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Q9R0M1

- XCR1_MOUSE

UniProt

Q9R0M1 - XCR1_MOUSE

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Protein
Chemokine XC receptor 1
Gene
Xcr1, Ccxcr1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Receptor for chemokines SCYC1 and SCYC2. Subsequently transduces a signal by increasing the intracellular calcium ions level.

GO - Molecular functioni

  1. chemokine receptor activity Source: InterPro

GO - Biological processi

  1. chemotaxis Source: MGI
  2. release of sequestered calcium ion into cytosol Source: MGI
  3. response to cytokine Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_207651. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Chemokine XC receptor 1
Alternative name(s):
Lymphotactin receptor
SCM1 receptor
XC chemokine receptor 1
mXCR1
Gene namesi
Name:Xcr1
Synonyms:Ccxcr1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 9

Organism-specific databases

MGIiMGI:1346338. Xcr1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2727Extracellular Reviewed prediction
Add
BLAST
Transmembranei28 – 5528Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini56 – 6510Cytoplasmic Reviewed prediction
Transmembranei66 – 8520Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini86 – 9813Extracellular Reviewed prediction
Add
BLAST
Transmembranei99 – 12022Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini121 – 13717Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei138 – 16225Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini163 – 18523Extracellular Reviewed prediction
Add
BLAST
Transmembranei186 – 20419Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini205 – 22016Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei221 – 24323Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini244 – 25916Extracellular Reviewed prediction
Add
BLAST
Transmembranei260 – 28324Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini284 – 32239Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 322322Chemokine XC receptor 1
PRO_0000070222Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi97 ↔ 170 By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiQ9R0M1.

PTM databases

PhosphoSiteiQ9R0M1.

Expressioni

Gene expression databases

ArrayExpressiQ9R0M1.
BgeeiQ9R0M1.
CleanExiMM_XCR1.
GenevestigatoriQ9R0M1.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000077813.

Structurei

3D structure databases

ProteinModelPortaliQ9R0M1.
SMRiQ9R0M1. Positions 31-287.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG151106.
GeneTreeiENSGT00700000104251.
HOGENOMiHOG000234122.
HOVERGENiHBG101128.
InParanoidiQ9R0M1.
OrthoDBiEOG7M3J0V.
PhylomeDBiQ9R0M1.
TreeFamiTF330966.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000355. Chemokine_rcpt.
IPR005393. Chemokine_XCR1.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24227. PTHR24227. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01568. LYMPHOTACTNR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9R0M1-1 [UniParc]FASTAAdd to Basket

« Hide

MESSTAFYDY HDKLSLLCEN NVIFFSTIST IVLYSLVFLL SLVGNSLVLW    50
VLVKYENLES LTNIFILNLC LSDLMFSCLL PVLISAQWSW FLGDFFCKFF 100
NMIFGISLYS SIFFLTIMTI HRYLSVVSPI STLGIHTLRC RVLVTSCVWA 150
ASILFSIPDA VFHKVISLNC KYSEHHGFLA SVYQHNIFFL LSMGIILFCY 200
VQILRTLFRT RSRQRHRTVR LIFTVVVAYF LSWAPYNLTL FLKTGIIQQS 250
CESLQQLDIA MIICRHLAFS HCCFNPVLYV FVGIKFRRHL KHLFQQVWLC 300
RKTSSTVPCS PGTFTYEGPS FY 322
Length:322
Mass (Da):37,308
Last modified:May 1, 2000 - v1
Checksum:i89A5573BD97A1CA3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB028459 Genomic DNA. Translation: BAA85419.1.
UniGeneiMm.390241.

Genome annotation databases

EnsembliENSMUST00000078755; ENSMUSP00000077813; ENSMUSG00000060509.
UCSCiuc009sgw.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB028459 Genomic DNA. Translation: BAA85419.1 .
UniGenei Mm.390241.

3D structure databases

ProteinModelPortali Q9R0M1.
SMRi Q9R0M1. Positions 31-287.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000077813.

Chemistry

GuidetoPHARMACOLOGYi 75.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q9R0M1.

Proteomic databases

PRIDEi Q9R0M1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000078755 ; ENSMUSP00000077813 ; ENSMUSG00000060509 .
UCSCi uc009sgw.1. mouse.

Organism-specific databases

MGIi MGI:1346338. Xcr1.

Phylogenomic databases

eggNOGi NOG151106.
GeneTreei ENSGT00700000104251.
HOGENOMi HOG000234122.
HOVERGENi HBG101128.
InParanoidi Q9R0M1.
OrthoDBi EOG7M3J0V.
PhylomeDBi Q9R0M1.
TreeFami TF330966.

Enzyme and pathway databases

Reactomei REACT_207651. G alpha (q) signalling events.

Miscellaneous databases

NextBioi 13895065.
PROi Q9R0M1.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9R0M1.
Bgeei Q9R0M1.
CleanExi MM_XCR1.
Genevestigatori Q9R0M1.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000355. Chemokine_rcpt.
IPR005393. Chemokine_XCR1.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
PANTHERi PTHR24227. PTHR24227. 1 hit.
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR01568. LYMPHOTACTNR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning of mXCR1, the murine SCM-1/lymphotactin receptor."
    Yoshida T., Izawa D., Nakayama T., Nakahara K., Kakizaki M., Imai T., Suzuki R., Miyasaka M., Yoshie O.
    FEBS Lett. 458:37-40(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/SvJ.

Entry informationi

Entry nameiXCR1_MOUSE
AccessioniPrimary (citable) accession number: Q9R0M1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: May 1, 2000
Last modified: September 3, 2014
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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