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Protein

Peroxisomal membrane protein PEX14

Gene

Pex14

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Peroxisome membrane protein that is an essential component of the peroxisomal import machinery. Functions as a docking factor for the predominantly cytoplasmic PTS1 receptor (PEX5). Plays a key role for peroxisome movement through a direct interaction with tubulin.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Translocation, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisomal membrane protein PEX14
Alternative name(s):
PTS1 receptor-docking protein
Peroxin-14
Peroxisomal membrane anchor protein PEX14
Gene namesi
Name:Pex14
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1927868. Pex14.

Subcellular locationi

  • Peroxisome membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity

GO - Cellular componenti

  • integral component of membrane Source: Ensembl
  • intracellular Source: MGI
  • intracellular membrane-bounded organelle Source: MGI
  • membrane Source: MGI
  • nucleolus Source: MGI
  • peroxisomal membrane Source: MGI
  • peroxisome Source: UniProtKB
  • protein complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000583262 – 376Peroxisomal membrane protein PEX14Add BLAST375

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei34N6-acetyllysineBy similarity1
Modified residuei232PhosphoserineBy similarity1
Modified residuei282PhosphoserineBy similarity1
Modified residuei334PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9R0A0.
MaxQBiQ9R0A0.
PaxDbiQ9R0A0.
PeptideAtlasiQ9R0A0.
PRIDEiQ9R0A0.

PTM databases

iPTMnetiQ9R0A0.
PhosphoSitePlusiQ9R0A0.

Expressioni

Gene expression databases

BgeeiENSMUSG00000028975.
CleanExiMM_PEX14.
ExpressionAtlasiQ9R0A0. baseline and differential.
GenevisibleiQ9R0A0. MM.

Interactioni

Subunit structurei

Interacts with PEX5, PEX13 and PEX19. Interacts with tubulin.By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ9R0A0. 2 interactors.
MINTiMINT-4107217.
STRINGi10090.ENSMUSP00000099506.

Structurei

3D structure databases

ProteinModelPortaliQ9R0A0.
SMRiQ9R0A0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxin-14 family.Curated

Phylogenomic databases

eggNOGiKOG2629. Eukaryota.
ENOG4111P8A. LUCA.
GeneTreeiENSGT00390000015047.
HOGENOMiHOG000220930.
HOVERGENiHBG053571.
InParanoidiQ9R0A0.
KOiK13343.
OMAiWQIPVKP.
OrthoDBiEOG091G0LT7.
PhylomeDBiQ9R0A0.
TreeFamiTF323535.

Family and domain databases

Gene3Di1.20.1200.10. 1 hit.
InterProiIPR016030. AdoCbl_synth_CblAdoTrfase-like.
IPR025655. PEX14.
IPR006785. Pex14_N.
[Graphical view]
PANTHERiPTHR23058. PTHR23058. 1 hit.
PfamiPF04695. Pex14_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9R0A0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASSEQAEQP NQPSSPPGSE NVVPREPLIA TAVKFLQNSR VRQSPLATRR
60 70 80 90 100
AFLKKKGLTD EEIDLAFQQS GTAADEPSPL GPATPVVPVQ PPHLTPQPYS
110 120 130 140 150
PRGSRWRDYG ALAIIMAGIA FGFHQLYKRY LLPLILGGRE DRKQLERMAA
160 170 180 190 200
SLSELSGTVA QTVTQVQTTL ASVQELLRQQ QQKVQELAHE LATAKATTST
210 220 230 240 250
NWILESQNIN ELKSEINSLK GLLLNRRQFP PSPSAPKIPS WQIPVKSSSP
260 270 280 290 300
SSPAAVNHHS SSDISPVSNE STSSSPGKDS HSPEGSTATY HLLGPQEEGE
310 320 330 340 350
GVLDVKGQVR MEVQGEEEKR EDKEDEDDED DDVSHVDEED VLGVQREDRR
360 370
GGDGQINEQV EKLRRPEGAS NETERD
Length:376
Mass (Da):41,208
Last modified:May 1, 2000 - v1
Checksum:iF7863CE4B6433580
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF097512 mRNA. Translation: AAF04616.1.
BC028952 mRNA. Translation: AAH28952.1.
CCDSiCCDS18950.1.
RefSeqiNP_062755.1. NM_019781.2.
UniGeneiMm.184172.

Genome annotation databases

EnsembliENSMUST00000103217; ENSMUSP00000099506; ENSMUSG00000028975.
GeneIDi56273.
KEGGimmu:56273.
UCSCiuc008vvp.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF097512 mRNA. Translation: AAF04616.1.
BC028952 mRNA. Translation: AAH28952.1.
CCDSiCCDS18950.1.
RefSeqiNP_062755.1. NM_019781.2.
UniGeneiMm.184172.

3D structure databases

ProteinModelPortaliQ9R0A0.
SMRiQ9R0A0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9R0A0. 2 interactors.
MINTiMINT-4107217.
STRINGi10090.ENSMUSP00000099506.

PTM databases

iPTMnetiQ9R0A0.
PhosphoSitePlusiQ9R0A0.

Proteomic databases

EPDiQ9R0A0.
MaxQBiQ9R0A0.
PaxDbiQ9R0A0.
PeptideAtlasiQ9R0A0.
PRIDEiQ9R0A0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000103217; ENSMUSP00000099506; ENSMUSG00000028975.
GeneIDi56273.
KEGGimmu:56273.
UCSCiuc008vvp.1. mouse.

Organism-specific databases

CTDi5195.
MGIiMGI:1927868. Pex14.

Phylogenomic databases

eggNOGiKOG2629. Eukaryota.
ENOG4111P8A. LUCA.
GeneTreeiENSGT00390000015047.
HOGENOMiHOG000220930.
HOVERGENiHBG053571.
InParanoidiQ9R0A0.
KOiK13343.
OMAiWQIPVKP.
OrthoDBiEOG091G0LT7.
PhylomeDBiQ9R0A0.
TreeFamiTF323535.

Miscellaneous databases

ChiTaRSiPex14. mouse.
PROiQ9R0A0.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028975.
CleanExiMM_PEX14.
ExpressionAtlasiQ9R0A0. baseline and differential.
GenevisibleiQ9R0A0. MM.

Family and domain databases

Gene3Di1.20.1200.10. 1 hit.
InterProiIPR016030. AdoCbl_synth_CblAdoTrfase-like.
IPR025655. PEX14.
IPR006785. Pex14_N.
[Graphical view]
PANTHERiPTHR23058. PTHR23058. 1 hit.
PfamiPF04695. Pex14_N. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPEX14_MOUSE
AccessioniPrimary (citable) accession number: Q9R0A0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: May 1, 2000
Last modified: November 30, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.