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Q9R0A0

- PEX14_MOUSE

UniProt

Q9R0A0 - PEX14_MOUSE

Protein

Peroxisomal membrane protein PEX14

Gene

Pex14

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Component of the peroxisomal translocation machinery with PEX13 and PEX17. Interacts with both the PTS1 and PTS2 receptors. Binds directly to PEX17 By similarity.By similarity

    GO - Molecular functioni

    1. transcription corepressor activity Source: Ensembl

    GO - Biological processi

    1. microtubule anchoring Source: Ensembl
    2. negative regulation of protein binding Source: Ensembl
    3. negative regulation of protein homotetramerization Source: Ensembl
    4. negative regulation of sequence-specific DNA binding transcription factor activity Source: Ensembl
    5. negative regulation of transcription, DNA-templated Source: Ensembl
    6. peroxisome transport along microtubule Source: Ensembl
    7. protein homooligomerization Source: Ensembl
    8. protein import into peroxisome matrix, docking Source: InterPro
    9. protein import into peroxisome matrix, substrate release Source: Ensembl
    10. protein import into peroxisome matrix, translocation Source: Ensembl

    Keywords - Biological processi

    Protein transport, Translocation, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Peroxisomal membrane protein PEX14
    Alternative name(s):
    PTS1 receptor-docking protein
    Peroxin-14
    Peroxisomal membrane anchor protein PEX14
    Gene namesi
    Name:Pex14
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 4

    Organism-specific databases

    MGIiMGI:1927868. Pex14.

    Subcellular locationi

    Peroxisome membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: Ensembl
    2. peroxisomal membrane Source: MGI
    3. peroxisome Source: UniProtKB
    4. protein complex Source: Ensembl

    Keywords - Cellular componenti

    Membrane, Peroxisome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 376375Peroxisomal membrane protein PEX14PRO_0000058326Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanineBy similarity
    Modified residuei34 – 341N6-acetyllysineBy similarity
    Modified residuei334 – 3341Phosphoserine1 Publication

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ9R0A0.
    PaxDbiQ9R0A0.
    PRIDEiQ9R0A0.

    PTM databases

    PhosphoSiteiQ9R0A0.

    Expressioni

    Gene expression databases

    BgeeiQ9R0A0.
    CleanExiMM_PEX14.
    GenevestigatoriQ9R0A0.

    Interactioni

    Subunit structurei

    Interacts with PEX5 and PEX19.By similarity

    Protein-protein interaction databases

    IntActiQ9R0A0. 1 interaction.
    MINTiMINT-4107217.
    STRINGi10090.ENSMUSP00000099506.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9R0A0.
    SMRiQ9R0A0. Positions 25-70.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peroxin-14 family.Curated

    Phylogenomic databases

    eggNOGiNOG136629.
    GeneTreeiENSGT00390000015047.
    HOGENOMiHOG000220930.
    HOVERGENiHBG053571.
    InParanoidiQ9R0A0.
    KOiK13343.
    OMAiWQIPVKP.
    OrthoDBiEOG7DFXD4.
    PhylomeDBiQ9R0A0.
    TreeFamiTF323535.

    Family and domain databases

    InterProiIPR025655. PEX14.
    IPR006785. Pex14_N.
    [Graphical view]
    PANTHERiPTHR23058. PTHR23058. 1 hit.
    PfamiPF04695. Pex14_N. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9R0A0-1 [UniParc]FASTAAdd to Basket

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    MASSEQAEQP NQPSSPPGSE NVVPREPLIA TAVKFLQNSR VRQSPLATRR    50
    AFLKKKGLTD EEIDLAFQQS GTAADEPSPL GPATPVVPVQ PPHLTPQPYS 100
    PRGSRWRDYG ALAIIMAGIA FGFHQLYKRY LLPLILGGRE DRKQLERMAA 150
    SLSELSGTVA QTVTQVQTTL ASVQELLRQQ QQKVQELAHE LATAKATTST 200
    NWILESQNIN ELKSEINSLK GLLLNRRQFP PSPSAPKIPS WQIPVKSSSP 250
    SSPAAVNHHS SSDISPVSNE STSSSPGKDS HSPEGSTATY HLLGPQEEGE 300
    GVLDVKGQVR MEVQGEEEKR EDKEDEDDED DDVSHVDEED VLGVQREDRR 350
    GGDGQINEQV EKLRRPEGAS NETERD 376
    Length:376
    Mass (Da):41,208
    Last modified:May 1, 2000 - v1
    Checksum:iF7863CE4B6433580
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF097512 mRNA. Translation: AAF04616.1.
    BC028952 mRNA. Translation: AAH28952.1.
    CCDSiCCDS18950.1.
    RefSeqiNP_062755.1. NM_019781.2.
    UniGeneiMm.184172.

    Genome annotation databases

    EnsembliENSMUST00000103217; ENSMUSP00000099506; ENSMUSG00000028975.
    GeneIDi56273.
    KEGGimmu:56273.
    UCSCiuc008vvp.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF097512 mRNA. Translation: AAF04616.1 .
    BC028952 mRNA. Translation: AAH28952.1 .
    CCDSi CCDS18950.1.
    RefSeqi NP_062755.1. NM_019781.2.
    UniGenei Mm.184172.

    3D structure databases

    ProteinModelPortali Q9R0A0.
    SMRi Q9R0A0. Positions 25-70.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q9R0A0. 1 interaction.
    MINTi MINT-4107217.
    STRINGi 10090.ENSMUSP00000099506.

    PTM databases

    PhosphoSitei Q9R0A0.

    Proteomic databases

    MaxQBi Q9R0A0.
    PaxDbi Q9R0A0.
    PRIDEi Q9R0A0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000103217 ; ENSMUSP00000099506 ; ENSMUSG00000028975 .
    GeneIDi 56273.
    KEGGi mmu:56273.
    UCSCi uc008vvp.1. mouse.

    Organism-specific databases

    CTDi 5195.
    MGIi MGI:1927868. Pex14.

    Phylogenomic databases

    eggNOGi NOG136629.
    GeneTreei ENSGT00390000015047.
    HOGENOMi HOG000220930.
    HOVERGENi HBG053571.
    InParanoidi Q9R0A0.
    KOi K13343.
    OMAi WQIPVKP.
    OrthoDBi EOG7DFXD4.
    PhylomeDBi Q9R0A0.
    TreeFami TF323535.

    Miscellaneous databases

    ChiTaRSi PEX14. mouse.
    NextBioi 312156.
    PROi Q9R0A0.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9R0A0.
    CleanExi MM_PEX14.
    Genevestigatori Q9R0A0.

    Family and domain databases

    InterProi IPR025655. PEX14.
    IPR006785. Pex14_N.
    [Graphical view ]
    PANTHERi PTHR23058. PTHR23058. 1 hit.
    Pfami PF04695. Pex14_N. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Physical linkage of Pex14 and Cast genes on mouse chromosome 4."
      Bliskovsky V., Miller M., Mock B.
      Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Retina.
    3. Lubec G., Sunyer B., Chen W.-Q.
      Submitted (JAN-2009) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 228-237, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: OF1.
      Tissue: Hippocampus.
    4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-334, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.

    Entry informationi

    Entry nameiPEX14_MOUSE
    AccessioniPrimary (citable) accession number: Q9R0A0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 21, 2001
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 104 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3