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Protein

Stanniocalcin-2

Gene

Stc2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Has an anti-hypocalcemic action on calcium and phosphate homeostasis.

GO - Biological processi

  1. cellular calcium ion homeostasis Source: MGI
  2. cellular response to hypoxia Source: RGD
  3. decidualization Source: RGD
  4. embryo implantation Source: RGD
  5. endoplasmic reticulum unfolded protein response Source: Ensembl
  6. negative regulation of multicellular organism growth Source: Ensembl
  7. regulation of store-operated calcium entry Source: Ensembl
  8. response to oxidative stress Source: Ensembl
  9. response to peptide hormone Source: RGD
  10. response to vitamin D Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Hormone

Names & Taxonomyi

Protein namesi
Recommended name:
Stanniocalcin-2
Short name:
STC-2
Gene namesi
Name:Stc2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 10

Organism-specific databases

RGDi621777. Stc2.

Subcellular locationi

Secreted Curated

GO - Cellular componenti

  1. endoplasmic reticulum Source: Ensembl
  2. extracellular space Source: Ensembl
  3. Golgi apparatus Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence AnalysisAdd
BLAST
Chaini25 – 296272Stanniocalcin-2PRO_0000033307Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi73 – 731N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ9R0K8.

Expressioni

Tissue specificityi

Expressed in a variety of tissues. Strongly expressed in ovary and to a lesser extent in kidney.

Gene expression databases

GenevestigatoriQ9R0K8.

Interactioni

Subunit structurei

Homodimer; disulfide-linked.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028146.

Family & Domainsi

Sequence similaritiesi

Belongs to the stanniocalcin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG44223.
GeneTreeiENSGT00390000005989.
HOGENOMiHOG000220830.
HOVERGENiHBG001048.
InParanoidiQ9R0K8.
OMAiFCTSAIQ.
OrthoDBiEOG76T9S0.
PhylomeDBiQ9R0K8.
TreeFamiTF324693.

Family and domain databases

InterProiIPR004978. Stanniocalcin.
[Graphical view]
PANTHERiPTHR11245. PTHR11245. 1 hit.
PfamiPF03298. Stanniocalcin. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9R0K8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MCAERLGQFV TLALVFATLD PARGTDSTNP PEGPQDRGSQ QKGRLSLQNT
60 70 80 90 100
AEIQHCLVNA GDVGCGVFEC FENNSCEIQG LHGICMTFLH NAGKFDAQGK
110 120 130 140 150
SFIKDALRCK AHALRHKFGC ISRKCPAIRE MVYQLQRECY LKHDLCSAAQ
160 170 180 190 200
ENVVVIVEMI HFKDLLLHEP YVDLVNLLLT CGEDVREAVT RSVQAQCEQS
210 220 230 240 250
WGGLCSILSF CTSNIQRPPT AAPEHQPLAD RAQLSRPYHR DTDHHLTANR
260 270 280 290
GAKGERGSKS HLHAHARGGA GGQSAQGPSG SSEWEDEQSE YSDIRR
Length:296
Mass (Da):32,622
Last modified:May 1, 2000 - v1
Checksum:i0903639858D9B2DC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB030707 mRNA. Translation: BAA85251.1.
RefSeqiNP_071566.1. NM_022230.2.
UniGeneiRn.44823.

Genome annotation databases

EnsembliENSRNOT00000028146; ENSRNOP00000028146; ENSRNOG00000020729.
GeneIDi63878.
KEGGirno:63878.
UCSCiRGD:621777. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB030707 mRNA. Translation: BAA85251.1.
RefSeqiNP_071566.1. NM_022230.2.
UniGeneiRn.44823.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028146.

Proteomic databases

PRIDEiQ9R0K8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000028146; ENSRNOP00000028146; ENSRNOG00000020729.
GeneIDi63878.
KEGGirno:63878.
UCSCiRGD:621777. rat.

Organism-specific databases

CTDi8614.
RGDi621777. Stc2.

Phylogenomic databases

eggNOGiNOG44223.
GeneTreeiENSGT00390000005989.
HOGENOMiHOG000220830.
HOVERGENiHBG001048.
InParanoidiQ9R0K8.
OMAiFCTSAIQ.
OrthoDBiEOG76T9S0.
PhylomeDBiQ9R0K8.
TreeFamiTF324693.

Miscellaneous databases

NextBioi612492.
PROiQ9R0K8.

Gene expression databases

GenevestigatoriQ9R0K8.

Family and domain databases

InterProiIPR004978. Stanniocalcin.
[Graphical view]
PANTHERiPTHR11245. PTHR11245. 1 hit.
PfamiPF03298. Stanniocalcin. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Regulation by 1alpha,25-dihydroxyvitamin D(3) of expression of stanniocalcin messages in the rat kidney and ovary."
    Honda S., Kashiwagi M., Ookata K., Tojo A., Hirose S.
    FEBS Lett. 459:119-122(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.

Entry informationi

Entry nameiSTC2_RAT
AccessioniPrimary (citable) accession number: Q9R0K8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: January 7, 2015
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.