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Q9R0L9

- MUC24_MOUSE

UniProt

Q9R0L9 - MUC24_MOUSE

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Protein
Sialomucin core protein 24
Gene
Cd164
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Sialomucin that may play a key role in hematopoiesis. May be involved in cell adhesion By similarity. Promotes myogenesis by enhancing CXCR4-dependent cell motility. Positively regulates myoblast migration and promotes myoblast fusion into myotubes.1 Publication

GO - Molecular functioni

  1. protein binding Source: UniProtKB

GO - Biological processi

  1. cell adhesion Source: MGI
  2. heterophilic cell-cell adhesion Source: MGI
  3. muscle organ development Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Cell adhesion, Myogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Sialomucin core protein 24
Short name:
MUC-24
Alternative name(s):
Endolyn
Multi-glycosylated core protein 24
Short name:
MGC-24
Short name:
MGC-24v
CD_antigen: CD164
Gene namesi
Name:Cd164
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 10

Organism-specific databases

MGIiMGI:1859568. Cd164.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini24 – 162139Extracellular Reviewed prediction
Add
BLAST
Transmembranei163 – 18321Helical; Reviewed prediction
Add
BLAST
Topological domaini184 – 19714Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. endosome membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
  3. lysosomal membrane Source: UniProtKB-SubCell
  4. plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endosome, Lysosome, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi193 – 1931N → G: Increased targeting to the endosomal/lysosomal compartment and reduced myotube formation. 1 Publication
Mutagenesisi194 – 1941Y → A: Ineffcient targeting to the endosomal/lysosomal compartment and enhanced myotube formation. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323 Reviewed prediction
Add
BLAST
Chaini24 – 197174Sialomucin core protein 24
PRO_0000383341Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi26 – 261N-linked (GlcNAc...) Reviewed prediction
Glycosylationi33 – 331N-linked (GlcNAc...) Reviewed prediction
Glycosylationi69 – 691N-linked (GlcNAc...) Reviewed prediction
Glycosylationi75 – 751N-linked (GlcNAc...) Reviewed prediction
Glycosylationi87 – 871N-linked (GlcNAc...) Reviewed prediction
Glycosylationi98 – 981N-linked (GlcNAc...) Reviewed prediction
Glycosylationi103 – 1031N-linked (GlcNAc...) Reviewed prediction
Glycosylationi120 – 1201N-linked (GlcNAc...) Reviewed prediction
Glycosylationi146 – 1461N-linked (GlcNAc...) Reviewed prediction

Post-translational modificationi

Highly N- and O-glycosylated; contains sialic acid By similarity.

Keywords - PTMi

Glycoprotein

Expressioni

Tissue specificityi

Expressed at high levels in the submaxillary gland and kidney, at moderate levels in the brain, heart, lung, liver, intestine, testis, muscle and bone marrow, and at low levels in the pancreas, spleen and thymus.2 Publications

Developmental stagei

During embryogenesis, expression in found in all stages examined, with the highest levels of expression at early stages (E8.5) and moderate levels of expression being found at mid- to late stages of embryogenesis. Expressed during early stages of skeletal muscle development. At embryonic stages E9.5 and E10.5, expressed strongly in the dorsal somite (the structure of origin for skeletal muscle precursors). It is also expressed at later stages of muscle development;.2 Publications

Gene expression databases

BgeeiQ9R0L9.
GenevestigatoriQ9R0L9.

Interactioni

Subunit structurei

Interacts with CXCR4.1 Publication

Protein-protein interaction databases

IntActiQ9R0L9. 1 interaction.
MINTiMINT-1744078.

Structurei

3D structure databases

ProteinModelPortaliQ9R0L9.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni191 – 1977Required for endosomal and lysosomal localization By similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi28 – 152125Thr-rich
Add
BLAST

Sequence similaritiesi

Belongs to the CD164 family.

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG77756.
GeneTreeiENSGT00530000063929.
HOGENOMiHOG000070053.
InParanoidiQ3UM47.
KOiK06546.
OMAiQPGRKST.
OrthoDBiEOG7XDBJ6.
PhylomeDBiQ9R0L9.
TreeFamiTF333380.

Family and domain databases

InterProiIPR007947. CD164_MGC24.
[Graphical view]
PANTHERiPTHR11337. PTHR11337. 1 hit.
PfamiPF05283. MGC-24. 1 hit.
[Graphical view]
PRINTSiPR01701. CD164ANTIGEN.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9R0L9-1 [UniParc]FASTAAdd to Basket

« Hide

MSGSSRRLLW AATCLAVLCV SAAQPNITTL APNVTEVPTT TTKVVPTTQM    50
PTVLPETCAS FNSCVSCVNA TFTNNITCFW LHCQEANKTY CANEPLSNCS 100
QVNRTDLCSV IPPTTPVPTN STAKPTTRPS SPTPTPSVVT SAGTTNTTLT 150
PTSQPERKST FDAASFIGGI VLVLGVQAVI FFLYKFCKSK ERNYHTL 197
Length:197
Mass (Da):21,059
Last modified:May 1, 2000 - v1
Checksum:i8099FFF978430C91
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti2 – 21S → L in BAE26251. 1 Publication
Sequence conflicti24 – 252QP → HA in BAA34547. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB028895 mRNA. Translation: BAA78909.1.
AF299345 mRNA. Translation: AAG53910.1.
AF299344 Genomic DNA. Translation: AAG53909.1.
AB014464 mRNA. Translation: BAA34547.1.
AK145131 mRNA. Translation: BAE26251.1.
AK169275 mRNA. Translation: BAE41034.1.
BC005414 mRNA. Translation: AAH05414.1.
CCDSiCCDS23806.1.
RefSeqiNP_058594.1. NM_016898.2.
UniGeneiMm.269815.

Genome annotation databases

EnsembliENSMUST00000019962; ENSMUSP00000019962; ENSMUSG00000019818.
GeneIDi53599.
KEGGimmu:53599.
UCSCiuc007exv.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB028895 mRNA. Translation: BAA78909.1 .
AF299345 mRNA. Translation: AAG53910.1 .
AF299344 Genomic DNA. Translation: AAG53909.1 .
AB014464 mRNA. Translation: BAA34547.1 .
AK145131 mRNA. Translation: BAE26251.1 .
AK169275 mRNA. Translation: BAE41034.1 .
BC005414 mRNA. Translation: AAH05414.1 .
CCDSi CCDS23806.1.
RefSeqi NP_058594.1. NM_016898.2.
UniGenei Mm.269815.

3D structure databases

ProteinModelPortali Q9R0L9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q9R0L9. 1 interaction.
MINTi MINT-1744078.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000019962 ; ENSMUSP00000019962 ; ENSMUSG00000019818 .
GeneIDi 53599.
KEGGi mmu:53599.
UCSCi uc007exv.1. mouse.

Organism-specific databases

CTDi 8763.
MGIi MGI:1859568. Cd164.

Phylogenomic databases

eggNOGi NOG77756.
GeneTreei ENSGT00530000063929.
HOGENOMi HOG000070053.
InParanoidi Q3UM47.
KOi K06546.
OMAi QPGRKST.
OrthoDBi EOG7XDBJ6.
PhylomeDBi Q9R0L9.
TreeFami TF333380.

Miscellaneous databases

ChiTaRSi CD164. mouse.
NextBioi 310273.
PROi Q9R0L9.
SOURCEi Search...

Gene expression databases

Bgeei Q9R0L9.
Genevestigatori Q9R0L9.

Family and domain databases

InterProi IPR007947. CD164_MGC24.
[Graphical view ]
PANTHERi PTHR11337. PTHR11337. 1 hit.
Pfami PF05283. MGC-24. 1 hit.
[Graphical view ]
PRINTSi PR01701. CD164ANTIGEN.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genomic analysis of a murine cell-surface sialomucin, MGC-24/CD164."
    Kurosawa N., Kanemitsu Y., Matsui T., Shimada K., Ishihama H., Muramatsu T.
    Eur. J. Biochem. 265:466-472(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
  2. "Relationship between novel isoforms, functionally important domains, and subcellular distribution of CD164/endolyn."
    Chan J.Y.-H., Lee-Prudhoe J.E., Jorgensen B., Ihrke G., Doyonnas R., Zannettino A.C.W., Buckle V.J., Ward C.J., Simmons P.J., Watt S.M.
    J. Biol. Chem. 276:2139-2152(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], TISSUE SPECIFICITY.
  3. "Mouse MGC-24v."
    Kurosawa N., Matsui T., Muramatsu T.
    Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: ICR.
    Tissue: Brain.
  4. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary gland.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.
  6. "Regulation of myoblast motility and fusion by the CXCR4-associated sialomucin, CD164."
    Bae G.-U., Gaio U., Yang Y.-J., Lee H.-J., Kang J.-S., Krauss R.S.
    J. Biol. Chem. 283:8301-8309(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH CXCR4, DEVELOPMENTAL STAGE, MUTAGENESIS OF ASN-193 AND TYR-194.

Entry informationi

Entry nameiMUC24_MOUSE
AccessioniPrimary (citable) accession number: Q9R0L9
Secondary accession number(s): Q3UM47, Q9Z317
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 1, 2009
Last sequence update: May 1, 2000
Last modified: July 9, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi