UDP-gal_transpt. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9R0M8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAVGVGGST AAAGAGAVSS GALEPGSTTA AHRRLKYISL AVLVVQNASL
60 70 80 90 100
ILSIRYARTL PGDRFFATTA VVMAEVLKGL TCLLLLFAQK RGNVKHLVLF
110 120 130 140 150
LHEAVLVQYV DTLKLAVPSL IYTLQNNLQY VAISNLPAAT FQVTYQLKIL
160 170 180 190 200
TTALFSVLML NRSLSRLQWA SLLLLFTGVA IVQAQQAGGS GPRPLDQNPG
210 220 230 240 250
AGLAAVVASC LSSGFAGVYF EKILKGSSGS VWLRNLQLGL FGTALGLVGL
260 270 280 290 300
WWAEGTAVAS QGFFFGYTPA VWGVVLNQAF GGLLVAVVVK YADNILKGFA
310 320 330 340 350
TSLSIVLSTV ASIRLFGFHL DPLFALGAGL VIGAVYLYSL PRGAVKAIAS
360 370 380 390
ASASGPCIHQ QPPGQPPPPQ LSSRGDLTTE PFLPKSVLVK
Length:390
Mass (Da):40,766
Last modified:May 1, 2000 - v1
Checksum:iF7CD57C5C0D401B8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB027147 mRNA. Translation: BAA86885.1.
BC037701 mRNA. Translation: AAH37701.1.
CCDSiCCDS52987.1.
PIRiJC7162.
RefSeqiNP_001077406.1. NM_001083937.1.
UniGeneiMm.214976.

Genome annotation databases

EnsembliENSMUST00000115660; ENSMUSP00000111324; ENSMUSG00000031156.
ENSMUST00000155967; ENSMUSP00000146730; ENSMUSG00000031156.
GeneIDi22232.
KEGGimmu:22232.
UCSCiuc009sna.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB027147 mRNA. Translation: BAA86885.1.
BC037701 mRNA. Translation: AAH37701.1.
CCDSiCCDS52987.1.
PIRiJC7162.
RefSeqiNP_001077406.1. NM_001083937.1.
UniGeneiMm.214976.

3D structure databases

ProteinModelPortaliQ9R0M8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000111327.

Protein family/group databases

TCDBi2.A.7.12.8. the drug/metabolite transporter (dmt) superfamily.

PTM databases

iPTMnetiQ9R0M8.
PhosphoSitePlusiQ9R0M8.

Proteomic databases

MaxQBiQ9R0M8.
PaxDbiQ9R0M8.
PRIDEiQ9R0M8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000115660; ENSMUSP00000111324; ENSMUSG00000031156.
ENSMUST00000155967; ENSMUSP00000146730; ENSMUSG00000031156.
GeneIDi22232.
KEGGimmu:22232.
UCSCiuc009sna.1. mouse.

Organism-specific databases

CTDi7355.
MGIiMGI:1345297. Slc35a2.

Phylogenomic databases

eggNOGiKOG2234. Eukaryota.
COG0697. LUCA.
GeneTreeiENSGT00550000074563.
HOVERGENiHBG054025.
InParanoidiQ9R0M8.
KOiK15272.

Enzyme and pathway databases

ReactomeiR-MMU-727802. Transport of nucleotide sugars.

Miscellaneous databases

PROiQ9R0M8.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000031156.
ExpressionAtlasiQ9R0M8. baseline and differential.
GenevisibleiQ9R0M8. MM.

Family and domain databases

InterProiIPR007271. Nuc_sug_transpt.
[Graphical view]
PANTHERiPTHR10231. PTHR10231. 1 hit.
PfamiPF04142. Nuc_sug_transp. 1 hit.
[Graphical view]
PIRSFiPIRSF005799. UDP-gal_transpt. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiS35A2_MOUSE
AccessioniPrimary (citable) accession number: Q9R0M8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: November 2, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.