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Protein

Zinc finger protein 346

Gene

Znf346

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Binds with low affinity to dsDNA and ssRNA, and with high affinity to dsRNA, with no detectable sequence specificity.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi75 – 751Zinc 1By similarity
Metal bindingi78 – 781Zinc 1By similarity
Metal bindingi91 – 911Zinc 1; via tele nitrogenBy similarity
Metal bindingi97 – 971Zinc 1; via pros nitrogenBy similarity
Metal bindingi136 – 1361Zinc 2By similarity
Metal bindingi139 – 1391Zinc 2By similarity
Metal bindingi152 – 1521Zinc 2; via tele nitrogenBy similarity
Metal bindingi158 – 1581Zinc 2; via pros nitrogenBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri70 – 10435Matrin-type 1Add
BLAST
Zinc fingeri131 – 16535Matrin-type 2Add
BLAST
Zinc fingeri182 – 21635Matrin-type 3Add
BLAST
Zinc fingeri236 – 27035Matrin-type 4Add
BLAST

GO - Molecular functioni

  1. double-stranded RNA binding Source: UniProtKB
  2. enzyme binding Source: MGI
  3. poly(A) RNA binding Source: MGI
  4. zinc ion binding Source: InterPro

GO - Biological processi

  1. positive regulation of apoptotic process Source: MGI
Complete GO annotation...

Keywords - Ligandi

Metal-binding, RNA-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 346
Alternative name(s):
Just another zinc finger protein
Gene namesi
Name:Znf346
Synonyms:Jaz, Zfp346
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1349417. Zfp346.

Subcellular locationi

Nucleusnucleolus By similarity. Cytoplasm By similarity
Note: Nuclear at steady state, primarily in the nucleolus. Shuttles between the nucleus and cytoplasm when associated with XPO5 (By similarity).By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. nucleolus Source: MGI
  3. nucleoplasm Source: MGI
  4. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi91 – 911H → A: No loss of dsRNA binding capacity. Binding capacity was reduced 40-60%; when associated with A-203. Binding capacity was reduced to 5-10%; when associated with A-152 and A-203. Loss of binding capacity; when associated with A-152; A-203 and A-257. 1 Publication
Mutagenesisi152 – 1521H → A: No loss of dsRNA binding capacity. Loss of 40-60% dsRNA binding; when associated with A-203. Binding capacity was reduced to 5-10%; when associated with A-91 and A-203. Loss of binding capacity; when associated with A-91; A-203 and A-257. 1 Publication
Mutagenesisi203 – 2031H → A: No loss of dsRNA binding capacity. Binding capacity was reduced 40-60%; when associated with A-91. Binding capacity was reduced to 5-10%; when associated with A-91 and A-152. Loss of binding capacity; when associated with A-91; A-152 and A-257. 1 Publication
Mutagenesisi257 – 2571H → A: No loss of dsRNA binding capacity. Loss of 5-10 % dsRNA binding capacity; when associated with A-152 and A-203. Loss of binding capacity; when associated with A-91; A-152 and A-203. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 294294Zinc finger protein 346PRO_0000191810Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ9R0B7.
PaxDbiQ9R0B7.
PRIDEiQ9R0B7.

Expressioni

Tissue specificityi

Expressed in all tissues tested, including heart, brain, spleen, lung, liver, muscle, kidney and testis. Exogenous expression induced apoptosis.1 Publication

Gene expression databases

BgeeiQ9R0B7.
CleanExiMM_ZFP346.
ExpressionAtlasiQ9R0B7. baseline and differential.
GenevestigatoriQ9R0B7.

Interactioni

Subunit structurei

Forms a heteromeric complex with XPO5 and ILF3. Found in a nuclear export complex with XPO5, RAN, ILF3, ZNF346 and double-stranded RNA. Interacts with XPO5. Interacts with ILF3 in an RNA-independent manner (By similarity).By similarity

Protein-protein interaction databases

BioGridi205063. 1 interaction.
MINTiMINT-4084241.

Structurei

3D structure databases

ProteinModelPortaliQ9R0B7.
SMRiQ9R0B7. Positions 53-167, 181-224.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The zinc-finger domains are required for binding to dsRNA, and also for nuclear localization.

Sequence similaritiesi

Contains 4 matrin-type zinc fingers.Curated

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri70 – 10435Matrin-type 1Add
BLAST
Zinc fingeri131 – 16535Matrin-type 2Add
BLAST
Zinc fingeri182 – 21635Matrin-type 3Add
BLAST
Zinc fingeri236 – 27035Matrin-type 4Add
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG85918.
GeneTreeiENSGT00510000046606.
HOGENOMiHOG000008682.
HOVERGENiHBG061007.
InParanoidiQ9R0B7.
PhylomeDBiQ9R0B7.
TreeFamiTF350019.

Family and domain databases

InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR003604. Znf_U1.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 4 hits.
SM00451. ZnF_U1. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9R0B7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MECPAPDATD AADPGEAGPY KGSEEPEGRE PDGVRFDRER ARRLWEAVSG
60 70 80 90 100
AQPAGREEVE HMIQKNQCLF TSTQCKVCCA MLISESQKLA HYQSKKHANK
110 120 130 140 150
VKRYLAIHGM ETIKGDVKRL DSDQKSSRSK DKNHCCPICN MTFSSPAVAQ
160 170 180 190 200
SHYLGKTHAK SLKLKQQSTK GAALQQNREM LDPDKFCSLC HSTFNDPAMA
210 220 230 240 250
QQHYMGKRHR KQETKLKLMA HYGRLADPAV SDLPAGKGYP CKTCKIVLNS
260 270 280 290
IEQYQAHVSG FKHKNQSPKT LVTLGSQTPV QTQPTPKDSS TVQD
Length:294
Mass (Da):32,698
Last modified:April 30, 2000 - v1
Checksum:i6BD916262EDBA71E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF083339 mRNA. Translation: AAD52017.1.
BC055075 mRNA. Translation: AAH55075.1.
CCDSiCCDS26539.1.
RefSeqiNP_036147.1. NM_012017.2.
UniGeneiMm.22795.

Genome annotation databases

EnsembliENSMUST00000021937; ENSMUSP00000021937; ENSMUSG00000021481.
GeneIDi26919.
KEGGimmu:26919.
UCSCiuc007qpy.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF083339 mRNA. Translation: AAD52017.1.
BC055075 mRNA. Translation: AAH55075.1.
CCDSiCCDS26539.1.
RefSeqiNP_036147.1. NM_012017.2.
UniGeneiMm.22795.

3D structure databases

ProteinModelPortaliQ9R0B7.
SMRiQ9R0B7. Positions 53-167, 181-224.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi205063. 1 interaction.
MINTiMINT-4084241.

Proteomic databases

MaxQBiQ9R0B7.
PaxDbiQ9R0B7.
PRIDEiQ9R0B7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000021937; ENSMUSP00000021937; ENSMUSG00000021481.
GeneIDi26919.
KEGGimmu:26919.
UCSCiuc007qpy.1. mouse.

Organism-specific databases

CTDi26919.
MGIiMGI:1349417. Zfp346.

Phylogenomic databases

eggNOGiNOG85918.
GeneTreeiENSGT00510000046606.
HOGENOMiHOG000008682.
HOVERGENiHBG061007.
InParanoidiQ9R0B7.
PhylomeDBiQ9R0B7.
TreeFamiTF350019.

Miscellaneous databases

NextBioi304801.
PROiQ9R0B7.
SOURCEiSearch...

Gene expression databases

BgeeiQ9R0B7.
CleanExiMM_ZFP346.
ExpressionAtlasiQ9R0B7. baseline and differential.
GenevestigatoriQ9R0B7.

Family and domain databases

InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR003604. Znf_U1.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 4 hits.
SM00451. ZnF_U1. 4 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "JAZ requires the double-stranded RNA-binding zinc finger motifs for nuclear localization."
    Yang M., May W.S., Ito T.
    J. Biol. Chem. 274:27399-27406(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, MUTAGENESIS OF HIS-91; HIS-152; HIS-203 AND HIS-257.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C3H/He.
    Tissue: Osteoblast.

Entry informationi

Entry nameiZN346_MOUSE
AccessioniPrimary (citable) accession number: Q9R0B7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 24, 2005
Last sequence update: April 30, 2000
Last modified: March 3, 2015
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.