Q9R0M1 (XCR1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Chemokine XC receptor 1

Alternative name(s):
Lymphotactin receptor
SCM1 receptor
XC chemokine receptor 1
mXCR1

Gene names

Name:	Xcr1
Synonyms:	Ccxcr1

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	322 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Receptor for chemokines SCYC1 and SCYC2. Subsequently transduces a signal by increasing the intracellular calcium ions level.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	chemokine-mediated signaling pathway Inferred from electronic annotation. Source: GOC chemotaxis Inferred from direct assay Ref.1. Source: MGI release of sequestered calcium ion into cytosol Inferred from direct assay Ref.1. Source: MGI
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	chemokine receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 322	322	Chemokine XC receptor 1		PRO_0000070222
Regions
	Topological domain	1 – 27	27	Extracellular Potential
	Transmembrane	28 – 55	28	Helical; Name=1; Potential
	Topological domain	56 – 65	10	Cytoplasmic Potential
	Transmembrane	66 – 85	20	Helical; Name=2; Potential
	Topological domain	86 – 98	13	Extracellular Potential
	Transmembrane	99 – 120	22	Helical; Name=3; Potential
	Topological domain	121 – 137	17	Cytoplasmic Potential
	Transmembrane	138 – 162	25	Helical; Name=4; Potential
	Topological domain	163 – 185	23	Extracellular Potential
	Transmembrane	186 – 204	19	Helical; Name=5; Potential
	Topological domain	205 – 220	16	Cytoplasmic Potential
	Transmembrane	221 – 243	23	Helical; Name=6; Potential
	Topological domain	244 – 259	16	Extracellular Potential
	Transmembrane	260 – 283	24	Helical; Name=7; Potential
	Topological domain	284 – 322	39	Cytoplasmic Potential
Amino acid modifications
	Disulfide bond	97 ↔ 170		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9R0M1 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 89A5573BD97A1CA3	FASTA	322	37,308
	10 20 30 40 50 60 MESSTAFYDY HDKLSLLCEN NVIFFSTIST IVLYSLVFLL SLVGNSLVLW VLVKYENLES 70 80 90 100 110 120 LTNIFILNLC LSDLMFSCLL PVLISAQWSW FLGDFFCKFF NMIFGISLYS SIFFLTIMTI 130 140 150 160 170 180 HRYLSVVSPI STLGIHTLRC RVLVTSCVWA ASILFSIPDA VFHKVISLNC KYSEHHGFLA 190 200 210 220 230 240 SVYQHNIFFL LSMGIILFCY VQILRTLFRT RSRQRHRTVR LIFTVVVAYF LSWAPYNLTL 250 260 270 280 290 300 FLKTGIIQQS CESLQQLDIA MIICRHLAFS HCCFNPVLYV FVGIKFRRHL KHLFQQVWLC 310 320 RKTSSTVPCS PGTFTYEGPS FY

References

[1]	"Molecular cloning of mXCR1, the murine SCM-1/lymphotactin receptor." Yoshida T., Izawa D., Nakayama T., Nakahara K., Kakizaki M., Imai T., Suzuki R., Miyasaka M., Yoshie O. FEBS Lett. 458:37-40(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 129/SvJ.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB028459 Genomic DNA. Translation: BAA85419.1.
IPI	IPI00127812.
UniGene	Mm.390241.
3D structure databases
ProteinModelPortal	Q9R0M1.
SMR	Q9R0M1. Positions 31-287.
ModBase	Search...
Protein-protein interaction databases
STRING	10090.ENSMUSP00000077813.
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	Q9R0M1.
Proteomic databases
PRIDE	Q9R0M1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000078755; ENSMUSP00000077813; ENSMUSG00000060509.
Organism-specific databases
MGI	MGI:1346338. Xcr1.
Phylogenomic databases
eggNOG	NOG151106.
GeneTree	ENSGT00700000104251.
HOGENOM	HOG000234122.
HOVERGEN	HBG101128.
InParanoid	Q9R0M1.
OMA	APYNLIL.
OrthoDB	EOG4HQDK9.
Gene expression databases
ArrayExpress	Q9R0M1.
Bgee	Q9R0M1.
CleanEx	MM_XCR1.
Genevestigator	Q9R0M1.
GermOnline	ENSMUSG00000060509. Mus musculus.
Family and domain databases
InterPro	IPR005393. Chemokine_XCR1. IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN. PR01568. LYMPHOTACTNR.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	13895065.
SOURCE	Search...

Entry information

Entry name

XCR1_MOUSE

Accession

Primary (citable) accession number: Q9R0M1

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 24, 2001
Last sequence update:	May 1, 2000
Last modified:	May 1, 2013
This is version 98 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program