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Protein

17-beta-hydroxysteroid dehydrogenase type 6

Gene

Hsd17b6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

NAD-dependent oxidoreductase with broad substrate specificity that shows both oxidative and reductive activity (in vitro). Has 17-beta-hydroxysteroid dehydrogenase activity towards various steroids (in vitro). Converts 5-alpha-androstan-3-alpha,17-beta-diol to androsterone and estradiol to estrone (in vitro). Has 3-alpha-hydroxysteroid dehydrogenase activity towards androsterone (in vitro). Has retinol dehydrogenase activity towards all-trans-retinol (in vitro).1 Publication

Catalytic activityi

17-beta-estradiol + NAD(P)+ = estrone + NAD(P)H.
Testosterone + NAD+ = androstenedione + NADH.
All-trans-retinol-[cellular-retinol-binding-protein] + NAD+ = all-trans-retinal-[cellular-retinol-binding-protein] + NADH.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei164SubstrateSequence analysis1
Active sitei176Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi33 – 57NADBy similarityAdd BLAST25

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processLipid metabolism, Steroid metabolism
LigandNAD

Names & Taxonomyi

Protein namesi
Recommended name:
17-beta-hydroxysteroid dehydrogenase type 6 (EC:1.1.1.105, EC:1.1.1.239, EC:1.1.1.62)
Short name:
17-beta-HSD 6
Short name:
17-beta-HSD6
Alternative name(s):
17-beta-HSD9
3-alpha->beta-hydroxysteroid epimerase
Short name:
3-alpha->beta-HSE
Oxidative 3-alpha hydroxysteroid dehydrogenase
Gene namesi
Name:Hsd17b6
Synonyms:Gm182, Hsd17b9, Rdh8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1351670. Hsd17b6.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Endosome, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_000030321218 – 31717-beta-hydroxysteroid dehydrogenase type 6Add BLAST300

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi71N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi161N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ9R092.
PaxDbiQ9R092.
PeptideAtlasiQ9R092.
PRIDEiQ9R092.

PTM databases

iPTMnetiQ9R092.
PhosphoSitePlusiQ9R092.

Expressioni

Tissue specificityi

Detected in liver.1 Publication

Gene expression databases

BgeeiENSMUSG00000025396.
CleanExiMM_HSD17B6.
GenevisibleiQ9R092. MM.

Interactioni

Protein-protein interaction databases

IntActiQ9R092. 2 interactors.
MINTiMINT-1864897.
STRINGi10090.ENSMUSP00000026462.

Structurei

3D structure databases

ProteinModelPortaliQ9R092.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1610. Eukaryota.
ENOG410Y7FK. LUCA.
GeneTreeiENSGT00900000140775.
HOVERGENiHBG005482.
InParanoidiQ9R092.
KOiK13369.
OMAiDVTKMES.
OrthoDBiEOG091G0LMI.
PhylomeDBiQ9R092.
TreeFamiTF325617.

Family and domain databases

InterProiView protein in InterPro
IPR036291. NAD(P)-bd_dom_sf.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
PfamiView protein in Pfam
PF00106. adh_short. 1 hit.
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 2 hits.
PROSITEiView protein in PROSITE
PS00061. ADH_SHORT. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9R092-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWFYLVTLVG LYHLLRWYRE RQVVSHLQDK YVFITGCDSG FGNLLARQLD
60 70 80 90 100
RRGMRVLAAC LTEKGAEELR NKTSDRLETV ILDVTKTESI VAATQWVKER
110 120 130 140 150
VGDRGLWGLV NNAGVLQPFA YIEWYRPEDY MPIFQVNLIG LTQVTISMLF
160 170 180 190 200
LVKKARGRIV NVSSALGRVA LFGGFYSCSK YGVEAFSDVL RHEVQDFGVK
210 220 230 240 250
VSIIEPGSFK TEMTDAELTI ERTKKVWEAA PEHIKESYGQ QFFDDFCSTT
260 270 280 290 300
KRELMKCSRN LSLVTDCMEH ALTSTHPRTR YSAGWDAKFF FIPLSYLPAS
310
LVDYLLAISR GKPAQAA
Length:317
Mass (Da):36,103
Last modified:May 1, 2000 - v1
Checksum:i7B09D741424D3881
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF103797 mRNA. Translation: AAF04761.1.
AK008212 mRNA. Translation: BAB25536.1.
BC021836 mRNA. Translation: AAH21836.1.
CCDSiCCDS24257.1.
RefSeqiNP_038814.1. NM_013786.2.
XP_011241765.1. XM_011243463.2.
XP_011241766.1. XM_011243464.2.
XP_011241767.1. XM_011243465.2.
XP_011241769.1. XM_011243467.2.
UniGeneiMm.26719.

Genome annotation databases

EnsembliENSMUST00000026462; ENSMUSP00000026462; ENSMUSG00000025396.
ENSMUST00000219183; ENSMUSP00000151661; ENSMUSG00000025396.
ENSMUST00000219447; ENSMUSP00000151556; ENSMUSG00000025396.
GeneIDi27400.
KEGGimmu:27400.
UCSCiuc007hky.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiH17B6_MOUSE
AccessioniPrimary (citable) accession number: Q9R092
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: May 1, 2000
Last modified: October 25, 2017
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families