Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9R0B7

- ZN346_MOUSE

UniProt

Q9R0B7 - ZN346_MOUSE

Protein

Zinc finger protein 346

Gene

Znf346

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Binds with low affinity to dsDNA and ssRNA, and with high affinity to dsRNA, with no detectable sequence specificity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi75 – 751Zinc 1By similarity
    Metal bindingi78 – 781Zinc 1By similarity
    Metal bindingi91 – 911Zinc 1; via tele nitrogenBy similarity
    Metal bindingi97 – 971Zinc 1; via pros nitrogenBy similarity
    Metal bindingi136 – 1361Zinc 2By similarity
    Metal bindingi139 – 1391Zinc 2By similarity
    Metal bindingi152 – 1521Zinc 2; via tele nitrogenBy similarity
    Metal bindingi158 – 1581Zinc 2; via pros nitrogenBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri70 – 10435Matrin-type 1Add
    BLAST
    Zinc fingeri131 – 16535Matrin-type 2Add
    BLAST
    Zinc fingeri182 – 21635Matrin-type 3Add
    BLAST
    Zinc fingeri236 – 27035Matrin-type 4Add
    BLAST

    GO - Molecular functioni

    1. double-stranded RNA binding Source: UniProtKB
    2. protein binding Source: MGI
    3. zinc ion binding Source: InterPro

    GO - Biological processi

    1. positive regulation of apoptotic process Source: MGI

    Keywords - Ligandi

    Metal-binding, RNA-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger protein 346
    Alternative name(s):
    Just another zinc finger protein
    Gene namesi
    Name:Znf346
    Synonyms:Jaz, Zfp346
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 13

    Organism-specific databases

    MGIiMGI:1349417. Zfp346.

    Subcellular locationi

    Nucleusnucleolus By similarity. Cytoplasm By similarity
    Note: Nuclear at steady state, primarily in the nucleolus. Shuttles between the nucleus and cytoplasm when associated with XPO5 By similarity.By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleolus Source: MGI
    3. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi91 – 911H → A: No loss of dsRNA binding capacity. Binding capacity was reduced 40-60%; when associated with A-203. Binding capacity was reduced to 5-10%; when associated with A-152 and A-203. Loss of binding capacity; when associated with A-152; A-203 and A-257. 1 Publication
    Mutagenesisi152 – 1521H → A: No loss of dsRNA binding capacity. Loss of 40-60% dsRNA binding; when associated with A-203. Binding capacity was reduced to 5-10%; when associated with A-91 and A-203. Loss of binding capacity; when associated with A-91; A-203 and A-257. 1 Publication
    Mutagenesisi203 – 2031H → A: No loss of dsRNA binding capacity. Binding capacity was reduced 40-60%; when associated with A-91. Binding capacity was reduced to 5-10%; when associated with A-91 and A-152. Loss of binding capacity; when associated with A-91; A-152 and A-257. 1 Publication
    Mutagenesisi257 – 2571H → A: No loss of dsRNA binding capacity. Loss of 5-10 % dsRNA binding capacity; when associated with A-152 and A-203. Loss of binding capacity; when associated with A-91; A-152 and A-203. 1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 294294Zinc finger protein 346PRO_0000191810Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PaxDbiQ9R0B7.
    PRIDEiQ9R0B7.

    Expressioni

    Tissue specificityi

    Expressed in all tissues tested, including heart, brain, spleen, lung, liver, muscle, kidney and testis. Exogenous expression induced apoptosis.1 Publication

    Gene expression databases

    ArrayExpressiQ9R0B7.
    BgeeiQ9R0B7.
    CleanExiMM_ZFP346.
    GenevestigatoriQ9R0B7.

    Interactioni

    Subunit structurei

    Forms a heteromeric complex with XPO5 and ILF3. Found in a nuclear export complex with XPO5, RAN, ILF3, ZNF346 and double-stranded RNA. Interacts with XPO5. Interacts with ILF3 in an RNA-independent manner By similarity.By similarity

    Protein-protein interaction databases

    BioGridi205063. 1 interaction.
    MINTiMINT-4084241.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9R0B7.
    SMRiQ9R0B7. Positions 53-167, 181-224, 239-267.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domaini

    The zinc-finger domains are required for binding to dsRNA, and also for nuclear localization.

    Sequence similaritiesi

    Contains 4 matrin-type zinc fingers.Curated

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri70 – 10435Matrin-type 1Add
    BLAST
    Zinc fingeri131 – 16535Matrin-type 2Add
    BLAST
    Zinc fingeri182 – 21635Matrin-type 3Add
    BLAST
    Zinc fingeri236 – 27035Matrin-type 4Add
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG85918.
    GeneTreeiENSGT00510000046606.
    HOGENOMiHOG000008682.
    HOVERGENiHBG061007.
    InParanoidiQ9R0B7.
    PhylomeDBiQ9R0B7.
    TreeFamiTF350019.

    Family and domain databases

    InterProiIPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR003604. Znf_U1.
    [Graphical view]
    SMARTiSM00355. ZnF_C2H2. 4 hits.
    SM00451. ZnF_U1. 4 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9R0B7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MECPAPDATD AADPGEAGPY KGSEEPEGRE PDGVRFDRER ARRLWEAVSG    50
    AQPAGREEVE HMIQKNQCLF TSTQCKVCCA MLISESQKLA HYQSKKHANK 100
    VKRYLAIHGM ETIKGDVKRL DSDQKSSRSK DKNHCCPICN MTFSSPAVAQ 150
    SHYLGKTHAK SLKLKQQSTK GAALQQNREM LDPDKFCSLC HSTFNDPAMA 200
    QQHYMGKRHR KQETKLKLMA HYGRLADPAV SDLPAGKGYP CKTCKIVLNS 250
    IEQYQAHVSG FKHKNQSPKT LVTLGSQTPV QTQPTPKDSS TVQD 294
    Length:294
    Mass (Da):32,698
    Last modified:May 1, 2000 - v1
    Checksum:i6BD916262EDBA71E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF083339 mRNA. Translation: AAD52017.1.
    BC055075 mRNA. Translation: AAH55075.1.
    CCDSiCCDS26539.1.
    RefSeqiNP_036147.1. NM_012017.2.
    UniGeneiMm.22795.

    Genome annotation databases

    EnsembliENSMUST00000021937; ENSMUSP00000021937; ENSMUSG00000021481.
    GeneIDi26919.
    KEGGimmu:26919.
    UCSCiuc007qpy.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF083339 mRNA. Translation: AAD52017.1 .
    BC055075 mRNA. Translation: AAH55075.1 .
    CCDSi CCDS26539.1.
    RefSeqi NP_036147.1. NM_012017.2.
    UniGenei Mm.22795.

    3D structure databases

    ProteinModelPortali Q9R0B7.
    SMRi Q9R0B7. Positions 53-167, 181-224, 239-267.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 205063. 1 interaction.
    MINTi MINT-4084241.

    Proteomic databases

    PaxDbi Q9R0B7.
    PRIDEi Q9R0B7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000021937 ; ENSMUSP00000021937 ; ENSMUSG00000021481 .
    GeneIDi 26919.
    KEGGi mmu:26919.
    UCSCi uc007qpy.1. mouse.

    Organism-specific databases

    CTDi 26919.
    MGIi MGI:1349417. Zfp346.

    Phylogenomic databases

    eggNOGi NOG85918.
    GeneTreei ENSGT00510000046606.
    HOGENOMi HOG000008682.
    HOVERGENi HBG061007.
    InParanoidi Q9R0B7.
    PhylomeDBi Q9R0B7.
    TreeFami TF350019.

    Miscellaneous databases

    ChiTaRSi ZNF346. mouse.
    NextBioi 304801.
    PROi Q9R0B7.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9R0B7.
    Bgeei Q9R0B7.
    CleanExi MM_ZFP346.
    Genevestigatori Q9R0B7.

    Family and domain databases

    InterProi IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR003604. Znf_U1.
    [Graphical view ]
    SMARTi SM00355. ZnF_C2H2. 4 hits.
    SM00451. ZnF_U1. 4 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "JAZ requires the double-stranded RNA-binding zinc finger motifs for nuclear localization."
      Yang M., May W.S., Ito T.
      J. Biol. Chem. 274:27399-27406(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, MUTAGENESIS OF HIS-91; HIS-152; HIS-203 AND HIS-257.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C3H/He.
      Tissue: Osteoblast.

    Entry informationi

    Entry nameiZN346_MOUSE
    AccessioniPrimary (citable) accession number: Q9R0B7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 25, 2005
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 97 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3