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Q9R0C9

- SGMR1_RAT

UniProt

Q9R0C9 - SGMR1_RAT

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Protein

Sigma non-opioid intracellular receptor 1

Gene

Sigmar1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. Involved in the regulation of different receptors it plays a role in BDNF signaling and EGF signaling. Also regulates ion channels like the potassium channel and could modulate neurotransmitter release. Plays a role in calcium signaling through modulation together with ANK2 of the ITP3R-dependent calcium efflux at the endoplasmic reticulum. Plays a role in several other cell functions including proliferation, survival and death. Originally identified for its ability to bind various psychoactive drugs it is involved in learning processes, memory and mood alteration.6 Publications

GO - Molecular functioni

  1. opioid receptor activity Source: RGD

GO - Biological processi

  1. lipid transport Source: UniProtKB-KW
  2. nervous system development Source: RGD
  3. opioid receptor signaling pathway Source: GOC
  4. regulation of neuron apoptotic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Lipid transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Sigma non-opioid intracellular receptor 1
Alternative name(s):
Sigma 1-type opioid receptor
Short name:
Sigma1-receptor
Short name:
Sigma1R
Gene namesi
Name:Sigmar1
Synonyms:Oprs1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 5

Organism-specific databases

RGDi68364. Sigmar1.

Subcellular locationi

Nucleus inner membrane. Nucleus outer membrane. Endoplasmic reticulum membrane. Lipid droplet. Cell junction. Cell membrane. Cell projectiongrowth cone
Note: Targeted to lipid droplets, cholesterol and galactosylceramide-enriched domains of the endoplasmic reticulum. Enriched at cell-cell communication regions, growth cone and postsynaptic structures. Localization is modulated by ligand-binding.

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. cell projection Source: UniProtKB-KW
  3. endoplasmic reticulum Source: RGD
  4. integral component of membrane Source: UniProtKB-KW
  5. lipid particle Source: UniProtKB-KW
  6. nuclear envelope Source: Ensembl
  7. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Endoplasmic reticulum, Lipid droplet, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 223223Sigma non-opioid intracellular receptor 1PRO_0000268655Add
BLAST

Proteomic databases

PaxDbiQ9R0C9.
PRIDEiQ9R0C9.

Expressioni

Tissue specificityi

Expressed in ependymocytes and neurons throughout the CNS from the olfactory bulb to the spinal cord. Expressed by progenitor, mature and satellite oligodendrocytes and by Schwann cells (at protein level). Expressed in liver, intestine, kidney, brain, lung and heart. Expressed by retinal cells.5 Publications

Gene expression databases

GenevestigatoriQ9R0C9.

Interactioni

Subunit structurei

Forms a ternary complex with ANK2 and ITPR3. The complex is disrupted by agonists. Interacts with KCNA4.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Hspa5P067613EBI-1557826,EBI-916036
Kcna2P631413EBI-1557826,EBI-644033From a different organism.

Protein-protein interaction databases

IntActiQ9R0C9. 3 interactions.

Structurei

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 99CytoplasmicSequence Analysis
Topological domaini31 – 8050ExtracellularSequence AnalysisAdd
BLAST
Topological domaini102 – 223122CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei10 – 3021HelicalSequence AnalysisAdd
BLAST
Transmembranei81 – 10121HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni2 – 87Targeting to lipid dropletsBy similarity
Regioni118 – 14831Mediates ligand-bindingBy similarityAdd
BLAST

Sequence similaritiesi

Belongs to the ERG2 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG296707.
GeneTreeiENSGT00390000012082.
HOVERGENiHBG058220.
InParanoidiQ9R0C9.
OMAiFYTLRAY.
OrthoDBiEOG7GFB5Z.
PhylomeDBiQ9R0C9.
TreeFamiTF300106.

Family and domain databases

InterProiIPR006716. ERG2_sigma1_rcpt-like.
IPR028545. SIGMAR1.
[Graphical view]
PANTHERiPTHR10868. PTHR10868. 1 hit.
PfamiPF04622. ERG2_Sigma1R. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9R0C9-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPWAVGRRWA WITLFLTIVA VLIQAVWLWL GTQSFVFQRE EIAQLARQYA
60 70 80 90 100
GLDHELAFSR LIVELRRLHP GHVLPDEELQ WVFVNAGGWM GAMCLLHASL
110 120 130 140 150
SEYVLLFGTA LGSHGHSGRY WAEISDTIIS GTFHQWREGT TKSEVYYPGE
160 170 180 190 200
TVVHGPGEAT AVEWGPNTWM VEYGRGVIPS TLAFALSDTI FSTQDFLTLF
210 220
YTLRAYARGL RLELTTYLFG QDP
Length:223
Mass (Da):25,270
Last modified:May 1, 2000 - v1
Checksum:iB125A0388F1FFC6E
GO
Isoform 2 (identifier: Q9R0C9-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     103-106: YVLL → TILG
     107-223: Missing.

Show »
Length:106
Mass (Da):12,153
Checksum:i8BA4159B6A9E2A0F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti161 – 1611A → D in AAD01198. (PubMed:9489711)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei103 – 1064YVLL → TILG in isoform 2. 1 PublicationVSP_021988
Alternative sequencei107 – 223117Missing in isoform 2. 1 PublicationVSP_021989Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF004218 mRNA. Translation: AAD01198.1.
AF067769 mRNA. Translation: AAF08342.1.
AF087827 mRNA. Translation: AAD49439.1.
BC061978 mRNA. Translation: AAH61978.1.
RefSeqiNP_112258.1. NM_030996.1.
UniGeneiRn.1129.

Genome annotation databases

EnsembliENSRNOT00000019795; ENSRNOP00000019795; ENSRNOG00000014604. [Q9R0C9-1]
GeneIDi29336.
KEGGirno:29336.
UCSCiRGD:68364. rat. [Q9R0C9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF004218 mRNA. Translation: AAD01198.1 .
AF067769 mRNA. Translation: AAF08342.1 .
AF087827 mRNA. Translation: AAD49439.1 .
BC061978 mRNA. Translation: AAH61978.1 .
RefSeqi NP_112258.1. NM_030996.1.
UniGenei Rn.1129.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q9R0C9. 3 interactions.

Chemistry

BindingDBi Q9R0C9.
ChEMBLi CHEMBL3602.

Proteomic databases

PaxDbi Q9R0C9.
PRIDEi Q9R0C9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000019795 ; ENSRNOP00000019795 ; ENSRNOG00000014604 . [Q9R0C9-1 ]
GeneIDi 29336.
KEGGi rno:29336.
UCSCi RGD:68364. rat. [Q9R0C9-1 ]

Organism-specific databases

CTDi 10280.
RGDi 68364. Sigmar1.

Phylogenomic databases

eggNOGi NOG296707.
GeneTreei ENSGT00390000012082.
HOVERGENi HBG058220.
InParanoidi Q9R0C9.
OMAi FYTLRAY.
OrthoDBi EOG7GFB5Z.
PhylomeDBi Q9R0C9.
TreeFami TF300106.

Miscellaneous databases

NextBioi 608816.
PROi Q9R0C9.

Gene expression databases

Genevestigatori Q9R0C9.

Family and domain databases

InterProi IPR006716. ERG2_sigma1_rcpt-like.
IPR028545. SIGMAR1.
[Graphical view ]
PANTHERi PTHR10868. PTHR10868. 1 hit.
Pfami PF04622. ERG2_Sigma1R. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and functional characterization of a sigma receptor from rat brain."
    Seth P., Fei Y.-J., Li H.W., Huang W., Leibach F.H., Ganapathy V.
    J. Neurochem. 70:922-931(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY.
    Strain: Sprague-Dawley.
    Tissue: Brain.
  2. "Sigma1 receptor modulation of opioid analgesia in the mouse."
    Mei J., Pasternak G.W.
    J. Pharmacol. Exp. Ther. 300:1070-1074(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION.
    Tissue: Brain.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Prostate.
  4. "Immunocytochemical localization of the sigma(1) receptor in the adult rat central nervous system."
    Alonso G., Phan V.-L., Guillemain I., Saunier M., Legrand A., Anoal M., Maurice T.
    Neuroscience 97:155-170(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
  5. Cited for: TISSUE SPECIFICITY.
  6. "Regulating ankyrin dynamics: roles of sigma-1 receptors."
    Hayashi T., Su T.-P.
    Proc. Natl. Acad. Sci. U.S.A. 98:491-496(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ANK2 AND ITPR3, SUBCELLULAR LOCATION.
  7. "The sigma receptor as a ligand-regulated auxiliary potassium channel subunit."
    Aydar E., Palmer C.P., Klyachko V.A., Jackson M.B.
    Neuron 34:399-410(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TOPOLOGY, SUBCELLULAR LOCATION, INTERACTION WITH KCNA4.
  8. "Immunohistochemical localization of the sigma1-receptor in oligodendrocytes in the rat central nervous system."
    Palacios G., Muro A., Vela J.M., Molina-Holgado E., Guitart X., Ovalle S., Zamanillo D.
    Brain Res. 961:92-99(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  9. "Immunohistochemical localization of the sigma1 receptor in Schwann cells of rat sciatic nerve."
    Palacios G., Muro A., Verdu E., Pumarola M., Vela J.M.
    Brain Res. 1007:65-70(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  10. "Sigma-1 receptors at galactosylceramide-enriched lipid microdomains regulate oligodendrocyte differentiation."
    Hayashi T., Su T.-P.
    Proc. Natl. Acad. Sci. U.S.A. 101:14949-14954(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  11. "Sigma-1 receptors potentiate epidermal growth factor signaling towards neuritogenesis in PC12 cells: potential relation to lipid raft reconstitution."
    Takebayashi M., Hayashi T., Su T.-P.
    Synapse 53:90-103(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  12. "Chronic antidepressants potentiate via sigma-1 receptors the brain-derived neurotrophic factor-induced signaling for glutamate release."
    Yagasaki Y., Numakawa T., Kumamaru E., Hayashi T., Su T.-P., Kunugi H.
    J. Biol. Chem. 281:12941-12949(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiSGMR1_RAT
AccessioniPrimary (citable) accession number: Q9R0C9
Secondary accession number(s): Q9R1J7, Q9Z2W2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: May 1, 2000
Last modified: October 29, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Depletion by RNAi alters oligodendrocyte differentiation and enhances opioid analgesia.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3