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Protein

Transcobalamin-2

Gene

Tcn2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Primary vitamin B12-binding and transport protein. Delivers cobalamin to cells (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi193Cobalt (cobalamin axial ligand)By similarity1
Binding sitei245CobalaminBy similarity1
Binding sitei248CobalaminBy similarity1
Binding sitei292CobalaminBy similarity1

GO - Molecular functioni

  • cobalamin binding Source: RGD
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

  • cobalamin transport Source: RGD
  • cobalt ion transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Cobalt transport, Ion transport, Transport

Keywords - Ligandi

Cobalt, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Transcobalamin-2
Short name:
TC-2
Alternative name(s):
Transcobalamin II
Short name:
TC II
Short name:
TCII
Gene namesi
Name:Tcn2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi620681. Tcn2.

Subcellular locationi

GO - Cellular componenti

  • extracellular space Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18By similarityAdd BLAST18
ChainiPRO_000000556719 – 427Transcobalamin-2Add BLAST409

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi21 ↔ 268By similarity
Disulfide bondi116 ↔ 310By similarity
Disulfide bondi165 ↔ 208By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ9R0D6.
PRIDEiQ9R0D6.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000005934.

Structurei

3D structure databases

ProteinModelPortaliQ9R0D6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni152 – 156Cobalamin bindingBy similarity5
Regioni193 – 197Cobalamin bindingBy similarity5
Regioni395 – 397Cobalamin bindingBy similarity3

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IDZK. Eukaryota.
ENOG410XSU1. LUCA.
HOGENOMiHOG000074060.
HOVERGENiHBG001328.
InParanoidiQ9R0D6.
PhylomeDBiQ9R0D6.

Family and domain databases

InterProiIPR002157. Cbl-bd_transpt_euk.
IPR027954. DUF4430.
[Graphical view]
PANTHERiPTHR10559. PTHR10559. 1 hit.
PfamiPF01122. Cobalamin_bind. 1 hit.
PF14478. DUF4430. 1 hit.
[Graphical view]
PROSITEiPS00468. COBALAMIN_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9R0D6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELLKALLLL SGVLGALAEF CVIPKMDGQL VEKLGQRLLP WMDRLSSEQL
60 70 80 90 100
NPSIYVGLRL SSMQAGTKEN LYLHNLKLHY QQCLLRSTSS DDNSGCQTKI
110 120 130 140 150
SGGSLALYLL ALRANCELLG SRKGDRMVSQ LKWFLEDEKK AIGHHHEGHP
160 170 180 190 200
HTSYYQYGLS ILALCVHRKR VHDSVVGKLL YAVEHDYFTY QGHLSVDTEA
210 220 230 240 250
MAGLAFTCLE RFNFNSDLRP RITTAIETVR EKILKAQAPE GYFGNIYSTP
260 270 280 290 300
LALQMLMTSP GVGLGPACLK ARKSLLLSLQ DGAFQNPMMI SQLLPVLNHK
310 320 330 340 350
TYLNLISPDC QAPRVMLVPA TEDPVHLSEV SVTLKVSSVL PPYERTVSVF
360 370 380 390 400
AGASLEDVLN RARDLGEFTY GTQASLSGPY LTSVLGKEAG DREYWQLLRV
410 420
PDTPLLQGIA DYKPKNGETI ELRLVKM
Length:427
Mass (Da):47,420
Last modified:May 1, 2000 - v1
Checksum:iBA7E1351667BDF0C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF054810 mRNA. Translation: AAD55672.1.
UniGeneiRn.1829.

Genome annotation databases

UCSCiRGD:620681. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF054810 mRNA. Translation: AAD55672.1.
UniGeneiRn.1829.

3D structure databases

ProteinModelPortaliQ9R0D6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000005934.

Proteomic databases

PaxDbiQ9R0D6.
PRIDEiQ9R0D6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiRGD:620681. rat.

Organism-specific databases

RGDi620681. Tcn2.

Phylogenomic databases

eggNOGiENOG410IDZK. Eukaryota.
ENOG410XSU1. LUCA.
HOGENOMiHOG000074060.
HOVERGENiHBG001328.
InParanoidiQ9R0D6.
PhylomeDBiQ9R0D6.

Miscellaneous databases

PROiQ9R0D6.

Family and domain databases

InterProiIPR002157. Cbl-bd_transpt_euk.
IPR027954. DUF4430.
[Graphical view]
PANTHERiPTHR10559. PTHR10559. 1 hit.
PfamiPF01122. Cobalamin_bind. 1 hit.
PF14478. DUF4430. 1 hit.
[Graphical view]
PROSITEiPS00468. COBALAMIN_BINDING. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTCO2_RAT
AccessioniPrimary (citable) accession number: Q9R0D6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 13, 2001
Last sequence update: May 1, 2000
Last modified: October 5, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.