Q9R0M8 (S35A2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
UDP-galactose translocator

Alternative name(s):
Solute carrier family 35 member A2
UDP-galactose transporter
Short name=UDP-Gal-Tr
Short name=UGT
Short name=mUGT1

Gene names

Name:	Slc35a2
Synonyms:	Ugt1

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	390 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Transports nucleotide sugars from the cytosol into Golgi vesicles where glycosyltransferases function.
Subcellular location	Golgi apparatus membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.

Ontologies

Keywords
Biological process	Sugar transport Transport
Cellular component	Golgi apparatus Membrane
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	Golgi membrane Inferred from direct assay Ref.1. Source: MGI integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	UDP-galactose transmembrane transporter activity Inferred from direct assay Ref.1. Source: MGI sugar:hydrogen symporter activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 390	390	UDP-galactose translocator		PRO_0000213354
Regions
	Transmembrane	3 – 23	21	Helical; Potential
	Transmembrane	37 – 57	21	Helical; Potential
	Transmembrane	65 – 85	21	Helical; Potential
	Transmembrane	97 – 117	21	Helical; Potential
	Transmembrane	140 – 160	21	Helical; Potential
	Transmembrane	169 – 189	21	Helical; Potential
	Transmembrane	200 – 220	21	Helical; Potential
	Transmembrane	238 – 258	21	Helical; Potential
	Transmembrane	269 – 289	21	Helical; Potential
	Transmembrane	315 – 335	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	Q9R0M8 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: F7CD57C5C0D401B8	FASTA	390	40,766
	10 20 30 40 50 60 MAAVGVGGST AAAGAGAVSS GALEPGSTTA AHRRLKYISL AVLVVQNASL ILSIRYARTL 70 80 90 100 110 120 PGDRFFATTA VVMAEVLKGL TCLLLLFAQK RGNVKHLVLF LHEAVLVQYV DTLKLAVPSL 130 140 150 160 170 180 IYTLQNNLQY VAISNLPAAT FQVTYQLKIL TTALFSVLML NRSLSRLQWA SLLLLFTGVA 190 200 210 220 230 240 IVQAQQAGGS GPRPLDQNPG AGLAAVVASC LSSGFAGVYF EKILKGSSGS VWLRNLQLGL 250 260 270 280 290 300 FGTALGLVGL WWAEGTAVAS QGFFFGYTPA VWGVVLNQAF GGLLVAVVVK YADNILKGFA 310 320 330 340 350 360 TSLSIVLSTV ASIRLFGFHL DPLFALGAGL VIGAVYLYSL PRGAVKAIAS ASASGPCIHQ 370 380 390 QPPGQPPPPQ LSSRGDLTTE PFLPKSVLVK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Indispensability of transmembrane domains of Golgi UDP-galactose transporter as revealed by analysis of genetic defects in UDP-galactose transporter-deficient murine had-1 mutant cell lines and construction of deletion mutants." Ishida N., Yoshioka S., Iida M., Sudo K., Miura N., Aoki K., Kawakita M. J. Biochem. 126:1107-1117(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: BALB/c.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: FVB/N. Tissue: Salivary gland.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB027147 mRNA. Translation: BAA86885.1. BC037701 mRNA. Translation: AAH37701.1.
IPI	IPI00654207.
PIR	JC7162.
RefSeq	NP_001077406.1. NM_001083937.1.
UniGene	Mm.214976.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	10090.ENSMUSP00000111327.
Protein family/group databases
TCDB	2.A.7.12.8. drug/metabolite transporter (DMT) superfamily.
PTM databases
PhosphoSite	Q9R0M8.
Proteomic databases
PaxDb	Q9R0M8.
PRIDE	Q9R0M8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000115660; ENSMUSP00000111324; ENSMUSG00000031156.
GeneID	22232.
KEGG	mmu:22232.
Organism-specific databases
CTD	7355.
MGI	MGI:1345297. Slc35a2.
Phylogenomic databases
eggNOG	COG0697.
GeneTree	ENSGT00550000074563.
HOVERGEN	HBG054025.
KO	K15272.
OrthoDB	EOG4R7VB9.
Gene expression databases
ArrayExpress	Q9R0M8.
Bgee	Q9R0M8.
Genevestigator	Q9R0M8.
GermOnline	ENSMUSG00000031156. Mus musculus.
Family and domain databases
InterPro	IPR007271. Nuc_sug_transpt. IPR021189. UDP/CMP-sugar_transptr. IPR004689. UDPgal_transpt. [Graphical view]
PANTHER	PTHR10231. PTHR10231. 1 hit.
Pfam	PF04142. Nuc_sug_transp. 1 hit. [Graphical view]
PIRSF	PIRSF005799. UDP-gal_transpt. 1 hit.
TIGRFAMs	TIGR00803. nst. 1 hit.
ProtoNet	Search...
Other
NextBio	302275.
SOURCE	Search...

Entry information

Entry name

S35A2_MOUSE

Accession

Primary (citable) accession number: Q9R0M8

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	May 1, 2000
Last modified:	April 3, 2013
This is version 93 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program