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Q9R0B6

- LAMC3_MOUSE

UniProt

Q9R0B6 - LAMC3_MOUSE

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Protein

Laminin subunit gamma-3

Gene
Lamc3
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.

GO - Biological processi

  1. astrocyte development Source: MGI
  2. cell adhesion Source: UniProtKB-KW
  3. cell morphogenesis involved in differentiation Source: MGI
  4. retina development in camera-type eye Source: MGI
  5. visual perception Source: MGI
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Enzyme and pathway databases

ReactomeiREACT_196607. Non-integrin membrane-ECM interactions.
REACT_202342. Laminin interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Laminin subunit gamma-3
Alternative name(s):
Laminin-12 subunit gamma
Laminin-14 subunit gamma
Laminin-15 subunit gamma
Gene namesi
Name:Lamc3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:1344394. Lamc3.

Subcellular locationi

GO - Cellular componenti

  1. basement membrane Source: MGI
  2. extracellular region Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Basement membrane, Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2828 Reviewed predictionAdd
BLAST
Chaini29 – 15811553Laminin subunit gamma-3PRO_0000017080Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi128 – 1281N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi280 ↔ 289 By similarity
Disulfide bondi282 ↔ 299 By similarity
Disulfide bondi301 ↔ 310 By similarity
Glycosylationi304 – 3041N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi313 ↔ 333 By similarity
Disulfide bondi336 ↔ 345 By similarity
Glycosylationi337 – 3371N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi338 ↔ 361 By similarity
Disulfide bondi364 ↔ 373 By similarity
Disulfide bondi376 ↔ 389 By similarity
Disulfide bondi392 ↔ 404 By similarity
Disulfide bondi394 ↔ 410 By similarity
Disulfide bondi412 ↔ 421 By similarity
Disulfide bondi424 ↔ 436 By similarity
Disulfide bondi439 ↔ 450 By similarity
Disulfide bondi441 ↔ 457 By similarity
Disulfide bondi459 ↔ 468 By similarity
Disulfide bondi471 ↔ 486 By similarity
Glycosylationi640 – 6401N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi719 ↔ 727 By similarity
Disulfide bondi721 ↔ 734 By similarity
Disulfide bondi736 ↔ 745 By similarity
Disulfide bondi748 ↔ 764 By similarity
Disulfide bondi767 ↔ 775 By similarity
Disulfide bondi769 ↔ 786 By similarity
Disulfide bondi789 ↔ 798 By similarity
Disulfide bondi801 ↔ 819 By similarity
Disulfide bondi822 ↔ 836 By similarity
Disulfide bondi824 ↔ 843 By similarity
Disulfide bondi846 ↔ 855 By similarity
Glycosylationi849 – 8491N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi858 ↔ 875 By similarity
Disulfide bondi878 ↔ 891 By similarity
Disulfide bondi880 ↔ 898 By similarity
Disulfide bondi900 ↔ 909 By similarity
Disulfide bondi912 ↔ 925 By similarity
Disulfide bondi928 ↔ 940 By similarity
Disulfide bondi930 ↔ 947 By similarity
Disulfide bondi949 ↔ 958 By similarity
Disulfide bondi961 ↔ 973 By similarity
Disulfide bondi976 ↔ 988 By similarity
Disulfide bondi978 ↔ 994 By similarity
Glycosylationi991 – 9911N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi996 ↔ 1005 By similarity
Disulfide bondi1008 ↔ 1021 By similarity
Glycosylationi1162 – 11621N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1196 – 11961N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1320 – 13201N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1514 – 15141N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9R0B6.
PRIDEiQ9R0B6.

Expressioni

Tissue specificityi

Strongly expressed in capillaries and arterioles of kidney as well as in interstitial Leydig cells of testis.

Gene expression databases

ArrayExpressiQ9R0B6.
BgeeiQ9R0B6.
CleanExiMM_LAMC3.
GenevestigatoriQ9R0B6.

Interactioni

Subunit structurei

Laminin is a complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma), which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms with globules at each end. Gamma-3 is a subunit of laminin-12 (laminin-213), laminin-14 (laminin-423) and laminin-15 (laminin-523).

Protein-protein interaction databases

BioGridi204801. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ9R0B6.
SMRiQ9R0B6. Positions 34-391.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini40 – 279240Laminin N-terminalAdd
BLAST
Domaini280 – 33556Laminin EGF-like 1Add
BLAST
Domaini336 – 39156Laminin EGF-like 2Add
BLAST
Domaini392 – 43847Laminin EGF-like 3Add
BLAST
Domaini439 – 48850Laminin EGF-like 4Add
BLAST
Domaini489 – 49810Laminin EGF-like 5; first part
Domaini508 – 684177Laminin IV type AAdd
BLAST
Domaini685 – 71834Laminin EGF-like 5; second partAdd
BLAST
Domaini719 – 76648Laminin EGF-like 6Add
BLAST
Domaini767 – 82155Laminin EGF-like 7Add
BLAST
Domaini822 – 87756Laminin EGF-like 8Add
BLAST
Domaini878 – 92750Laminin EGF-like 9Add
BLAST
Domaini928 – 97548Laminin EGF-like 10Add
BLAST
Domaini976 – 102449Laminin EGF-like 11Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1025 – 1581557Domain II and IAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili1029 – 104618 Reviewed predictionAdd
BLAST
Coiled coili1112 – 115342 Reviewed predictionAdd
BLAST
Coiled coili1208 – 123124 Reviewed predictionAdd
BLAST
Coiled coili1438 – 146831 Reviewed predictionAdd
BLAST
Coiled coili1510 – 157566 Reviewed predictionAdd
BLAST

Domaini

The alpha-helical domains I and II are thought to interact with other laminin chains to form a coiled coil structure.
Domain IV is globular.

Sequence similaritiesi

Keywords - Domaini

Coiled coil, Laminin EGF-like domain, Repeat, Signal

Phylogenomic databases

eggNOGiNOG235720.
GeneTreeiENSGT00750000117374.
HOGENOMiHOG000019301.
HOVERGENiHBG100808.
KOiK06247.
OMAiQRGRRCE.
TreeFamiTF352481.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
InterProiIPR002049. EGF_laminin.
IPR008979. Galactose-bd-like.
IPR000034. Laminin_B_type_IV.
IPR008211. Laminin_N.
[Graphical view]
PfamiPF00052. Laminin_B. 1 hit.
PF00053. Laminin_EGF. 10 hits.
PF00055. Laminin_N. 1 hit.
[Graphical view]
SMARTiSM00180. EGF_Lam. 10 hits.
SM00136. LamNT. 1 hit.
[Graphical view]
PROSITEiPS00022. EGF_1. 8 hits.
PS01186. EGF_2. 2 hits.
PS01248. EGF_LAM_1. 11 hits.
PS50027. EGF_LAM_2. 10 hits.
PS51115. LAMININ_IVA. 1 hit.
PS51117. LAMININ_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9R0B6-1 [UniParc]FASTAAdd to Basket

« Hide

MAVSRVLSLL ATVASMALVI QETHFAAGAD MGSCYDGVGR AQRCLPEFEN     50
AAFGRRAEAS HTCGRPPEDF CPHVGAPGAG LQCQRCDDAD PGRRHDASYL 100
TDFHSPDDST WWQSPSMAFG VQYPTSVNLT LSLGKAYEIT YVRLKFHTSR 150
PESFAIYKRT YASGPWEPYQ YYSASCQKTY GRPEGHYLRP GEDERVAFCT 200
SEFSDISPLN GGNVAFSTLE GRPSAYNFEE SPVLQEWVTS TDILISLDRL 250
NTFGDDIFKD PRVLQSYYYA VSDFSVGGRC KCNGHASECE PNAAGQLACR 300
CQHNTTGVDC ERCLPFFQDR PWARGTAEDA NECLPCNCSG HSEECTFDRE 350
LYRSTGHGGH CQRCRDHTTG PHCERCEKNY YRWSPKTPCQ PCDCHPAGSL 400
SLQCDNSGVC PCKPTVTGWK CDRCLPGFHS LSEGGCRPCA CNVAGSLGTC 450
DPRSGNCPCK ENVEGSLCDR CRPGTFNLQP HNPVGCSSCF CYGHSKVCSP 500
AAGFQEHHIR SDFRHGAGGW QIRSMGVSKR PLQWSQSGLL LGLRGGEELS 550
APKKFLGDQR LSYGQPVILT LQVPPGGSPP PIQLRLEGAG LALSLRPSSL 600
PSPQDTRQPR RVQLQFLLQE TSEEAESPLP TFHFQRLLSN LTALSIWTSG 650
QGPGHSGQVL LCEVQLTSAW PQRELAPPAS WVETCLCPQG YTGQFCEFCA 700
LGYKREIPHG GPYANCIPCT CNQHGTCDPN TGICLCGHHT EGPSCERCMP 750
GFYGNAFSGR ADDCQPCPCP GQSACATIPE SGDVVCTHCP PGQRGRRCES 800
CEDGFFGDPL GLSGAPQPCR RCQCSGNVDL NAVGNCDPHS GHCLRCLYNT 850
TGAHCEHCRE GFYGSAVATR PVDKCAPCSC DLRGSVSEKT CNPVTGQCVC 900
LPYVSGRDCS RCSPGFYDLQ SGRGCQSCKC HPLGSLENKC HPKTGQCPCR 950
PGVTGQACDR CQLGFFGFSI KGCRDCRCSP LGAASSQCHE NSTCVCRPGF 1000
VGYKCDRCQD NFFLADGDTG CQECPTCYAL VKEEAAKLKA RLMLMEGWLQ 1050
RSDCGSPWGP LDILQGEAPL GDVYQGHHLL QETRGTFLQQ MVGLEDSVKA 1100
TWEQLQVLRG HVHCAQAGAQ KTCIQLAELE ETLQSSEEEV LRAASALSFL 1150
ASLQKGSSTP TNWSHLASEA QILARSHRDT ATKIEATSER ALLASNASYE 1200
LLKLMEGRVA SEAQQELEDR YQEVQAAQTA LGIAVAEALP KAEKALATVK 1250
QVIGDAAPHL GLLVTPEAMN FQARGLSWKV KALEQKLEQK EPEVGQSVGA 1300
LQVEAGRALE KMEPFMQLRN KTTAAFTRAS SAVQAAKVTV IGAETLLADL 1350
EGMKLRSPLP KEQAALKKKA GSIRTRLLED TKRKTKQAER MLGNAASLSS 1400
STKKKSKEAE LMSKDNAKLS RALLREGKQG YRHASRLASQ TQATLRRASR 1450
LLLTSEAHKQ ELEEAKQVTS GLSTVERQIR ESRISLEKDT KVLSELLVKL 1500
GSLGVHQAPA QTLNETQRAL ESLRLQLDSH GALHHKLRQL EEESARQELQ 1550
IQSFEDDLAE IRADKHNLET ILSSLPENCA S 1581
Length:1,581
Mass (Da):172,322
Last modified:July 27, 2011 - v2
Checksum:iA6E83A8F9C678830
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti9 – 91L → F in AAD29851. 1 Publication
Sequence conflicti190 – 1901P → T in AAD29851. 1 Publication
Sequence conflicti195 – 1951R → K in AAD29851. 1 Publication
Sequence conflicti221 – 2211G → S in AAD29851. 1 Publication
Sequence conflicti394 – 3941C → R in AAD29851. 1 Publication
Sequence conflicti471 – 4711C → Y in AAD29851. 1 Publication
Sequence conflicti1150 – 11501L → LDEPQLFSLLLK in AAD29851. 1 Publication
Sequence conflicti1387 – 13871Q → H in AAF08983. 1 Publication
Sequence conflicti1438 – 14392AS → TI in AAD29851. 1 Publication
Sequence conflicti1479 – 14791I → V in AAF08983. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF083372 mRNA. Translation: AAF08983.1.
AL928893, BX511243 Genomic DNA. Translation: CAM26043.1.
BX511243, AL928893 Genomic DNA. Translation: CAM26482.1.
CH466542 Genomic DNA. Translation: EDL08519.1.
BC096366 mRNA. Translation: AAH96366.1.
AF079520 mRNA. Translation: AAD29851.1.
CCDSiCCDS15903.1.
RefSeqiNP_035966.2. NM_011836.3.
UniGeneiMm.302362.

Genome annotation databases

EnsembliENSMUST00000028187; ENSMUSP00000028187; ENSMUSG00000026840.
GeneIDi23928.
KEGGimmu:23928.
UCSCiuc008jef.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF083372 mRNA. Translation: AAF08983.1 .
AL928893 , BX511243 Genomic DNA. Translation: CAM26043.1 .
BX511243 , AL928893 Genomic DNA. Translation: CAM26482.1 .
CH466542 Genomic DNA. Translation: EDL08519.1 .
BC096366 mRNA. Translation: AAH96366.1 .
AF079520 mRNA. Translation: AAD29851.1 .
CCDSi CCDS15903.1.
RefSeqi NP_035966.2. NM_011836.3.
UniGenei Mm.302362.

3D structure databases

ProteinModelPortali Q9R0B6.
SMRi Q9R0B6. Positions 34-391.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 204801. 1 interaction.

Proteomic databases

PaxDbi Q9R0B6.
PRIDEi Q9R0B6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000028187 ; ENSMUSP00000028187 ; ENSMUSG00000026840 .
GeneIDi 23928.
KEGGi mmu:23928.
UCSCi uc008jef.1. mouse.

Organism-specific databases

CTDi 10319.
MGIi MGI:1344394. Lamc3.

Phylogenomic databases

eggNOGi NOG235720.
GeneTreei ENSGT00750000117374.
HOGENOMi HOG000019301.
HOVERGENi HBG100808.
KOi K06247.
OMAi QRGRRCE.
TreeFami TF352481.

Enzyme and pathway databases

Reactomei REACT_196607. Non-integrin membrane-ECM interactions.
REACT_202342. Laminin interactions.

Miscellaneous databases

NextBioi 303725.
PROi Q9R0B6.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9R0B6.
Bgeei Q9R0B6.
CleanExi MM_LAMC3.
Genevestigatori Q9R0B6.

Family and domain databases

Gene3Di 2.60.120.260. 1 hit.
InterProi IPR002049. EGF_laminin.
IPR008979. Galactose-bd-like.
IPR000034. Laminin_B_type_IV.
IPR008211. Laminin_N.
[Graphical view ]
Pfami PF00052. Laminin_B. 1 hit.
PF00053. Laminin_EGF. 10 hits.
PF00055. Laminin_N. 1 hit.
[Graphical view ]
SMARTi SM00180. EGF_Lam. 10 hits.
SM00136. LamNT. 1 hit.
[Graphical view ]
PROSITEi PS00022. EGF_1. 8 hits.
PS01186. EGF_2. 2 hits.
PS01248. EGF_LAM_1. 11 hits.
PS50027. EGF_LAM_2. 10 hits.
PS51115. LAMININ_IVA. 1 hit.
PS51117. LAMININ_NTER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Mouse laminin 12 gamma 3 chain."
    Albus A.M., Burgeson B., Champliaud M.-F., Koch M., Olson P.
    Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.
  5. "Molecular cloning and tissue-specific expression of a novel murine laminin gamma3 chain."
    Iivanainen A., Morita T., Tryggvason K.
    J. Biol. Chem. 274:14107-14111(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-1526.

Entry informationi

Entry nameiLAMC3_MOUSE
AccessioniPrimary (citable) accession number: Q9R0B6
Secondary accession number(s): Q4VAI3, Q9WTW6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 13, 2001
Last sequence update: July 27, 2011
Last modified: September 3, 2014
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi