Q9R0C8 (VAV3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Guanine nucleotide exchange factor VAV3
Short name=VAV-3

Gene names

Name:

Vav3

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	847 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Exchange factor for GTP-binding proteins RhoA, RhoG and, to a lesser extent, Rac1. Binds physically to the nucleotide-free states of those GTPases By similarity. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. May be important for integrin-mediated signaling, at least in some cell types. In osteoclasts, along with SYK tyrosine kinase, required for signaling through integrin alpha-v/beta-1 (ITAGV-ITGB1), a crucial event for osteoclast proper cytoskeleton organization and function. This signaling pathway involves RAC1, but not RHO, activation. Necessary for proper wound healing. In the course of wound healing, required for the phagocytotic cup formation preceding macrophage phagocytosis of apoptotic neutrophils. Responsible for integrin beta-2-mediated macrophage adhesion and, to a lesser extent, contributes to beta-3-mediated adhesion. Does not affect integrin beta-1-mediated adhesion. Ref.6 Ref.7 Ref.8
Subunit structure	Interacts with the PH domain of APS. Interacts with ROS1; constitutive interaction that mediates VAV3 phosphorylation By similarity. Interacts (via SH2 domains) with the phosphorylated form of EPHA2. Ref.7
Tissue specificity	Abundantly expressed in osteoclasts and mature osteoblasts. Also expressed in bone marrow macrophages (at protein level):.
Post-translational modification	Phosphorylated. Phosphorylation can be mediated by ROS1 By similarity. In osteoclasts, undergoes tyrosine phosphorylation in response to CSF1.
Disruption phenotype	Mutant mice exhibit increased bone density, due to diminished bone resorption, including following parathyroid hormone treatment. This phenotype is due to defective terminal osteoclast differentiation. They also show a delayed wound repair program, characterized by a deficit in macrophage emigration to the wound, a reduced myofibroblast-dependent wound contraction and a diminished neovascularization in the restoration tissue. Ref.6 Ref.8
Sequence similarities	Contains 1 CH (calponin-homology) domain. Contains 1 DH (DBL-homology) domain. Contains 1 PH domain. Contains 1 phorbol-ester/DAG-type zinc finger. Contains 1 SH2 domain. Contains 2 SH3 domains.

Ontologies

Keywords
Biological process	Angiogenesis
Coding sequence diversity	Alternative promoter usage Alternative splicing
Domain	Repeat SH2 domain SH3 domain Zinc-finger
Ligand	Metal-binding Zinc
Molecular function	Guanine-nucleotide releasing factor
PTM	Phosphoprotein
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	B cell receptor signaling pathway Inferred from electronic annotation. Source: Compara angiogenesis Inferred from electronic annotation. Source: UniProtKB-KW cell migration Inferred from genetic interaction PubMed 15728722. Source: MGI integrin-mediated signaling pathway Inferred from genetic interaction PubMed 15249579. Source: MGI lamellipodium assembly Inferred from genetic interaction PubMed 15728722. Source: MGI positive regulation of B cell proliferation Inferred from electronic annotation. Source: Compara positive regulation of cell adhesion Inferred from genetic interaction PubMed 15249579. Source: MGI positive regulation of phosphatidylinositol 3-kinase activity Inferred from genetic interaction PubMed 15728722. Source: MGI regulation of GTPase activity Inferred from genetic interaction PubMed 15249579. Source: MGI regulation of Rho protein signal transduction Inferred from electronic annotation. Source: InterPro response to DNA damage stimulus Inferred from electronic annotation. Source: Compara response to drug Inferred from electronic annotation. Source: Compara small GTPase mediated signal transduction Inferred from mutant phenotype PubMed 15728722. Source: MGI vesicle fusion Inferred from genetic interaction PubMed 15249579. Source: MGI
Cellular_component	cytoplasm Inferred from direct assay PubMed 15728722. Source: MGI plasma membrane Inferred from direct assay PubMed 15728722. Source: MGI
Molecular_function	Rac guanyl-nucleotide exchange factor activity Inferred from genetic interaction PubMed 15249579. Source: MGI metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW phospholipid binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative promoter usage and alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9R0C8-1)

Also known as: Alpha;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9R0C8-2)

Also known as: Beta;

The sequence of this isoform is not available.

Isoform 3 (identifier: Q9R0C8-3)

Also known as: VAV3.1;

The sequence of this isoform differs from the canonical sequence as follows:
     1-560: Missing.
     561-568: NCGRVNSV → MPIFTFVS

Note: Produced by alternative promoter usage.

Isoform 4 (identifier: Q9R0C8-4)

The sequence of this isoform differs from the canonical sequence as follows:
     569-574: EQGPFK → GKSCLL
     575-847: Missing.

Note: Produced by alternative splicing. No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 847	847	Guanine nucleotide exchange factor VAV3		PRO_0000080987
Regions
	Domain	1 – 119	119	CH
	Domain	192 – 371	180	DH
	Domain	400 – 502	103	PH
	Domain	592 – 660	69	SH3 1
	Domain	672 – 766	95	SH2
	Domain	788 – 847	60	SH3 2
	Zinc finger	513 – 562	50	Phorbol-ester/DAG-type
	Region	560 – 847	288	Sufficient for interaction with ROS1 By similarity
Amino acid modifications
	Modified residue	141	1	Phosphotyrosine By similarity
Natural variations
	Alternative sequence	1 – 560	560	Missing in isoform 3.		VSP_042360
	Alternative sequence	561 – 568	8	NCGRVNSV → MPIFTFVS in isoform 3.		VSP_042361
	Alternative sequence	569 – 574	6	EQGPFK → GKSCLL in isoform 4.		VSP_042362
	Alternative sequence	575 – 847	273	Missing in isoform 4.		VSP_042363
Experimental info
	Sequence conflict	355	1	K → R in BAC30879. Ref.2
	Sequence conflict	452	1	I → T in BAC28212. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (Alpha) [UniParc]. Last modified August 16, 2004. Version 2. Checksum: 727C9BF50DF8CF19	FASTA	847	97,968
	10 20 30 40 50 60 MEPWKQCAQW LIHSKVLPPN HRVTWDSAQV FDLAQTLRDG VLLCQLLNNL RPHSINLKEI 70 80 90 100 110 120 NLRPQMSQFL CLKNIRTFLA ACCDTFGMRK SELFEAFDLF DVRDFGKVIE TLSRLSRTPI 130 140 150 160 170 180 ALATGIRPFP TEESINDEDI YKGLPDLIDE TRVEDEEDLY DCVYGEDEGG EVYEDLMKAE 190 200 210 220 230 240 EAQQPKSQEN DIRSCCLAEI RQTEEKYTET LESIEKYFMA PLKRFLTAAE FDSVFINIPD 250 260 270 280 290 300 LVKVHRSLMQ EIHDSIVNKD DQNLYQVFIN YKERLVIYGQ YCSGVESAIS NLDYISKTKE 310 320 330 340 350 360 DVKLKLEECS KRANNGKFTL RDLLVVPMQR VLKYHLLLQE LVKHTHDPME KANLKLALDA 370 380 390 400 410 420 MKDLAQYVNE VKRDNETLRE IKQFQLSIEN LNQPVLLFGR PQGDGEIRIT TLDKHTKQER 430 440 450 460 470 480 HIFLFDLAVI VCKRKGDNYE MKEIIDLQQY KIANNPTTDK ENKKWSYGFY LIHTQGQNGL 490 500 510 520 530 540 EFYCKTKDLK KKWLEQFEMA LSNIRPDYAD SNFHDFKMHT FTRVTSCRVC QMLLRGTFYQ 550 560 570 580 590 600 GYLCFKCGAK AHKECLGRVD NCGRVNSVEQ GPFKPPEKRT NGLRRASRQV DPGLPKMQVI 610 620 630 640 650 660 RNYTGTPAPG LHEGPPLHIQ AGDTVELLRG DAHSVFWQGR NLASGEVGFF PSDAVKPSPC 670 680 690 700 710 720 VPKPVDYSCQ PWYAGPMERL QAETELINRV NSTYLVRHRT KESGEYAISI KYNNEAKHIK 730 740 750 760 770 780 ILTRDGFFHI AENRKFKSLM ELVEYYKHHS LKEGFRTLDT TLQFPYKEPE QPAGQRGNRT 790 800 810 820 830 840 GNSLLSPKVL GIAIARYDFC ARDMRELSLL KGDMVKIYTK MSANGWWRGE VNGRVGWFPS TYVEEDE
	Isoform 2 (Beta) (Sequence not available).		–	–
	Isoform 3 (VAV3.1) [UniParc]. Checksum: BF2850B8F921F048	FASTA	287	32,662
	10 20 30 40 50 60 MPIFTFVSEQ GPFKPPEKRT NGLRRASRQV DPGLPKMQVI RNYTGTPAPG LHEGPPLHIQ 70 80 90 100 110 120 AGDTVELLRG DAHSVFWQGR NLASGEVGFF PSDAVKPSPC VPKPVDYSCQ PWYAGPMERL 130 140 150 160 170 180 QAETELINRV NSTYLVRHRT KESGEYAISI KYNNEAKHIK ILTRDGFFHI AENRKFKSLM 190 200 210 220 230 240 ELVEYYKHHS LKEGFRTLDT TLQFPYKEPE QPAGQRGNRT GNSLLSPKVL GIAIARYDFC 250 260 270 280 ARDMRELSLL KGDMVKIYTK MSANGWWRGE VNGRVGWFPS TYVEEDE
	Isoform 4 [UniParc]. Checksum: 6AB7C243493B6F2B	FASTA	574	66,849
	10 20 30 40 50 60 MEPWKQCAQW LIHSKVLPPN HRVTWDSAQV FDLAQTLRDG VLLCQLLNNL RPHSINLKEI 70 80 90 100 110 120 NLRPQMSQFL CLKNIRTFLA ACCDTFGMRK SELFEAFDLF DVRDFGKVIE TLSRLSRTPI 130 140 150 160 170 180 ALATGIRPFP TEESINDEDI YKGLPDLIDE TRVEDEEDLY DCVYGEDEGG EVYEDLMKAE 190 200 210 220 230 240 EAQQPKSQEN DIRSCCLAEI RQTEEKYTET LESIEKYFMA PLKRFLTAAE FDSVFINIPD 250 260 270 280 290 300 LVKVHRSLMQ EIHDSIVNKD DQNLYQVFIN YKERLVIYGQ YCSGVESAIS NLDYISKTKE 310 320 330 340 350 360 DVKLKLEECS KRANNGKFTL RDLLVVPMQR VLKYHLLLQE LVKHTHDPME KANLKLALDA 370 380 390 400 410 420 MKDLAQYVNE VKRDNETLRE IKQFQLSIEN LNQPVLLFGR PQGDGEIRIT TLDKHTKQER 430 440 450 460 470 480 HIFLFDLAVI VCKRKGDNYE MKEIIDLQQY KIANNPTTDK ENKKWSYGFY LIHTQGQNGL 490 500 510 520 530 540 EFYCKTKDLK KKWLEQFEMA LSNIRPDYAD SNFHDFKMHT FTRVTSCRVC QMLLRGTFYQ 550 560 570 GYLCFKCGAK AHKECLGRVD NCGRVNSVGK SCLL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Major transcript variants of VAV3, a new member of the VAV family of guanine nucleotide exchange factors." Trenkle T., McClelland M., Adlkofer K., Welsh J. Gene 245:139-149(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [MRNA] OF 1-789 (ISOFORM 3). Tissue: Skin.
[2]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-731 (ISOFORM 1). Strain: C57BL/6J. Tissue: Embryonic stomach and Embryonic testis.
[3]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6. Tissue: Brain and Mammary tumor.
[5]	Lubec G., Sunyer B., Chen W.-Q. Submitted (JAN-2009) to UniProtKB Cited for: PROTEIN SEQUENCE OF 143-152, MASS SPECTROMETRY. Strain: OF1. Tissue: Hippocampus.
[6]	"Vav3 regulates osteoclast function and bone mass." Faccio R., Teitelbaum S.L., Fujikawa K., Chappel J., Zallone A., Tybulewicz V.L., Ross F.P., Swat W. Nat. Med. 11:284-290(2005) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, DISRUPTION PHENOTYPE.
[7]	"Essential role of Vav family guanine nucleotide exchange factors in EphA receptor-mediated angiogenesis." Hunter S.G., Zhuang G., Brantley-Sieders D.M., Swat W., Cowan C.W., Chen J. Mol. Cell. Biol. 26:4830-4842(2006) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH EPHA2.
[8]	"Wound healing defect of Vav3-/- mice due to impaired {beta}2-integrin-dependent macrophage phagocytosis of apoptotic neutrophils." Sindrilaru A., Peters T., Schymeinsky J., Oreshkova T., Wang H., Gompf A., Mannella F., Wlaschek M., Sunderkotter C., Rudolph K.L., Walzog B., Bustelo X.R., Fischer K.D., Scharffetter-Kochanek K. Blood 113:5266-5276(2009) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, DISRUPTION PHENOTYPE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF067816 mRNA. Translation: AAF09171.1. AF140280 mRNA. Translation: AAF20330.2. AK033253 mRNA. Translation: BAC28212.1. AK041249 mRNA. Translation: BAC30879.2. AK147053 mRNA. Translation: BAE27637.1. AL731716, AL671857, AL671987 Genomic DNA. Translation: CAM14541.1. AL671857, AL671987, AL731716 Genomic DNA. Translation: CAM16459.1. AL671987, AL731716, AL671857 Genomic DNA. Translation: CAM18527.1. CR936838 , CR936848, CR936849, CR938729 Genomic DNA. Translation: CAM28077.1. CR938729, CR936848 Genomic DNA. Translation: CAM28109.1. CR938729 , CR936838, CR936848, CR936849 Genomic DNA. Translation: CAM28111.1. CR936849 , CR936838, CR936848, CR938729 Genomic DNA. Translation: CAM28160.1. CR936848, CR938729 Genomic DNA. Translation: CAM28169.1. CR936848 , CR936838, CR936849, CR938729 Genomic DNA. Translation: CAM28172.1. BC027242 mRNA. Translation: AAH27242.1. BC052739 mRNA. Translation: AAH52739.1.
IPI	IPI00127338.
RefSeq	NP_065251.2. NM_020505.2. NP_666251.1. NM_146139.2.
UniGene	Mm.282257.
3D structure databases
ProteinModelPortal	Q9R0C8.
SMR	Q9R0C8. Positions 1-563, 593-846.
ModBase	Search...
Protein-protein interaction databases
STRING	10090.ENSMUSP00000036270.
PTM databases
PhosphoSite	Q9R0C8.
Proteomic databases
PaxDb	Q9R0C8.
PRIDE	Q9R0C8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000046864; ENSMUSP00000036270; ENSMUSG00000033721.
GeneID	57257.
KEGG	mmu:57257.
Organism-specific databases
CTD	10451.
MGI	MGI:1888518. Vav3.
Phylogenomic databases
eggNOG	NOG326494.
GeneTree	ENSGT00700000104383.
HOGENOM	HOG000234364.
HOVERGEN	HBG018066.
InParanoid	Q9R0C8.
KO	K05730.
OMA	EAKHIKI.
OrthoDB	EOG4TB49P.
Gene expression databases
ArrayExpress	Q9R0C8.
Bgee	Q9R0C8.
CleanEx	MM_VAV3.
Genevestigator	Q9R0C8.
GermOnline	ENSMUSG00000033721. Mus musculus.
Family and domain databases
Gene3D	1.10.418.10. 1 hit. 1.20.900.10. 1 hit. 2.30.29.30. 1 hit. 3.30.505.10. 1 hit.
InterPro	IPR022613. CAMSAP_CH. IPR001715. CH-domain. IPR000219. DH-domain. IPR001331. GDS_CDC24_CS. IPR011993. PH_like_dom. IPR001849. Pleckstrin_homology. IPR002219. Prot_Kinase_C-like_PE/DAG-bd. IPR000980. SH2. IPR011511. SH3_2. IPR001452. SH3_domain. IPR003096. SM22_calponin. [Graphical view]
Pfam	PF00130. C1_1. 1 hit. PF11971. CAMSAP_CH. 1 hit. PF00169. PH. 1 hit. PF00621. RhoGEF. 1 hit. PF00017. SH2. 1 hit. PF07653. SH3_2. 2 hits. [Graphical view]
PRINTS	PR00401. SH2DOMAIN. PR00452. SH3DOMAIN. PR00888. SM22CALPONIN.
SMART	SM00109. C1. 1 hit. SM00033. CH. 1 hit. SM00233. PH. 1 hit. SM00325. RhoGEF. 1 hit. SM00252. SH2. 1 hit. SM00326. SH3. 2 hits. [Graphical view]
SUPFAM	SSF47576. Calponin-homology. 1 hit. SSF48065. DH-domain. 1 hit. SSF50044. SH3. 2 hits.
PROSITE	PS50021. CH. 1 hit. PS00741. DH_1. 1 hit. PS50010. DH_2. 1 hit. PS50003. PH_DOMAIN. 1 hit. PS50001. SH2. 1 hit. PS50002. SH3. 2 hits. PS00479. ZF_DAG_PE_1. 1 hit. PS50081. ZF_DAG_PE_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	VAV3. mouse.
NextBio	313559.
SOURCE	Search...

Entry information

Entry name

VAV3_MOUSE

Accession

Primary (citable) accession number: Q9R0C8
Secondary accession number(s): A2CFD7 , Q7TS85, Q8BRV2, Q8CCF5, Q8R076, Q9JLS6

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 24, 2001
Last sequence update:	August 16, 2004
Last modified:	May 1, 2013
This is version 117 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program