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Q9R0K8

- STC2_RAT

UniProt

Q9R0K8 - STC2_RAT

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Protein

Stanniocalcin-2

Gene

Stc2

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Has an anti-hypocalcemic action on calcium and phosphate homeostasis.

GO - Biological processi

  1. cellular calcium ion homeostasis Source: MGI
  2. cellular response to hypoxia Source: RGD
  3. decidualization Source: RGD
  4. embryo implantation Source: RGD
  5. endoplasmic reticulum unfolded protein response Source: Ensembl
  6. negative regulation of multicellular organism growth Source: Ensembl
  7. regulation of store-operated calcium entry Source: Ensembl
  8. response to oxidative stress Source: Ensembl
  9. response to peptide hormone Source: RGD
  10. response to vitamin D Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Hormone

Names & Taxonomyi

Protein namesi
Recommended name:
Stanniocalcin-2
Short name:
STC-2
Gene namesi
Name:Stc2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 10

Organism-specific databases

RGDi621777. Stc2.

Subcellular locationi

Secreted Curated

GO - Cellular componenti

  1. endoplasmic reticulum Source: Ensembl
  2. extracellular space Source: Ensembl
  3. Golgi apparatus Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence AnalysisAdd
BLAST
Chaini25 – 296272Stanniocalcin-2PRO_0000033307Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi73 – 731N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ9R0K8.

Expressioni

Tissue specificityi

Expressed in a variety of tissues. Strongly expressed in ovary and to a lesser extent in kidney.

Gene expression databases

GenevestigatoriQ9R0K8.

Interactioni

Subunit structurei

Homodimer; disulfide-linked.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028146.

Family & Domainsi

Sequence similaritiesi

Belongs to the stanniocalcin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG44223.
GeneTreeiENSGT00390000005989.
HOGENOMiHOG000220830.
HOVERGENiHBG001048.
InParanoidiQ9R0K8.
OMAiFCTSAIQ.
OrthoDBiEOG76T9S0.
PhylomeDBiQ9R0K8.
TreeFamiTF324693.

Family and domain databases

InterProiIPR004978. Stanniocalcin.
[Graphical view]
PANTHERiPTHR11245. PTHR11245. 1 hit.
PfamiPF03298. Stanniocalcin. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9R0K8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MCAERLGQFV TLALVFATLD PARGTDSTNP PEGPQDRGSQ QKGRLSLQNT
60 70 80 90 100
AEIQHCLVNA GDVGCGVFEC FENNSCEIQG LHGICMTFLH NAGKFDAQGK
110 120 130 140 150
SFIKDALRCK AHALRHKFGC ISRKCPAIRE MVYQLQRECY LKHDLCSAAQ
160 170 180 190 200
ENVVVIVEMI HFKDLLLHEP YVDLVNLLLT CGEDVREAVT RSVQAQCEQS
210 220 230 240 250
WGGLCSILSF CTSNIQRPPT AAPEHQPLAD RAQLSRPYHR DTDHHLTANR
260 270 280 290
GAKGERGSKS HLHAHARGGA GGQSAQGPSG SSEWEDEQSE YSDIRR
Length:296
Mass (Da):32,622
Last modified:May 1, 2000 - v1
Checksum:i0903639858D9B2DC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB030707 mRNA. Translation: BAA85251.1.
RefSeqiNP_071566.1. NM_022230.2.
UniGeneiRn.44823.

Genome annotation databases

EnsembliENSRNOT00000028146; ENSRNOP00000028146; ENSRNOG00000020729.
GeneIDi63878.
KEGGirno:63878.
UCSCiRGD:621777. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB030707 mRNA. Translation: BAA85251.1 .
RefSeqi NP_071566.1. NM_022230.2.
UniGenei Rn.44823.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000028146.

Proteomic databases

PRIDEi Q9R0K8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000028146 ; ENSRNOP00000028146 ; ENSRNOG00000020729 .
GeneIDi 63878.
KEGGi rno:63878.
UCSCi RGD:621777. rat.

Organism-specific databases

CTDi 8614.
RGDi 621777. Stc2.

Phylogenomic databases

eggNOGi NOG44223.
GeneTreei ENSGT00390000005989.
HOGENOMi HOG000220830.
HOVERGENi HBG001048.
InParanoidi Q9R0K8.
OMAi FCTSAIQ.
OrthoDBi EOG76T9S0.
PhylomeDBi Q9R0K8.
TreeFami TF324693.

Miscellaneous databases

NextBioi 612492.
PROi Q9R0K8.

Gene expression databases

Genevestigatori Q9R0K8.

Family and domain databases

InterProi IPR004978. Stanniocalcin.
[Graphical view ]
PANTHERi PTHR11245. PTHR11245. 1 hit.
Pfami PF03298. Stanniocalcin. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Regulation by 1alpha,25-dihydroxyvitamin D(3) of expression of stanniocalcin messages in the rat kidney and ovary."
    Honda S., Kashiwagi M., Ookata K., Tojo A., Hirose S.
    FEBS Lett. 459:119-122(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.

Entry informationi

Entry nameiSTC2_RAT
AccessioniPrimary (citable) accession number: Q9R0K8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: October 29, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3