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Q9R0M1

- XCR1_MOUSE

UniProt

Q9R0M1 - XCR1_MOUSE

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Protein

Chemokine XC receptor 1

Gene

Xcr1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Receptor for chemokines SCYC1 and SCYC2. Subsequently transduces a signal by increasing the intracellular calcium ions level.

GO - Molecular functioni

  1. chemokine receptor activity Source: InterPro

GO - Biological processi

  1. chemotaxis Source: MGI
  2. release of sequestered calcium ion into cytosol Source: MGI
  3. response to cytokine Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_207651. G alpha (q) signalling events.
REACT_230248. Chemokine receptors bind chemokines.

Names & Taxonomyi

Protein namesi
Recommended name:
Chemokine XC receptor 1
Alternative name(s):
Lymphotactin receptor
SCM1 receptor
XC chemokine receptor 1
mXCR1
Gene namesi
Name:Xcr1
Synonyms:Ccxcr1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:1346338. Xcr1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2727ExtracellularSequence AnalysisAdd
BLAST
Transmembranei28 – 5528Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini56 – 6510CytoplasmicSequence Analysis
Transmembranei66 – 8520Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini86 – 9813ExtracellularSequence AnalysisAdd
BLAST
Transmembranei99 – 12022Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini121 – 13717CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei138 – 16225Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini163 – 18523ExtracellularSequence AnalysisAdd
BLAST
Transmembranei186 – 20419Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini205 – 22016CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei221 – 24323Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini244 – 25916ExtracellularSequence AnalysisAdd
BLAST
Transmembranei260 – 28324Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini284 – 32239CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 322322Chemokine XC receptor 1PRO_0000070222Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi97 ↔ 170PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiQ9R0M1.

PTM databases

PhosphoSiteiQ9R0M1.

Expressioni

Gene expression databases

BgeeiQ9R0M1.
CleanExiMM_XCR1.
ExpressionAtlasiQ9R0M1. baseline and differential.
GenevestigatoriQ9R0M1.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000077813.

Structurei

3D structure databases

ProteinModelPortaliQ9R0M1.
SMRiQ9R0M1. Positions 31-287.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG151106.
HOGENOMiHOG000234122.
HOVERGENiHBG101128.
InParanoidiQ9R0M1.
OrthoDBiEOG7M3J0V.
PhylomeDBiQ9R0M1.
TreeFamiTF330966.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000355. Chemokine_rcpt.
IPR005393. Chemokine_XCR1.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24227. PTHR24227. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01568. LYMPHOTACTNR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9R0M1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MESSTAFYDY HDKLSLLCEN NVIFFSTIST IVLYSLVFLL SLVGNSLVLW
60 70 80 90 100
VLVKYENLES LTNIFILNLC LSDLMFSCLL PVLISAQWSW FLGDFFCKFF
110 120 130 140 150
NMIFGISLYS SIFFLTIMTI HRYLSVVSPI STLGIHTLRC RVLVTSCVWA
160 170 180 190 200
ASILFSIPDA VFHKVISLNC KYSEHHGFLA SVYQHNIFFL LSMGIILFCY
210 220 230 240 250
VQILRTLFRT RSRQRHRTVR LIFTVVVAYF LSWAPYNLTL FLKTGIIQQS
260 270 280 290 300
CESLQQLDIA MIICRHLAFS HCCFNPVLYV FVGIKFRRHL KHLFQQVWLC
310 320
RKTSSTVPCS PGTFTYEGPS FY
Length:322
Mass (Da):37,308
Last modified:May 1, 2000 - v1
Checksum:i89A5573BD97A1CA3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB028459 Genomic DNA. Translation: BAA85419.1.
UniGeneiMm.390241.

Genome annotation databases

UCSCiuc009sgw.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB028459 Genomic DNA. Translation: BAA85419.1 .
UniGenei Mm.390241.

3D structure databases

ProteinModelPortali Q9R0M1.
SMRi Q9R0M1. Positions 31-287.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000077813.

Chemistry

GuidetoPHARMACOLOGYi 75.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q9R0M1.

Proteomic databases

PRIDEi Q9R0M1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

UCSCi uc009sgw.1. mouse.

Organism-specific databases

MGIi MGI:1346338. Xcr1.

Phylogenomic databases

eggNOGi NOG151106.
HOGENOMi HOG000234122.
HOVERGENi HBG101128.
InParanoidi Q9R0M1.
OrthoDBi EOG7M3J0V.
PhylomeDBi Q9R0M1.
TreeFami TF330966.

Enzyme and pathway databases

Reactomei REACT_207651. G alpha (q) signalling events.
REACT_230248. Chemokine receptors bind chemokines.

Miscellaneous databases

NextBioi 13895065.
PROi Q9R0M1.
SOURCEi Search...

Gene expression databases

Bgeei Q9R0M1.
CleanExi MM_XCR1.
ExpressionAtlasi Q9R0M1. baseline and differential.
Genevestigatori Q9R0M1.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000355. Chemokine_rcpt.
IPR005393. Chemokine_XCR1.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
PANTHERi PTHR24227. PTHR24227. 1 hit.
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR01568. LYMPHOTACTNR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning of mXCR1, the murine SCM-1/lymphotactin receptor."
    Yoshida T., Izawa D., Nakayama T., Nakahara K., Kakizaki M., Imai T., Suzuki R., Miyasaka M., Yoshie O.
    FEBS Lett. 458:37-40(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/SvJ.

Entry informationi

Entry nameiXCR1_MOUSE
AccessioniPrimary (citable) accession number: Q9R0M1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: May 1, 2000
Last modified: November 26, 2014
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3