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Protein

Chemokine XC receptor 1

Gene

Xcr1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Receptor for chemokines SCYC1 and SCYC2. Subsequently transduces a signal by increasing the intracellular calcium ions level.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_288802. Chemokine receptors bind chemokines.
REACT_347934. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Chemokine XC receptor 1
Alternative name(s):
Lymphotactin receptor
SCM1 receptor
XC chemokine receptor 1
mXCR1
Gene namesi
Name:Xcr1
Synonyms:Ccxcr1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1346338. Xcr1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2727ExtracellularSequence AnalysisAdd
BLAST
Transmembranei28 – 5528Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini56 – 6510CytoplasmicSequence Analysis
Transmembranei66 – 8520Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini86 – 9813ExtracellularSequence AnalysisAdd
BLAST
Transmembranei99 – 12022Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini121 – 13717CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei138 – 16225Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini163 – 18523ExtracellularSequence AnalysisAdd
BLAST
Transmembranei186 – 20419Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini205 – 22016CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei221 – 24323Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini244 – 25916ExtracellularSequence AnalysisAdd
BLAST
Transmembranei260 – 28324Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini284 – 32239CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 322322Chemokine XC receptor 1PRO_0000070222Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi97 ↔ 170PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiQ9R0M1.

PTM databases

PhosphoSiteiQ9R0M1.

Expressioni

Gene expression databases

BgeeiQ9R0M1.
CleanExiMM_XCR1.
ExpressionAtlasiQ9R0M1. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000077813.

Structurei

3D structure databases

ProteinModelPortaliQ9R0M1.
SMRiQ9R0M1. Positions 31-287.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG151106.
HOGENOMiHOG000234122.
HOVERGENiHBG101128.
InParanoidiQ9R0M1.
OrthoDBiEOG7M3J0V.
PhylomeDBiQ9R0M1.
TreeFamiTF330966.

Family and domain databases

InterProiIPR000355. Chemokine_rcpt.
IPR005393. Chemokine_XCR1.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24227. PTHR24227. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01568. LYMPHOTACTNR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9R0M1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESSTAFYDY HDKLSLLCEN NVIFFSTIST IVLYSLVFLL SLVGNSLVLW
60 70 80 90 100
VLVKYENLES LTNIFILNLC LSDLMFSCLL PVLISAQWSW FLGDFFCKFF
110 120 130 140 150
NMIFGISLYS SIFFLTIMTI HRYLSVVSPI STLGIHTLRC RVLVTSCVWA
160 170 180 190 200
ASILFSIPDA VFHKVISLNC KYSEHHGFLA SVYQHNIFFL LSMGIILFCY
210 220 230 240 250
VQILRTLFRT RSRQRHRTVR LIFTVVVAYF LSWAPYNLTL FLKTGIIQQS
260 270 280 290 300
CESLQQLDIA MIICRHLAFS HCCFNPVLYV FVGIKFRRHL KHLFQQVWLC
310 320
RKTSSTVPCS PGTFTYEGPS FY
Length:322
Mass (Da):37,308
Last modified:May 1, 2000 - v1
Checksum:i89A5573BD97A1CA3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB028459 Genomic DNA. Translation: BAA85419.1.
UniGeneiMm.390241.

Genome annotation databases

UCSCiuc009sgw.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB028459 Genomic DNA. Translation: BAA85419.1.
UniGeneiMm.390241.

3D structure databases

ProteinModelPortaliQ9R0M1.
SMRiQ9R0M1. Positions 31-287.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000077813.

Chemistry

GuidetoPHARMACOLOGYi75.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ9R0M1.

Proteomic databases

PRIDEiQ9R0M1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiuc009sgw.1. mouse.

Organism-specific databases

MGIiMGI:1346338. Xcr1.

Phylogenomic databases

eggNOGiNOG151106.
HOGENOMiHOG000234122.
HOVERGENiHBG101128.
InParanoidiQ9R0M1.
OrthoDBiEOG7M3J0V.
PhylomeDBiQ9R0M1.
TreeFamiTF330966.

Enzyme and pathway databases

ReactomeiREACT_288802. Chemokine receptors bind chemokines.
REACT_347934. G alpha (q) signalling events.

Miscellaneous databases

NextBioi13895065.
PROiQ9R0M1.
SOURCEiSearch...

Gene expression databases

BgeeiQ9R0M1.
CleanExiMM_XCR1.
ExpressionAtlasiQ9R0M1. baseline and differential.

Family and domain databases

InterProiIPR000355. Chemokine_rcpt.
IPR005393. Chemokine_XCR1.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24227. PTHR24227. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01568. LYMPHOTACTNR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning of mXCR1, the murine SCM-1/lymphotactin receptor."
    Yoshida T., Izawa D., Nakayama T., Nakahara K., Kakizaki M., Imai T., Suzuki R., Miyasaka M., Yoshie O.
    FEBS Lett. 458:37-40(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/SvJ.

Entry informationi

Entry nameiXCR1_MOUSE
AccessioniPrimary (citable) accession number: Q9R0M1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: May 1, 2000
Last modified: June 24, 2015
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.