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Protein

Ras-related protein Rab-9A

Gene

Rab9a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the transport of proteins between the endosomes and the trans-Golgi network.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi14 – 229GTPBy similarity
Nucleotide bindingi62 – 665GTPBy similarity
Nucleotide bindingi124 – 1274GTPBy similarity
Nucleotide bindingi154 – 1563GTPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-6811440. Retrograde transport at the Trans-Golgi-Network.

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-9A
Alternative name(s):
Sid 99
Gene namesi
Name:Rab9a
Synonyms:Rab9, Sid99
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:1890695. Rab9.

Subcellular locationi

  • Cell membrane By similarity; Lipid-anchor Curated; Cytoplasmic side Curated
  • Endoplasmic reticulum membrane By similarity
  • Golgi apparatus membrane By similarity
  • Late endosome By similarity
  • Cytoplasmic vesiclephagosome membrane By similarity; Lipid-anchor Curated; Cytoplasmic side Curated
  • Cytoplasmic vesiclephagosome By similarity

  • Note: Colocalizes with OSBPL1A at the late endosome. Recruited to phagosomes containing S.aureus or M.tuberculosis.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasmic vesicle, Endoplasmic reticulum, Endosome, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 201200Ras-related protein Rab-9APRO_0000121140Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei34 – 341PhosphoserineCombined sources
Modified residuei179 – 1791PhosphoserineBy similarity
Modified residuei187 – 1871PhosphothreonineBy similarity
Lipidationi200 – 2001S-geranylgeranyl cysteineBy similarity
Lipidationi201 – 2011S-geranylgeranyl cysteineBy similarity

Keywords - PTMi

Acetylation, Lipoprotein, Phosphoprotein, Prenylation

Proteomic databases

EPDiQ9R0M6.
MaxQBiQ9R0M6.
PaxDbiQ9R0M6.
PRIDEiQ9R0M6.

PTM databases

iPTMnetiQ9R0M6.
PhosphoSiteiQ9R0M6.

Expressioni

Gene expression databases

BgeeiQ9R0M6.
CleanExiMM_RAB9.
ExpressionAtlasiQ9R0M6. baseline and differential.
GenevisibleiQ9R0M6. MM.

Interactioni

Subunit structurei

Interacts (preferentially in its GTP-bound form) with GCC2 (via its GRIP domain).By similarity

Protein-protein interaction databases

DIPiDIP-61068N.
IntActiQ9R0M6. 2 interactions.
STRINGi10090.ENSMUSP00000123325.

Structurei

Secondary structure

1
201
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi6 – 138Combined sources
Helixi20 – 2910Combined sources
Beta strandi43 – 6220Combined sources
Helixi67 – 693Combined sources
Helixi70 – 734Combined sources
Helixi74 – 763Combined sources
Turni77 – 793Combined sources
Beta strandi81 – 888Combined sources
Helixi92 – 965Combined sources
Helixi98 – 10912Combined sources
Helixi114 – 1163Combined sources
Beta strandi119 – 1246Combined sources
Helixi135 – 14410Combined sources
Beta strandi150 – 1523Combined sources
Turni155 – 1573Combined sources
Helixi161 – 17313Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1YZLX-ray1.85A2-175[»]
4QXAX-ray2.30A1-199[»]
ProteinModelPortaliQ9R0M6.
SMRiQ9R0M6. Positions 4-175.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9R0M6.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi36 – 449Effector regionBy similarity

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0394. Eukaryota.
ENOG410XNZV. LUCA.
GeneTreeiENSGT00760000119125.
HOVERGENiHBG009351.
InParanoidiQ9R0M6.
KOiK07899.
OMAiKIDINER.
OrthoDBiEOG7G4QG8.
PhylomeDBiQ9R0M6.
TreeFamiTF326442.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9R0M6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGKSSLFKI ILLGDGGVGK SSLMNRYVTN KFDSQLFHTI GVEFLNKDLE
60 70 80 90 100
VDGHFVTMQI WDTAGQERFR SLRTPFYRGS DCCLLTFSVD DSQSFQNLSN
110 120 130 140 150
WKKEFIYYAD VKEPESFPFV ILGNKTDIKE RQVSTEEAQA WCKDNGDYPY
160 170 180 190 200
FETSAKDSTN VAAAFEEAVR RILATEDRSE HLIQTDTVNL HRKPKPNSSC

C
Length:201
Mass (Da):22,910
Last modified:May 1, 2000 - v1
Checksum:i43F490EAA67D2C9A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB027290 mRNA. Translation: BAA84709.1.
AK010710 mRNA. Translation: BAB27135.1.
AK017301 mRNA. Translation: BAB30681.1.
AK032133 mRNA. Translation: BAC27720.1.
BC008160 mRNA. Translation: AAH08160.1.
CCDSiCCDS30527.1.
RefSeqiNP_062747.1. NM_019773.2.
XP_006528985.1. XM_006528922.1.
UniGeneiMm.25306.

Genome annotation databases

EnsembliENSMUST00000112091; ENSMUSP00000123325; ENSMUSG00000079316.
GeneIDi56382.
KEGGimmu:56382.
UCSCiuc009uwu.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB027290 mRNA. Translation: BAA84709.1.
AK010710 mRNA. Translation: BAB27135.1.
AK017301 mRNA. Translation: BAB30681.1.
AK032133 mRNA. Translation: BAC27720.1.
BC008160 mRNA. Translation: AAH08160.1.
CCDSiCCDS30527.1.
RefSeqiNP_062747.1. NM_019773.2.
XP_006528985.1. XM_006528922.1.
UniGeneiMm.25306.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1YZLX-ray1.85A2-175[»]
4QXAX-ray2.30A1-199[»]
ProteinModelPortaliQ9R0M6.
SMRiQ9R0M6. Positions 4-175.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-61068N.
IntActiQ9R0M6. 2 interactions.
STRINGi10090.ENSMUSP00000123325.

PTM databases

iPTMnetiQ9R0M6.
PhosphoSiteiQ9R0M6.

Proteomic databases

EPDiQ9R0M6.
MaxQBiQ9R0M6.
PaxDbiQ9R0M6.
PRIDEiQ9R0M6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000112091; ENSMUSP00000123325; ENSMUSG00000079316.
GeneIDi56382.
KEGGimmu:56382.
UCSCiuc009uwu.2. mouse.

Organism-specific databases

CTDi56382.
MGIiMGI:1890695. Rab9.

Phylogenomic databases

eggNOGiKOG0394. Eukaryota.
ENOG410XNZV. LUCA.
GeneTreeiENSGT00760000119125.
HOVERGENiHBG009351.
InParanoidiQ9R0M6.
KOiK07899.
OMAiKIDINER.
OrthoDBiEOG7G4QG8.
PhylomeDBiQ9R0M6.
TreeFamiTF326442.

Enzyme and pathway databases

ReactomeiR-MMU-6811440. Retrograde transport at the Trans-Golgi-Network.

Miscellaneous databases

EvolutionaryTraceiQ9R0M6.
PROiQ9R0M6.
SOURCEiSearch...

Gene expression databases

BgeeiQ9R0M6.
CleanExiMM_RAB9.
ExpressionAtlasiQ9R0M6. baseline and differential.
GenevisibleiQ9R0M6. MM.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Mouse small GTP binding protein."
    Seki N., Hattori A., Hayashi A., Kozuma S., Muramatsu M., Saito T.
    Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryonic stem cell, Head and Olfactory bulb.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary gland.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-34, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Spleen and Testis.

Entry informationi

Entry nameiRAB9A_MOUSE
AccessioniPrimary (citable) accession number: Q9R0M6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: May 1, 2000
Last modified: July 6, 2016
This is version 132 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.