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Q9R0C8

- VAV3_MOUSE

UniProt

Q9R0C8 - VAV3_MOUSE

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Protein

Guanine nucleotide exchange factor VAV3

Gene
Vav3
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Exchange factor for GTP-binding proteins RhoA, RhoG and, to a lesser extent, Rac1. Binds physically to the nucleotide-free states of those GTPases By similarity. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. May be important for integrin-mediated signaling, at least in some cell types. In osteoclasts, along with SYK tyrosine kinase, required for signaling through integrin alpha-v/beta-1 (ITAGV-ITGB1), a crucial event for osteoclast proper cytoskeleton organization and function. This signaling pathway involves RAC1, but not RHO, activation. Necessary for proper wound healing. In the course of wound healing, required for the phagocytotic cup formation preceding macrophage phagocytosis of apoptotic neutrophils. Responsible for integrin beta-2-mediated macrophage adhesion and, to a lesser extent, contributes to beta-3-mediated adhesion. Does not affect integrin beta-1-mediated adhesion.3 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri513 – 56250Phorbol-ester/DAG-typeAdd
BLAST

GO - Molecular functioni

  1. epidermal growth factor receptor binding Source: MGI
  2. guanyl-nucleotide exchange factor activity Source: MGI
  3. metal ion binding Source: UniProtKB-KW
  4. protein binding Source: UniProtKB
  5. Rac guanyl-nucleotide exchange factor activity Source: MGI
  6. Rho guanyl-nucleotide exchange factor activity Source: MGI

GO - Biological processi

  1. angiogenesis Source: UniProtKB-KW
  2. B cell receptor signaling pathway Source: Ensembl
  3. cell migration Source: MGI
  4. cell projection assembly Source: MGI
  5. cellular response to DNA damage stimulus Source: Ensembl
  6. integrin-mediated signaling pathway Source: MGI
  7. lamellipodium assembly Source: MGI
  8. neutrophil chemotaxis Source: MGI
  9. positive regulation of B cell proliferation Source: Ensembl
  10. positive regulation of cell adhesion Source: MGI
  11. positive regulation of phosphatidylinositol 3-kinase activity Source: MGI
  12. regulation of GTPase activity Source: MGI
  13. regulation of Rac GTPase activity Source: GOC
  14. regulation of Rho GTPase activity Source: GOC
  15. response to drug Source: Ensembl
  16. small GTPase mediated signal transduction Source: MGI
  17. vesicle fusion Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Guanine-nucleotide releasing factor

Keywords - Biological processi

Angiogenesis

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_188185. DAP12 signaling.
REACT_188202. FCERI mediated Ca+2 mobilization.
REACT_188530. FCERI mediated MAPK activation.
REACT_198374. Regulation of actin dynamics for phagocytic cup formation.
REACT_204733. G alpha (12/13) signalling events.
REACT_209641. NRAGE signals death through JNK.
REACT_210090. Rho GTPase cycle.
REACT_220092. GPVI-mediated activation cascade.

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide exchange factor VAV3
Short name:
VAV-3
Gene namesi
Name:Vav3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 3

Organism-specific databases

MGIiMGI:1888518. Vav3.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. plasma membrane Source: MGI
Complete GO annotation...

Pathology & Biotechi

Disruption phenotypei

Mutant mice exhibit increased bone density, due to diminished bone resorption, including following parathyroid hormone treatment. This phenotype is due to defective terminal osteoclast differentiation. They also show a delayed wound repair program, characterized by a deficit in macrophage emigration to the wound, a reduced myofibroblast-dependent wound contraction and a diminished neovascularization in the restoration tissue.2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 847847Guanine nucleotide exchange factor VAV3PRO_0000080987Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei141 – 1411Phosphotyrosine By similarity

Post-translational modificationi

Phosphorylated. Phosphorylation can be mediated by ROS1 By similarity. In osteoclasts, undergoes tyrosine phosphorylation in response to CSF1.

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9R0C8.
PRIDEiQ9R0C8.

PTM databases

PhosphoSiteiQ9R0C8.

Expressioni

Tissue specificityi

Abundantly expressed in osteoclasts and mature osteoblasts. Also expressed in bone marrow macrophages (at protein level):.

Gene expression databases

ArrayExpressiQ9R0C8.
BgeeiQ9R0C8.
CleanExiMM_VAV3.
GenevestigatoriQ9R0C8.

Interactioni

Subunit structurei

Interacts with the PH domain of APS. Interacts with ROS1; constitutive interaction that mediates VAV3 phosphorylation By similarity. Interacts (via SH2 domains) with the phosphorylated form of EPHA2.1 Publication

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000036270.

Structurei

3D structure databases

ProteinModelPortaliQ9R0C8.
SMRiQ9R0C8. Positions 1-563, 593-846.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 119119CHAdd
BLAST
Domaini192 – 371180DHAdd
BLAST
Domaini400 – 502103PHAdd
BLAST
Domaini592 – 66069SH3 1Add
BLAST
Domaini672 – 76695SH2Add
BLAST
Domaini788 – 84760SH3 2Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni560 – 847288Sufficient for interaction with ROS1 By similarityAdd
BLAST

Sequence similaritiesi

Contains 1 PH domain.
Contains 1 SH2 domain.
Contains 2 SH3 domains.

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri513 – 56250Phorbol-ester/DAG-typeAdd
BLAST

Keywords - Domaini

Repeat, SH2 domain, SH3 domain, Zinc-finger

Phylogenomic databases

eggNOGiNOG326494.
GeneTreeiENSGT00740000115307.
HOGENOMiHOG000234364.
HOVERGENiHBG018066.
InParanoidiQ9R0C8.
KOiK05730.
OMAiDPGLPKM.
OrthoDBiEOG73FQKZ.
PhylomeDBiQ9R0C8.
TreeFamiTF316171.

Family and domain databases

Gene3Di1.10.418.10. 1 hit.
1.20.900.10. 1 hit.
2.30.29.30. 1 hit.
3.30.505.10. 1 hit.
InterProiIPR022613. CAMSAP_CH.
IPR001715. CH-domain.
IPR000219. DH-domain.
IPR001331. GDS_CDC24_CS.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR002219. Prot_Kinase_C-like_PE/DAG-bd.
IPR000980. SH2.
IPR011511. SH3_2.
IPR001452. SH3_domain.
IPR003096. SM22_calponin.
IPR028530. Vav.
[Graphical view]
PANTHERiPTHR22826:SF97. PTHR22826:SF97. 1 hit.
PfamiPF00130. C1_1. 1 hit.
PF11971. CAMSAP_CH. 1 hit.
PF00169. PH. 1 hit.
PF00621. RhoGEF. 1 hit.
PF00017. SH2. 1 hit.
PF07653. SH3_2. 2 hits.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
PR00452. SH3DOMAIN.
PR00888. SM22CALPONIN.
SMARTiSM00109. C1. 1 hit.
SM00033. CH. 1 hit.
SM00233. PH. 1 hit.
SM00325. RhoGEF. 1 hit.
SM00252. SH2. 1 hit.
SM00326. SH3. 2 hits.
[Graphical view]
SUPFAMiSSF47576. SSF47576. 1 hit.
SSF48065. SSF48065. 1 hit.
SSF50044. SSF50044. 2 hits.
SSF55550. SSF55550. 2 hits.
PROSITEiPS50021. CH. 1 hit.
PS00741. DH_1. 1 hit.
PS50010. DH_2. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS50001. SH2. 1 hit.
PS50002. SH3. 2 hits.
PS00479. ZF_DAG_PE_1. 1 hit.
PS50081. ZF_DAG_PE_2. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative promoter usage and alternative splicing. Align

Isoform 1 (identifier: Q9R0C8-1) [UniParc]FASTAAdd to Basket

Also known as: Alpha

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MEPWKQCAQW LIHSKVLPPN HRVTWDSAQV FDLAQTLRDG VLLCQLLNNL    50
RPHSINLKEI NLRPQMSQFL CLKNIRTFLA ACCDTFGMRK SELFEAFDLF 100
DVRDFGKVIE TLSRLSRTPI ALATGIRPFP TEESINDEDI YKGLPDLIDE 150
TRVEDEEDLY DCVYGEDEGG EVYEDLMKAE EAQQPKSQEN DIRSCCLAEI 200
RQTEEKYTET LESIEKYFMA PLKRFLTAAE FDSVFINIPD LVKVHRSLMQ 250
EIHDSIVNKD DQNLYQVFIN YKERLVIYGQ YCSGVESAIS NLDYISKTKE 300
DVKLKLEECS KRANNGKFTL RDLLVVPMQR VLKYHLLLQE LVKHTHDPME 350
KANLKLALDA MKDLAQYVNE VKRDNETLRE IKQFQLSIEN LNQPVLLFGR 400
PQGDGEIRIT TLDKHTKQER HIFLFDLAVI VCKRKGDNYE MKEIIDLQQY 450
KIANNPTTDK ENKKWSYGFY LIHTQGQNGL EFYCKTKDLK KKWLEQFEMA 500
LSNIRPDYAD SNFHDFKMHT FTRVTSCRVC QMLLRGTFYQ GYLCFKCGAK 550
AHKECLGRVD NCGRVNSVEQ GPFKPPEKRT NGLRRASRQV DPGLPKMQVI 600
RNYTGTPAPG LHEGPPLHIQ AGDTVELLRG DAHSVFWQGR NLASGEVGFF 650
PSDAVKPSPC VPKPVDYSCQ PWYAGPMERL QAETELINRV NSTYLVRHRT 700
KESGEYAISI KYNNEAKHIK ILTRDGFFHI AENRKFKSLM ELVEYYKHHS 750
LKEGFRTLDT TLQFPYKEPE QPAGQRGNRT GNSLLSPKVL GIAIARYDFC 800
ARDMRELSLL KGDMVKIYTK MSANGWWRGE VNGRVGWFPS TYVEEDE 847
Length:847
Mass (Da):97,968
Last modified:August 16, 2004 - v2
Checksum:i727C9BF50DF8CF19
GO
Isoform 2 (identifier: Q9R0C8-2)

Also known as: Beta

Sequence is not available
Length:
Mass (Da):
Isoform 3 (identifier: Q9R0C8-3) [UniParc]FASTAAdd to Basket

Also known as: VAV3.1

The sequence of this isoform differs from the canonical sequence as follows:
     1-560: Missing.
     561-568: NCGRVNSV → MPIFTFVS

Note: Produced by alternative promoter usage.

Show »
Length:287
Mass (Da):32,662
Checksum:iBF2850B8F921F048
GO
Isoform 4 (identifier: Q9R0C8-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     569-574: EQGPFK → GKSCLL
     575-847: Missing.

Note: Produced by alternative splicing. No experimental confirmation available.

Show »
Length:574
Mass (Da):66,849
Checksum:i6AB7C243493B6F2B
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 560560Missing in isoform 3. VSP_042360Add
BLAST
Alternative sequencei561 – 5688NCGRVNSV → MPIFTFVS in isoform 3. VSP_042361
Alternative sequencei569 – 5746EQGPFK → GKSCLL in isoform 4. VSP_042362
Alternative sequencei575 – 847273Missing in isoform 4. VSP_042363Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti355 – 3551K → R in BAC30879. 1 Publication
Sequence conflicti452 – 4521I → T in BAC28212. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF067816 mRNA. Translation: AAF09171.1.
AF140280 mRNA. Translation: AAF20330.2.
AK033253 mRNA. Translation: BAC28212.1.
AK041249 mRNA. Translation: BAC30879.2.
AK147053 mRNA. Translation: BAE27637.1.
AL731716, AL671857, AL671987 Genomic DNA. Translation: CAM14541.1.
AL671857, AL671987, AL731716 Genomic DNA. Translation: CAM16459.1.
AL671987, AL731716, AL671857 Genomic DNA. Translation: CAM18527.1.
CR936838
, CR936848, CR936849, CR938729 Genomic DNA. Translation: CAM28077.1.
CR938729, CR936848 Genomic DNA. Translation: CAM28109.1.
CR938729
, CR936838, CR936848, CR936849 Genomic DNA. Translation: CAM28111.1.
CR936849
, CR936838, CR936848, CR938729 Genomic DNA. Translation: CAM28160.1.
CR936848, CR938729 Genomic DNA. Translation: CAM28169.1.
CR936848
, CR936838, CR936849, CR938729 Genomic DNA. Translation: CAM28172.1.
BC027242 mRNA. Translation: AAH27242.1.
BC052739 mRNA. Translation: AAH52739.1.
CCDSiCCDS17773.1. [Q9R0C8-1]
CCDS59650.1. [Q9R0C8-3]
RefSeqiNP_065251.2. NM_020505.2. [Q9R0C8-1]
NP_666251.1. NM_146139.2. [Q9R0C8-3]
UniGeneiMm.282257.

Genome annotation databases

EnsembliENSMUST00000046864; ENSMUSP00000036270; ENSMUSG00000033721. [Q9R0C8-1]
ENSMUST00000106576; ENSMUSP00000102186; ENSMUSG00000033721. [Q9R0C8-3]
GeneIDi57257.
KEGGimmu:57257.
UCSCiuc008raf.1. mouse. [Q9R0C8-4]
uc008rag.1. mouse. [Q9R0C8-1]
uc008rah.1. mouse. [Q9R0C8-3]

Keywords - Coding sequence diversityi

Alternative promoter usage, Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF067816 mRNA. Translation: AAF09171.1 .
AF140280 mRNA. Translation: AAF20330.2 .
AK033253 mRNA. Translation: BAC28212.1 .
AK041249 mRNA. Translation: BAC30879.2 .
AK147053 mRNA. Translation: BAE27637.1 .
AL731716 , AL671857 , AL671987 Genomic DNA. Translation: CAM14541.1 .
AL671857 , AL671987 , AL731716 Genomic DNA. Translation: CAM16459.1 .
AL671987 , AL731716 , AL671857 Genomic DNA. Translation: CAM18527.1 .
CR936838
, CR936848 , CR936849 , CR938729 Genomic DNA. Translation: CAM28077.1 .
CR938729 , CR936848 Genomic DNA. Translation: CAM28109.1 .
CR938729
, CR936838 , CR936848 , CR936849 Genomic DNA. Translation: CAM28111.1 .
CR936849
, CR936838 , CR936848 , CR938729 Genomic DNA. Translation: CAM28160.1 .
CR936848 , CR938729 Genomic DNA. Translation: CAM28169.1 .
CR936848
, CR936838 , CR936849 , CR938729 Genomic DNA. Translation: CAM28172.1 .
BC027242 mRNA. Translation: AAH27242.1 .
BC052739 mRNA. Translation: AAH52739.1 .
CCDSi CCDS17773.1. [Q9R0C8-1 ]
CCDS59650.1. [Q9R0C8-3 ]
RefSeqi NP_065251.2. NM_020505.2. [Q9R0C8-1 ]
NP_666251.1. NM_146139.2. [Q9R0C8-3 ]
UniGenei Mm.282257.

3D structure databases

ProteinModelPortali Q9R0C8.
SMRi Q9R0C8. Positions 1-563, 593-846.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000036270.

PTM databases

PhosphoSitei Q9R0C8.

Proteomic databases

PaxDbi Q9R0C8.
PRIDEi Q9R0C8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000046864 ; ENSMUSP00000036270 ; ENSMUSG00000033721 . [Q9R0C8-1 ]
ENSMUST00000106576 ; ENSMUSP00000102186 ; ENSMUSG00000033721 . [Q9R0C8-3 ]
GeneIDi 57257.
KEGGi mmu:57257.
UCSCi uc008raf.1. mouse. [Q9R0C8-4 ]
uc008rag.1. mouse. [Q9R0C8-1 ]
uc008rah.1. mouse. [Q9R0C8-3 ]

Organism-specific databases

CTDi 10451.
MGIi MGI:1888518. Vav3.

Phylogenomic databases

eggNOGi NOG326494.
GeneTreei ENSGT00740000115307.
HOGENOMi HOG000234364.
HOVERGENi HBG018066.
InParanoidi Q9R0C8.
KOi K05730.
OMAi DPGLPKM.
OrthoDBi EOG73FQKZ.
PhylomeDBi Q9R0C8.
TreeFami TF316171.

Enzyme and pathway databases

Reactomei REACT_188185. DAP12 signaling.
REACT_188202. FCERI mediated Ca+2 mobilization.
REACT_188530. FCERI mediated MAPK activation.
REACT_198374. Regulation of actin dynamics for phagocytic cup formation.
REACT_204733. G alpha (12/13) signalling events.
REACT_209641. NRAGE signals death through JNK.
REACT_210090. Rho GTPase cycle.
REACT_220092. GPVI-mediated activation cascade.

Miscellaneous databases

ChiTaRSi VAV3. mouse.
NextBioi 313559.
PROi Q9R0C8.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9R0C8.
Bgeei Q9R0C8.
CleanExi MM_VAV3.
Genevestigatori Q9R0C8.

Family and domain databases

Gene3Di 1.10.418.10. 1 hit.
1.20.900.10. 1 hit.
2.30.29.30. 1 hit.
3.30.505.10. 1 hit.
InterProi IPR022613. CAMSAP_CH.
IPR001715. CH-domain.
IPR000219. DH-domain.
IPR001331. GDS_CDC24_CS.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR002219. Prot_Kinase_C-like_PE/DAG-bd.
IPR000980. SH2.
IPR011511. SH3_2.
IPR001452. SH3_domain.
IPR003096. SM22_calponin.
IPR028530. Vav.
[Graphical view ]
PANTHERi PTHR22826:SF97. PTHR22826:SF97. 1 hit.
Pfami PF00130. C1_1. 1 hit.
PF11971. CAMSAP_CH. 1 hit.
PF00169. PH. 1 hit.
PF00621. RhoGEF. 1 hit.
PF00017. SH2. 1 hit.
PF07653. SH3_2. 2 hits.
[Graphical view ]
PRINTSi PR00401. SH2DOMAIN.
PR00452. SH3DOMAIN.
PR00888. SM22CALPONIN.
SMARTi SM00109. C1. 1 hit.
SM00033. CH. 1 hit.
SM00233. PH. 1 hit.
SM00325. RhoGEF. 1 hit.
SM00252. SH2. 1 hit.
SM00326. SH3. 2 hits.
[Graphical view ]
SUPFAMi SSF47576. SSF47576. 1 hit.
SSF48065. SSF48065. 1 hit.
SSF50044. SSF50044. 2 hits.
SSF55550. SSF55550. 2 hits.
PROSITEi PS50021. CH. 1 hit.
PS00741. DH_1. 1 hit.
PS50010. DH_2. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS50001. SH2. 1 hit.
PS50002. SH3. 2 hits.
PS00479. ZF_DAG_PE_1. 1 hit.
PS50081. ZF_DAG_PE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Major transcript variants of VAV3, a new member of the VAV family of guanine nucleotide exchange factors."
    Trenkle T., McClelland M., Adlkofer K., Welsh J.
    Gene 245:139-149(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [MRNA] OF 1-789 (ISOFORM 3).
    Tissue: Skin.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-731 (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Embryonic stomach and Embryonic testis.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain and Mammary tumor.
  5. Lubec G., Sunyer B., Chen W.-Q.
    Submitted (JAN-2009) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 143-152, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: OF1.
    Tissue: Hippocampus.
  6. Cited for: FUNCTION, DISRUPTION PHENOTYPE.
  7. "Essential role of Vav family guanine nucleotide exchange factors in EphA receptor-mediated angiogenesis."
    Hunter S.G., Zhuang G., Brantley-Sieders D.M., Swat W., Cowan C.W., Chen J.
    Mol. Cell. Biol. 26:4830-4842(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH EPHA2.
  8. "Wound healing defect of Vav3-/- mice due to impaired {beta}2-integrin-dependent macrophage phagocytosis of apoptotic neutrophils."
    Sindrilaru A., Peters T., Schymeinsky J., Oreshkova T., Wang H., Gompf A., Mannella F., Wlaschek M., Sunderkotter C., Rudolph K.L., Walzog B., Bustelo X.R., Fischer K.D., Scharffetter-Kochanek K.
    Blood 113:5266-5276(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiVAV3_MOUSE
AccessioniPrimary (citable) accession number: Q9R0C8
Secondary accession number(s): A2CFD7
, Q7TS85, Q8BRV2, Q8CCF5, Q8R076, Q9JLS6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: August 16, 2004
Last modified: September 3, 2014
This is version 130 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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