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Q9R0M8

- S35A2_MOUSE

UniProt

Q9R0M8 - S35A2_MOUSE

Protein

UDP-galactose translocator

Gene

Slc35a2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Transports nucleotide sugars from the cytosol into Golgi vesicles where glycosyltransferases function.

    GO - Molecular functioni

    1. sugar:proton symporter activity Source: InterPro
    2. UDP-galactose transmembrane transporter activity Source: MGI

    GO - Biological processi

    1. carbohydrate transport Source: MGI
    2. transport Source: MGI
    3. UDP-galactose transmembrane transport Source: GOC

    Keywords - Biological processi

    Sugar transport, Transport

    Enzyme and pathway databases

    ReactomeiREACT_203051. Transport of nucleotide sugars.

    Protein family/group databases

    TCDBi2.A.7.12.8. the drug/metabolite transporter (dmt) superfamily.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    UDP-galactose translocator
    Alternative name(s):
    Solute carrier family 35 member A2
    UDP-galactose transporter
    Short name:
    UDP-Gal-Tr
    Short name:
    UGT
    Short name:
    mUGT1
    Gene namesi
    Name:Slc35a2
    Synonyms:Ugt1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome X

    Organism-specific databases

    MGIiMGI:1345297. Slc35a2.

    Subcellular locationi

    GO - Cellular componenti

    1. Golgi membrane Source: MGI
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 390390UDP-galactose translocatorPRO_0000213354Add
    BLAST

    Proteomic databases

    PaxDbiQ9R0M8.
    PRIDEiQ9R0M8.

    PTM databases

    PhosphoSiteiQ9R0M8.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9R0M8.
    BgeeiQ9R0M8.
    GenevestigatoriQ9R0M8.

    Interactioni

    Subunit structurei

    Interacts with SLC35A3.By similarity

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000111327.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei3 – 2321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei37 – 5721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei65 – 8521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei97 – 11721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei140 – 16021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei169 – 18921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei200 – 22021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei238 – 25821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei269 – 28921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei315 – 33521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0697.
    GeneTreeiENSGT00550000074563.
    HOVERGENiHBG054025.
    KOiK15272.
    OrthoDBiEOG7NCV4D.

    Family and domain databases

    InterProiIPR007271. Nuc_sug_transpt.
    IPR021189. UDP/CMP-sugar_transptr.
    IPR004689. UDPgal_transpt.
    [Graphical view]
    PANTHERiPTHR10231. PTHR10231. 1 hit.
    PfamiPF04142. Nuc_sug_transp. 1 hit.
    [Graphical view]
    PIRSFiPIRSF005799. UDP-gal_transpt. 1 hit.
    TIGRFAMsiTIGR00803. nst. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9R0M8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAAVGVGGST AAAGAGAVSS GALEPGSTTA AHRRLKYISL AVLVVQNASL    50
    ILSIRYARTL PGDRFFATTA VVMAEVLKGL TCLLLLFAQK RGNVKHLVLF 100
    LHEAVLVQYV DTLKLAVPSL IYTLQNNLQY VAISNLPAAT FQVTYQLKIL 150
    TTALFSVLML NRSLSRLQWA SLLLLFTGVA IVQAQQAGGS GPRPLDQNPG 200
    AGLAAVVASC LSSGFAGVYF EKILKGSSGS VWLRNLQLGL FGTALGLVGL 250
    WWAEGTAVAS QGFFFGYTPA VWGVVLNQAF GGLLVAVVVK YADNILKGFA 300
    TSLSIVLSTV ASIRLFGFHL DPLFALGAGL VIGAVYLYSL PRGAVKAIAS 350
    ASASGPCIHQ QPPGQPPPPQ LSSRGDLTTE PFLPKSVLVK 390
    Length:390
    Mass (Da):40,766
    Last modified:May 1, 2000 - v1
    Checksum:iF7CD57C5C0D401B8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB027147 mRNA. Translation: BAA86885.1.
    BC037701 mRNA. Translation: AAH37701.1.
    CCDSiCCDS52987.1.
    PIRiJC7162.
    RefSeqiNP_001077406.1. NM_001083937.1.
    UniGeneiMm.214976.

    Genome annotation databases

    EnsembliENSMUST00000115660; ENSMUSP00000111324; ENSMUSG00000031156.
    GeneIDi22232.
    KEGGimmu:22232.
    UCSCiuc009sna.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB027147 mRNA. Translation: BAA86885.1 .
    BC037701 mRNA. Translation: AAH37701.1 .
    CCDSi CCDS52987.1.
    PIRi JC7162.
    RefSeqi NP_001077406.1. NM_001083937.1.
    UniGenei Mm.214976.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000111327.

    Protein family/group databases

    TCDBi 2.A.7.12.8. the drug/metabolite transporter (dmt) superfamily.

    PTM databases

    PhosphoSitei Q9R0M8.

    Proteomic databases

    PaxDbi Q9R0M8.
    PRIDEi Q9R0M8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000115660 ; ENSMUSP00000111324 ; ENSMUSG00000031156 .
    GeneIDi 22232.
    KEGGi mmu:22232.
    UCSCi uc009sna.1. mouse.

    Organism-specific databases

    CTDi 7355.
    MGIi MGI:1345297. Slc35a2.

    Phylogenomic databases

    eggNOGi COG0697.
    GeneTreei ENSGT00550000074563.
    HOVERGENi HBG054025.
    KOi K15272.
    OrthoDBi EOG7NCV4D.

    Enzyme and pathway databases

    Reactomei REACT_203051. Transport of nucleotide sugars.

    Miscellaneous databases

    NextBioi 302275.
    PROi Q9R0M8.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9R0M8.
    Bgeei Q9R0M8.
    Genevestigatori Q9R0M8.

    Family and domain databases

    InterProi IPR007271. Nuc_sug_transpt.
    IPR021189. UDP/CMP-sugar_transptr.
    IPR004689. UDPgal_transpt.
    [Graphical view ]
    PANTHERi PTHR10231. PTHR10231. 1 hit.
    Pfami PF04142. Nuc_sug_transp. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF005799. UDP-gal_transpt. 1 hit.
    TIGRFAMsi TIGR00803. nst. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Indispensability of transmembrane domains of Golgi UDP-galactose transporter as revealed by analysis of genetic defects in UDP-galactose transporter-deficient murine had-1 mutant cell lines and construction of deletion mutants."
      Ishida N., Yoshioka S., Iida M., Sudo K., Miura N., Aoki K., Kawakita M.
      J. Biochem. 126:1107-1117(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: BALB/c.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Salivary gland.

    Entry informationi

    Entry nameiS35A2_MOUSE
    AccessioniPrimary (citable) accession number: Q9R0M8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 105 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3