Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Chemokine XC receptor 1

Gene

Xcr1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for chemokines SCYC1 and SCYC2. Subsequently transduces a signal by increasing the intracellular calcium ions level. Receptor for XCL1/Lymphotactin (Probable).1 Publication

GO - Molecular functioni

GO - Biological processi

  • chemotaxis Source: MGI
  • release of sequestered calcium ion into cytosol Source: MGI
  • response to cytokine Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Chemokine XC receptor 1
Alternative name(s):
Lymphotactin receptor
SCM1 receptor
XC chemokine receptor 1
mXCR1
Gene namesi
Name:Xcr1
Synonyms:Ccxcr1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1346338. Xcr1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 27ExtracellularSequence analysisAdd BLAST27
Transmembranei28 – 55Helical; Name=1Sequence analysisAdd BLAST28
Topological domaini56 – 65CytoplasmicSequence analysis10
Transmembranei66 – 85Helical; Name=2Sequence analysisAdd BLAST20
Topological domaini86 – 98ExtracellularSequence analysisAdd BLAST13
Transmembranei99 – 120Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini121 – 137CytoplasmicSequence analysisAdd BLAST17
Transmembranei138 – 162Helical; Name=4Sequence analysisAdd BLAST25
Topological domaini163 – 185ExtracellularSequence analysisAdd BLAST23
Transmembranei186 – 204Helical; Name=5Sequence analysisAdd BLAST19
Topological domaini205 – 220CytoplasmicSequence analysisAdd BLAST16
Transmembranei221 – 243Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini244 – 259ExtracellularSequence analysisAdd BLAST16
Transmembranei260 – 283Helical; Name=7Sequence analysisAdd BLAST24
Topological domaini284 – 322CytoplasmicSequence analysisAdd BLAST39

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000702221 – 322Chemokine XC receptor 1Add BLAST322

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi97 ↔ 170PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ9R0M1.
PRIDEiQ9R0M1.

PTM databases

PhosphoSitePlusiQ9R0M1.

Expressioni

Tissue specificityi

Expressed by dendritic cells from the thymus, slpeen, subcutaneous lymph nodes and mesenteric lymph nodes.1 Publication

Gene expression databases

BgeeiENSMUSG00000060509.
CleanExiMM_XCR1.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000077813.

Structurei

3D structure databases

ProteinModelPortaliQ9R0M1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHYH. Eukaryota.
ENOG410XUKS. LUCA.
HOGENOMiHOG000234122.
HOVERGENiHBG101128.
InParanoidiQ9R0M1.
PhylomeDBiQ9R0M1.
TreeFamiTF330966.

Family and domain databases

InterProiIPR005393. Chemokine_XCR1.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01568. LYMPHOTACTNR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9R0M1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESSTAFYDY HDKLSLLCEN NVIFFSTIST IVLYSLVFLL SLVGNSLVLW
60 70 80 90 100
VLVKYENLES LTNIFILNLC LSDLMFSCLL PVLISAQWSW FLGDFFCKFF
110 120 130 140 150
NMIFGISLYS SIFFLTIMTI HRYLSVVSPI STLGIHTLRC RVLVTSCVWA
160 170 180 190 200
ASILFSIPDA VFHKVISLNC KYSEHHGFLA SVYQHNIFFL LSMGIILFCY
210 220 230 240 250
VQILRTLFRT RSRQRHRTVR LIFTVVVAYF LSWAPYNLTL FLKTGIIQQS
260 270 280 290 300
CESLQQLDIA MIICRHLAFS HCCFNPVLYV FVGIKFRRHL KHLFQQVWLC
310 320
RKTSSTVPCS PGTFTYEGPS FY
Length:322
Mass (Da):37,308
Last modified:May 1, 2000 - v1
Checksum:i89A5573BD97A1CA3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB028459 Genomic DNA. Translation: BAA85419.1.
UniGeneiMm.390241.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB028459 Genomic DNA. Translation: BAA85419.1.
UniGeneiMm.390241.

3D structure databases

ProteinModelPortaliQ9R0M1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000077813.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiQ9R0M1.

Proteomic databases

PaxDbiQ9R0M1.
PRIDEiQ9R0M1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:1346338. Xcr1.

Phylogenomic databases

eggNOGiENOG410IHYH. Eukaryota.
ENOG410XUKS. LUCA.
HOGENOMiHOG000234122.
HOVERGENiHBG101128.
InParanoidiQ9R0M1.
PhylomeDBiQ9R0M1.
TreeFamiTF330966.

Miscellaneous databases

PROiQ9R0M1.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000060509.
CleanExiMM_XCR1.

Family and domain databases

InterProiIPR005393. Chemokine_XCR1.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01568. LYMPHOTACTNR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiXCR1_MOUSE
AccessioniPrimary (citable) accession number: Q9R0M1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: May 1, 2000
Last modified: November 30, 2016
This is version 131 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.