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Q9R0C9

- SGMR1_RAT

UniProt

Q9R0C9 - SGMR1_RAT

Protein

Sigma non-opioid intracellular receptor 1

Gene

Sigmar1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. Involved in the regulation of different receptors it plays a role in BDNF signaling and EGF signaling. Also regulates ion channels like the potassium channel and could modulate neurotransmitter release. Plays a role in calcium signaling through modulation together with ANK2 of the ITP3R-dependent calcium efflux at the endoplasmic reticulum. Plays a role in several other cell functions including proliferation, survival and death. Originally identified for its ability to bind various psychoactive drugs it is involved in learning processes, memory and mood alteration.6 Publications

    GO - Molecular functioni

    1. opioid receptor activity Source: RGD
    2. protein binding Source: IntAct

    GO - Biological processi

    1. lipid transport Source: UniProtKB-KW
    2. nervous system development Source: RGD
    3. opioid receptor signaling pathway Source: GOC
    4. regulation of neuron apoptotic process Source: UniProtKB

    Keywords - Molecular functioni

    Receptor

    Keywords - Biological processi

    Lipid transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sigma non-opioid intracellular receptor 1
    Alternative name(s):
    Sigma 1-type opioid receptor
    Short name:
    Sigma1-receptor
    Short name:
    Sigma1R
    Gene namesi
    Name:Sigmar1
    Synonyms:Oprs1
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 5

    Organism-specific databases

    RGDi68364. Sigmar1.

    Subcellular locationi

    Nucleus inner membrane. Nucleus outer membrane. Endoplasmic reticulum membrane. Lipid droplet. Cell junction. Cell membrane. Cell projectiongrowth cone
    Note: Targeted to lipid droplets, cholesterol and galactosylceramide-enriched domains of the endoplasmic reticulum. Enriched at cell-cell communication regions, growth cone and postsynaptic structures. Localization is modulated by ligand-binding.

    GO - Cellular componenti

    1. cell junction Source: UniProtKB-SubCell
    2. endoplasmic reticulum Source: RGD
    3. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    4. growth cone Source: UniProtKB-SubCell
    5. integral component of membrane Source: UniProtKB-KW
    6. lipid particle Source: UniProtKB-SubCell
    7. nuclear inner membrane Source: UniProtKB-SubCell
    8. nuclear outer membrane Source: UniProtKB-SubCell
    9. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Cell projection, Endoplasmic reticulum, Lipid droplet, Membrane, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 223223Sigma non-opioid intracellular receptor 1PRO_0000268655Add
    BLAST

    Proteomic databases

    PaxDbiQ9R0C9.
    PRIDEiQ9R0C9.

    Expressioni

    Tissue specificityi

    Expressed in ependymocytes and neurons throughout the CNS from the olfactory bulb to the spinal cord. Expressed by progenitor, mature and satellite oligodendrocytes and by Schwann cells (at protein level). Expressed in liver, intestine, kidney, brain, lung and heart. Expressed by retinal cells.5 Publications

    Gene expression databases

    GenevestigatoriQ9R0C9.

    Interactioni

    Subunit structurei

    Forms a ternary complex with ANK2 and ITPR3. The complex is disrupted by agonists. Interacts with KCNA4.2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Hspa5P067613EBI-1557826,EBI-916036
    Kcna2P631413EBI-1557826,EBI-644033From a different organism.

    Protein-protein interaction databases

    IntActiQ9R0C9. 3 interactions.

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 99CytoplasmicSequence Analysis
    Topological domaini31 – 8050ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini102 – 223122CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei10 – 3021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei81 – 10121HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni2 – 87Targeting to lipid dropletsBy similarity
    Regioni118 – 14831Mediates ligand-bindingBy similarityAdd
    BLAST

    Sequence similaritiesi

    Belongs to the ERG2 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG296707.
    GeneTreeiENSGT00390000012082.
    HOVERGENiHBG058220.
    InParanoidiQ9R0C9.
    OMAiFYTLRAY.
    OrthoDBiEOG7GFB5Z.
    PhylomeDBiQ9R0C9.
    TreeFamiTF300106.

    Family and domain databases

    InterProiIPR006716. ERG2_sigma1_rcpt-like.
    IPR028545. SIGMAR1.
    [Graphical view]
    PANTHERiPTHR10868. PTHR10868. 1 hit.
    PfamiPF04622. ERG2_Sigma1R. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9R0C9-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MPWAVGRRWA WITLFLTIVA VLIQAVWLWL GTQSFVFQRE EIAQLARQYA    50
    GLDHELAFSR LIVELRRLHP GHVLPDEELQ WVFVNAGGWM GAMCLLHASL 100
    SEYVLLFGTA LGSHGHSGRY WAEISDTIIS GTFHQWREGT TKSEVYYPGE 150
    TVVHGPGEAT AVEWGPNTWM VEYGRGVIPS TLAFALSDTI FSTQDFLTLF 200
    YTLRAYARGL RLELTTYLFG QDP 223
    Length:223
    Mass (Da):25,270
    Last modified:May 1, 2000 - v1
    Checksum:iB125A0388F1FFC6E
    GO
    Isoform 2 (identifier: Q9R0C9-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         103-106: YVLL → TILG
         107-223: Missing.

    Show »
    Length:106
    Mass (Da):12,153
    Checksum:i8BA4159B6A9E2A0F
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti161 – 1611A → D in AAD01198. (PubMed:9489711)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei103 – 1064YVLL → TILG in isoform 2. 1 PublicationVSP_021988
    Alternative sequencei107 – 223117Missing in isoform 2. 1 PublicationVSP_021989Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF004218 mRNA. Translation: AAD01198.1.
    AF067769 mRNA. Translation: AAF08342.1.
    AF087827 mRNA. Translation: AAD49439.1.
    BC061978 mRNA. Translation: AAH61978.1.
    RefSeqiNP_112258.1. NM_030996.1.
    UniGeneiRn.1129.

    Genome annotation databases

    EnsembliENSRNOT00000019795; ENSRNOP00000019795; ENSRNOG00000014604. [Q9R0C9-1]
    GeneIDi29336.
    KEGGirno:29336.
    UCSCiRGD:68364. rat. [Q9R0C9-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF004218 mRNA. Translation: AAD01198.1 .
    AF067769 mRNA. Translation: AAF08342.1 .
    AF087827 mRNA. Translation: AAD49439.1 .
    BC061978 mRNA. Translation: AAH61978.1 .
    RefSeqi NP_112258.1. NM_030996.1.
    UniGenei Rn.1129.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q9R0C9. 3 interactions.

    Chemistry

    BindingDBi Q9R0C9.
    ChEMBLi CHEMBL3602.

    Proteomic databases

    PaxDbi Q9R0C9.
    PRIDEi Q9R0C9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000019795 ; ENSRNOP00000019795 ; ENSRNOG00000014604 . [Q9R0C9-1 ]
    GeneIDi 29336.
    KEGGi rno:29336.
    UCSCi RGD:68364. rat. [Q9R0C9-1 ]

    Organism-specific databases

    CTDi 10280.
    RGDi 68364. Sigmar1.

    Phylogenomic databases

    eggNOGi NOG296707.
    GeneTreei ENSGT00390000012082.
    HOVERGENi HBG058220.
    InParanoidi Q9R0C9.
    OMAi FYTLRAY.
    OrthoDBi EOG7GFB5Z.
    PhylomeDBi Q9R0C9.
    TreeFami TF300106.

    Miscellaneous databases

    NextBioi 608816.
    PROi Q9R0C9.

    Gene expression databases

    Genevestigatori Q9R0C9.

    Family and domain databases

    InterProi IPR006716. ERG2_sigma1_rcpt-like.
    IPR028545. SIGMAR1.
    [Graphical view ]
    PANTHERi PTHR10868. PTHR10868. 1 hit.
    Pfami PF04622. ERG2_Sigma1R. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and functional characterization of a sigma receptor from rat brain."
      Seth P., Fei Y.-J., Li H.W., Huang W., Leibach F.H., Ganapathy V.
      J. Neurochem. 70:922-931(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY.
      Strain: Sprague-Dawley.
      Tissue: Brain.
    2. "Sigma1 receptor modulation of opioid analgesia in the mouse."
      Mei J., Pasternak G.W.
      J. Pharmacol. Exp. Ther. 300:1070-1074(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION.
      Tissue: Brain.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Prostate.
    4. "Immunocytochemical localization of the sigma(1) receptor in the adult rat central nervous system."
      Alonso G., Phan V.-L., Guillemain I., Saunier M., Legrand A., Anoal M., Maurice T.
      Neuroscience 97:155-170(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
    5. Cited for: TISSUE SPECIFICITY.
    6. "Regulating ankyrin dynamics: roles of sigma-1 receptors."
      Hayashi T., Su T.-P.
      Proc. Natl. Acad. Sci. U.S.A. 98:491-496(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH ANK2 AND ITPR3, SUBCELLULAR LOCATION.
    7. "The sigma receptor as a ligand-regulated auxiliary potassium channel subunit."
      Aydar E., Palmer C.P., Klyachko V.A., Jackson M.B.
      Neuron 34:399-410(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TOPOLOGY, SUBCELLULAR LOCATION, INTERACTION WITH KCNA4.
    8. "Immunohistochemical localization of the sigma1-receptor in oligodendrocytes in the rat central nervous system."
      Palacios G., Muro A., Vela J.M., Molina-Holgado E., Guitart X., Ovalle S., Zamanillo D.
      Brain Res. 961:92-99(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    9. "Immunohistochemical localization of the sigma1 receptor in Schwann cells of rat sciatic nerve."
      Palacios G., Muro A., Verdu E., Pumarola M., Vela J.M.
      Brain Res. 1007:65-70(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    10. "Sigma-1 receptors at galactosylceramide-enriched lipid microdomains regulate oligodendrocyte differentiation."
      Hayashi T., Su T.-P.
      Proc. Natl. Acad. Sci. U.S.A. 101:14949-14954(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.
    11. "Sigma-1 receptors potentiate epidermal growth factor signaling towards neuritogenesis in PC12 cells: potential relation to lipid raft reconstitution."
      Takebayashi M., Hayashi T., Su T.-P.
      Synapse 53:90-103(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    12. "Chronic antidepressants potentiate via sigma-1 receptors the brain-derived neurotrophic factor-induced signaling for glutamate release."
      Yagasaki Y., Numakawa T., Kumamaru E., Hayashi T., Su T.-P., Kunugi H.
      J. Biol. Chem. 281:12941-12949(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiSGMR1_RAT
    AccessioniPrimary (citable) accession number: Q9R0C9
    Secondary accession number(s): Q9R1J7, Q9Z2W2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 12, 2006
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 80 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Depletion by RNAi alters oligodendrocyte differentiation and enhances opioid analgesia.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3