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Protein

Stanniocalcin-2

Gene

Stc2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Has an anti-hypocalcemic action on calcium and phosphate homeostasis.

GO - Molecular functioni

GO - Biological processi

  • cellular calcium ion homeostasis Source: MGI
  • cellular response to hypoxia Source: RGD
  • decidualization Source: RGD
  • embryo implantation Source: RGD
  • endoplasmic reticulum unfolded protein response Source: Ensembl
  • negative regulation of gene expression Source: Ensembl
  • negative regulation of multicellular organism growth Source: Ensembl
  • regulation of hormone biosynthetic process Source: Ensembl
  • regulation of store-operated calcium entry Source: Ensembl
  • response to oxidative stress Source: Ensembl
  • response to peptide hormone Source: RGD
  • response to vitamin D Source: RGD

Keywordsi

Molecular functionHormone

Enzyme and pathway databases

ReactomeiR-RNO-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-RNO-8957275 Post-translational protein phosphorylation

Names & Taxonomyi

Protein namesi
Recommended name:
Stanniocalcin-2
Short name:
STC-2
Gene namesi
Name:Stc2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi

Organism-specific databases

RGDi621777 Stc2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000003330725 – 296Stanniocalcin-2Add BLAST272

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi73N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9R0K8
PRIDEiQ9R0K8

Expressioni

Tissue specificityi

Expressed in a variety of tissues. Strongly expressed in ovary and to a lesser extent in kidney.

Gene expression databases

BgeeiENSRNOG00000020729
GenevisibleiQ9R0K8 RN

Interactioni

Subunit structurei

Homodimer; disulfide-linked.By similarity

GO - Molecular functioni

Family & Domainsi

Sequence similaritiesi

Belongs to the stanniocalcin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IIGP Eukaryota
ENOG410XT17 LUCA
GeneTreeiENSGT00390000005989
HOGENOMiHOG000220830
HOVERGENiHBG001048
InParanoidiQ9R0K8
OMAiMCAERLG
OrthoDBiEOG091G0HC1
PhylomeDBiQ9R0K8
TreeFamiTF324693

Family and domain databases

InterProiView protein in InterPro
IPR004978 Stanniocalcin
PANTHERiPTHR11245 PTHR11245, 1 hit
PfamiView protein in Pfam
PF03298 Stanniocalcin, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9R0K8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCAERLGQFV TLALVFATLD PARGTDSTNP PEGPQDRGSQ QKGRLSLQNT
60 70 80 90 100
AEIQHCLVNA GDVGCGVFEC FENNSCEIQG LHGICMTFLH NAGKFDAQGK
110 120 130 140 150
SFIKDALRCK AHALRHKFGC ISRKCPAIRE MVYQLQRECY LKHDLCSAAQ
160 170 180 190 200
ENVVVIVEMI HFKDLLLHEP YVDLVNLLLT CGEDVREAVT RSVQAQCEQS
210 220 230 240 250
WGGLCSILSF CTSNIQRPPT AAPEHQPLAD RAQLSRPYHR DTDHHLTANR
260 270 280 290
GAKGERGSKS HLHAHARGGA GGQSAQGPSG SSEWEDEQSE YSDIRR
Length:296
Mass (Da):32,622
Last modified:May 1, 2000 - v1
Checksum:i0903639858D9B2DC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB030707 mRNA Translation: BAA85251.1
RefSeqiNP_071566.1, NM_022230.2
UniGeneiRn.44823

Genome annotation databases

EnsembliENSRNOT00000028146; ENSRNOP00000028146; ENSRNOG00000020729
GeneIDi63878
KEGGirno:63878
UCSCiRGD:621777 rat

Similar proteinsi

Entry informationi

Entry nameiSTC2_RAT
AccessioniPrimary (citable) accession number: Q9R0K8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: May 23, 2018
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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