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Q9R0I8

- PI42A_RAT

UniProt

Q9R0I8 - PI42A_RAT

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Protein
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha
Gene
Pip4k2a, Pip5k2a
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the phosphorylation of phosphatidylinositol 5-phosphate (PtdIns5P) on the fourth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). May exert its function by regulating the levels of PtdIns5P, which functions in the cytosol by increasing AKT activity and in the nucleus signals through ING2. May regulate the pool of cytosolic PtdIns5P in response to the activation of tyrosine phosphorylation. May be involved in thrombopoiesis and the terminal maturation of megakaryocytes and regulation of their size By similarity. May negatively regulate insulin-stimulated glucose uptake by lowering the levels of PtdIns5P.1 Publication

Catalytic activityi

ATP + 1-phosphatidyl-1D-myo-inositol 5-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate.

GO - Molecular functioni

  1. 1-phosphatidylinositol-5-phosphate 4-kinase activity Source: UniProtKB-EC
  2. ATP binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha (EC:2.7.1.149)
Alternative name(s):
1-phosphatidylinositol 5-phosphate 4-kinase 2-alpha
Diphosphoinositide kinase 2-alpha
PIPK2 alpha
Phosphatidylinositol 5-phosphate 4-kinase type II alpha
Short name:
PI(5)P 4-kinase type II alpha
Short name:
PIP4KII-alpha
PtdIns(5)P-4-kinase isoform 2-alpha
Gene namesi
Name:Pip4k2a
Synonyms:Pip5k2a
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi621708. Pip4k2a.

Subcellular locationi

Nucleus By similarity. Cytoplasm By similarity. Cell membrane By similarity
Note: Localization to the nucleus is modulated by the interaction with PIP4K2B By similarity. May translocate from the cytosol to the cell membrane upon activation of tyrosine phosphorylation By similarity. May translocate from the inner to the outer segments of the rod photoreceptor cells in response to light By similarity.

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. nucleus Source: UniProtKB-SubCell
  3. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 406406Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha
PRO_0000185468Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei89 – 891N6-acetyllysine By similarity
Modified residuei145 – 1451N6-acetyllysine By similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ9R0I8.
PRIDEiQ9R0I8.

Expressioni

Gene expression databases

GenevestigatoriQ9R0I8.

Interactioni

Subunit structurei

Homodimer. Interacts with PIP4K2B. Interaction with PIP4K2B may modulate localization to the nucleus By similarity.

Protein-protein interaction databases

IntActiQ9R0I8. 1 interaction.
STRINGi10116.ENSRNOP00000022375.

Structurei

3D structure databases

ProteinModelPortaliQ9R0I8.
SMRiQ9R0I8. Positions 29-406.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini33 – 405373PIPK
Add
BLAST

Sequence similaritiesi

Contains 1 PIPK domain.

Phylogenomic databases

eggNOGiCOG5253.
HOVERGENiHBG000072.
KOiK00920.
PhylomeDBiQ9R0I8.

Family and domain databases

Gene3Di3.30.800.10. 1 hit.
3.30.810.10. 1 hit.
InterProiIPR023610. PInositol-4-P-5-kinase.
IPR027483. PInositol-4-P-5-kinase_C.
IPR002498. PInositol-4-P-5-kinase_core.
IPR027484. PInositol-4-P-5-kinase_N.
IPR016034. PInositol-4P-5-kinase_core_sub.
[Graphical view]
PANTHERiPTHR23086. PTHR23086. 1 hit.
PfamiPF01504. PIP5K. 1 hit.
[Graphical view]
SMARTiSM00330. PIPKc. 1 hit.
[Graphical view]
PROSITEiPS51455. PIPK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9R0I8-1 [UniParc]FASTAAdd to Basket

« Hide

MATPSNLGSS VLASKTKTKK KHFVAQKVKL FRASDPLLSV LMWGVNHSIN    50
ELSHVQIPVM LMPDDFKAYS KIKVDNHLFN KENMPSHFKF KEYCPMVFRN 100
LRERFGIDDQ DFQNSLTRSA PLPNDSQARS GARFHTSYDK RYVIKTITSE 150
DVAEMHNILK KYHQYIVECH GVTLLPQFLG MYRLNVDGVE IYVIVTRNVF 200
SHRLSVYRKY DLKGSTVARE ASDKEKAKEL PTLKDNDFIN EGQKIYIDDS 250
NKKIFLEKLK KDVEFLAQLK LMDYSLLVGI HDVERAEQEE VECEENEGEE 300
EGESDGAHPI GTPPDSPGNT LNSSPPLAPG EFDPNIDVYA IKCHENAPRK 350
EVYFMAIIDI LTHYDAKKKA AHAAKTVKHG AGAEISTVNP EQYSKRFLDF 400
IGHILT 406
Length:406
Mass (Da):46,210
Last modified:May 1, 2000 - v1
Checksum:iCA54529BC7FD8622
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB032899 mRNA. Translation: BAA85160.1.
RefSeqiNP_446378.1. NM_053926.2.
UniGeneiRn.24177.

Genome annotation databases

GeneIDi116723.
KEGGirno:116723.
UCSCiRGD:621708. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB032899 mRNA. Translation: BAA85160.1 .
RefSeqi NP_446378.1. NM_053926.2.
UniGenei Rn.24177.

3D structure databases

ProteinModelPortali Q9R0I8.
SMRi Q9R0I8. Positions 29-406.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q9R0I8. 1 interaction.
STRINGi 10116.ENSRNOP00000022375.

Proteomic databases

PaxDbi Q9R0I8.
PRIDEi Q9R0I8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 116723.
KEGGi rno:116723.
UCSCi RGD:621708. rat.

Organism-specific databases

CTDi 5305.
RGDi 621708. Pip4k2a.

Phylogenomic databases

eggNOGi COG5253.
HOVERGENi HBG000072.
KOi K00920.
PhylomeDBi Q9R0I8.

Miscellaneous databases

NextBioi 619640.

Gene expression databases

Genevestigatori Q9R0I8.

Family and domain databases

Gene3Di 3.30.800.10. 1 hit.
3.30.810.10. 1 hit.
InterProi IPR023610. PInositol-4-P-5-kinase.
IPR027483. PInositol-4-P-5-kinase_C.
IPR002498. PInositol-4-P-5-kinase_core.
IPR027484. PInositol-4-P-5-kinase_N.
IPR016034. PInositol-4P-5-kinase_core_sub.
[Graphical view ]
PANTHERi PTHR23086. PTHR23086. 1 hit.
Pfami PF01504. PIP5K. 1 hit.
[Graphical view ]
SMARTi SM00330. PIPKc. 1 hit.
[Graphical view ]
PROSITEi PS51455. PIPK. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Rattus rat phosphatidylinositol 5-phosphate 4-kinase alpha, complete cds."
    Kudo M., Saito S., Kondo H.
    Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Involvement of phosphatidylinositol 5-phosphate in insulin-stimulated glucose uptake in the L6 myotube model of skeletal muscle."
    Grainger D.L., Tavelis C., Ryan A.J., Hinchliffe K.A.
    Pflugers Arch. 462:723-732(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN INSULIN-MEDIATED GLUCOSE UPTAKE.

Entry informationi

Entry nameiPI42A_RAT
AccessioniPrimary (citable) accession number: Q9R0I8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: May 1, 2000
Last modified: April 16, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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