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Protein

Peroxisomal membrane protein PEX14

Gene

Pex14

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Peroxisome membrane protein that is an essential component of the peroxisomal import machinery. Functions as a docking factor for the predominantly cytoplasmic PTS1 receptor (PEX5). Plays a key role for peroxisome movement through a direct interaction with tubulin.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processProtein transport, Translocation, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisomal membrane protein PEX14
Alternative name(s):
PTS1 receptor-docking protein
Peroxin-14
Peroxisomal membrane anchor protein PEX14
Gene namesi
Name:Pex14
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1927868 Pex14

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000583262 – 376Peroxisomal membrane protein PEX14Add BLAST375

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei34N6-acetyllysineBy similarity1
Modified residuei232PhosphoserineBy similarity1
Modified residuei282PhosphoserineBy similarity1
Modified residuei334PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9R0A0
MaxQBiQ9R0A0
PaxDbiQ9R0A0
PeptideAtlasiQ9R0A0
PRIDEiQ9R0A0

PTM databases

iPTMnetiQ9R0A0
PhosphoSitePlusiQ9R0A0

Expressioni

Gene expression databases

BgeeiENSMUSG00000028975
CleanExiMM_PEX14
ExpressionAtlasiQ9R0A0 baseline and differential
GenevisibleiQ9R0A0 MM

Interactioni

Subunit structurei

Interacts with PEX5, PEX13 and PEX19. Interacts with tubulin.By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ9R0A0, 2 interactors
MINTiQ9R0A0
STRINGi10090.ENSMUSP00000099506

Structurei

3D structure databases

ProteinModelPortaliQ9R0A0
SMRiQ9R0A0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxin-14 family.Curated

Phylogenomic databases

eggNOGiKOG2629 Eukaryota
ENOG4111P8A LUCA
GeneTreeiENSGT00390000015047
HOGENOMiHOG000220930
HOVERGENiHBG053571
InParanoidiQ9R0A0
KOiK13343
OMAiASIPAWQ
OrthoDBiEOG091G0LT7
PhylomeDBiQ9R0A0
TreeFamiTF323535

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR025655 PEX14
IPR006785 Pex14_N
IPR036388 WH-like_DNA-bd_sf
PANTHERiPTHR23058 PTHR23058, 1 hit
PfamiView protein in Pfam
PF04695 Pex14_N, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9R0A0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASSEQAEQP NQPSSPPGSE NVVPREPLIA TAVKFLQNSR VRQSPLATRR
60 70 80 90 100
AFLKKKGLTD EEIDLAFQQS GTAADEPSPL GPATPVVPVQ PPHLTPQPYS
110 120 130 140 150
PRGSRWRDYG ALAIIMAGIA FGFHQLYKRY LLPLILGGRE DRKQLERMAA
160 170 180 190 200
SLSELSGTVA QTVTQVQTTL ASVQELLRQQ QQKVQELAHE LATAKATTST
210 220 230 240 250
NWILESQNIN ELKSEINSLK GLLLNRRQFP PSPSAPKIPS WQIPVKSSSP
260 270 280 290 300
SSPAAVNHHS SSDISPVSNE STSSSPGKDS HSPEGSTATY HLLGPQEEGE
310 320 330 340 350
GVLDVKGQVR MEVQGEEEKR EDKEDEDDED DDVSHVDEED VLGVQREDRR
360 370
GGDGQINEQV EKLRRPEGAS NETERD
Length:376
Mass (Da):41,208
Last modified:May 1, 2000 - v1
Checksum:iF7863CE4B6433580
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF097512 mRNA Translation: AAF04616.1
BC028952 mRNA Translation: AAH28952.1
CCDSiCCDS18950.1
RefSeqiNP_062755.1, NM_019781.2
UniGeneiMm.184172

Genome annotation databases

EnsembliENSMUST00000103217; ENSMUSP00000099506; ENSMUSG00000028975
GeneIDi56273
KEGGimmu:56273
UCSCiuc008vvp.1 mouse

Similar proteinsi

Entry informationi

Entry nameiPEX14_MOUSE
AccessioniPrimary (citable) accession number: Q9R0A0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: May 1, 2000
Last modified: April 25, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
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Main funding by: National Institutes of Health