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Protein

Transducin beta-like protein 2

Gene

Tbl2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Transducin beta-like protein 2
Gene namesi
Name:Tbl2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1351652. Tbl2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 442442Transducin beta-like protein 2PRO_0000051271Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei428 – 4281PhosphothreonineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9R099.
MaxQBiQ9R099.
PaxDbiQ9R099.
PRIDEiQ9R099.

PTM databases

iPTMnetiQ9R099.
PhosphoSiteiQ9R099.

Expressioni

Gene expression databases

BgeeiQ9R099.
CleanExiMM_TBL2.
ExpressionAtlasiQ9R099. baseline and differential.
GenevisibleiQ9R099. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi205175. 1 interaction.
IntActiQ9R099. 3 interactions.
MINTiMINT-4137179.
STRINGi10090.ENSMUSP00000115011.

Structurei

3D structure databases

ProteinModelPortaliQ9R099.
SMRiQ9R099. Positions 78-353.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati84 – 12340WD 1Add
BLAST
Repeati130 – 17041WD 2Add
BLAST
Repeati182 – 22241WD 3Add
BLAST
Repeati224 – 26340WD 4Add
BLAST
Repeati273 – 31240WD 5Add
BLAST
Repeati323 – 36240WD 6Add
BLAST
Repeati366 – 40439WD 7Add
BLAST

Sequence similaritiesi

Contains 7 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG2096. Eukaryota.
COG2319. LUCA.
GeneTreeiENSGT00390000013836.
HOGENOMiHOG000007065.
HOVERGENiHBG009735.
InParanoidiQ9R099.
OMAiVRLFHNT.
OrthoDBiEOG7XWPNG.
PhylomeDBiQ9R099.
TreeFamiTF315054.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 2 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 5 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9R099-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELPQMPELM GLSLLVGLLA LVATAAVARG WLRAEEKPSQ PVCQKENEPK
60 70 80 90 100
KSGSKKQKQN QRVRKEKPQQ HSFTHPLLAA ALKSHSGNIS CMDFSSNGKY
110 120 130 140 150
LATCADDRTV RIWSTKDFLQ REHRSMRANV ELDHATLVRF SPDCRAFIVW
160 170 180 190 200
LANGDTLRVF KMTKREDGGF TFTATPEDFP KKHKAPIINI GIADTGKFIM
210 220 230 240 250
TASSDTTVLI WNLKGQVLST INTNQMNNSH AVISPCSRFV GSCGFTPDVK
260 270 280 290 300
VWEVCFGKKG EFQEVLRAFE LKGHSASVHS FAFSNDSRRM ASVSKDGTWK
310 320 330 340 350
LWDTDVEYKK QQDPYLLRTG RFEEASTMPC RLALSPDTHV LALATGTNIH
360 370 380 390 400
LFNTRRGEKE EYFECVHGEC IADLTFDITG RFLASCGDRA VRLFHNTPGH
410 420 430 440
RAVVEEMQSL LKRASSESTR QRLQQQLTQA QEALKSLGAL KK
Length:442
Mass (Da):49,584
Last modified:July 27, 2011 - v2
Checksum:i483685E07C66BA40
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti156 – 1561T → S in AAF06825 (PubMed:10575226).Curated
Sequence conflicti357 – 3571G → A in AAF06825 (PubMed:10575226).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF097523 mRNA. Translation: AAF06825.1.
AK132366 mRNA. Translation: BAE21128.1.
AK165686 mRNA. Translation: BAE38338.1.
BC039273 mRNA. Translation: AAH39273.1.
BC048185 mRNA. Translation: AAH48185.1.
CCDSiCCDS19735.1.
RefSeqiNP_038791.2. NM_013763.2.
UniGeneiMm.36746.
Mm.441276.

Genome annotation databases

EnsembliENSMUST00000153183; ENSMUSP00000115011; ENSMUSG00000005374.
GeneIDi27368.
KEGGimmu:27368.
UCSCiuc008zxu.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF097523 mRNA. Translation: AAF06825.1.
AK132366 mRNA. Translation: BAE21128.1.
AK165686 mRNA. Translation: BAE38338.1.
BC039273 mRNA. Translation: AAH39273.1.
BC048185 mRNA. Translation: AAH48185.1.
CCDSiCCDS19735.1.
RefSeqiNP_038791.2. NM_013763.2.
UniGeneiMm.36746.
Mm.441276.

3D structure databases

ProteinModelPortaliQ9R099.
SMRiQ9R099. Positions 78-353.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi205175. 1 interaction.
IntActiQ9R099. 3 interactions.
MINTiMINT-4137179.
STRINGi10090.ENSMUSP00000115011.

PTM databases

iPTMnetiQ9R099.
PhosphoSiteiQ9R099.

Proteomic databases

EPDiQ9R099.
MaxQBiQ9R099.
PaxDbiQ9R099.
PRIDEiQ9R099.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000153183; ENSMUSP00000115011; ENSMUSG00000005374.
GeneIDi27368.
KEGGimmu:27368.
UCSCiuc008zxu.1. mouse.

Organism-specific databases

CTDi26608.
MGIiMGI:1351652. Tbl2.

Phylogenomic databases

eggNOGiKOG2096. Eukaryota.
COG2319. LUCA.
GeneTreeiENSGT00390000013836.
HOGENOMiHOG000007065.
HOVERGENiHBG009735.
InParanoidiQ9R099.
OMAiVRLFHNT.
OrthoDBiEOG7XWPNG.
PhylomeDBiQ9R099.
TreeFamiTF315054.

Miscellaneous databases

ChiTaRSiTbl2. mouse.
PROiQ9R099.
SOURCEiSearch...

Gene expression databases

BgeeiQ9R099.
CleanExiMM_TBL2.
ExpressionAtlasiQ9R099. baseline and differential.
GenevisibleiQ9R099. MM.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 2 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 5 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "TBL2, a novel transducin family member in the WBS deletion: characterization of the complete sequence, genomic structure, transcriptional variants and the mouse ortholog."
    Perez Jurado L.A., Wang Y.-K., Francke U., Cruces J.
    Cytogenet. Cell Genet. 86:277-284(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Head.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and FVB/N.
    Tissue: Brain and Liver.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brown adipose tissue, Kidney, Liver, Lung, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiTBL2_MOUSE
AccessioniPrimary (citable) accession number: Q9R099
Secondary accession number(s): Q8CFY0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: July 27, 2011
Last modified: June 8, 2016
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.