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Q9R0L9

- MUC24_MOUSE

UniProt

Q9R0L9 - MUC24_MOUSE

Protein

Sialomucin core protein 24

Gene

Cd164

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Sialomucin that may play a key role in hematopoiesis. May be involved in cell adhesion By similarity. Promotes myogenesis by enhancing CXCR4-dependent cell motility. Positively regulates myoblast migration and promotes myoblast fusion into myotubes.By similarity1 Publication

    GO - Molecular functioni

    1. protein binding Source: UniProtKB

    GO - Biological processi

    1. cell adhesion Source: MGI
    2. heterophilic cell-cell adhesion Source: MGI
    3. muscle organ development Source: UniProtKB-KW

    Keywords - Biological processi

    Cell adhesion, Myogenesis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sialomucin core protein 24
    Short name:
    MUC-24
    Alternative name(s):
    Endolyn
    Multi-glycosylated core protein 24
    Short name:
    MGC-24
    Short name:
    MGC-24v
    CD_antigen: CD164
    Gene namesi
    Name:Cd164
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 10

    Organism-specific databases

    MGIiMGI:1859568. Cd164.

    Subcellular locationi

    GO - Cellular componenti

    1. endosome membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW
    3. lysosomal membrane Source: UniProtKB-SubCell
    4. plasma membrane Source: MGI

    Keywords - Cellular componenti

    Cell membrane, Endosome, Lysosome, Membrane

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi193 – 1931N → G: Increased targeting to the endosomal/lysosomal compartment and reduced myotube formation. 1 Publication
    Mutagenesisi194 – 1941Y → A: Ineffcient targeting to the endosomal/lysosomal compartment and enhanced myotube formation. 1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Chaini24 – 197174Sialomucin core protein 24PRO_0000383341Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi26 – 261N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi33 – 331N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi69 – 691N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi75 – 751N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi87 – 871N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi98 – 981N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi103 – 1031N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi120 – 1201N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi146 – 1461N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    Highly N- and O-glycosylated; contains sialic acid.By similarity

    Keywords - PTMi

    Glycoprotein

    Expressioni

    Tissue specificityi

    Expressed at high levels in the submaxillary gland and kidney, at moderate levels in the brain, heart, lung, liver, intestine, testis, muscle and bone marrow, and at low levels in the pancreas, spleen and thymus.2 Publications

    Developmental stagei

    During embryogenesis, expression in found in all stages examined, with the highest levels of expression at early stages (E8.5) and moderate levels of expression being found at mid- to late stages of embryogenesis. Expressed during early stages of skeletal muscle development. At embryonic stages E9.5 and E10.5, expressed strongly in the dorsal somite (the structure of origin for skeletal muscle precursors). It is also expressed at later stages of muscle development;.2 Publications

    Gene expression databases

    BgeeiQ9R0L9.
    GenevestigatoriQ9R0L9.

    Interactioni

    Subunit structurei

    Interacts with CXCR4.1 Publication

    Protein-protein interaction databases

    IntActiQ9R0L9. 1 interaction.
    MINTiMINT-1744078.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9R0L9.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini24 – 162139ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini184 – 19714CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei163 – 18321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni191 – 1977Required for endosomal and lysosomal localizationBy similarity

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi28 – 152125Thr-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the CD164 family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG77756.
    GeneTreeiENSGT00530000063929.
    HOGENOMiHOG000070053.
    InParanoidiQ3UM47.
    KOiK06546.
    OMAiQPGRKST.
    OrthoDBiEOG7XDBJ6.
    PhylomeDBiQ9R0L9.
    TreeFamiTF333380.

    Family and domain databases

    InterProiIPR007947. CD164_MGC24.
    [Graphical view]
    PANTHERiPTHR11337. PTHR11337. 1 hit.
    PfamiPF05283. MGC-24. 1 hit.
    [Graphical view]
    PRINTSiPR01701. CD164ANTIGEN.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9R0L9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSGSSRRLLW AATCLAVLCV SAAQPNITTL APNVTEVPTT TTKVVPTTQM    50
    PTVLPETCAS FNSCVSCVNA TFTNNITCFW LHCQEANKTY CANEPLSNCS 100
    QVNRTDLCSV IPPTTPVPTN STAKPTTRPS SPTPTPSVVT SAGTTNTTLT 150
    PTSQPERKST FDAASFIGGI VLVLGVQAVI FFLYKFCKSK ERNYHTL 197
    Length:197
    Mass (Da):21,059
    Last modified:May 1, 2000 - v1
    Checksum:i8099FFF978430C91
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti2 – 21S → L in BAE26251. (PubMed:16141072)Curated
    Sequence conflicti24 – 252QP → HA in BAA34547. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB028895 mRNA. Translation: BAA78909.1.
    AF299345 mRNA. Translation: AAG53910.1.
    AF299344 Genomic DNA. Translation: AAG53909.1.
    AB014464 mRNA. Translation: BAA34547.1.
    AK145131 mRNA. Translation: BAE26251.1.
    AK169275 mRNA. Translation: BAE41034.1.
    BC005414 mRNA. Translation: AAH05414.1.
    CCDSiCCDS23806.1.
    RefSeqiNP_058594.1. NM_016898.2.
    UniGeneiMm.269815.

    Genome annotation databases

    EnsembliENSMUST00000019962; ENSMUSP00000019962; ENSMUSG00000019818.
    GeneIDi53599.
    KEGGimmu:53599.
    UCSCiuc007exv.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB028895 mRNA. Translation: BAA78909.1 .
    AF299345 mRNA. Translation: AAG53910.1 .
    AF299344 Genomic DNA. Translation: AAG53909.1 .
    AB014464 mRNA. Translation: BAA34547.1 .
    AK145131 mRNA. Translation: BAE26251.1 .
    AK169275 mRNA. Translation: BAE41034.1 .
    BC005414 mRNA. Translation: AAH05414.1 .
    CCDSi CCDS23806.1.
    RefSeqi NP_058594.1. NM_016898.2.
    UniGenei Mm.269815.

    3D structure databases

    ProteinModelPortali Q9R0L9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q9R0L9. 1 interaction.
    MINTi MINT-1744078.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000019962 ; ENSMUSP00000019962 ; ENSMUSG00000019818 .
    GeneIDi 53599.
    KEGGi mmu:53599.
    UCSCi uc007exv.1. mouse.

    Organism-specific databases

    CTDi 8763.
    MGIi MGI:1859568. Cd164.

    Phylogenomic databases

    eggNOGi NOG77756.
    GeneTreei ENSGT00530000063929.
    HOGENOMi HOG000070053.
    InParanoidi Q3UM47.
    KOi K06546.
    OMAi QPGRKST.
    OrthoDBi EOG7XDBJ6.
    PhylomeDBi Q9R0L9.
    TreeFami TF333380.

    Miscellaneous databases

    ChiTaRSi CD164. mouse.
    NextBioi 310273.
    PROi Q9R0L9.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9R0L9.
    Genevestigatori Q9R0L9.

    Family and domain databases

    InterProi IPR007947. CD164_MGC24.
    [Graphical view ]
    PANTHERi PTHR11337. PTHR11337. 1 hit.
    Pfami PF05283. MGC-24. 1 hit.
    [Graphical view ]
    PRINTSi PR01701. CD164ANTIGEN.
    ProtoNeti Search...

    Publicationsi

    1. "Genomic analysis of a murine cell-surface sialomucin, MGC-24/CD164."
      Kurosawa N., Kanemitsu Y., Matsui T., Shimada K., Ishihama H., Muramatsu T.
      Eur. J. Biochem. 265:466-472(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    2. "Relationship between novel isoforms, functionally important domains, and subcellular distribution of CD164/endolyn."
      Chan J.Y.-H., Lee-Prudhoe J.E., Jorgensen B., Ihrke G., Doyonnas R., Zannettino A.C.W., Buckle V.J., Ward C.J., Simmons P.J., Watt S.M.
      J. Biol. Chem. 276:2139-2152(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], TISSUE SPECIFICITY.
    3. "Mouse MGC-24v."
      Kurosawa N., Matsui T., Muramatsu T.
      Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: ICR.
      Tissue: Brain.
    4. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Mammary gland.
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Mammary tumor.
    6. "Regulation of myoblast motility and fusion by the CXCR4-associated sialomucin, CD164."
      Bae G.-U., Gaio U., Yang Y.-J., Lee H.-J., Kang J.-S., Krauss R.S.
      J. Biol. Chem. 283:8301-8309(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH CXCR4, DEVELOPMENTAL STAGE, MUTAGENESIS OF ASN-193 AND TYR-194.

    Entry informationi

    Entry nameiMUC24_MOUSE
    AccessioniPrimary (citable) accession number: Q9R0L9
    Secondary accession number(s): Q3UM47, Q9Z317
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 1, 2009
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 90 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3