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Protein

Guanine nucleotide exchange factor VAV3

Gene

Vav3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Exchange factor for GTP-binding proteins RhoA, RhoG and, to a lesser extent, Rac1. Binds physically to the nucleotide-free states of those GTPases (By similarity). Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. May be important for integrin-mediated signaling, at least in some cell types. In osteoclasts, along with SYK tyrosine kinase, required for signaling through integrin alpha-v/beta-1 (ITAGV-ITGB1), a crucial event for osteoclast proper cytoskeleton organization and function. This signaling pathway involves RAC1, but not RHO, activation. Necessary for proper wound healing. In the course of wound healing, required for the phagocytotic cup formation preceding macrophage phagocytosis of apoptotic neutrophils. Responsible for integrin beta-2-mediated macrophage adhesion and, to a lesser extent, contributes to beta-3-mediated adhesion. Does not affect integrin beta-1-mediated adhesion.By similarity3 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri513 – 56250Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • epidermal growth factor receptor binding Source: MGI
  • guanyl-nucleotide exchange factor activity Source: MGI
  • metal ion binding Source: UniProtKB-KW
  • Rac guanyl-nucleotide exchange factor activity Source: MGI
  • Rho guanyl-nucleotide exchange factor activity Source: MGI

GO - Biological processi

  • angiogenesis Source: UniProtKB-KW
  • B cell receptor signaling pathway Source: MGI
  • cell migration Source: MGI
  • cell projection assembly Source: MGI
  • cellular response to DNA damage stimulus Source: MGI
  • integrin-mediated signaling pathway Source: MGI
  • lamellipodium assembly Source: MGI
  • neutrophil chemotaxis Source: MGI
  • positive regulation of B cell proliferation Source: MGI
  • positive regulation of cell adhesion Source: MGI
  • positive regulation of GTPase activity Source: GOC
  • positive regulation of phosphatidylinositol 3-kinase activity Source: MGI
  • regulation of GTPase activity Source: MGI
  • response to drug Source: MGI
  • small GTPase mediated signal transduction Source: MGI
  • vesicle fusion Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Guanine-nucleotide releasing factor

Keywords - Biological processi

Angiogenesis

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_289095. NRAGE signals death through JNK.
REACT_297947. Rho GTPase cycle.
REACT_299052. G alpha (12/13) signalling events.
REACT_301936. DAP12 signaling.
REACT_314186. FCERI mediated MAPK activation.
REACT_314615. EPH-ephrin mediated repulsion of cells.
REACT_315885. VEGFA-VEGFR2 Pathway.
REACT_321965. VEGFR2 mediated vascular permeability.
REACT_337915. GPVI-mediated activation cascade.
REACT_344463. Regulation of actin dynamics for phagocytic cup formation.
REACT_348733. FCERI mediated Ca+2 mobilization.

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide exchange factor VAV3
Short name:
VAV-3
Gene namesi
Name:Vav3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1888518. Vav3.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: MGI
  • extracellular exosome Source: MGI
  • plasma membrane Source: MGI
Complete GO annotation...

Pathology & Biotechi

Disruption phenotypei

Mutant mice exhibit increased bone density, due to diminished bone resorption, including following parathyroid hormone treatment. This phenotype is due to defective terminal osteoclast differentiation. They also show a delayed wound repair program, characterized by a deficit in macrophage emigration to the wound, a reduced myofibroblast-dependent wound contraction and a diminished neovascularization in the restoration tissue.2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 847847Guanine nucleotide exchange factor VAV3PRO_0000080987Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei141 – 1411PhosphotyrosineBy similarity

Post-translational modificationi

Phosphorylated. Phosphorylation can be mediated by ROS1 (By similarity). In osteoclasts, undergoes tyrosine phosphorylation in response to CSF1.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9R0C8.
PaxDbiQ9R0C8.
PRIDEiQ9R0C8.

PTM databases

PhosphoSiteiQ9R0C8.

Expressioni

Tissue specificityi

Abundantly expressed in osteoclasts and mature osteoblasts. Also expressed in bone marrow macrophages (at protein level):.

Gene expression databases

BgeeiQ9R0C8.
CleanExiMM_VAV3.
GenevisibleiQ9R0C8. MM.

Interactioni

Subunit structurei

Interacts with the PH domain of APS. Interacts with ROS1; constitutive interaction that mediates VAV3 phosphorylation (By similarity). Interacts (via SH2 domains) with the phosphorylated form of EPHA2.By similarity1 Publication

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000036270.

Structurei

3D structure databases

ProteinModelPortaliQ9R0C8.
SMRiQ9R0C8. Positions 1-563, 593-846.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 119119CHPROSITE-ProRule annotationAdd
BLAST
Domaini192 – 371180DHPROSITE-ProRule annotationAdd
BLAST
Domaini400 – 502103PHPROSITE-ProRule annotationAdd
BLAST
Domaini592 – 66069SH3 1PROSITE-ProRule annotationAdd
BLAST
Domaini672 – 76695SH2PROSITE-ProRule annotationAdd
BLAST
Domaini788 – 84760SH3 2PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni560 – 847288Sufficient for interaction with ROS1By similarityAdd
BLAST

Sequence similaritiesi

Contains 1 CH (calponin-homology) domain.PROSITE-ProRule annotation
Contains 1 DH (DBL-homology) domain.PROSITE-ProRule annotation
Contains 1 PH domain.PROSITE-ProRule annotation
Contains 1 phorbol-ester/DAG-type zinc finger.PROSITE-ProRule annotation
Contains 1 SH2 domain.PROSITE-ProRule annotation
Contains 2 SH3 domains.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri513 – 56250Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, SH2 domain, SH3 domain, Zinc-finger

Phylogenomic databases

eggNOGiNOG326494.
GeneTreeiENSGT00800000124085.
HOGENOMiHOG000234364.
HOVERGENiHBG018066.
InParanoidiQ9R0C8.
KOiK05730.
OMAiGPPLHIQ.
OrthoDBiEOG73FQKZ.
PhylomeDBiQ9R0C8.
TreeFamiTF316171.

Family and domain databases

Gene3Di1.10.418.10. 1 hit.
1.20.900.10. 1 hit.
2.30.29.30. 1 hit.
3.30.505.10. 1 hit.
InterProiIPR022613. CAMSAP_CH.
IPR001715. CH-domain.
IPR000219. DH-domain.
IPR001331. GDS_CDC24_CS.
IPR002219. PE/DAG-bd.
IPR011993. PH-like_dom.
IPR001849. PH_domain.
IPR000980. SH2.
IPR011511. SH3_2.
IPR001452. SH3_domain.
IPR003096. SM22_calponin.
IPR028530. Vav.
[Graphical view]
PANTHERiPTHR22826:SF97. PTHR22826:SF97. 1 hit.
PfamiPF00130. C1_1. 1 hit.
PF11971. CAMSAP_CH. 1 hit.
PF00169. PH. 1 hit.
PF00621. RhoGEF. 1 hit.
PF00017. SH2. 1 hit.
PF07653. SH3_2. 2 hits.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
PR00452. SH3DOMAIN.
PR00888. SM22CALPONIN.
SMARTiSM00109. C1. 1 hit.
SM00033. CH. 1 hit.
SM00233. PH. 1 hit.
SM00325. RhoGEF. 1 hit.
SM00252. SH2. 1 hit.
SM00326. SH3. 2 hits.
[Graphical view]
SUPFAMiSSF47576. SSF47576. 1 hit.
SSF48065. SSF48065. 1 hit.
SSF50044. SSF50044. 2 hits.
SSF55550. SSF55550. 2 hits.
PROSITEiPS50021. CH. 1 hit.
PS00741. DH_1. 1 hit.
PS50010. DH_2. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS50001. SH2. 1 hit.
PS50002. SH3. 2 hits.
PS00479. ZF_DAG_PE_1. 1 hit.
PS50081. ZF_DAG_PE_2. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative promoter usage and alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9R0C8-1) [UniParc]FASTAAdd to basket

Also known as: Alpha

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEPWKQCAQW LIHSKVLPPN HRVTWDSAQV FDLAQTLRDG VLLCQLLNNL
60 70 80 90 100
RPHSINLKEI NLRPQMSQFL CLKNIRTFLA ACCDTFGMRK SELFEAFDLF
110 120 130 140 150
DVRDFGKVIE TLSRLSRTPI ALATGIRPFP TEESINDEDI YKGLPDLIDE
160 170 180 190 200
TRVEDEEDLY DCVYGEDEGG EVYEDLMKAE EAQQPKSQEN DIRSCCLAEI
210 220 230 240 250
RQTEEKYTET LESIEKYFMA PLKRFLTAAE FDSVFINIPD LVKVHRSLMQ
260 270 280 290 300
EIHDSIVNKD DQNLYQVFIN YKERLVIYGQ YCSGVESAIS NLDYISKTKE
310 320 330 340 350
DVKLKLEECS KRANNGKFTL RDLLVVPMQR VLKYHLLLQE LVKHTHDPME
360 370 380 390 400
KANLKLALDA MKDLAQYVNE VKRDNETLRE IKQFQLSIEN LNQPVLLFGR
410 420 430 440 450
PQGDGEIRIT TLDKHTKQER HIFLFDLAVI VCKRKGDNYE MKEIIDLQQY
460 470 480 490 500
KIANNPTTDK ENKKWSYGFY LIHTQGQNGL EFYCKTKDLK KKWLEQFEMA
510 520 530 540 550
LSNIRPDYAD SNFHDFKMHT FTRVTSCRVC QMLLRGTFYQ GYLCFKCGAK
560 570 580 590 600
AHKECLGRVD NCGRVNSVEQ GPFKPPEKRT NGLRRASRQV DPGLPKMQVI
610 620 630 640 650
RNYTGTPAPG LHEGPPLHIQ AGDTVELLRG DAHSVFWQGR NLASGEVGFF
660 670 680 690 700
PSDAVKPSPC VPKPVDYSCQ PWYAGPMERL QAETELINRV NSTYLVRHRT
710 720 730 740 750
KESGEYAISI KYNNEAKHIK ILTRDGFFHI AENRKFKSLM ELVEYYKHHS
760 770 780 790 800
LKEGFRTLDT TLQFPYKEPE QPAGQRGNRT GNSLLSPKVL GIAIARYDFC
810 820 830 840
ARDMRELSLL KGDMVKIYTK MSANGWWRGE VNGRVGWFPS TYVEEDE
Length:847
Mass (Da):97,968
Last modified:August 16, 2004 - v2
Checksum:i727C9BF50DF8CF19
GO
Isoform 2 (identifier: Q9R0C8-2)

Also known as: Beta

Sequence is not available
Length:
Mass (Da):
Isoform 3 (identifier: Q9R0C8-3) [UniParc]FASTAAdd to basket

Also known as: VAV3.1

The sequence of this isoform differs from the canonical sequence as follows:
     1-560: Missing.
     561-568: NCGRVNSV → MPIFTFVS

Note: Produced by alternative promoter usage.
Show »
Length:287
Mass (Da):32,662
Checksum:iBF2850B8F921F048
GO
Isoform 4 (identifier: Q9R0C8-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     569-574: EQGPFK → GKSCLL
     575-847: Missing.

Note: Produced by alternative splicing. No experimental confirmation available.
Show »
Length:574
Mass (Da):66,849
Checksum:i6AB7C243493B6F2B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti355 – 3551K → R in BAC30879 (PubMed:16141072).Curated
Sequence conflicti452 – 4521I → T in BAC28212 (PubMed:16141072).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 560560Missing in isoform 3. 2 PublicationsVSP_042360Add
BLAST
Alternative sequencei561 – 5688NCGRVNSV → MPIFTFVS in isoform 3. 2 PublicationsVSP_042361
Alternative sequencei569 – 5746EQGPFK → GKSCLL in isoform 4. 1 PublicationVSP_042362
Alternative sequencei575 – 847273Missing in isoform 4. 1 PublicationVSP_042363Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF067816 mRNA. Translation: AAF09171.1.
AF140280 mRNA. Translation: AAF20330.2.
AK033253 mRNA. Translation: BAC28212.1.
AK041249 mRNA. Translation: BAC30879.2.
AK147053 mRNA. Translation: BAE27637.1.
AL731716, AL671857, AL671987 Genomic DNA. Translation: CAM14541.1.
AL671857, AL671987, AL731716 Genomic DNA. Translation: CAM16459.1.
AL671987, AL731716, AL671857 Genomic DNA. Translation: CAM18527.1.
CR936838
, CR936848, CR936849, CR938729 Genomic DNA. Translation: CAM28077.1.
CR938729, CR936848 Genomic DNA. Translation: CAM28109.1.
CR938729
, CR936838, CR936848, CR936849 Genomic DNA. Translation: CAM28111.1.
CR936849
, CR936838, CR936848, CR938729 Genomic DNA. Translation: CAM28160.1.
CR936848, CR938729 Genomic DNA. Translation: CAM28169.1.
CR936848
, CR936838, CR936849, CR938729 Genomic DNA. Translation: CAM28172.1.
BC027242 mRNA. Translation: AAH27242.1.
BC052739 mRNA. Translation: AAH52739.1.
CCDSiCCDS17773.1. [Q9R0C8-1]
CCDS59650.1. [Q9R0C8-3]
RefSeqiNP_065251.2. NM_020505.2. [Q9R0C8-1]
NP_666251.1. NM_146139.2. [Q9R0C8-3]
UniGeneiMm.282257.

Genome annotation databases

EnsembliENSMUST00000046864; ENSMUSP00000036270; ENSMUSG00000033721. [Q9R0C8-1]
ENSMUST00000106576; ENSMUSP00000102186; ENSMUSG00000033721. [Q9R0C8-3]
GeneIDi57257.
KEGGimmu:57257.
UCSCiuc008raf.1. mouse. [Q9R0C8-4]
uc008rag.1. mouse. [Q9R0C8-1]
uc008rah.1. mouse. [Q9R0C8-3]

Keywords - Coding sequence diversityi

Alternative promoter usage, Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF067816 mRNA. Translation: AAF09171.1.
AF140280 mRNA. Translation: AAF20330.2.
AK033253 mRNA. Translation: BAC28212.1.
AK041249 mRNA. Translation: BAC30879.2.
AK147053 mRNA. Translation: BAE27637.1.
AL731716, AL671857, AL671987 Genomic DNA. Translation: CAM14541.1.
AL671857, AL671987, AL731716 Genomic DNA. Translation: CAM16459.1.
AL671987, AL731716, AL671857 Genomic DNA. Translation: CAM18527.1.
CR936838
, CR936848, CR936849, CR938729 Genomic DNA. Translation: CAM28077.1.
CR938729, CR936848 Genomic DNA. Translation: CAM28109.1.
CR938729
, CR936838, CR936848, CR936849 Genomic DNA. Translation: CAM28111.1.
CR936849
, CR936838, CR936848, CR938729 Genomic DNA. Translation: CAM28160.1.
CR936848, CR938729 Genomic DNA. Translation: CAM28169.1.
CR936848
, CR936838, CR936849, CR938729 Genomic DNA. Translation: CAM28172.1.
BC027242 mRNA. Translation: AAH27242.1.
BC052739 mRNA. Translation: AAH52739.1.
CCDSiCCDS17773.1. [Q9R0C8-1]
CCDS59650.1. [Q9R0C8-3]
RefSeqiNP_065251.2. NM_020505.2. [Q9R0C8-1]
NP_666251.1. NM_146139.2. [Q9R0C8-3]
UniGeneiMm.282257.

3D structure databases

ProteinModelPortaliQ9R0C8.
SMRiQ9R0C8. Positions 1-563, 593-846.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000036270.

PTM databases

PhosphoSiteiQ9R0C8.

Proteomic databases

MaxQBiQ9R0C8.
PaxDbiQ9R0C8.
PRIDEiQ9R0C8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000046864; ENSMUSP00000036270; ENSMUSG00000033721. [Q9R0C8-1]
ENSMUST00000106576; ENSMUSP00000102186; ENSMUSG00000033721. [Q9R0C8-3]
GeneIDi57257.
KEGGimmu:57257.
UCSCiuc008raf.1. mouse. [Q9R0C8-4]
uc008rag.1. mouse. [Q9R0C8-1]
uc008rah.1. mouse. [Q9R0C8-3]

Organism-specific databases

CTDi10451.
MGIiMGI:1888518. Vav3.

Phylogenomic databases

eggNOGiNOG326494.
GeneTreeiENSGT00800000124085.
HOGENOMiHOG000234364.
HOVERGENiHBG018066.
InParanoidiQ9R0C8.
KOiK05730.
OMAiGPPLHIQ.
OrthoDBiEOG73FQKZ.
PhylomeDBiQ9R0C8.
TreeFamiTF316171.

Enzyme and pathway databases

ReactomeiREACT_289095. NRAGE signals death through JNK.
REACT_297947. Rho GTPase cycle.
REACT_299052. G alpha (12/13) signalling events.
REACT_301936. DAP12 signaling.
REACT_314186. FCERI mediated MAPK activation.
REACT_314615. EPH-ephrin mediated repulsion of cells.
REACT_315885. VEGFA-VEGFR2 Pathway.
REACT_321965. VEGFR2 mediated vascular permeability.
REACT_337915. GPVI-mediated activation cascade.
REACT_344463. Regulation of actin dynamics for phagocytic cup formation.
REACT_348733. FCERI mediated Ca+2 mobilization.

Miscellaneous databases

ChiTaRSiVav3. mouse.
NextBioi313559.
PROiQ9R0C8.
SOURCEiSearch...

Gene expression databases

BgeeiQ9R0C8.
CleanExiMM_VAV3.
GenevisibleiQ9R0C8. MM.

Family and domain databases

Gene3Di1.10.418.10. 1 hit.
1.20.900.10. 1 hit.
2.30.29.30. 1 hit.
3.30.505.10. 1 hit.
InterProiIPR022613. CAMSAP_CH.
IPR001715. CH-domain.
IPR000219. DH-domain.
IPR001331. GDS_CDC24_CS.
IPR002219. PE/DAG-bd.
IPR011993. PH-like_dom.
IPR001849. PH_domain.
IPR000980. SH2.
IPR011511. SH3_2.
IPR001452. SH3_domain.
IPR003096. SM22_calponin.
IPR028530. Vav.
[Graphical view]
PANTHERiPTHR22826:SF97. PTHR22826:SF97. 1 hit.
PfamiPF00130. C1_1. 1 hit.
PF11971. CAMSAP_CH. 1 hit.
PF00169. PH. 1 hit.
PF00621. RhoGEF. 1 hit.
PF00017. SH2. 1 hit.
PF07653. SH3_2. 2 hits.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
PR00452. SH3DOMAIN.
PR00888. SM22CALPONIN.
SMARTiSM00109. C1. 1 hit.
SM00033. CH. 1 hit.
SM00233. PH. 1 hit.
SM00325. RhoGEF. 1 hit.
SM00252. SH2. 1 hit.
SM00326. SH3. 2 hits.
[Graphical view]
SUPFAMiSSF47576. SSF47576. 1 hit.
SSF48065. SSF48065. 1 hit.
SSF50044. SSF50044. 2 hits.
SSF55550. SSF55550. 2 hits.
PROSITEiPS50021. CH. 1 hit.
PS00741. DH_1. 1 hit.
PS50010. DH_2. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS50001. SH2. 1 hit.
PS50002. SH3. 2 hits.
PS00479. ZF_DAG_PE_1. 1 hit.
PS50081. ZF_DAG_PE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Major transcript variants of VAV3, a new member of the VAV family of guanine nucleotide exchange factors."
    Trenkle T., McClelland M., Adlkofer K., Welsh J.
    Gene 245:139-149(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [MRNA] OF 1-789 (ISOFORM 3).
    Tissue: Skin.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-731 (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Embryonic stomach and Embryonic testis.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain and Mammary tumor.
  5. Lubec G., Sunyer B., Chen W.-Q.
    Submitted (JAN-2009) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 143-152, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: OF1.
    Tissue: Hippocampus.
  6. Cited for: FUNCTION, DISRUPTION PHENOTYPE.
  7. "Essential role of Vav family guanine nucleotide exchange factors in EphA receptor-mediated angiogenesis."
    Hunter S.G., Zhuang G., Brantley-Sieders D.M., Swat W., Cowan C.W., Chen J.
    Mol. Cell. Biol. 26:4830-4842(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH EPHA2.
  8. "Wound healing defect of Vav3-/- mice due to impaired {beta}2-integrin-dependent macrophage phagocytosis of apoptotic neutrophils."
    Sindrilaru A., Peters T., Schymeinsky J., Oreshkova T., Wang H., Gompf A., Mannella F., Wlaschek M., Sunderkotter C., Rudolph K.L., Walzog B., Bustelo X.R., Fischer K.D., Scharffetter-Kochanek K.
    Blood 113:5266-5276(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiVAV3_MOUSE
AccessioniPrimary (citable) accession number: Q9R0C8
Secondary accession number(s): A2CFD7
, Q7TS85, Q8BRV2, Q8CCF5, Q8R076, Q9JLS6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: August 16, 2004
Last modified: July 22, 2015
This is version 141 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.