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Protein

Zinc finger protein 346

Gene

Znf346

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds with low affinity to dsDNA and ssRNA, and with high affinity to dsRNA, with no detectable sequence specificity.By similarity1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi75Zinc 1By similarity1
Metal bindingi78Zinc 1By similarity1
Metal bindingi91Zinc 1; via tele nitrogenBy similarity1
Metal bindingi97Zinc 1; via pros nitrogenBy similarity1
Metal bindingi136Zinc 2By similarity1
Metal bindingi139Zinc 2By similarity1
Metal bindingi152Zinc 2; via tele nitrogenBy similarity1
Metal bindingi158Zinc 2; via pros nitrogenBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri70 – 104Matrin-type 1Add BLAST35
Zinc fingeri131 – 165Matrin-type 2Add BLAST35
Zinc fingeri182 – 216Matrin-type 3Add BLAST35
Zinc fingeri236 – 270Matrin-type 4Add BLAST35

GO - Molecular functioni

GO - Biological processi

  • intrinsic apoptotic signaling pathway by p53 class mediator Source: GO_Central
  • positive regulation of apoptotic process Source: MGI
Complete GO annotation...

Keywords - Ligandi

Metal-binding, RNA-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 346
Alternative name(s):
Just another zinc finger protein
Gene namesi
Name:Znf346
Synonyms:Jaz, Zfp346
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1349417. Zfp346.

Subcellular locationi

  • Nucleusnucleolus By similarity
  • Cytoplasm By similarity

  • Note: Nuclear at steady state, primarily in the nucleolus. Shuttles between the nucleus and cytoplasm when associated with XPO5 (By similarity).By similarity

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-SubCell
  • nucleolus Source: MGI
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi91H → A: No loss of dsRNA binding capacity. Binding capacity was reduced 40-60%; when associated with A-203. Binding capacity was reduced to 5-10%; when associated with A-152 and A-203. Loss of binding capacity; when associated with A-152; A-203 and A-257. 1 Publication1
Mutagenesisi152H → A: No loss of dsRNA binding capacity. Loss of 40-60% dsRNA binding; when associated with A-203. Binding capacity was reduced to 5-10%; when associated with A-91 and A-203. Loss of binding capacity; when associated with A-91; A-203 and A-257. 1 Publication1
Mutagenesisi203H → A: No loss of dsRNA binding capacity. Binding capacity was reduced 40-60%; when associated with A-91. Binding capacity was reduced to 5-10%; when associated with A-91 and A-152. Loss of binding capacity; when associated with A-91; A-152 and A-257. 1 Publication1
Mutagenesisi257H → A: No loss of dsRNA binding capacity. Loss of 5-10 % dsRNA binding capacity; when associated with A-152 and A-203. Loss of binding capacity; when associated with A-91; A-152 and A-203. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001918101 – 294Zinc finger protein 346Add BLAST294

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9R0B7.
MaxQBiQ9R0B7.
PaxDbiQ9R0B7.
PRIDEiQ9R0B7.

PTM databases

iPTMnetiQ9R0B7.
PhosphoSitePlusiQ9R0B7.

Expressioni

Tissue specificityi

Expressed in all tissues tested, including heart, brain, spleen, lung, liver, muscle, kidney and testis. Exogenous expression induced apoptosis.1 Publication

Gene expression databases

BgeeiENSMUSG00000021481.
CleanExiMM_ZFP346.
ExpressionAtlasiQ9R0B7. baseline and differential.
GenevisibleiQ9R0B7. MM.

Interactioni

Subunit structurei

Forms a heteromeric complex with XPO5 and ILF3. Found in a nuclear export complex with XPO5, RAN, ILF3, ZNF346 and double-stranded RNA. Interacts with XPO5. Interacts with ILF3 in an RNA-independent manner (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi205063. 1 interactor.
MINTiMINT-4084241.
STRINGi10090.ENSMUSP00000021937.

Structurei

3D structure databases

ProteinModelPortaliQ9R0B7.
SMRiQ9R0B7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The zinc-finger domains are required for binding to dsRNA, and also for nuclear localization.

Sequence similaritiesi

Contains 4 matrin-type zinc fingers.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri70 – 104Matrin-type 1Add BLAST35
Zinc fingeri131 – 165Matrin-type 2Add BLAST35
Zinc fingeri182 – 216Matrin-type 3Add BLAST35
Zinc fingeri236 – 270Matrin-type 4Add BLAST35

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IQ4K. Eukaryota.
ENOG4111JFP. LUCA.
GeneTreeiENSGT00510000046606.
HOGENOMiHOG000008682.
HOVERGENiHBG061007.
InParanoidiQ9R0B7.
PhylomeDBiQ9R0B7.
TreeFamiTF350019.

Family and domain databases

InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR003604. Znf_U1.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 4 hits.
SM00451. ZnF_U1. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9R0B7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MECPAPDATD AADPGEAGPY KGSEEPEGRE PDGVRFDRER ARRLWEAVSG
60 70 80 90 100
AQPAGREEVE HMIQKNQCLF TSTQCKVCCA MLISESQKLA HYQSKKHANK
110 120 130 140 150
VKRYLAIHGM ETIKGDVKRL DSDQKSSRSK DKNHCCPICN MTFSSPAVAQ
160 170 180 190 200
SHYLGKTHAK SLKLKQQSTK GAALQQNREM LDPDKFCSLC HSTFNDPAMA
210 220 230 240 250
QQHYMGKRHR KQETKLKLMA HYGRLADPAV SDLPAGKGYP CKTCKIVLNS
260 270 280 290
IEQYQAHVSG FKHKNQSPKT LVTLGSQTPV QTQPTPKDSS TVQD
Length:294
Mass (Da):32,698
Last modified:May 1, 2000 - v1
Checksum:i6BD916262EDBA71E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF083339 mRNA. Translation: AAD52017.1.
BC055075 mRNA. Translation: AAH55075.1.
CCDSiCCDS26539.1.
RefSeqiNP_036147.1. NM_012017.2.
UniGeneiMm.22795.

Genome annotation databases

EnsembliENSMUST00000021937; ENSMUSP00000021937; ENSMUSG00000021481.
GeneIDi26919.
KEGGimmu:26919.
UCSCiuc007qpy.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF083339 mRNA. Translation: AAD52017.1.
BC055075 mRNA. Translation: AAH55075.1.
CCDSiCCDS26539.1.
RefSeqiNP_036147.1. NM_012017.2.
UniGeneiMm.22795.

3D structure databases

ProteinModelPortaliQ9R0B7.
SMRiQ9R0B7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi205063. 1 interactor.
MINTiMINT-4084241.
STRINGi10090.ENSMUSP00000021937.

PTM databases

iPTMnetiQ9R0B7.
PhosphoSitePlusiQ9R0B7.

Proteomic databases

EPDiQ9R0B7.
MaxQBiQ9R0B7.
PaxDbiQ9R0B7.
PRIDEiQ9R0B7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000021937; ENSMUSP00000021937; ENSMUSG00000021481.
GeneIDi26919.
KEGGimmu:26919.
UCSCiuc007qpy.1. mouse.

Organism-specific databases

CTDi26919.
MGIiMGI:1349417. Zfp346.

Phylogenomic databases

eggNOGiENOG410IQ4K. Eukaryota.
ENOG4111JFP. LUCA.
GeneTreeiENSGT00510000046606.
HOGENOMiHOG000008682.
HOVERGENiHBG061007.
InParanoidiQ9R0B7.
PhylomeDBiQ9R0B7.
TreeFamiTF350019.

Miscellaneous databases

PROiQ9R0B7.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000021481.
CleanExiMM_ZFP346.
ExpressionAtlasiQ9R0B7. baseline and differential.
GenevisibleiQ9R0B7. MM.

Family and domain databases

InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR003604. Znf_U1.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 4 hits.
SM00451. ZnF_U1. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN346_MOUSE
AccessioniPrimary (citable) accession number: Q9R0B7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: May 1, 2000
Last modified: November 2, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.