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Protein

Peroxisomal membrane protein PEX14

Gene

Pex14

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Peroxisome membrane protein that is an essential component of the peroxisomal import machinery. Functions as a docking factor for the predominantly cytoplasmic PTS1 receptor (PEX5). Plays a key role for peroxisome movement through a direct interaction with tubulin.By similarity

GO - Molecular functioni

  1. beta-tubulin binding Source: MGI
  2. microtubule binding Source: MGI
  3. protein N-terminus binding Source: MGI
  4. receptor binding Source: MGI
  5. transcription corepressor activity Source: MGI

GO - Biological processi

  1. microtubule anchoring Source: MGI
  2. negative regulation of protein binding Source: MGI
  3. negative regulation of protein homotetramerization Source: MGI
  4. negative regulation of sequence-specific DNA binding transcription factor activity Source: MGI
  5. negative regulation of transcription, DNA-templated Source: MGI
  6. peroxisome transport along microtubule Source: MGI
  7. protein complex assembly Source: MGI
  8. protein homooligomerization Source: MGI
  9. protein import into peroxisome matrix Source: MGI
  10. protein import into peroxisome matrix, docking Source: InterPro
  11. protein import into peroxisome matrix, substrate release Source: MGI
  12. protein import into peroxisome matrix, translocation Source: MGI
Complete GO annotation...

Keywords - Biological processi

Protein transport, Translocation, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisomal membrane protein PEX14
Alternative name(s):
PTS1 receptor-docking protein
Peroxin-14
Peroxisomal membrane anchor protein PEX14
Gene namesi
Name:Pex14
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1927868. Pex14.

Subcellular locationi

Peroxisome membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity

GO - Cellular componenti

  1. integral component of membrane Source: Ensembl
  2. intracellular Source: MGI
  3. intracellular membrane-bounded organelle Source: MGI
  4. membrane Source: MGI
  5. nucleolus Source: MGI
  6. peroxisomal membrane Source: MGI
  7. peroxisome Source: UniProtKB
  8. protein complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 376375Peroxisomal membrane protein PEX14PRO_0000058326Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei34 – 341N6-acetyllysineBy similarity
Modified residuei334 – 3341Phosphoserine1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ9R0A0.
PaxDbiQ9R0A0.
PRIDEiQ9R0A0.

PTM databases

PhosphoSiteiQ9R0A0.

Expressioni

Gene expression databases

BgeeiQ9R0A0.
CleanExiMM_PEX14.
ExpressionAtlasiQ9R0A0. baseline and differential.
GenevestigatoriQ9R0A0.

Interactioni

Subunit structurei

Interacts with PEX5, PEX13 and PEX19. Interacts with tubulin.By similarity

Protein-protein interaction databases

IntActiQ9R0A0. 1 interaction.
MINTiMINT-4107217.
STRINGi10090.ENSMUSP00000099506.

Structurei

3D structure databases

ProteinModelPortaliQ9R0A0.
SMRiQ9R0A0. Positions 25-70.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxin-14 family.Curated

Phylogenomic databases

eggNOGiNOG136629.
GeneTreeiENSGT00390000015047.
HOGENOMiHOG000220930.
HOVERGENiHBG053571.
InParanoidiQ9R0A0.
KOiK13343.
OMAiWQIPVKP.
OrthoDBiEOG7DFXD4.
PhylomeDBiQ9R0A0.
TreeFamiTF323535.

Family and domain databases

InterProiIPR025655. PEX14.
IPR006785. Pex14_N.
[Graphical view]
PANTHERiPTHR23058. PTHR23058. 1 hit.
PfamiPF04695. Pex14_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9R0A0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASSEQAEQP NQPSSPPGSE NVVPREPLIA TAVKFLQNSR VRQSPLATRR
60 70 80 90 100
AFLKKKGLTD EEIDLAFQQS GTAADEPSPL GPATPVVPVQ PPHLTPQPYS
110 120 130 140 150
PRGSRWRDYG ALAIIMAGIA FGFHQLYKRY LLPLILGGRE DRKQLERMAA
160 170 180 190 200
SLSELSGTVA QTVTQVQTTL ASVQELLRQQ QQKVQELAHE LATAKATTST
210 220 230 240 250
NWILESQNIN ELKSEINSLK GLLLNRRQFP PSPSAPKIPS WQIPVKSSSP
260 270 280 290 300
SSPAAVNHHS SSDISPVSNE STSSSPGKDS HSPEGSTATY HLLGPQEEGE
310 320 330 340 350
GVLDVKGQVR MEVQGEEEKR EDKEDEDDED DDVSHVDEED VLGVQREDRR
360 370
GGDGQINEQV EKLRRPEGAS NETERD
Length:376
Mass (Da):41,208
Last modified:April 30, 2000 - v1
Checksum:iF7863CE4B6433580
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF097512 mRNA. Translation: AAF04616.1.
BC028952 mRNA. Translation: AAH28952.1.
CCDSiCCDS18950.1.
RefSeqiNP_062755.1. NM_019781.2.
UniGeneiMm.184172.

Genome annotation databases

EnsembliENSMUST00000103217; ENSMUSP00000099506; ENSMUSG00000028975.
GeneIDi56273.
KEGGimmu:56273.
UCSCiuc008vvp.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF097512 mRNA. Translation: AAF04616.1.
BC028952 mRNA. Translation: AAH28952.1.
CCDSiCCDS18950.1.
RefSeqiNP_062755.1. NM_019781.2.
UniGeneiMm.184172.

3D structure databases

ProteinModelPortaliQ9R0A0.
SMRiQ9R0A0. Positions 25-70.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9R0A0. 1 interaction.
MINTiMINT-4107217.
STRINGi10090.ENSMUSP00000099506.

PTM databases

PhosphoSiteiQ9R0A0.

Proteomic databases

MaxQBiQ9R0A0.
PaxDbiQ9R0A0.
PRIDEiQ9R0A0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000103217; ENSMUSP00000099506; ENSMUSG00000028975.
GeneIDi56273.
KEGGimmu:56273.
UCSCiuc008vvp.1. mouse.

Organism-specific databases

CTDi5195.
MGIiMGI:1927868. Pex14.

Phylogenomic databases

eggNOGiNOG136629.
GeneTreeiENSGT00390000015047.
HOGENOMiHOG000220930.
HOVERGENiHBG053571.
InParanoidiQ9R0A0.
KOiK13343.
OMAiWQIPVKP.
OrthoDBiEOG7DFXD4.
PhylomeDBiQ9R0A0.
TreeFamiTF323535.

Miscellaneous databases

ChiTaRSiPex14. mouse.
NextBioi312156.
PROiQ9R0A0.
SOURCEiSearch...

Gene expression databases

BgeeiQ9R0A0.
CleanExiMM_PEX14.
ExpressionAtlasiQ9R0A0. baseline and differential.
GenevestigatoriQ9R0A0.

Family and domain databases

InterProiIPR025655. PEX14.
IPR006785. Pex14_N.
[Graphical view]
PANTHERiPTHR23058. PTHR23058. 1 hit.
PfamiPF04695. Pex14_N. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Physical linkage of Pex14 and Cast genes on mouse chromosome 4."
    Bliskovsky V., Miller M., Mock B.
    Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Retina.
  3. Lubec G., Sunyer B., Chen W.-Q.
    Submitted (DEC-2008) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 228-237, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: OF1.
    Tissue: Hippocampus.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-334, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiPEX14_MOUSE
AccessioniPrimary (citable) accession number: Q9R0A0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 20, 2001
Last sequence update: April 30, 2000
Last modified: February 3, 2015
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.