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Q9R0K8

- STC2_RAT

UniProt

Q9R0K8 - STC2_RAT

Protein

Stanniocalcin-2

Gene

Stc2

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Has an anti-hypocalcemic action on calcium and phosphate homeostasis.

    GO - Biological processi

    1. cellular calcium ion homeostasis Source: MGI
    2. cellular response to hypoxia Source: RGD
    3. decidualization Source: RGD
    4. embryo implantation Source: RGD
    5. endoplasmic reticulum unfolded protein response Source: Ensembl
    6. negative regulation of multicellular organism growth Source: Ensembl
    7. regulation of store-operated calcium entry Source: Ensembl
    8. response to oxidative stress Source: Ensembl
    9. response to peptide hormone Source: RGD
    10. response to vitamin D Source: RGD

    Keywords - Molecular functioni

    Hormone

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Stanniocalcin-2
    Short name:
    STC-2
    Gene namesi
    Name:Stc2
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 10

    Organism-specific databases

    RGDi621777. Stc2.

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. endoplasmic reticulum Source: Ensembl
    2. extracellular region Source: UniProtKB-SubCell
    3. Golgi apparatus Source: Ensembl

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2424Sequence AnalysisAdd
    BLAST
    Chaini25 – 296272Stanniocalcin-2PRO_0000033307Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi73 – 731N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiQ9R0K8.

    Expressioni

    Tissue specificityi

    Expressed in a variety of tissues. Strongly expressed in ovary and to a lesser extent in kidney.

    Gene expression databases

    GenevestigatoriQ9R0K8.

    Interactioni

    Subunit structurei

    Homodimer; disulfide-linked.By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000028146.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the stanniocalcin family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG44223.
    GeneTreeiENSGT00390000005989.
    HOGENOMiHOG000220830.
    HOVERGENiHBG001048.
    InParanoidiQ9R0K8.
    OMAiFCTSAIQ.
    OrthoDBiEOG76T9S0.
    PhylomeDBiQ9R0K8.
    TreeFamiTF324693.

    Family and domain databases

    InterProiIPR004978. Stanniocalcin.
    [Graphical view]
    PANTHERiPTHR11245. PTHR11245. 1 hit.
    PfamiPF03298. Stanniocalcin. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9R0K8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MCAERLGQFV TLALVFATLD PARGTDSTNP PEGPQDRGSQ QKGRLSLQNT    50
    AEIQHCLVNA GDVGCGVFEC FENNSCEIQG LHGICMTFLH NAGKFDAQGK 100
    SFIKDALRCK AHALRHKFGC ISRKCPAIRE MVYQLQRECY LKHDLCSAAQ 150
    ENVVVIVEMI HFKDLLLHEP YVDLVNLLLT CGEDVREAVT RSVQAQCEQS 200
    WGGLCSILSF CTSNIQRPPT AAPEHQPLAD RAQLSRPYHR DTDHHLTANR 250
    GAKGERGSKS HLHAHARGGA GGQSAQGPSG SSEWEDEQSE YSDIRR 296
    Length:296
    Mass (Da):32,622
    Last modified:May 1, 2000 - v1
    Checksum:i0903639858D9B2DC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB030707 mRNA. Translation: BAA85251.1.
    RefSeqiNP_071566.1. NM_022230.2.
    UniGeneiRn.44823.

    Genome annotation databases

    EnsembliENSRNOT00000028146; ENSRNOP00000028146; ENSRNOG00000020729.
    GeneIDi63878.
    KEGGirno:63878.
    UCSCiRGD:621777. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB030707 mRNA. Translation: BAA85251.1 .
    RefSeqi NP_071566.1. NM_022230.2.
    UniGenei Rn.44823.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000028146.

    Proteomic databases

    PRIDEi Q9R0K8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000028146 ; ENSRNOP00000028146 ; ENSRNOG00000020729 .
    GeneIDi 63878.
    KEGGi rno:63878.
    UCSCi RGD:621777. rat.

    Organism-specific databases

    CTDi 8614.
    RGDi 621777. Stc2.

    Phylogenomic databases

    eggNOGi NOG44223.
    GeneTreei ENSGT00390000005989.
    HOGENOMi HOG000220830.
    HOVERGENi HBG001048.
    InParanoidi Q9R0K8.
    OMAi FCTSAIQ.
    OrthoDBi EOG76T9S0.
    PhylomeDBi Q9R0K8.
    TreeFami TF324693.

    Miscellaneous databases

    NextBioi 612492.
    PROi Q9R0K8.

    Gene expression databases

    Genevestigatori Q9R0K8.

    Family and domain databases

    InterProi IPR004978. Stanniocalcin.
    [Graphical view ]
    PANTHERi PTHR11245. PTHR11245. 1 hit.
    Pfami PF03298. Stanniocalcin. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Regulation by 1alpha,25-dihydroxyvitamin D(3) of expression of stanniocalcin messages in the rat kidney and ovary."
      Honda S., Kashiwagi M., Ookata K., Tojo A., Hirose S.
      FEBS Lett. 459:119-122(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Sprague-Dawley.

    Entry informationi

    Entry nameiSTC2_RAT
    AccessioniPrimary (citable) accession number: Q9R0K8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 80 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3