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Protein

Sushi-repeat-containing protein SRPX

Gene

Srpx

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  • autophagy Source: MGI
  • negative regulation of cell proliferation involved in contact inhibition Source: MGI
  • phagolysosome assembly Source: MGI
  • positive regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: MGI
  • response to endoplasmic reticulum stress Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Sushi-repeat-containing protein SRPX
Alternative name(s):
DRS protein
Gene namesi
Name:Srpx
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:1858306. Srpx.

Subcellular locationi

GO - Cellular componenti

  • autophagosome Source: MGI
  • endoplasmic reticulum Source: MGI
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3030Sequence analysisAdd
BLAST
Chaini31 – 464434Sushi-repeat-containing protein SRPXPRO_0000022417Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi57 ↔ 85PROSITE-ProRule annotation
Disulfide bondi69 ↔ 103PROSITE-ProRule annotation
Disulfide bondi89 ↔ 115PROSITE-ProRule annotation
Disulfide bondi120 ↔ 161PROSITE-ProRule annotation
Disulfide bondi147 ↔ 174PROSITE-ProRule annotation
Disulfide bondi262 ↔ 304PROSITE-ProRule annotation
Disulfide bondi290 ↔ 317PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiQ9R0M3.
PaxDbiQ9R0M3.
PRIDEiQ9R0M3.

PTM databases

PhosphoSiteiQ9R0M3.

Expressioni

Gene expression databases

BgeeiENSMUSG00000090084.
CleanExiMM_SRPX.
ExpressionAtlasiQ9R0M3. baseline and differential.
GenevisibleiQ9R0M3. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000047926.

Structurei

3D structure databases

ProteinModelPortaliQ9R0M3.
SMRiQ9R0M3. Positions 81-355.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini57 – 11761Sushi 1PROSITE-ProRule annotationAdd
BLAST
Domaini118 – 17659Sushi 2PROSITE-ProRule annotationAdd
BLAST
Domaini177 – 25983HYRPROSITE-ProRule annotationAdd
BLAST
Domaini260 – 31960Sushi 3PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 HYR domain.PROSITE-ProRule annotation
Contains 3 Sushi (CCP/SCR) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Sushi

Phylogenomic databases

eggNOGiENOG410IEWW. Eukaryota.
ENOG410XP80. LUCA.
GeneTreeiENSGT00730000110685.
HOGENOMiHOG000232093.
HOVERGENiHBG007217.
InParanoidiQ9R0M3.
OMAiRVRRCGK.
OrthoDBiEOG091G045R.
PhylomeDBiQ9R0M3.
TreeFamiTF336515.

Family and domain databases

InterProiIPR025232. DUF4174.
IPR003410. HYR_dom.
IPR000436. Sushi_SCR_CCP_dom.
[Graphical view]
PfamiPF13778. DUF4174. 1 hit.
PF02494. HYR. 1 hit.
PF00084. Sushi. 3 hits.
[Graphical view]
SMARTiSM00032. CCP. 3 hits.
[Graphical view]
SUPFAMiSSF57535. SSF57535. 3 hits.
PROSITEiPS50825. HYR. 1 hit.
PS50923. SUSHI. 3 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9R0M3-1) [UniParc]FASTAAdd to basket
Also known as: Drs-1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGSPGLRPEL LLPQVLPLLL ALLHVLPSQG FPGSGDSPLE DDGVWYSHSL
60 70 80 90 100
YKDTPWCSPI KVKYGDVYCR APPGGYYKTA LGTRCDIRCR KGYELHGSSQ
110 120 130 140 150
LICQSNKRWS DKVICKQKRC PTLTMPANGG FKCVDGAYFN SRCEYYCSPG
160 170 180 190 200
YTLKGERTVT CMDNKAWSGR PASCVDLEPP RIKCPSVKER IAEPNKLTVR
210 220 230 240 250
VSWESPEGRD TADGILTDVI LKGLPPGSNF PEGDHKIEYT VYDRAENKGT
260 270 280 290 300
CKFRVKVRVR RCGKLNAPEN GYMKCSSDGD NYGATCEFSC IGGYELQGSP
310 320 330 340 350
ARVCQSNLAW SGTEPSCAAM NVNVGVRTAA ALLDQFYEKR RLLIVSTPTA
360 370 380 390 400
RNLLYRLQLG MLQQAQCGLD LRHVTVVELV GVFPTLIGRI RAKIMPPALA
410 420 430 440 450
LQLRLLLRIP LYSFSMVVVD KHGMDKERYV SLVTPMALFN LIDTFPLRKE
460
EMILQAEMGQ TCNV
Length:464
Mass (Da):51,574
Last modified:May 1, 2000 - v1
Checksum:i978C5B8F896B4333
GO
Isoform 2 (identifier: Q9R0M3-2) [UniParc]FASTAAdd to basket
Also known as: Drs-2

The sequence of this isoform differs from the canonical sequence as follows:
     33-117: GSGDSPLEDD...RWSDKVICKQ → E

Show »
Length:380
Mass (Da):42,097
Checksum:i4CB295AF5B712607
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei33 – 11785GSGDS…VICKQ → E in isoform 2. 1 PublicationVSP_014016Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB028049 mRNA. Translation: BAA87328.1.
AB028050 mRNA. Translation: BAA87329.1.
AK034696 mRNA. Translation: BAC28800.1.
BX005236 Genomic DNA. Translation: CAM18749.1.
BX005236 Genomic DNA. Translation: CAM18750.1.
BC022572 mRNA. Translation: AAH22572.1.
CCDSiCCDS30013.1. [Q9R0M3-1]
RefSeqiNP_058607.1. NM_016911.4. [Q9R0M3-1]
UniGeneiMm.1927.

Genome annotation databases

EnsembliENSMUST00000044789; ENSMUSP00000047926; ENSMUSG00000090084. [Q9R0M3-1]
ENSMUST00000115543; ENSMUSP00000111205; ENSMUSG00000090084. [Q9R0M3-2]
GeneIDi51795.
KEGGimmu:51795.
UCSCiuc009sqc.1. mouse. [Q9R0M3-1]
uc012het.1. mouse. [Q9R0M3-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB028049 mRNA. Translation: BAA87328.1.
AB028050 mRNA. Translation: BAA87329.1.
AK034696 mRNA. Translation: BAC28800.1.
BX005236 Genomic DNA. Translation: CAM18749.1.
BX005236 Genomic DNA. Translation: CAM18750.1.
BC022572 mRNA. Translation: AAH22572.1.
CCDSiCCDS30013.1. [Q9R0M3-1]
RefSeqiNP_058607.1. NM_016911.4. [Q9R0M3-1]
UniGeneiMm.1927.

3D structure databases

ProteinModelPortaliQ9R0M3.
SMRiQ9R0M3. Positions 81-355.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000047926.

PTM databases

PhosphoSiteiQ9R0M3.

Proteomic databases

MaxQBiQ9R0M3.
PaxDbiQ9R0M3.
PRIDEiQ9R0M3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000044789; ENSMUSP00000047926; ENSMUSG00000090084. [Q9R0M3-1]
ENSMUST00000115543; ENSMUSP00000111205; ENSMUSG00000090084. [Q9R0M3-2]
GeneIDi51795.
KEGGimmu:51795.
UCSCiuc009sqc.1. mouse. [Q9R0M3-1]
uc012het.1. mouse. [Q9R0M3-2]

Organism-specific databases

CTDi8406.
MGIiMGI:1858306. Srpx.

Phylogenomic databases

eggNOGiENOG410IEWW. Eukaryota.
ENOG410XP80. LUCA.
GeneTreeiENSGT00730000110685.
HOGENOMiHOG000232093.
HOVERGENiHBG007217.
InParanoidiQ9R0M3.
OMAiRVRRCGK.
OrthoDBiEOG091G045R.
PhylomeDBiQ9R0M3.
TreeFamiTF336515.

Miscellaneous databases

PROiQ9R0M3.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000090084.
CleanExiMM_SRPX.
ExpressionAtlasiQ9R0M3. baseline and differential.
GenevisibleiQ9R0M3. MM.

Family and domain databases

InterProiIPR025232. DUF4174.
IPR003410. HYR_dom.
IPR000436. Sushi_SCR_CCP_dom.
[Graphical view]
PfamiPF13778. DUF4174. 1 hit.
PF02494. HYR. 1 hit.
PF00084. Sushi. 3 hits.
[Graphical view]
SMARTiSM00032. CCP. 3 hits.
[Graphical view]
SUPFAMiSSF57535. SSF57535. 3 hits.
PROSITEiPS50825. HYR. 1 hit.
PS50923. SUSHI. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSRPX_MOUSE
AccessioniPrimary (citable) accession number: Q9R0M3
Secondary accession number(s): A2BE46, A2BE47, Q9R0M2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: May 1, 2000
Last modified: September 7, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.