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Q9R0L9

- MUC24_MOUSE

UniProt

Q9R0L9 - MUC24_MOUSE

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Protein

Sialomucin core protein 24

Gene

Cd164

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Sialomucin that may play a key role in hematopoiesis. May be involved in cell adhesion (By similarity). Promotes myogenesis by enhancing CXCR4-dependent cell motility. Positively regulates myoblast migration and promotes myoblast fusion into myotubes.By similarity1 Publication

GO - Biological processi

  1. cell adhesion Source: MGI
  2. heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules Source: MGI
  3. muscle organ development Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Cell adhesion, Myogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Sialomucin core protein 24
Short name:
MUC-24
Alternative name(s):
Endolyn
Multi-glycosylated core protein 24
Short name:
MGC-24
Short name:
MGC-24v
CD_antigen: CD164
Gene namesi
Name:Cd164
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 10

Organism-specific databases

MGIiMGI:1859568. Cd164.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini24 – 162139ExtracellularSequence AnalysisAdd
BLAST
Transmembranei163 – 18321HelicalSequence AnalysisAdd
BLAST
Topological domaini184 – 19714CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. endosome Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
  3. lysosome Source: UniProtKB-KW
  4. plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endosome, Lysosome, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi193 – 1931N → G: Increased targeting to the endosomal/lysosomal compartment and reduced myotube formation. 1 Publication
Mutagenesisi194 – 1941Y → A: Ineffcient targeting to the endosomal/lysosomal compartment and enhanced myotube formation. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence AnalysisAdd
BLAST
Chaini24 – 197174Sialomucin core protein 24PRO_0000383341Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi26 – 261N-linked (GlcNAc...)Sequence Analysis
Glycosylationi33 – 331N-linked (GlcNAc...)Sequence Analysis
Glycosylationi69 – 691N-linked (GlcNAc...)Sequence Analysis
Glycosylationi75 – 751N-linked (GlcNAc...)Sequence Analysis
Glycosylationi87 – 871N-linked (GlcNAc...)Sequence Analysis
Glycosylationi98 – 981N-linked (GlcNAc...)Sequence Analysis
Glycosylationi103 – 1031N-linked (GlcNAc...)Sequence Analysis
Glycosylationi120 – 1201N-linked (GlcNAc...)Sequence Analysis
Glycosylationi146 – 1461N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

Highly N- and O-glycosylated; contains sialic acid.By similarity

Keywords - PTMi

Glycoprotein

Expressioni

Tissue specificityi

Expressed at high levels in the submaxillary gland and kidney, at moderate levels in the brain, heart, lung, liver, intestine, testis, muscle and bone marrow, and at low levels in the pancreas, spleen and thymus.2 Publications

Developmental stagei

During embryogenesis, expression in found in all stages examined, with the highest levels of expression at early stages (E8.5) and moderate levels of expression being found at mid- to late stages of embryogenesis. Expressed during early stages of skeletal muscle development. At embryonic stages E9.5 and E10.5, expressed strongly in the dorsal somite (the structure of origin for skeletal muscle precursors). It is also expressed at later stages of muscle development;.2 Publications

Gene expression databases

BgeeiQ9R0L9.
ExpressionAtlasiQ9R0L9. baseline and differential.
GenevestigatoriQ9R0L9.

Interactioni

Subunit structurei

Interacts with CXCR4.1 Publication

Protein-protein interaction databases

IntActiQ9R0L9. 1 interaction.
MINTiMINT-1744078.

Structurei

3D structure databases

ProteinModelPortaliQ9R0L9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni191 – 1977Required for endosomal and lysosomal localizationBy similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi28 – 152125Thr-richAdd
BLAST

Sequence similaritiesi

Belongs to the CD164 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG77756.
GeneTreeiENSGT00530000063929.
HOGENOMiHOG000070053.
InParanoidiQ9R0L9.
KOiK06546.
OMAiQPGRKST.
OrthoDBiEOG7XDBJ6.
PhylomeDBiQ9R0L9.
TreeFamiTF333380.

Family and domain databases

InterProiIPR007947. CD164_MGC24.
[Graphical view]
PANTHERiPTHR11337. PTHR11337. 1 hit.
PfamiPF05283. MGC-24. 1 hit.
[Graphical view]
PRINTSiPR01701. CD164ANTIGEN.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9R0L9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSGSSRRLLW AATCLAVLCV SAAQPNITTL APNVTEVPTT TTKVVPTTQM
60 70 80 90 100
PTVLPETCAS FNSCVSCVNA TFTNNITCFW LHCQEANKTY CANEPLSNCS
110 120 130 140 150
QVNRTDLCSV IPPTTPVPTN STAKPTTRPS SPTPTPSVVT SAGTTNTTLT
160 170 180 190
PTSQPERKST FDAASFIGGI VLVLGVQAVI FFLYKFCKSK ERNYHTL
Length:197
Mass (Da):21,059
Last modified:May 1, 2000 - v1
Checksum:i8099FFF978430C91
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti2 – 21S → L in BAE26251. (PubMed:16141072)Curated
Sequence conflicti24 – 252QP → HA in BAA34547. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB028895 mRNA. Translation: BAA78909.1.
AF299345 mRNA. Translation: AAG53910.1.
AF299344 Genomic DNA. Translation: AAG53909.1.
AB014464 mRNA. Translation: BAA34547.1.
AK145131 mRNA. Translation: BAE26251.1.
AK169275 mRNA. Translation: BAE41034.1.
BC005414 mRNA. Translation: AAH05414.1.
CCDSiCCDS23806.1.
RefSeqiNP_058594.1. NM_016898.2.
UniGeneiMm.269815.

Genome annotation databases

EnsembliENSMUST00000019962; ENSMUSP00000019962; ENSMUSG00000019818.
GeneIDi53599.
KEGGimmu:53599.
UCSCiuc007exv.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB028895 mRNA. Translation: BAA78909.1 .
AF299345 mRNA. Translation: AAG53910.1 .
AF299344 Genomic DNA. Translation: AAG53909.1 .
AB014464 mRNA. Translation: BAA34547.1 .
AK145131 mRNA. Translation: BAE26251.1 .
AK169275 mRNA. Translation: BAE41034.1 .
BC005414 mRNA. Translation: AAH05414.1 .
CCDSi CCDS23806.1.
RefSeqi NP_058594.1. NM_016898.2.
UniGenei Mm.269815.

3D structure databases

ProteinModelPortali Q9R0L9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q9R0L9. 1 interaction.
MINTi MINT-1744078.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000019962 ; ENSMUSP00000019962 ; ENSMUSG00000019818 .
GeneIDi 53599.
KEGGi mmu:53599.
UCSCi uc007exv.1. mouse.

Organism-specific databases

CTDi 8763.
MGIi MGI:1859568. Cd164.

Phylogenomic databases

eggNOGi NOG77756.
GeneTreei ENSGT00530000063929.
HOGENOMi HOG000070053.
InParanoidi Q9R0L9.
KOi K06546.
OMAi QPGRKST.
OrthoDBi EOG7XDBJ6.
PhylomeDBi Q9R0L9.
TreeFami TF333380.

Miscellaneous databases

NextBioi 310273.
PROi Q9R0L9.
SOURCEi Search...

Gene expression databases

Bgeei Q9R0L9.
ExpressionAtlasi Q9R0L9. baseline and differential.
Genevestigatori Q9R0L9.

Family and domain databases

InterProi IPR007947. CD164_MGC24.
[Graphical view ]
PANTHERi PTHR11337. PTHR11337. 1 hit.
Pfami PF05283. MGC-24. 1 hit.
[Graphical view ]
PRINTSi PR01701. CD164ANTIGEN.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genomic analysis of a murine cell-surface sialomucin, MGC-24/CD164."
    Kurosawa N., Kanemitsu Y., Matsui T., Shimada K., Ishihama H., Muramatsu T.
    Eur. J. Biochem. 265:466-472(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
  2. "Relationship between novel isoforms, functionally important domains, and subcellular distribution of CD164/endolyn."
    Chan J.Y.-H., Lee-Prudhoe J.E., Jorgensen B., Ihrke G., Doyonnas R., Zannettino A.C.W., Buckle V.J., Ward C.J., Simmons P.J., Watt S.M.
    J. Biol. Chem. 276:2139-2152(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], TISSUE SPECIFICITY.
  3. "Mouse MGC-24v."
    Kurosawa N., Matsui T., Muramatsu T.
    Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: ICR.
    Tissue: Brain.
  4. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary gland.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.
  6. "Regulation of myoblast motility and fusion by the CXCR4-associated sialomucin, CD164."
    Bae G.-U., Gaio U., Yang Y.-J., Lee H.-J., Kang J.-S., Krauss R.S.
    J. Biol. Chem. 283:8301-8309(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH CXCR4, DEVELOPMENTAL STAGE, MUTAGENESIS OF ASN-193 AND TYR-194.

Entry informationi

Entry nameiMUC24_MOUSE
AccessioniPrimary (citable) accession number: Q9R0L9
Secondary accession number(s): Q3UM47, Q9Z317
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 1, 2009
Last sequence update: May 1, 2000
Last modified: November 26, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3