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Q9R0M1 (XCR1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 108. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Chemokine XC receptor 1
Alternative name(s):
Lymphotactin receptor
SCM1 receptor
XC chemokine receptor 1
mXCR1
Gene names
Name:Xcr1
Synonyms:Ccxcr1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length322 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Receptor for chemokines SCYC1 and SCYC2. Subsequently transduces a signal by increasing the intracellular calcium ions level.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 322322Chemokine XC receptor 1
PRO_0000070222

Regions

Topological domain1 – 2727Extracellular Potential
Transmembrane28 – 5528Helical; Name=1; Potential
Topological domain56 – 6510Cytoplasmic Potential
Transmembrane66 – 8520Helical; Name=2; Potential
Topological domain86 – 9813Extracellular Potential
Transmembrane99 – 12022Helical; Name=3; Potential
Topological domain121 – 13717Cytoplasmic Potential
Transmembrane138 – 16225Helical; Name=4; Potential
Topological domain163 – 18523Extracellular Potential
Transmembrane186 – 20419Helical; Name=5; Potential
Topological domain205 – 22016Cytoplasmic Potential
Transmembrane221 – 24323Helical; Name=6; Potential
Topological domain244 – 25916Extracellular Potential
Transmembrane260 – 28324Helical; Name=7; Potential
Topological domain284 – 32239Cytoplasmic Potential

Amino acid modifications

Disulfide bond97 ↔ 170 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9R0M1 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 89A5573BD97A1CA3

FASTA32237,308
        10         20         30         40         50         60 
MESSTAFYDY HDKLSLLCEN NVIFFSTIST IVLYSLVFLL SLVGNSLVLW VLVKYENLES 

        70         80         90        100        110        120 
LTNIFILNLC LSDLMFSCLL PVLISAQWSW FLGDFFCKFF NMIFGISLYS SIFFLTIMTI 

       130        140        150        160        170        180 
HRYLSVVSPI STLGIHTLRC RVLVTSCVWA ASILFSIPDA VFHKVISLNC KYSEHHGFLA 

       190        200        210        220        230        240 
SVYQHNIFFL LSMGIILFCY VQILRTLFRT RSRQRHRTVR LIFTVVVAYF LSWAPYNLTL 

       250        260        270        280        290        300 
FLKTGIIQQS CESLQQLDIA MIICRHLAFS HCCFNPVLYV FVGIKFRRHL KHLFQQVWLC 

       310        320 
RKTSSTVPCS PGTFTYEGPS FY 

« Hide

References

[1]"Molecular cloning of mXCR1, the murine SCM-1/lymphotactin receptor."
Yoshida T., Izawa D., Nakayama T., Nakahara K., Kakizaki M., Imai T., Suzuki R., Miyasaka M., Yoshie O.
FEBS Lett. 458:37-40(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 129/SvJ.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB028459 Genomic DNA. Translation: BAA85419.1.
UniGeneMm.390241.

3D structure databases

ProteinModelPortalQ9R0M1.
SMRQ9R0M1. Positions 1-287.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000077813.

Chemistry

GuidetoPHARMACOLOGY75.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ9R0M1.

Proteomic databases

PRIDEQ9R0M1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000078755; ENSMUSP00000077813; ENSMUSG00000060509.
UCSCuc009sgw.1. mouse.

Organism-specific databases

MGIMGI:1346338. Xcr1.

Phylogenomic databases

eggNOGNOG151106.
GeneTreeENSGT00700000104251.
HOGENOMHOG000234122.
HOVERGENHBG101128.
InParanoidQ9R0M1.
OMARNVAFSH.
OrthoDBEOG7M3J0V.
PhylomeDBQ9R0M1.
TreeFamTF330966.

Gene expression databases

ArrayExpressQ9R0M1.
BgeeQ9R0M1.
CleanExMM_XCR1.
GenevestigatorQ9R0M1.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000355. Chemokine_rcpt.
IPR005393. Chemokine_XCR1.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERPTHR24227. PTHR24227. 1 hit.
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR01568. LYMPHOTACTNR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio13895065.
PROQ9R0M1.
SOURCESearch...

Entry information

Entry nameXCR1_MOUSE
AccessionPrimary (citable) accession number: Q9R0M1
Entry history
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: May 1, 2000
Last modified: April 16, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries