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Q9R0C8

- VAV3_MOUSE

UniProt

Q9R0C8 - VAV3_MOUSE

Protein

Guanine nucleotide exchange factor VAV3

Gene

Vav3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 131 (01 Oct 2014)
      Sequence version 2 (16 Aug 2004)
      Previous versions | rss
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    Functioni

    Exchange factor for GTP-binding proteins RhoA, RhoG and, to a lesser extent, Rac1. Binds physically to the nucleotide-free states of those GTPases By similarity. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. May be important for integrin-mediated signaling, at least in some cell types. In osteoclasts, along with SYK tyrosine kinase, required for signaling through integrin alpha-v/beta-1 (ITAGV-ITGB1), a crucial event for osteoclast proper cytoskeleton organization and function. This signaling pathway involves RAC1, but not RHO, activation. Necessary for proper wound healing. In the course of wound healing, required for the phagocytotic cup formation preceding macrophage phagocytosis of apoptotic neutrophils. Responsible for integrin beta-2-mediated macrophage adhesion and, to a lesser extent, contributes to beta-3-mediated adhesion. Does not affect integrin beta-1-mediated adhesion.By similarity3 Publications

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri513 – 56250Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. epidermal growth factor receptor binding Source: MGI
    2. guanyl-nucleotide exchange factor activity Source: MGI
    3. metal ion binding Source: UniProtKB-KW
    4. protein binding Source: UniProtKB
    5. Rac guanyl-nucleotide exchange factor activity Source: MGI
    6. Rho guanyl-nucleotide exchange factor activity Source: MGI

    GO - Biological processi

    1. angiogenesis Source: UniProtKB-KW
    2. B cell receptor signaling pathway Source: Ensembl
    3. cell migration Source: MGI
    4. cell projection assembly Source: MGI
    5. cellular response to DNA damage stimulus Source: Ensembl
    6. integrin-mediated signaling pathway Source: MGI
    7. lamellipodium assembly Source: MGI
    8. neutrophil chemotaxis Source: MGI
    9. positive regulation of B cell proliferation Source: Ensembl
    10. positive regulation of cell adhesion Source: MGI
    11. positive regulation of GTPase activity Source: GOC
    12. positive regulation of phosphatidylinositol 3-kinase activity Source: MGI
    13. positive regulation of Rac GTPase activity Source: GOC
    14. positive regulation of Rho GTPase activity Source: GOC
    15. regulation of GTPase activity Source: MGI
    16. response to drug Source: Ensembl
    17. small GTPase mediated signal transduction Source: MGI
    18. vesicle fusion Source: MGI

    Keywords - Molecular functioni

    Guanine-nucleotide releasing factor

    Keywords - Biological processi

    Angiogenesis

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_188185. DAP12 signaling.
    REACT_188202. FCERI mediated Ca+2 mobilization.
    REACT_188530. FCERI mediated MAPK activation.
    REACT_198374. Regulation of actin dynamics for phagocytic cup formation.
    REACT_204733. G alpha (12/13) signalling events.
    REACT_209641. NRAGE signals death through JNK.
    REACT_210090. Rho GTPase cycle.
    REACT_220092. GPVI-mediated activation cascade.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Guanine nucleotide exchange factor VAV3
    Short name:
    VAV-3
    Gene namesi
    Name:Vav3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 3

    Organism-specific databases

    MGIiMGI:1888518. Vav3.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: MGI
    2. plasma membrane Source: MGI

    Pathology & Biotechi

    Disruption phenotypei

    Mutant mice exhibit increased bone density, due to diminished bone resorption, including following parathyroid hormone treatment. This phenotype is due to defective terminal osteoclast differentiation. They also show a delayed wound repair program, characterized by a deficit in macrophage emigration to the wound, a reduced myofibroblast-dependent wound contraction and a diminished neovascularization in the restoration tissue.2 Publications

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 847847Guanine nucleotide exchange factor VAV3PRO_0000080987Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei141 – 1411PhosphotyrosineBy similarity

    Post-translational modificationi

    Phosphorylated. Phosphorylation can be mediated by ROS1 By similarity. In osteoclasts, undergoes tyrosine phosphorylation in response to CSF1.By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ9R0C8.
    PRIDEiQ9R0C8.

    PTM databases

    PhosphoSiteiQ9R0C8.

    Expressioni

    Tissue specificityi

    Abundantly expressed in osteoclasts and mature osteoblasts. Also expressed in bone marrow macrophages (at protein level):.

    Gene expression databases

    ArrayExpressiQ9R0C8.
    BgeeiQ9R0C8.
    CleanExiMM_VAV3.
    GenevestigatoriQ9R0C8.

    Interactioni

    Subunit structurei

    Interacts with the PH domain of APS. Interacts with ROS1; constitutive interaction that mediates VAV3 phosphorylation By similarity. Interacts (via SH2 domains) with the phosphorylated form of EPHA2.By similarity1 Publication

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000036270.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9R0C8.
    SMRiQ9R0C8. Positions 1-563, 593-846.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 119119CHPROSITE-ProRule annotationAdd
    BLAST
    Domaini192 – 371180DHPROSITE-ProRule annotationAdd
    BLAST
    Domaini400 – 502103PHPROSITE-ProRule annotationAdd
    BLAST
    Domaini592 – 66069SH3 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini672 – 76695SH2PROSITE-ProRule annotationAdd
    BLAST
    Domaini788 – 84760SH3 2PROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni560 – 847288Sufficient for interaction with ROS1By similarityAdd
    BLAST

    Sequence similaritiesi

    Contains 1 CH (calponin-homology) domain.PROSITE-ProRule annotation
    Contains 1 DH (DBL-homology) domain.PROSITE-ProRule annotation
    Contains 1 PH domain.PROSITE-ProRule annotation
    Contains 1 phorbol-ester/DAG-type zinc finger.PROSITE-ProRule annotation
    Contains 1 SH2 domain.PROSITE-ProRule annotation
    Contains 2 SH3 domains.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri513 – 56250Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, SH2 domain, SH3 domain, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG326494.
    GeneTreeiENSGT00740000115307.
    HOGENOMiHOG000234364.
    HOVERGENiHBG018066.
    InParanoidiQ9R0C8.
    KOiK05730.
    OMAiDPGLPKM.
    OrthoDBiEOG73FQKZ.
    PhylomeDBiQ9R0C8.
    TreeFamiTF316171.

    Family and domain databases

    Gene3Di1.10.418.10. 1 hit.
    1.20.900.10. 1 hit.
    2.30.29.30. 1 hit.
    3.30.505.10. 1 hit.
    InterProiIPR022613. CAMSAP_CH.
    IPR001715. CH-domain.
    IPR000219. DH-domain.
    IPR001331. GDS_CDC24_CS.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    IPR002219. Prot_Kinase_C-like_PE/DAG-bd.
    IPR000980. SH2.
    IPR011511. SH3_2.
    IPR001452. SH3_domain.
    IPR003096. SM22_calponin.
    IPR028530. Vav.
    [Graphical view]
    PANTHERiPTHR22826:SF97. PTHR22826:SF97. 1 hit.
    PfamiPF00130. C1_1. 1 hit.
    PF11971. CAMSAP_CH. 1 hit.
    PF00169. PH. 1 hit.
    PF00621. RhoGEF. 1 hit.
    PF00017. SH2. 1 hit.
    PF07653. SH3_2. 2 hits.
    [Graphical view]
    PRINTSiPR00401. SH2DOMAIN.
    PR00452. SH3DOMAIN.
    PR00888. SM22CALPONIN.
    SMARTiSM00109. C1. 1 hit.
    SM00033. CH. 1 hit.
    SM00233. PH. 1 hit.
    SM00325. RhoGEF. 1 hit.
    SM00252. SH2. 1 hit.
    SM00326. SH3. 2 hits.
    [Graphical view]
    SUPFAMiSSF47576. SSF47576. 1 hit.
    SSF48065. SSF48065. 1 hit.
    SSF50044. SSF50044. 2 hits.
    SSF55550. SSF55550. 2 hits.
    PROSITEiPS50021. CH. 1 hit.
    PS00741. DH_1. 1 hit.
    PS50010. DH_2. 1 hit.
    PS50003. PH_DOMAIN. 1 hit.
    PS50001. SH2. 1 hit.
    PS50002. SH3. 2 hits.
    PS00479. ZF_DAG_PE_1. 1 hit.
    PS50081. ZF_DAG_PE_2. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative promoter usage and alternative splicing. Align

    Isoform 1 (identifier: Q9R0C8-1) [UniParc]FASTAAdd to Basket

    Also known as: Alpha

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEPWKQCAQW LIHSKVLPPN HRVTWDSAQV FDLAQTLRDG VLLCQLLNNL    50
    RPHSINLKEI NLRPQMSQFL CLKNIRTFLA ACCDTFGMRK SELFEAFDLF 100
    DVRDFGKVIE TLSRLSRTPI ALATGIRPFP TEESINDEDI YKGLPDLIDE 150
    TRVEDEEDLY DCVYGEDEGG EVYEDLMKAE EAQQPKSQEN DIRSCCLAEI 200
    RQTEEKYTET LESIEKYFMA PLKRFLTAAE FDSVFINIPD LVKVHRSLMQ 250
    EIHDSIVNKD DQNLYQVFIN YKERLVIYGQ YCSGVESAIS NLDYISKTKE 300
    DVKLKLEECS KRANNGKFTL RDLLVVPMQR VLKYHLLLQE LVKHTHDPME 350
    KANLKLALDA MKDLAQYVNE VKRDNETLRE IKQFQLSIEN LNQPVLLFGR 400
    PQGDGEIRIT TLDKHTKQER HIFLFDLAVI VCKRKGDNYE MKEIIDLQQY 450
    KIANNPTTDK ENKKWSYGFY LIHTQGQNGL EFYCKTKDLK KKWLEQFEMA 500
    LSNIRPDYAD SNFHDFKMHT FTRVTSCRVC QMLLRGTFYQ GYLCFKCGAK 550
    AHKECLGRVD NCGRVNSVEQ GPFKPPEKRT NGLRRASRQV DPGLPKMQVI 600
    RNYTGTPAPG LHEGPPLHIQ AGDTVELLRG DAHSVFWQGR NLASGEVGFF 650
    PSDAVKPSPC VPKPVDYSCQ PWYAGPMERL QAETELINRV NSTYLVRHRT 700
    KESGEYAISI KYNNEAKHIK ILTRDGFFHI AENRKFKSLM ELVEYYKHHS 750
    LKEGFRTLDT TLQFPYKEPE QPAGQRGNRT GNSLLSPKVL GIAIARYDFC 800
    ARDMRELSLL KGDMVKIYTK MSANGWWRGE VNGRVGWFPS TYVEEDE 847
    Length:847
    Mass (Da):97,968
    Last modified:August 16, 2004 - v2
    Checksum:i727C9BF50DF8CF19
    GO
    Isoform 2 (identifier: Q9R0C8-2)

    Also known as: Beta

    Sequence is not available
    Length:
    Mass (Da):
    Isoform 3 (identifier: Q9R0C8-3) [UniParc]FASTAAdd to Basket

    Also known as: VAV3.1

    The sequence of this isoform differs from the canonical sequence as follows:
         1-560: Missing.
         561-568: NCGRVNSV → MPIFTFVS

    Note: Produced by alternative promoter usage.

    Show »
    Length:287
    Mass (Da):32,662
    Checksum:iBF2850B8F921F048
    GO
    Isoform 4 (identifier: Q9R0C8-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         569-574: EQGPFK → GKSCLL
         575-847: Missing.

    Note: Produced by alternative splicing. No experimental confirmation available.

    Show »
    Length:574
    Mass (Da):66,849
    Checksum:i6AB7C243493B6F2B
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti355 – 3551K → R in BAC30879. (PubMed:16141072)Curated
    Sequence conflicti452 – 4521I → T in BAC28212. (PubMed:16141072)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 560560Missing in isoform 3. 2 PublicationsVSP_042360Add
    BLAST
    Alternative sequencei561 – 5688NCGRVNSV → MPIFTFVS in isoform 3. 2 PublicationsVSP_042361
    Alternative sequencei569 – 5746EQGPFK → GKSCLL in isoform 4. 1 PublicationVSP_042362
    Alternative sequencei575 – 847273Missing in isoform 4. 1 PublicationVSP_042363Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF067816 mRNA. Translation: AAF09171.1.
    AF140280 mRNA. Translation: AAF20330.2.
    AK033253 mRNA. Translation: BAC28212.1.
    AK041249 mRNA. Translation: BAC30879.2.
    AK147053 mRNA. Translation: BAE27637.1.
    AL731716, AL671857, AL671987 Genomic DNA. Translation: CAM14541.1.
    AL671857, AL671987, AL731716 Genomic DNA. Translation: CAM16459.1.
    AL671987, AL731716, AL671857 Genomic DNA. Translation: CAM18527.1.
    CR936838
    , CR936848, CR936849, CR938729 Genomic DNA. Translation: CAM28077.1.
    CR938729, CR936848 Genomic DNA. Translation: CAM28109.1.
    CR938729
    , CR936838, CR936848, CR936849 Genomic DNA. Translation: CAM28111.1.
    CR936849
    , CR936838, CR936848, CR938729 Genomic DNA. Translation: CAM28160.1.
    CR936848, CR938729 Genomic DNA. Translation: CAM28169.1.
    CR936848
    , CR936838, CR936849, CR938729 Genomic DNA. Translation: CAM28172.1.
    BC027242 mRNA. Translation: AAH27242.1.
    BC052739 mRNA. Translation: AAH52739.1.
    CCDSiCCDS17773.1. [Q9R0C8-1]
    CCDS59650.1. [Q9R0C8-3]
    RefSeqiNP_065251.2. NM_020505.2. [Q9R0C8-1]
    NP_666251.1. NM_146139.2. [Q9R0C8-3]
    UniGeneiMm.282257.

    Genome annotation databases

    EnsembliENSMUST00000046864; ENSMUSP00000036270; ENSMUSG00000033721. [Q9R0C8-1]
    ENSMUST00000106576; ENSMUSP00000102186; ENSMUSG00000033721. [Q9R0C8-3]
    GeneIDi57257.
    KEGGimmu:57257.
    UCSCiuc008raf.1. mouse. [Q9R0C8-4]
    uc008rag.1. mouse. [Q9R0C8-1]
    uc008rah.1. mouse. [Q9R0C8-3]

    Keywords - Coding sequence diversityi

    Alternative promoter usage, Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF067816 mRNA. Translation: AAF09171.1 .
    AF140280 mRNA. Translation: AAF20330.2 .
    AK033253 mRNA. Translation: BAC28212.1 .
    AK041249 mRNA. Translation: BAC30879.2 .
    AK147053 mRNA. Translation: BAE27637.1 .
    AL731716 , AL671857 , AL671987 Genomic DNA. Translation: CAM14541.1 .
    AL671857 , AL671987 , AL731716 Genomic DNA. Translation: CAM16459.1 .
    AL671987 , AL731716 , AL671857 Genomic DNA. Translation: CAM18527.1 .
    CR936838
    , CR936848 , CR936849 , CR938729 Genomic DNA. Translation: CAM28077.1 .
    CR938729 , CR936848 Genomic DNA. Translation: CAM28109.1 .
    CR938729
    , CR936838 , CR936848 , CR936849 Genomic DNA. Translation: CAM28111.1 .
    CR936849
    , CR936838 , CR936848 , CR938729 Genomic DNA. Translation: CAM28160.1 .
    CR936848 , CR938729 Genomic DNA. Translation: CAM28169.1 .
    CR936848
    , CR936838 , CR936849 , CR938729 Genomic DNA. Translation: CAM28172.1 .
    BC027242 mRNA. Translation: AAH27242.1 .
    BC052739 mRNA. Translation: AAH52739.1 .
    CCDSi CCDS17773.1. [Q9R0C8-1 ]
    CCDS59650.1. [Q9R0C8-3 ]
    RefSeqi NP_065251.2. NM_020505.2. [Q9R0C8-1 ]
    NP_666251.1. NM_146139.2. [Q9R0C8-3 ]
    UniGenei Mm.282257.

    3D structure databases

    ProteinModelPortali Q9R0C8.
    SMRi Q9R0C8. Positions 1-563, 593-846.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000036270.

    PTM databases

    PhosphoSitei Q9R0C8.

    Proteomic databases

    PaxDbi Q9R0C8.
    PRIDEi Q9R0C8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000046864 ; ENSMUSP00000036270 ; ENSMUSG00000033721 . [Q9R0C8-1 ]
    ENSMUST00000106576 ; ENSMUSP00000102186 ; ENSMUSG00000033721 . [Q9R0C8-3 ]
    GeneIDi 57257.
    KEGGi mmu:57257.
    UCSCi uc008raf.1. mouse. [Q9R0C8-4 ]
    uc008rag.1. mouse. [Q9R0C8-1 ]
    uc008rah.1. mouse. [Q9R0C8-3 ]

    Organism-specific databases

    CTDi 10451.
    MGIi MGI:1888518. Vav3.

    Phylogenomic databases

    eggNOGi NOG326494.
    GeneTreei ENSGT00740000115307.
    HOGENOMi HOG000234364.
    HOVERGENi HBG018066.
    InParanoidi Q9R0C8.
    KOi K05730.
    OMAi DPGLPKM.
    OrthoDBi EOG73FQKZ.
    PhylomeDBi Q9R0C8.
    TreeFami TF316171.

    Enzyme and pathway databases

    Reactomei REACT_188185. DAP12 signaling.
    REACT_188202. FCERI mediated Ca+2 mobilization.
    REACT_188530. FCERI mediated MAPK activation.
    REACT_198374. Regulation of actin dynamics for phagocytic cup formation.
    REACT_204733. G alpha (12/13) signalling events.
    REACT_209641. NRAGE signals death through JNK.
    REACT_210090. Rho GTPase cycle.
    REACT_220092. GPVI-mediated activation cascade.

    Miscellaneous databases

    ChiTaRSi VAV3. mouse.
    NextBioi 313559.
    PROi Q9R0C8.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9R0C8.
    Bgeei Q9R0C8.
    CleanExi MM_VAV3.
    Genevestigatori Q9R0C8.

    Family and domain databases

    Gene3Di 1.10.418.10. 1 hit.
    1.20.900.10. 1 hit.
    2.30.29.30. 1 hit.
    3.30.505.10. 1 hit.
    InterProi IPR022613. CAMSAP_CH.
    IPR001715. CH-domain.
    IPR000219. DH-domain.
    IPR001331. GDS_CDC24_CS.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    IPR002219. Prot_Kinase_C-like_PE/DAG-bd.
    IPR000980. SH2.
    IPR011511. SH3_2.
    IPR001452. SH3_domain.
    IPR003096. SM22_calponin.
    IPR028530. Vav.
    [Graphical view ]
    PANTHERi PTHR22826:SF97. PTHR22826:SF97. 1 hit.
    Pfami PF00130. C1_1. 1 hit.
    PF11971. CAMSAP_CH. 1 hit.
    PF00169. PH. 1 hit.
    PF00621. RhoGEF. 1 hit.
    PF00017. SH2. 1 hit.
    PF07653. SH3_2. 2 hits.
    [Graphical view ]
    PRINTSi PR00401. SH2DOMAIN.
    PR00452. SH3DOMAIN.
    PR00888. SM22CALPONIN.
    SMARTi SM00109. C1. 1 hit.
    SM00033. CH. 1 hit.
    SM00233. PH. 1 hit.
    SM00325. RhoGEF. 1 hit.
    SM00252. SH2. 1 hit.
    SM00326. SH3. 2 hits.
    [Graphical view ]
    SUPFAMi SSF47576. SSF47576. 1 hit.
    SSF48065. SSF48065. 1 hit.
    SSF50044. SSF50044. 2 hits.
    SSF55550. SSF55550. 2 hits.
    PROSITEi PS50021. CH. 1 hit.
    PS00741. DH_1. 1 hit.
    PS50010. DH_2. 1 hit.
    PS50003. PH_DOMAIN. 1 hit.
    PS50001. SH2. 1 hit.
    PS50002. SH3. 2 hits.
    PS00479. ZF_DAG_PE_1. 1 hit.
    PS50081. ZF_DAG_PE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Major transcript variants of VAV3, a new member of the VAV family of guanine nucleotide exchange factors."
      Trenkle T., McClelland M., Adlkofer K., Welsh J.
      Gene 245:139-149(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [MRNA] OF 1-789 (ISOFORM 3).
      Tissue: Skin.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-731 (ISOFORM 1).
      Strain: C57BL/6J.
      Tissue: Embryonic stomach and Embryonic testis.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Brain and Mammary tumor.
    5. Lubec G., Sunyer B., Chen W.-Q.
      Submitted (JAN-2009) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 143-152, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: OF1.
      Tissue: Hippocampus.
    6. Cited for: FUNCTION, DISRUPTION PHENOTYPE.
    7. "Essential role of Vav family guanine nucleotide exchange factors in EphA receptor-mediated angiogenesis."
      Hunter S.G., Zhuang G., Brantley-Sieders D.M., Swat W., Cowan C.W., Chen J.
      Mol. Cell. Biol. 26:4830-4842(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH EPHA2.
    8. "Wound healing defect of Vav3-/- mice due to impaired {beta}2-integrin-dependent macrophage phagocytosis of apoptotic neutrophils."
      Sindrilaru A., Peters T., Schymeinsky J., Oreshkova T., Wang H., Gompf A., Mannella F., Wlaschek M., Sunderkotter C., Rudolph K.L., Walzog B., Bustelo X.R., Fischer K.D., Scharffetter-Kochanek K.
      Blood 113:5266-5276(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, DISRUPTION PHENOTYPE.

    Entry informationi

    Entry nameiVAV3_MOUSE
    AccessioniPrimary (citable) accession number: Q9R0C8
    Secondary accession number(s): A2CFD7
    , Q7TS85, Q8BRV2, Q8CCF5, Q8R076, Q9JLS6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 24, 2001
    Last sequence update: August 16, 2004
    Last modified: October 1, 2014
    This is version 131 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3