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Q9R0A0

- PEX14_MOUSE

UniProt

Q9R0A0 - PEX14_MOUSE

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Protein

Peroxisomal membrane protein PEX14

Gene

Pex14

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Component of the peroxisomal translocation machinery with PEX13 and PEX17. Interacts with both the PTS1 and PTS2 receptors. Binds directly to PEX17 (By similarity).By similarity

GO - Molecular functioni

  1. transcription corepressor activity Source: Ensembl

GO - Biological processi

  1. microtubule anchoring Source: Ensembl
  2. negative regulation of protein binding Source: Ensembl
  3. negative regulation of protein homotetramerization Source: Ensembl
  4. negative regulation of sequence-specific DNA binding transcription factor activity Source: Ensembl
  5. negative regulation of transcription, DNA-templated Source: Ensembl
  6. peroxisome transport along microtubule Source: Ensembl
  7. protein homooligomerization Source: Ensembl
  8. protein import into peroxisome matrix, docking Source: InterPro
  9. protein import into peroxisome matrix, substrate release Source: Ensembl
  10. protein import into peroxisome matrix, translocation Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Protein transport, Translocation, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisomal membrane protein PEX14
Alternative name(s):
PTS1 receptor-docking protein
Peroxin-14
Peroxisomal membrane anchor protein PEX14
Gene namesi
Name:Pex14
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:1927868. Pex14.

Subcellular locationi

Peroxisome membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity

GO - Cellular componenti

  1. integral component of membrane Source: Ensembl
  2. nucleolus Source: Ensembl
  3. peroxisomal membrane Source: MGI
  4. peroxisome Source: UniProtKB
  5. protein complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 376375Peroxisomal membrane protein PEX14PRO_0000058326Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei34 – 341N6-acetyllysineBy similarity
Modified residuei334 – 3341Phosphoserine1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ9R0A0.
PaxDbiQ9R0A0.
PRIDEiQ9R0A0.

PTM databases

PhosphoSiteiQ9R0A0.

Expressioni

Gene expression databases

BgeeiQ9R0A0.
CleanExiMM_PEX14.
ExpressionAtlasiQ9R0A0. baseline and differential.
GenevestigatoriQ9R0A0.

Interactioni

Subunit structurei

Interacts with PEX5 and PEX19.By similarity

Protein-protein interaction databases

IntActiQ9R0A0. 1 interaction.
MINTiMINT-4107217.
STRINGi10090.ENSMUSP00000099506.

Structurei

3D structure databases

ProteinModelPortaliQ9R0A0.
SMRiQ9R0A0. Positions 25-70.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxin-14 family.Curated

Phylogenomic databases

eggNOGiNOG136629.
GeneTreeiENSGT00390000015047.
HOGENOMiHOG000220930.
HOVERGENiHBG053571.
InParanoidiQ9R0A0.
KOiK13343.
OMAiWQIPVKP.
OrthoDBiEOG7DFXD4.
PhylomeDBiQ9R0A0.
TreeFamiTF323535.

Family and domain databases

InterProiIPR025655. PEX14.
IPR006785. Pex14_N.
[Graphical view]
PANTHERiPTHR23058. PTHR23058. 1 hit.
PfamiPF04695. Pex14_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9R0A0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MASSEQAEQP NQPSSPPGSE NVVPREPLIA TAVKFLQNSR VRQSPLATRR
60 70 80 90 100
AFLKKKGLTD EEIDLAFQQS GTAADEPSPL GPATPVVPVQ PPHLTPQPYS
110 120 130 140 150
PRGSRWRDYG ALAIIMAGIA FGFHQLYKRY LLPLILGGRE DRKQLERMAA
160 170 180 190 200
SLSELSGTVA QTVTQVQTTL ASVQELLRQQ QQKVQELAHE LATAKATTST
210 220 230 240 250
NWILESQNIN ELKSEINSLK GLLLNRRQFP PSPSAPKIPS WQIPVKSSSP
260 270 280 290 300
SSPAAVNHHS SSDISPVSNE STSSSPGKDS HSPEGSTATY HLLGPQEEGE
310 320 330 340 350
GVLDVKGQVR MEVQGEEEKR EDKEDEDDED DDVSHVDEED VLGVQREDRR
360 370
GGDGQINEQV EKLRRPEGAS NETERD
Length:376
Mass (Da):41,208
Last modified:May 1, 2000 - v1
Checksum:iF7863CE4B6433580
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF097512 mRNA. Translation: AAF04616.1.
BC028952 mRNA. Translation: AAH28952.1.
CCDSiCCDS18950.1.
RefSeqiNP_062755.1. NM_019781.2.
UniGeneiMm.184172.

Genome annotation databases

EnsembliENSMUST00000103217; ENSMUSP00000099506; ENSMUSG00000028975.
GeneIDi56273.
KEGGimmu:56273.
UCSCiuc008vvp.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF097512 mRNA. Translation: AAF04616.1 .
BC028952 mRNA. Translation: AAH28952.1 .
CCDSi CCDS18950.1.
RefSeqi NP_062755.1. NM_019781.2.
UniGenei Mm.184172.

3D structure databases

ProteinModelPortali Q9R0A0.
SMRi Q9R0A0. Positions 25-70.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q9R0A0. 1 interaction.
MINTi MINT-4107217.
STRINGi 10090.ENSMUSP00000099506.

PTM databases

PhosphoSitei Q9R0A0.

Proteomic databases

MaxQBi Q9R0A0.
PaxDbi Q9R0A0.
PRIDEi Q9R0A0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000103217 ; ENSMUSP00000099506 ; ENSMUSG00000028975 .
GeneIDi 56273.
KEGGi mmu:56273.
UCSCi uc008vvp.1. mouse.

Organism-specific databases

CTDi 5195.
MGIi MGI:1927868. Pex14.

Phylogenomic databases

eggNOGi NOG136629.
GeneTreei ENSGT00390000015047.
HOGENOMi HOG000220930.
HOVERGENi HBG053571.
InParanoidi Q9R0A0.
KOi K13343.
OMAi WQIPVKP.
OrthoDBi EOG7DFXD4.
PhylomeDBi Q9R0A0.
TreeFami TF323535.

Miscellaneous databases

ChiTaRSi PEX14. mouse.
NextBioi 312156.
PROi Q9R0A0.
SOURCEi Search...

Gene expression databases

Bgeei Q9R0A0.
CleanExi MM_PEX14.
ExpressionAtlasi Q9R0A0. baseline and differential.
Genevestigatori Q9R0A0.

Family and domain databases

InterProi IPR025655. PEX14.
IPR006785. Pex14_N.
[Graphical view ]
PANTHERi PTHR23058. PTHR23058. 1 hit.
Pfami PF04695. Pex14_N. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Physical linkage of Pex14 and Cast genes on mouse chromosome 4."
    Bliskovsky V., Miller M., Mock B.
    Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Retina.
  3. Lubec G., Sunyer B., Chen W.-Q.
    Submitted (JAN-2009) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 228-237, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: OF1.
    Tissue: Hippocampus.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-334, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiPEX14_MOUSE
AccessioniPrimary (citable) accession number: Q9R0A0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: May 1, 2000
Last modified: October 29, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3