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Q9R0G6

- COMP_MOUSE

UniProt

Q9R0G6 - COMP_MOUSE

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Protein
Cartilage oligomeric matrix protein
Gene
Comp
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

May play a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins such as the collagens and fibronectin. Can mediate the interaction of chondrocytes with the cartilage extracellular matrix through interaction with cell surface integrin receptors. Could play a role in the pathogenesis of osteoarthritis. Potent suppressor of apoptosis in both primary chondrocytes and transformed cells. Suppresses apoptosis by blocking the activation of caspase-3 and by inducing the IAP family of survival proteins (BIRC3, BIRC2, BIRC5 and XIAP). Essential for maintaining a vascular smooth muscle cells (VSMCs) contractile/differentiated phenotype under physiological and pathological stimuli. Maintains this phenotype of VSMCs by interacting with ITGA7 By similarity.

Cofactori

Binds 11-14 calcium ions per subunit By similarity.

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. extracellular matrix structural constituent Source: InterPro
  3. heparin binding Source: UniProtKB-KW
  4. protease binding Source: BHF-UCL
  5. protein binding Source: IntAct

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
  2. cell adhesion Source: UniProtKB-KW
  3. extracellular matrix organization Source: InterPro
  4. growth plate cartilage development Source: MGI
  5. limb development Source: Ensembl
  6. negative regulation of apoptotic process Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Apoptosis, Cell adhesion

Keywords - Ligandi

Calcium, Heparin-binding

Enzyme and pathway databases

ReactomeiREACT_196606. ECM proteoglycans.
REACT_216309. Integrin cell surface interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Cartilage oligomeric matrix protein
Short name:
COMP
Gene namesi
Name:Comp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 8

Organism-specific databases

MGIiMGI:88469. Comp.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: Ensembl
  2. proteinaceous extracellular matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919 Reviewed prediction
Add
BLAST
Chaini20 – 755736Cartilage oligomeric matrix protein
PRO_0000035858Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi68 – 68Interchain
Disulfide bondi71 – 71Interchain
Disulfide bondi89 ↔ 100 By similarity
Disulfide bondi94 ↔ 109 By similarity
Disulfide bondi112 ↔ 123 By similarity
Glycosylationi119 – 1191N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi129 ↔ 140 By similarity
Disulfide bondi134 ↔ 149 By similarity
Disulfide bondi152 ↔ 176 By similarity
Disulfide bondi182 ↔ 195 By similarity
Disulfide bondi189 ↔ 204 By similarity
Disulfide bondi207 ↔ 219 By similarity
Disulfide bondi227 ↔ 241 By similarity
Disulfide bondi235 ↔ 251 By similarity
Disulfide bondi253 ↔ 264 By similarity
Disulfide bondi280 ↔ 285 By similarity
Disulfide bondi290 ↔ 310 By similarity
Disulfide bondi326 ↔ 346 By similarity
Disulfide bondi349 ↔ 369 By similarity
Disulfide bondi385 ↔ 405 By similarity
Disulfide bondi408 ↔ 428 By similarity
Disulfide bondi446 ↔ 466 By similarity
Disulfide bondi482 ↔ 502 By similarity
Disulfide bondi518 ↔ 739 By similarity
Glycosylationi740 – 7401N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9R0G6.
PRIDEiQ9R0G6.

PTM databases

PhosphoSiteiQ9R0G6.

Expressioni

Gene expression databases

CleanExiMM_COMP.
GenevestigatoriQ9R0G6.

Interactioni

Subunit structurei

Pentamer; disulfide-linked. Exists in a more compact conformation in the presence of calcium and shows a more extended conformation in the absence of calcium. Interacts with ITGB3, ITGA5 and FN1. Binding to FN1 requires the presence of divalent cations (Ca2+, Mg2+ or Mn2+). The greatest amount of binding is seen in the presence of Mn2+. Interacts with MATN1, MATN3, MATN4 and ACAN. Binds heparin, heparan sulfate and chondroitin sulfate. EDTA dimishes significantly its binding to ACAN and abolishes its binding to MATN3, MATN4 and chondroitin sulfate. Interacts with collagen I, II and IX and interaction with these collagens is dependent on the presence of zinc ions. Interacts with ADAMTS12. Interacts with ITGA7 By similarity.

Binary interactionsi

WithEntry#Exp.IntActNotes
ADAMTS12P583973EBI-9028018,EBI-9028051From a different organism.

Protein-protein interaction databases

IntActiQ9R0G6. 2 interactions.
STRINGi10090.ENSMUSP00000003659.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi30 – 6637

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1MZ9X-ray1.70A/B/C/D/E28-71[»]
3V2NX-ray1.80A/B/C/D/E28-71[»]
3V2PX-ray1.87A/B/C/D/E28-71[»]
3V2QX-ray2.20A/B/C/D/E28-71[»]
3V2RX-ray2.75A/B/C/D/E28-71[»]
ProteinModelPortaliQ9R0G6.
SMRiQ9R0G6. Positions 28-71, 89-754.

Miscellaneous databases

EvolutionaryTraceiQ9R0G6.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini85 – 12440EGF-like 1
Add
BLAST
Domaini125 – 17753EGF-like 2; calcium-binding Reviewed prediction
Add
BLAST
Domaini178 – 22043EGF-like 3; calcium-binding Reviewed prediction
Add
BLAST
Domaini223 – 26543EGF-like 4
Add
BLAST
Repeati266 – 29833TSP type-3 1
Add
BLAST
Repeati299 – 33436TSP type-3 2
Add
BLAST
Repeati335 – 35723TSP type-3 3
Add
BLAST
Repeati358 – 39336TSP type-3 4
Add
BLAST
Repeati394 – 41623TSP type-3 5
Add
BLAST
Repeati417 – 45438TSP type-3 6
Add
BLAST
Repeati455 – 49036TSP type-3 7
Add
BLAST
Repeati491 – 52636TSP type-3 8
Add
BLAST
Domaini530 – 744215TSP C-terminal
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni21 – 8464COMP N-terminal
Add
BLAST
Regioni525 – 755231Mediates cell survival and induction of the IAP family of survival proteins By similarity
Add
BLAST

Domaini

The cell attachment motif mediates the attachment to chondrocytes. It mediates the induction of both the IAP family of survival proteins and the antiapoptotic response By similarity.
The TSP C-terminal domain mediates interaction with FN1 and ACAN By similarity.
Each of the eight TSP type-3 repeats binds two calcium ions. The TSP C-terminal domain binds three calcium ions By similarity.

Sequence similaritiesi

Belongs to the thrombospondin family.
Contains 4 EGF-like domains.
Contains 8 TSP type-3 repeats.

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

eggNOGiNOG12793.
GeneTreeiENSGT00550000074507.
HOVERGENiHBG000636.
InParanoidiQ9R0G6.
KOiK04659.
OMAiPEDYETQ.
OrthoDBiEOG76QFGD.
TreeFamiTF324917.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
4.10.1080.10. 2 hits.
InterProiIPR028492. Comp.
IPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_N_dom.
IPR024665. Thbs/COMP_coiled-coil.
IPR003367. Thrombospondin_3-like_rpt.
IPR017897. Thrombospondin_3_rpt.
IPR008859. Thrombospondin_C.
IPR028974. TSP_type-3_rpt.
[Graphical view]
PANTHERiPTHR10199:SF81. PTHR10199:SF81. 1 hit.
PfamiPF11598. COMP. 1 hit.
PF07645. EGF_CA. 2 hits.
PF02412. TSP_3. 6 hits.
PF05735. TSP_C. 1 hit.
[Graphical view]
SMARTiSM00181. EGF. 2 hits.
SM00179. EGF_CA. 2 hits.
[Graphical view]
SUPFAMiSSF103647. SSF103647. 3 hits.
SSF49899. SSF49899. 1 hit.
SSF57184. SSF57184. 1 hit.
PROSITEiPS00018. EF_HAND_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 3 hits.
PS01187. EGF_CA. 2 hits.
PS51234. TSP3. 8 hits.
PS51236. TSP_CTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9R0G6-1 [UniParc]FASTAAdd to Basket

« Hide

MGPTACVLVL ALAILRATGQ GQIPLGGDLA PQMLRELQET NAALQDVREL    50
LRQQVKEITF LKNTVMECDA CGMQPARTPG LSVRPVPLCA PGSCFPGVVC 100
SETATGARCG PCPPGYTGNG SHCTDVNECN AHPCFPRVRC INTSPGFHCE 150
ACPPGFSGPT HEGVGLTFAK SNKQVCTDIN ECETGQHNCV PNSVCVNTRG 200
SFQCGPCQPG FVGDQTSGCQ RRGQHFCPDG SPSPCHEKAN CVLERDGSRS 250
CVCAVGWAGN GLLCGRDTDL DGFPDEKLRC SERQCRKDNC VTVPNSGQED 300
VDRDGIGDAC DPDADGDGVP NEQDNCPLVR NPDQRNSDSD KWGDACDNCR 350
SKKNDDQKDT DLDGRGDACD DDIDGDRIRN VADNCPRVPN FDQSDSDGDG 400
VGDACDNCPQ KDNPDQRDVD HDFVGDACDS DQDQDGDGHQ DSRDNCPTVP 450
NSAQQDSDHD GKGDACDDDD DNDGVPDSRD NCRLVPNPGQ EDNDRDGVGD 500
ACQGDFDADK VIDKIDVCPE NAEVTLTDFR AFQTVVLDPE GDAQIDPNWV 550
VLNQGMEIVQ TMNSDPGLAV GYTAFNGVDF EGTFHVNTAT DDDYAGFIFG 600
YQDSSSFYVV MWKQMEQTYW QANPFRAVAE PGIQLKAVKS STGPGEQLRN 650
ALWHTGDTAS QVRLLWKDPR NVGWKDKTSY RWFLQHRPQV GYIRVRFYEG 700
PELVADSNVV LDTAMRGGRL GVFCFSQENI IWANLRYRCN DTIPEDYESH 750
RLQRV 755
Length:755
Mass (Da):82,342
Last modified:October 3, 2012 - v2
Checksum:i24C2F113E7945C0F
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti53 – 542QQ → HE in AAD01972. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF033530 mRNA. Translation: AAD01972.1.
AC158553 Genomic DNA. No translation available.
CH466569 Genomic DNA. Translation: EDL28815.1.
CCDSiCCDS22367.1.
RefSeqiNP_057894.2. NM_016685.2.
UniGeneiMm.45071.

Genome annotation databases

EnsembliENSMUST00000003659; ENSMUSP00000003659; ENSMUSG00000031849.
GeneIDi12845.
KEGGimmu:12845.
UCSCiuc009mad.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF033530 mRNA. Translation: AAD01972.1 .
AC158553 Genomic DNA. No translation available.
CH466569 Genomic DNA. Translation: EDL28815.1 .
CCDSi CCDS22367.1.
RefSeqi NP_057894.2. NM_016685.2.
UniGenei Mm.45071.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1MZ9 X-ray 1.70 A/B/C/D/E 28-71 [» ]
3V2N X-ray 1.80 A/B/C/D/E 28-71 [» ]
3V2P X-ray 1.87 A/B/C/D/E 28-71 [» ]
3V2Q X-ray 2.20 A/B/C/D/E 28-71 [» ]
3V2R X-ray 2.75 A/B/C/D/E 28-71 [» ]
ProteinModelPortali Q9R0G6.
SMRi Q9R0G6. Positions 28-71, 89-754.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q9R0G6. 2 interactions.
STRINGi 10090.ENSMUSP00000003659.

PTM databases

PhosphoSitei Q9R0G6.

Proteomic databases

PaxDbi Q9R0G6.
PRIDEi Q9R0G6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000003659 ; ENSMUSP00000003659 ; ENSMUSG00000031849 .
GeneIDi 12845.
KEGGi mmu:12845.
UCSCi uc009mad.2. mouse.

Organism-specific databases

CTDi 1311.
MGIi MGI:88469. Comp.

Phylogenomic databases

eggNOGi NOG12793.
GeneTreei ENSGT00550000074507.
HOVERGENi HBG000636.
InParanoidi Q9R0G6.
KOi K04659.
OMAi PEDYETQ.
OrthoDBi EOG76QFGD.
TreeFami TF324917.

Enzyme and pathway databases

Reactomei REACT_196606. ECM proteoglycans.
REACT_216309. Integrin cell surface interactions.

Miscellaneous databases

EvolutionaryTracei Q9R0G6.
NextBioi 282384.
PROi Q9R0G6.
SOURCEi Search...

Gene expression databases

CleanExi MM_COMP.
Genevestigatori Q9R0G6.

Family and domain databases

Gene3Di 2.60.120.200. 1 hit.
4.10.1080.10. 2 hits.
InterProi IPR028492. Comp.
IPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_N_dom.
IPR024665. Thbs/COMP_coiled-coil.
IPR003367. Thrombospondin_3-like_rpt.
IPR017897. Thrombospondin_3_rpt.
IPR008859. Thrombospondin_C.
IPR028974. TSP_type-3_rpt.
[Graphical view ]
PANTHERi PTHR10199:SF81. PTHR10199:SF81. 1 hit.
Pfami PF11598. COMP. 1 hit.
PF07645. EGF_CA. 2 hits.
PF02412. TSP_3. 6 hits.
PF05735. TSP_C. 1 hit.
[Graphical view ]
SMARTi SM00181. EGF. 2 hits.
SM00179. EGF_CA. 2 hits.
[Graphical view ]
SUPFAMi SSF103647. SSF103647. 3 hits.
SSF49899. SSF49899. 1 hit.
SSF57184. SSF57184. 1 hit.
PROSITEi PS00018. EF_HAND_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 3 hits.
PS01187. EGF_CA. 2 hits.
PS51234. TSP3. 8 hits.
PS51236. TSP_CTER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning, sequencing, and tissue and developmental expression of mouse cartilage oligomeric matrix protein (COMP)."
    Fang C., Carlson C.S., Leslie M.P., Tulli H., Stolerman E., Perris R., Ni L., Di Cesare P.E.
    J. Orthop. Res. 18:593-603(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Cartilage.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "Storage function of cartilage oligomeric matrix protein: the crystal structure of the coiled-coil domain in complex with vitamin D(3)."
    Ozbek S., Engel J., Stetefeld J.
    EMBO J. 21:5960-5968(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) OF 28-71.

Entry informationi

Entry nameiCOMP_MOUSE
AccessioniPrimary (citable) accession number: Q9R0G6
Secondary accession number(s): G3X8Q4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 3, 2012
Last modified: September 3, 2014
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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