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Q9R0I8

- PI42A_RAT

UniProt

Q9R0I8 - PI42A_RAT

Protein

Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha

Gene

Pip4k2a

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 71 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Catalyzes the phosphorylation of phosphatidylinositol 5-phosphate (PtdIns5P) on the fourth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). May exert its function by regulating the levels of PtdIns5P, which functions in the cytosol by increasing AKT activity and in the nucleus signals through ING2. May regulate the pool of cytosolic PtdIns5P in response to the activation of tyrosine phosphorylation. May be involved in thrombopoiesis and the terminal maturation of megakaryocytes and regulation of their size By similarity. May negatively regulate insulin-stimulated glucose uptake by lowering the levels of PtdIns5P.By similarity1 Publication

    Catalytic activityi

    ATP + 1-phosphatidyl-1D-myo-inositol 5-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate.

    GO - Molecular functioni

    1. 1-phosphatidylinositol-5-phosphate 4-kinase activity Source: UniProtKB-EC
    2. ATP binding Source: UniProtKB-KW

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha (EC:2.7.1.149)
    Alternative name(s):
    1-phosphatidylinositol 5-phosphate 4-kinase 2-alpha
    Diphosphoinositide kinase 2-alpha
    PIPK2 alpha
    Phosphatidylinositol 5-phosphate 4-kinase type II alpha
    Short name:
    PI(5)P 4-kinase type II alpha
    Short name:
    PIP4KII-alpha
    PtdIns(5)P-4-kinase isoform 2-alpha
    Gene namesi
    Name:Pip4k2a
    Synonyms:Pip5k2a
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi621708. Pip4k2a.

    Subcellular locationi

    Nucleus By similarity. Cytoplasm By similarity. Cell membrane By similarity
    Note: Localization to the nucleus is modulated by the interaction with PIP4K2B. May translocate from the cytosol to the cell membrane upon activation of tyrosine phosphorylation. May translocate from the inner to the outer segments of the rod photoreceptor cells in response to light.By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell
    3. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Cytoplasm, Membrane, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 406406Phosphatidylinositol 5-phosphate 4-kinase type-2 alphaPRO_0000185468Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei89 – 891N6-acetyllysineBy similarity
    Modified residuei145 – 1451N6-acetyllysineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PaxDbiQ9R0I8.
    PRIDEiQ9R0I8.

    Expressioni

    Gene expression databases

    GenevestigatoriQ9R0I8.

    Interactioni

    Subunit structurei

    Homodimer. Interacts with PIP4K2B. Interaction with PIP4K2B may modulate localization to the nucleus By similarity.By similarity

    Protein-protein interaction databases

    IntActiQ9R0I8. 1 interaction.
    STRINGi10116.ENSRNOP00000022375.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9R0I8.
    SMRiQ9R0I8. Positions 29-406.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini33 – 405373PIPKPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 PIPK domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG5253.
    HOVERGENiHBG000072.
    KOiK00920.
    PhylomeDBiQ9R0I8.

    Family and domain databases

    Gene3Di3.30.800.10. 1 hit.
    3.30.810.10. 1 hit.
    InterProiIPR023610. PInositol-4-P-5-kinase.
    IPR027483. PInositol-4-P-5-kinase_C.
    IPR002498. PInositol-4-P-5-kinase_core.
    IPR027484. PInositol-4-P-5-kinase_N.
    IPR016034. PInositol-4P-5-kinase_core_sub.
    [Graphical view]
    PANTHERiPTHR23086. PTHR23086. 1 hit.
    PfamiPF01504. PIP5K. 1 hit.
    [Graphical view]
    SMARTiSM00330. PIPKc. 1 hit.
    [Graphical view]
    PROSITEiPS51455. PIPK. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9R0I8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MATPSNLGSS VLASKTKTKK KHFVAQKVKL FRASDPLLSV LMWGVNHSIN    50
    ELSHVQIPVM LMPDDFKAYS KIKVDNHLFN KENMPSHFKF KEYCPMVFRN 100
    LRERFGIDDQ DFQNSLTRSA PLPNDSQARS GARFHTSYDK RYVIKTITSE 150
    DVAEMHNILK KYHQYIVECH GVTLLPQFLG MYRLNVDGVE IYVIVTRNVF 200
    SHRLSVYRKY DLKGSTVARE ASDKEKAKEL PTLKDNDFIN EGQKIYIDDS 250
    NKKIFLEKLK KDVEFLAQLK LMDYSLLVGI HDVERAEQEE VECEENEGEE 300
    EGESDGAHPI GTPPDSPGNT LNSSPPLAPG EFDPNIDVYA IKCHENAPRK 350
    EVYFMAIIDI LTHYDAKKKA AHAAKTVKHG AGAEISTVNP EQYSKRFLDF 400
    IGHILT 406
    Length:406
    Mass (Da):46,210
    Last modified:May 1, 2000 - v1
    Checksum:iCA54529BC7FD8622
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB032899 mRNA. Translation: BAA85160.1.
    RefSeqiNP_446378.1. NM_053926.2.
    UniGeneiRn.24177.

    Genome annotation databases

    GeneIDi116723.
    KEGGirno:116723.
    UCSCiRGD:621708. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB032899 mRNA. Translation: BAA85160.1 .
    RefSeqi NP_446378.1. NM_053926.2.
    UniGenei Rn.24177.

    3D structure databases

    ProteinModelPortali Q9R0I8.
    SMRi Q9R0I8. Positions 29-406.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q9R0I8. 1 interaction.
    STRINGi 10116.ENSRNOP00000022375.

    Proteomic databases

    PaxDbi Q9R0I8.
    PRIDEi Q9R0I8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 116723.
    KEGGi rno:116723.
    UCSCi RGD:621708. rat.

    Organism-specific databases

    CTDi 5305.
    RGDi 621708. Pip4k2a.

    Phylogenomic databases

    eggNOGi COG5253.
    HOVERGENi HBG000072.
    KOi K00920.
    PhylomeDBi Q9R0I8.

    Miscellaneous databases

    NextBioi 619640.

    Gene expression databases

    Genevestigatori Q9R0I8.

    Family and domain databases

    Gene3Di 3.30.800.10. 1 hit.
    3.30.810.10. 1 hit.
    InterProi IPR023610. PInositol-4-P-5-kinase.
    IPR027483. PInositol-4-P-5-kinase_C.
    IPR002498. PInositol-4-P-5-kinase_core.
    IPR027484. PInositol-4-P-5-kinase_N.
    IPR016034. PInositol-4P-5-kinase_core_sub.
    [Graphical view ]
    PANTHERi PTHR23086. PTHR23086. 1 hit.
    Pfami PF01504. PIP5K. 1 hit.
    [Graphical view ]
    SMARTi SM00330. PIPKc. 1 hit.
    [Graphical view ]
    PROSITEi PS51455. PIPK. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Rattus rat phosphatidylinositol 5-phosphate 4-kinase alpha, complete cds."
      Kudo M., Saito S., Kondo H.
      Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Involvement of phosphatidylinositol 5-phosphate in insulin-stimulated glucose uptake in the L6 myotube model of skeletal muscle."
      Grainger D.L., Tavelis C., Ryan A.J., Hinchliffe K.A.
      Pflugers Arch. 462:723-732(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN INSULIN-MEDIATED GLUCOSE UPTAKE.

    Entry informationi

    Entry nameiPI42A_RAT
    AccessioniPrimary (citable) accession number: Q9R0I8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 25, 2005
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 71 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3