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Protein

17-beta-hydroxysteroid dehydrogenase type 6

Gene

Hsd17b6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

NAD-dependent oxidoreductase with broad substrate specificity that shows both oxidative and reductive activity (in vitro). Has 17-beta-hydroxysteroid dehydrogenase activity towards various steroids (in vitro). Converts 5-alpha-androstan-3-alpha,17-beta-diol to androsterone and estradiol to estrone (in vitro). Has 3-alpha-hydroxysteroid dehydrogenase activity towards androsterone (in vitro). Has retinol dehydrogenase activity towards all-trans-retinol (in vitro).1 Publication

Catalytic activityi

17-beta-estradiol + NAD(P)+ = estrone + NAD(P)H.
Testosterone + NAD+ = androstenedione + NADH.
All-trans-retinol-[cellular-retinol-binding-protein] + NAD+ = all-trans-retinal-[cellular-retinol-binding-protein] + NADH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei164 – 1641SubstrateSequence analysis
Active sitei176 – 1761Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi33 – 5725NADBy similarityAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Lipid metabolism, Steroid metabolism

Keywords - Ligandi

NAD

Names & Taxonomyi

Protein namesi
Recommended name:
17-beta-hydroxysteroid dehydrogenase type 6 (EC:1.1.1.105, EC:1.1.1.239, EC:1.1.1.62)
Short name:
17-beta-HSD 6
Short name:
17-beta-HSD6
Alternative name(s):
17-beta-HSD9
3-alpha->beta-hydroxysteroid epimerase
Short name:
3-alpha->beta-HSE
Oxidative 3-alpha hydroxysteroid dehydrogenase
Gene namesi
Name:Hsd17b6
Synonyms:Gm182, Hsd17b9, Rdh8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1351670. Hsd17b6.

Subcellular locationi

  • Microsome membrane 1 Publication; Peripheral membrane protein 1 Publication; Lumenal side 1 Publication
  • Early endosome membrane Curated; Peripheral membrane protein Curated; Lumenal side Curated

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Endosome, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717Sequence analysisAdd
BLAST
Chaini18 – 31730017-beta-hydroxysteroid dehydrogenase type 6PRO_0000303212Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi71 – 711N-linked (GlcNAc...)Sequence analysis
Glycosylationi161 – 1611N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ9R092.
PaxDbiQ9R092.
PeptideAtlasiQ9R092.
PRIDEiQ9R092.

PTM databases

iPTMnetiQ9R092.
PhosphoSiteiQ9R092.

Expressioni

Tissue specificityi

Detected in liver.1 Publication

Gene expression databases

BgeeiENSMUSG00000025396.
CleanExiMM_HSD17B6.
GenevisibleiQ9R092. MM.

Interactioni

Protein-protein interaction databases

IntActiQ9R092. 2 interactions.
MINTiMINT-1864897.
STRINGi10090.ENSMUSP00000026462.

Structurei

3D structure databases

ProteinModelPortaliQ9R092.
SMRiQ9R092. Positions 25-281.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1610. Eukaryota.
ENOG410Y7FK. LUCA.
GeneTreeiENSGT00840000129713.
HOVERGENiHBG005482.
InParanoidiQ9R092.
KOiK13369.
OMAiTHIKEAY.
OrthoDBiEOG091G0LMI.
PhylomeDBiQ9R092.
TreeFamiTF325617.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 1 hit.
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 2 hits.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9R092-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWFYLVTLVG LYHLLRWYRE RQVVSHLQDK YVFITGCDSG FGNLLARQLD
60 70 80 90 100
RRGMRVLAAC LTEKGAEELR NKTSDRLETV ILDVTKTESI VAATQWVKER
110 120 130 140 150
VGDRGLWGLV NNAGVLQPFA YIEWYRPEDY MPIFQVNLIG LTQVTISMLF
160 170 180 190 200
LVKKARGRIV NVSSALGRVA LFGGFYSCSK YGVEAFSDVL RHEVQDFGVK
210 220 230 240 250
VSIIEPGSFK TEMTDAELTI ERTKKVWEAA PEHIKESYGQ QFFDDFCSTT
260 270 280 290 300
KRELMKCSRN LSLVTDCMEH ALTSTHPRTR YSAGWDAKFF FIPLSYLPAS
310
LVDYLLAISR GKPAQAA
Length:317
Mass (Da):36,103
Last modified:May 1, 2000 - v1
Checksum:i7B09D741424D3881
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF103797 mRNA. Translation: AAF04761.1.
AK008212 mRNA. Translation: BAB25536.1.
BC021836 mRNA. Translation: AAH21836.1.
CCDSiCCDS24257.1.
RefSeqiNP_038814.1. NM_013786.2.
XP_011241765.1. XM_011243463.1.
XP_011241766.1. XM_011243464.1.
XP_011241767.1. XM_011243465.1.
XP_011241768.1. XM_011243466.1.
XP_011241769.1. XM_011243467.1.
UniGeneiMm.26719.

Genome annotation databases

EnsembliENSMUST00000026462; ENSMUSP00000026462; ENSMUSG00000025396.
GeneIDi27400.
KEGGimmu:27400.
UCSCiuc007hky.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF103797 mRNA. Translation: AAF04761.1.
AK008212 mRNA. Translation: BAB25536.1.
BC021836 mRNA. Translation: AAH21836.1.
CCDSiCCDS24257.1.
RefSeqiNP_038814.1. NM_013786.2.
XP_011241765.1. XM_011243463.1.
XP_011241766.1. XM_011243464.1.
XP_011241767.1. XM_011243465.1.
XP_011241768.1. XM_011243466.1.
XP_011241769.1. XM_011243467.1.
UniGeneiMm.26719.

3D structure databases

ProteinModelPortaliQ9R092.
SMRiQ9R092. Positions 25-281.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9R092. 2 interactions.
MINTiMINT-1864897.
STRINGi10090.ENSMUSP00000026462.

PTM databases

iPTMnetiQ9R092.
PhosphoSiteiQ9R092.

Proteomic databases

MaxQBiQ9R092.
PaxDbiQ9R092.
PeptideAtlasiQ9R092.
PRIDEiQ9R092.

Protocols and materials databases

DNASUi27400.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000026462; ENSMUSP00000026462; ENSMUSG00000025396.
GeneIDi27400.
KEGGimmu:27400.
UCSCiuc007hky.1. mouse.

Organism-specific databases

CTDi8630.
MGIiMGI:1351670. Hsd17b6.

Phylogenomic databases

eggNOGiKOG1610. Eukaryota.
ENOG410Y7FK. LUCA.
GeneTreeiENSGT00840000129713.
HOVERGENiHBG005482.
InParanoidiQ9R092.
KOiK13369.
OMAiTHIKEAY.
OrthoDBiEOG091G0LMI.
PhylomeDBiQ9R092.
TreeFamiTF325617.

Miscellaneous databases

ChiTaRSiHsd17b6. mouse.
PROiQ9R092.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000025396.
CleanExiMM_HSD17B6.
GenevisibleiQ9R092. MM.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 1 hit.
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 2 hits.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiH17B6_MOUSE
AccessioniPrimary (citable) accession number: Q9R092
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: May 1, 2000
Last modified: September 7, 2016
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.