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Q9R0M1

- XCR1_MOUSE

UniProt

Q9R0M1 - XCR1_MOUSE

Protein

Chemokine XC receptor 1

Gene

Xcr1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 112 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Receptor for chemokines SCYC1 and SCYC2. Subsequently transduces a signal by increasing the intracellular calcium ions level.

    GO - Molecular functioni

    1. chemokine receptor activity Source: InterPro

    GO - Biological processi

    1. chemotaxis Source: MGI
    2. release of sequestered calcium ion into cytosol Source: MGI
    3. response to cytokine Source: MGI

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Enzyme and pathway databases

    ReactomeiREACT_207651. G alpha (q) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Chemokine XC receptor 1
    Alternative name(s):
    Lymphotactin receptor
    SCM1 receptor
    XC chemokine receptor 1
    mXCR1
    Gene namesi
    Name:Xcr1
    Synonyms:Ccxcr1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 9

    Organism-specific databases

    MGIiMGI:1346338. Xcr1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 322322Chemokine XC receptor 1PRO_0000070222Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi97 ↔ 170PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PRIDEiQ9R0M1.

    PTM databases

    PhosphoSiteiQ9R0M1.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9R0M1.
    BgeeiQ9R0M1.
    CleanExiMM_XCR1.
    GenevestigatoriQ9R0M1.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000077813.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9R0M1.
    SMRiQ9R0M1. Positions 31-287.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2727ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini56 – 6510CytoplasmicSequence Analysis
    Topological domaini86 – 9813ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini121 – 13717CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini163 – 18523ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini205 – 22016CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini244 – 25916ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini284 – 32239CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei28 – 5528Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei66 – 8520Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei99 – 12022Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei138 – 16225Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei186 – 20419Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei221 – 24323Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei260 – 28324Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG151106.
    GeneTreeiENSGT00700000104251.
    HOGENOMiHOG000234122.
    HOVERGENiHBG101128.
    InParanoidiQ9R0M1.
    OrthoDBiEOG7M3J0V.
    PhylomeDBiQ9R0M1.
    TreeFamiTF330966.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000355. Chemokine_rcpt.
    IPR005393. Chemokine_XCR1.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PANTHERiPTHR24227. PTHR24227. 1 hit.
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR01568. LYMPHOTACTNR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9R0M1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MESSTAFYDY HDKLSLLCEN NVIFFSTIST IVLYSLVFLL SLVGNSLVLW    50
    VLVKYENLES LTNIFILNLC LSDLMFSCLL PVLISAQWSW FLGDFFCKFF 100
    NMIFGISLYS SIFFLTIMTI HRYLSVVSPI STLGIHTLRC RVLVTSCVWA 150
    ASILFSIPDA VFHKVISLNC KYSEHHGFLA SVYQHNIFFL LSMGIILFCY 200
    VQILRTLFRT RSRQRHRTVR LIFTVVVAYF LSWAPYNLTL FLKTGIIQQS 250
    CESLQQLDIA MIICRHLAFS HCCFNPVLYV FVGIKFRRHL KHLFQQVWLC 300
    RKTSSTVPCS PGTFTYEGPS FY 322
    Length:322
    Mass (Da):37,308
    Last modified:May 1, 2000 - v1
    Checksum:i89A5573BD97A1CA3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB028459 Genomic DNA. Translation: BAA85419.1.
    UniGeneiMm.390241.

    Genome annotation databases

    EnsembliENSMUST00000078755; ENSMUSP00000077813; ENSMUSG00000060509.
    UCSCiuc009sgw.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB028459 Genomic DNA. Translation: BAA85419.1 .
    UniGenei Mm.390241.

    3D structure databases

    ProteinModelPortali Q9R0M1.
    SMRi Q9R0M1. Positions 31-287.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000077813.

    Chemistry

    GuidetoPHARMACOLOGYi 75.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q9R0M1.

    Proteomic databases

    PRIDEi Q9R0M1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000078755 ; ENSMUSP00000077813 ; ENSMUSG00000060509 .
    UCSCi uc009sgw.1. mouse.

    Organism-specific databases

    MGIi MGI:1346338. Xcr1.

    Phylogenomic databases

    eggNOGi NOG151106.
    GeneTreei ENSGT00700000104251.
    HOGENOMi HOG000234122.
    HOVERGENi HBG101128.
    InParanoidi Q9R0M1.
    OrthoDBi EOG7M3J0V.
    PhylomeDBi Q9R0M1.
    TreeFami TF330966.

    Enzyme and pathway databases

    Reactomei REACT_207651. G alpha (q) signalling events.

    Miscellaneous databases

    NextBioi 13895065.
    PROi Q9R0M1.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9R0M1.
    Bgeei Q9R0M1.
    CleanExi MM_XCR1.
    Genevestigatori Q9R0M1.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000355. Chemokine_rcpt.
    IPR005393. Chemokine_XCR1.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    PANTHERi PTHR24227. PTHR24227. 1 hit.
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR01568. LYMPHOTACTNR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of mXCR1, the murine SCM-1/lymphotactin receptor."
      Yoshida T., Izawa D., Nakayama T., Nakahara K., Kakizaki M., Imai T., Suzuki R., Miyasaka M., Yoshie O.
      FEBS Lett. 458:37-40(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 129/SvJ.

    Entry informationi

    Entry nameiXCR1_MOUSE
    AccessioniPrimary (citable) accession number: Q9R0M1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 24, 2001
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 112 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3