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Q9R0L9 (MUC24_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Sialomucin core protein 24

Short name=MUC-24
Alternative name(s):
Endolyn
Multi-glycosylated core protein 24
Short name=MGC-24
Short name=MGC-24v
CD_antigen=CD164
Gene names
Name:Cd164
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length197 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Sialomucin that may play a key role in hematopoiesis. May be involved in cell adhesion By similarity. Promotes myogenesis by enhancing CXCR4-dependent cell motility. Positively regulates myoblast migration and promotes myoblast fusion into myotubes. Ref.6

Subunit structure

Interacts with CXCR4. Ref.6

Subcellular location

Lysosome membrane; Single-pass type I membrane protein Potential. Endosome membrane; Single-pass type I membrane protein By similarity. Cell membrane; Single-pass type I membrane protein By similarity.

Tissue specificity

Expressed at high levels in the submaxillary gland and kidney, at moderate levels in the brain, heart, lung, liver, intestine, testis, muscle and bone marrow, and at low levels in the pancreas, spleen and thymus. Ref.1 Ref.2

Developmental stage

During embryogenesis, expression in found in all stages examined, with the highest levels of expression at early stages (E8.5) and moderate levels of expression being found at mid- to late stages of embryogenesis. Expressed during early stages of skeletal muscle development. At embryonic stages E9.5 and E10.5, expressed strongly in the dorsal somite (the structure of origin for skeletal muscle precursors). It is also expressed at later stages of muscle development;. Ref.1 Ref.6

Post-translational modification

Highly N- and O-glycosylated; contains sialic acid By similarity.

Sequence similarities

Belongs to the CD164 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Potential
Chain24 – 197174Sialomucin core protein 24
PRO_0000383341

Regions

Topological domain24 – 162139Extracellular Potential
Transmembrane163 – 18321Helical; Potential
Topological domain184 – 19714Cytoplasmic Potential
Region191 – 1977Required for endosomal and lysosomal localization By similarity
Compositional bias28 – 152125Thr-rich

Amino acid modifications

Glycosylation261N-linked (GlcNAc...) Potential
Glycosylation331N-linked (GlcNAc...) Potential
Glycosylation691N-linked (GlcNAc...) Potential
Glycosylation751N-linked (GlcNAc...) Potential
Glycosylation871N-linked (GlcNAc...) Potential
Glycosylation981N-linked (GlcNAc...) Potential
Glycosylation1031N-linked (GlcNAc...) Potential
Glycosylation1201N-linked (GlcNAc...) Potential
Glycosylation1461N-linked (GlcNAc...) Potential

Experimental info

Mutagenesis1931N → G: Increased targeting to the endosomal/lysosomal compartment and reduced myotube formation. Ref.6
Mutagenesis1941Y → A: Ineffcient targeting to the endosomal/lysosomal compartment and enhanced myotube formation. Ref.6
Sequence conflict21S → L in BAE26251. Ref.4
Sequence conflict24 – 252QP → HA in BAA34547. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q9R0L9 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 8099FFF978430C91

FASTA19721,059
        10         20         30         40         50         60 
MSGSSRRLLW AATCLAVLCV SAAQPNITTL APNVTEVPTT TTKVVPTTQM PTVLPETCAS 

        70         80         90        100        110        120 
FNSCVSCVNA TFTNNITCFW LHCQEANKTY CANEPLSNCS QVNRTDLCSV IPPTTPVPTN 

       130        140        150        160        170        180 
STAKPTTRPS SPTPTPSVVT SAGTTNTTLT PTSQPERKST FDAASFIGGI VLVLGVQAVI 

       190 
FFLYKFCKSK ERNYHTL 

« Hide

References

« Hide 'large scale' references
[1]"Genomic analysis of a murine cell-surface sialomucin, MGC-24/CD164."
Kurosawa N., Kanemitsu Y., Matsui T., Shimada K., Ishihama H., Muramatsu T.
Eur. J. Biochem. 265:466-472(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
[2]"Relationship between novel isoforms, functionally important domains, and subcellular distribution of CD164/endolyn."
Chan J.Y.-H., Lee-Prudhoe J.E., Jorgensen B., Ihrke G., Doyonnas R., Zannettino A.C.W., Buckle V.J., Ward C.J., Simmons P.J., Watt S.M.
J. Biol. Chem. 276:2139-2152(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], TISSUE SPECIFICITY.
[3]"Mouse MGC-24v."
Kurosawa N., Matsui T., Muramatsu T.
Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: ICR.
Tissue: Brain.
[4]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Mammary gland.
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Mammary tumor.
[6]"Regulation of myoblast motility and fusion by the CXCR4-associated sialomucin, CD164."
Bae G.-U., Gaio U., Yang Y.-J., Lee H.-J., Kang J.-S., Krauss R.S.
J. Biol. Chem. 283:8301-8309(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH CXCR4, DEVELOPMENTAL STAGE, MUTAGENESIS OF ASN-193 AND TYR-194.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB028895 mRNA. Translation: BAA78909.1.
AF299345 mRNA. Translation: AAG53910.1.
AF299344 Genomic DNA. Translation: AAG53909.1.
AB014464 mRNA. Translation: BAA34547.1.
AK145131 mRNA. Translation: BAE26251.1.
AK169275 mRNA. Translation: BAE41034.1.
BC005414 mRNA. Translation: AAH05414.1.
CCDSCCDS23806.1.
RefSeqNP_058594.1. NM_016898.2.
UniGeneMm.269815.

3D structure databases

ProteinModelPortalQ9R0L9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ9R0L9. 1 interaction.
MINTMINT-1744078.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000019962; ENSMUSP00000019962; ENSMUSG00000019818.
GeneID53599.
KEGGmmu:53599.
UCSCuc007exv.1. mouse.

Organism-specific databases

CTD8763.
MGIMGI:1859568. Cd164.

Phylogenomic databases

eggNOGNOG77756.
GeneTreeENSGT00530000063929.
HOGENOMHOG000070053.
InParanoidQ3UM47.
KOK06546.
OMAQPGRKST.
OrthoDBEOG7XDBJ6.
PhylomeDBQ9R0L9.
TreeFamTF333380.

Gene expression databases

BgeeQ9R0L9.
GenevestigatorQ9R0L9.

Family and domain databases

InterProIPR007947. CD164_MGC24.
[Graphical view]
PANTHERPTHR11337. PTHR11337. 1 hit.
PfamPF05283. MGC-24. 1 hit.
[Graphical view]
PRINTSPR01701. CD164ANTIGEN.
ProtoNetSearch...

Other

ChiTaRSCD164. mouse.
NextBio310273.
PROQ9R0L9.
SOURCESearch...

Entry information

Entry nameMUC24_MOUSE
AccessionPrimary (citable) accession number: Q9R0L9
Secondary accession number(s): Q3UM47, Q9Z317
Entry history
Integrated into UniProtKB/Swiss-Prot: September 1, 2009
Last sequence update: May 1, 2000
Last modified: July 9, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot