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Q9R0A0 (PEX14_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 103. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Peroxisomal membrane protein PEX14
Alternative name(s):
PTS1 receptor-docking protein
Peroxin-14
Peroxisomal membrane anchor protein PEX14
Gene names
Name:Pex14
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length376 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Component of the peroxisomal translocation machinery with PEX13 and PEX17. Interacts with both the PTS1 and PTS2 receptors. Binds directly to PEX17 By similarity.

Subunit structure

Interacts with PEX5 and PEX19 By similarity.

Subcellular location

Peroxisome membrane; Peripheral membrane protein; Cytoplasmic side By similarity.

Sequence similarities

Belongs to the peroxin-14 family.

Ontologies

Keywords
   Biological processProtein transport
Translocation
Transport
   Cellular componentMembrane
Peroxisome
   PTMAcetylation
Phosphoprotein
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processmicrotubule anchoring

Inferred from electronic annotation. Source: Ensembl

negative regulation of protein binding

Inferred from electronic annotation. Source: Ensembl

negative regulation of protein homotetramerization

Inferred from electronic annotation. Source: Ensembl

negative regulation of sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: Ensembl

negative regulation of transcription, DNA-templated

Inferred from electronic annotation. Source: Ensembl

peroxisome transport along microtubule

Inferred from electronic annotation. Source: Ensembl

protein homooligomerization

Inferred from electronic annotation. Source: Ensembl

protein import into peroxisome matrix, docking

Inferred from electronic annotation. Source: InterPro

protein import into peroxisome matrix, substrate release

Inferred from electronic annotation. Source: Ensembl

protein import into peroxisome matrix, translocation

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: Ensembl

peroxisomal membrane

Inferred from direct assay PubMed 16449325. Source: MGI

peroxisome

Inferred from direct assay PubMed 17881773. Source: UniProtKB

protein complex

Inferred from electronic annotation. Source: Ensembl

   Molecular_functiontranscription corepressor activity

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 376375Peroxisomal membrane protein PEX14
PRO_0000058326

Amino acid modifications

Modified residue21N-acetylalanine By similarity
Modified residue341N6-acetyllysine By similarity
Modified residue3341Phosphoserine Ref.4

Sequences

Sequence LengthMass (Da)Tools
Q9R0A0 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: F7863CE4B6433580

FASTA37641,208
        10         20         30         40         50         60 
MASSEQAEQP NQPSSPPGSE NVVPREPLIA TAVKFLQNSR VRQSPLATRR AFLKKKGLTD 

        70         80         90        100        110        120 
EEIDLAFQQS GTAADEPSPL GPATPVVPVQ PPHLTPQPYS PRGSRWRDYG ALAIIMAGIA 

       130        140        150        160        170        180 
FGFHQLYKRY LLPLILGGRE DRKQLERMAA SLSELSGTVA QTVTQVQTTL ASVQELLRQQ 

       190        200        210        220        230        240 
QQKVQELAHE LATAKATTST NWILESQNIN ELKSEINSLK GLLLNRRQFP PSPSAPKIPS 

       250        260        270        280        290        300 
WQIPVKSSSP SSPAAVNHHS SSDISPVSNE STSSSPGKDS HSPEGSTATY HLLGPQEEGE 

       310        320        330        340        350        360 
GVLDVKGQVR MEVQGEEEKR EDKEDEDDED DDVSHVDEED VLGVQREDRR GGDGQINEQV 

       370 
EKLRRPEGAS NETERD 

« Hide

References

« Hide 'large scale' references
[1]"Physical linkage of Pex14 and Cast genes on mouse chromosome 4."
Bliskovsky V., Miller M., Mock B.
Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6.
Tissue: Retina.
[3]Lubec G., Sunyer B., Chen W.-Q.
Submitted (JAN-2009) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 228-237, IDENTIFICATION BY MASS SPECTROMETRY.
Strain: OF1.
Tissue: Hippocampus.
[4]"Large-scale phosphorylation analysis of mouse liver."
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-334, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF097512 mRNA. Translation: AAF04616.1.
BC028952 mRNA. Translation: AAH28952.1.
CCDSCCDS18950.1.
RefSeqNP_062755.1. NM_019781.2.
UniGeneMm.184172.

3D structure databases

ProteinModelPortalQ9R0A0.
SMRQ9R0A0. Positions 25-70.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ9R0A0. 1 interaction.
MINTMINT-4107217.
STRING10090.ENSMUSP00000099506.

PTM databases

PhosphoSiteQ9R0A0.

Proteomic databases

MaxQBQ9R0A0.
PaxDbQ9R0A0.
PRIDEQ9R0A0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000103217; ENSMUSP00000099506; ENSMUSG00000028975.
GeneID56273.
KEGGmmu:56273.
UCSCuc008vvp.1. mouse.

Organism-specific databases

CTD5195.
MGIMGI:1927868. Pex14.

Phylogenomic databases

eggNOGNOG136629.
GeneTreeENSGT00390000015047.
HOGENOMHOG000220930.
HOVERGENHBG053571.
InParanoidQ9R0A0.
KOK13343.
OMAWQIPVKP.
OrthoDBEOG7DFXD4.
PhylomeDBQ9R0A0.
TreeFamTF323535.

Gene expression databases

BgeeQ9R0A0.
CleanExMM_PEX14.
GenevestigatorQ9R0A0.

Family and domain databases

InterProIPR025655. PEX14.
IPR006785. Pex14_N.
[Graphical view]
PANTHERPTHR23058. PTHR23058. 1 hit.
PfamPF04695. Pex14_N. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSPEX14. mouse.
NextBio312156.
PROQ9R0A0.
SOURCESearch...

Entry information

Entry namePEX14_MOUSE
AccessionPrimary (citable) accession number: Q9R0A0
Entry history
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: May 1, 2000
Last modified: July 9, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot