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Protein

Sialomucin core protein 24

Gene

Cd164

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Sialomucin that may play a key role in hematopoiesis. May be involved in cell adhesion (By similarity). Promotes myogenesis by enhancing CXCR4-dependent cell motility. Positively regulates myoblast migration and promotes myoblast fusion into myotubes.By similarity1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion, Myogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Sialomucin core protein 24
Short name:
MUC-24
Alternative name(s):
Endolyn
Multi-glycosylated core protein 24
Short name:
MGC-24
Short name:
MGC-24v
CD_antigen: CD164
Gene namesi
Name:Cd164
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1859568. Cd164.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini24 – 162ExtracellularSequence analysisAdd BLAST139
Transmembranei163 – 183HelicalSequence analysisAdd BLAST21
Topological domaini184 – 197CytoplasmicSequence analysisAdd BLAST14

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endosome, Lysosome, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi193N → G: Increased targeting to the endosomal/lysosomal compartment and reduced myotube formation. 1 Publication1
Mutagenesisi194Y → A: Ineffcient targeting to the endosomal/lysosomal compartment and enhanced myotube formation. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000038334124 – 197Sialomucin core protein 24Add BLAST174

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi26N-linked (GlcNAc...)Sequence analysis1
Glycosylationi33N-linked (GlcNAc...)Sequence analysis1
Glycosylationi69N-linked (GlcNAc...)Sequence analysis1
Glycosylationi75N-linked (GlcNAc...)Sequence analysis1
Glycosylationi87N-linked (GlcNAc...)Sequence analysis1
Glycosylationi98N-linked (GlcNAc...)Sequence analysis1
Glycosylationi103N-linked (GlcNAc...)Sequence analysis1
Glycosylationi120N-linked (GlcNAc...)Sequence analysis1
Glycosylationi146N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

Highly N- and O-glycosylated; contains sialic acid.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9R0L9.
PRIDEiQ9R0L9.

PTM databases

PhosphoSitePlusiQ9R0L9.

Expressioni

Tissue specificityi

Expressed at high levels in the submaxillary gland and kidney, at moderate levels in the brain, heart, lung, liver, intestine, testis, muscle and bone marrow, and at low levels in the pancreas, spleen and thymus.2 Publications

Developmental stagei

During embryogenesis, expression in found in all stages examined, with the highest levels of expression at early stages (E8.5) and moderate levels of expression being found at mid- to late stages of embryogenesis. Expressed during early stages of skeletal muscle development. At embryonic stages E9.5 and E10.5, expressed strongly in the dorsal somite (the structure of origin for skeletal muscle precursors). It is also expressed at later stages of muscle development;.2 Publications

Gene expression databases

BgeeiENSMUSG00000019818.
ExpressionAtlasiQ9R0L9. baseline and differential.
GenevisibleiQ9R0L9. MM.

Interactioni

Subunit structurei

Interacts with CXCR4.1 Publication

Protein-protein interaction databases

IntActiQ9R0L9. 1 interactor.
MINTiMINT-1744078.
STRINGi10090.ENSMUSP00000019962.

Structurei

3D structure databases

ProteinModelPortaliQ9R0L9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni191 – 197Required for endosomal and lysosomal localizationBy similarity7

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi28 – 152Thr-richAdd BLAST125

Sequence similaritiesi

Belongs to the CD164 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J0NP. Eukaryota.
ENOG410XVJX. LUCA.
GeneTreeiENSGT00530000063929.
HOGENOMiHOG000070053.
InParanoidiQ9R0L9.
KOiK06546.
OMAiVSCFNAS.
OrthoDBiEOG091G141K.
PhylomeDBiQ9R0L9.
TreeFamiTF333380.

Family and domain databases

InterProiIPR007947. CD164_MGC24.
[Graphical view]
PANTHERiPTHR11337. PTHR11337. 1 hit.
PfamiPF05283. MGC-24. 1 hit.
[Graphical view]
PRINTSiPR01701. CD164ANTIGEN.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9R0L9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGSSRRLLW AATCLAVLCV SAAQPNITTL APNVTEVPTT TTKVVPTTQM
60 70 80 90 100
PTVLPETCAS FNSCVSCVNA TFTNNITCFW LHCQEANKTY CANEPLSNCS
110 120 130 140 150
QVNRTDLCSV IPPTTPVPTN STAKPTTRPS SPTPTPSVVT SAGTTNTTLT
160 170 180 190
PTSQPERKST FDAASFIGGI VLVLGVQAVI FFLYKFCKSK ERNYHTL
Length:197
Mass (Da):21,059
Last modified:May 1, 2000 - v1
Checksum:i8099FFF978430C91
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti2S → L in BAE26251 (PubMed:16141072).Curated1
Sequence conflicti24 – 25QP → HA in BAA34547 (Ref. 3) Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB028895 mRNA. Translation: BAA78909.1.
AF299345 mRNA. Translation: AAG53910.1.
AF299344 Genomic DNA. Translation: AAG53909.1.
AB014464 mRNA. Translation: BAA34547.1.
AK145131 mRNA. Translation: BAE26251.1.
AK169275 mRNA. Translation: BAE41034.1.
BC005414 mRNA. Translation: AAH05414.1.
CCDSiCCDS23806.1.
RefSeqiNP_058594.1. NM_016898.2.
UniGeneiMm.269815.

Genome annotation databases

EnsembliENSMUST00000019962; ENSMUSP00000019962; ENSMUSG00000019818.
GeneIDi53599.
KEGGimmu:53599.
UCSCiuc007exv.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB028895 mRNA. Translation: BAA78909.1.
AF299345 mRNA. Translation: AAG53910.1.
AF299344 Genomic DNA. Translation: AAG53909.1.
AB014464 mRNA. Translation: BAA34547.1.
AK145131 mRNA. Translation: BAE26251.1.
AK169275 mRNA. Translation: BAE41034.1.
BC005414 mRNA. Translation: AAH05414.1.
CCDSiCCDS23806.1.
RefSeqiNP_058594.1. NM_016898.2.
UniGeneiMm.269815.

3D structure databases

ProteinModelPortaliQ9R0L9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9R0L9. 1 interactor.
MINTiMINT-1744078.
STRINGi10090.ENSMUSP00000019962.

PTM databases

PhosphoSitePlusiQ9R0L9.

Proteomic databases

PaxDbiQ9R0L9.
PRIDEiQ9R0L9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000019962; ENSMUSP00000019962; ENSMUSG00000019818.
GeneIDi53599.
KEGGimmu:53599.
UCSCiuc007exv.1. mouse.

Organism-specific databases

CTDi8763.
MGIiMGI:1859568. Cd164.

Phylogenomic databases

eggNOGiENOG410J0NP. Eukaryota.
ENOG410XVJX. LUCA.
GeneTreeiENSGT00530000063929.
HOGENOMiHOG000070053.
InParanoidiQ9R0L9.
KOiK06546.
OMAiVSCFNAS.
OrthoDBiEOG091G141K.
PhylomeDBiQ9R0L9.
TreeFamiTF333380.

Miscellaneous databases

PROiQ9R0L9.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000019818.
ExpressionAtlasiQ9R0L9. baseline and differential.
GenevisibleiQ9R0L9. MM.

Family and domain databases

InterProiIPR007947. CD164_MGC24.
[Graphical view]
PANTHERiPTHR11337. PTHR11337. 1 hit.
PfamiPF05283. MGC-24. 1 hit.
[Graphical view]
PRINTSiPR01701. CD164ANTIGEN.
ProtoNetiSearch...

Entry informationi

Entry nameiMUC24_MOUSE
AccessioniPrimary (citable) accession number: Q9R0L9
Secondary accession number(s): Q3UM47, Q9Z317
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 1, 2009
Last sequence update: May 1, 2000
Last modified: November 2, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.