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Protein

Basal cell adhesion molecule

Gene

Bcam

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Laminin alpha-5 receptor. May mediate intracellular signaling (By similarity).By similarity

GO - Molecular functioni

  1. laminin binding Source: MGI
  2. laminin receptor activity Source: MGI

GO - Biological processi

  1. cell adhesion Source: MGI
  2. cell-matrix adhesion Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Basal cell adhesion molecule
Alternative name(s):
B-CAM cell surface glycoprotein
Lutheran antigen
CD_antigen: CD239
Gene namesi
Name:Bcam
Synonyms:Gplu, Lu
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:1929940. Bcam.

Subcellular locationi

Membrane By similarity; Single-pass type I membrane protein By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini26 – 541516ExtracellularSequence AnalysisAdd
BLAST
Transmembranei542 – 56221HelicalSequence AnalysisAdd
BLAST
Topological domaini563 – 62260CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. cell surface Source: MGI
  2. extracellular vesicular exosome Source: MGI
  3. integral component of plasma membrane Source: MGI
  4. plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence AnalysisAdd
BLAST
Chaini26 – 622597Basal cell adhesion moleculePRO_0000383338Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi47 ↔ 118PROSITE-ProRule annotation
Disulfide bondi165 ↔ 230PROSITE-ProRule annotation
Disulfide bondi284 ↔ 330PROSITE-ProRule annotation
Glycosylationi314 – 3141N-linked (GlcNAc...)Sequence Analysis
Glycosylationi323 – 3231N-linked (GlcNAc...)Sequence Analysis
Glycosylationi370 – 3701N-linked (GlcNAc...)Sequence Analysis
Glycosylationi377 – 3771N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi378 ↔ 418PROSITE-ProRule annotation
Disulfide bondi467 ↔ 516PROSITE-ProRule annotation
Modified residuei590 – 5901PhosphoserineBy similarity
Modified residuei592 – 5921PhosphoserineBy similarity
Modified residuei594 – 5941PhosphoserineBy similarity
Modified residuei615 – 6151PhosphoserineBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ9R069.
PaxDbiQ9R069.
PRIDEiQ9R069.

PTM databases

PhosphoSiteiQ9R069.

Expressioni

Gene expression databases

BgeeiQ9R069.
ExpressionAtlasiQ9R069. baseline and differential.
GenevestigatoriQ9R069.

Interactioni

Protein-protein interaction databases

IntActiQ9R069. 1 interaction.
MINTiMINT-4130729.

Structurei

3D structure databases

ProteinModelPortaliQ9R069.
SMRiQ9R069. Positions 26-536.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini26 – 135110Ig-like V-type 1Add
BLAST
Domaini140 – 250111Ig-like V-type 2Add
BLAST
Domaini267 – 34276Ig-like C2-type 1Add
BLAST
Domaini356 – 43580Ig-like C2-type 2Add
BLAST
Domaini442 – 53291Ig-like C2-type 3Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG150030.
GeneTreeiENSGT00530000063457.
InParanoidiQ9R069.
KOiK06578.
OMAiHYPTEHV.
OrthoDBiEOG7GBFWH.
PhylomeDBiQ9R069.
TreeFamiTF330534.

Family and domain databases

Gene3Di2.60.40.10. 5 hits.
InterProiIPR013162. CD80_C2-set.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF08205. C2-set_2. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
SM00408. IGc2. 2 hits.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9R069-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPPDARAGL LWLTFLLSGY SGAQAELHVS VPPRVEVMRG EQVALDCTPR
60 70 80 90 100
EHPEHYVLEW FLVDGTGARH RLASVEPQGS EFLGTVHSLG RVPPYEVDSR
110 120 130 140 150
GRLVIAKVQV GDGRDYVCVV KAGAAGTSEA TSSVRVFATP EDTEVSPNKG
160 170 180 190 200
TLSVMDQFAQ EIATCSSNNG NPVPRITWYR NGQRLEVPME VNQKGYITIR
210 220 230 240 250
TVREASGLYS LTSTLYLRLH KDDRDANFHC AAHYDLPSGQ HGRLDSHTFR
260 270 280 290 300
LTLHYPTEHV EFWVGSPSTT EGWVREGDAV QLLCQGDGSP SPEYSFFRQQ
310 320 330 340 350
GTQEEQLNVN LKGNLTLERV HRNQSGIYGC RVEDYDADEE VQLVKKLKLH
360 370 380 390 400
VAYLDPLELS VPEELFVFLN SSSTVVNCSA RGLPTPTVRW TKDSVTLADG
410 420 430 440 450
PMLSLQSVTF DSAGTYTCEA STPTVPLLSR TQSFQLIVQG APELKPNEIM
460 470 480 490 500
PKSGNSWTEG DEVMLTCSAR GFPEPKLTWS QRGDTPAEPP FEGRGWKSSS
510 520 530 540 550
LMVKVTSALS REGVSCEASN IHGKKGHVFH FGSVAPQTAQ AGVAVMAVAV
560 570 580 590 600
SVGLLLLVVA AFYCMRRKGR PGCCRRAEKG APPAREPELS HSGSERPEHT
610 620
GLLMGGPSGG GRGGSGGFGD EC
Length:622
Mass (Da):67,670
Last modified:May 1, 2000 - v1
Checksum:i257903F08D47EB4A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti227 – 2271N → D in AAF61742 (Ref. 5) Curated
Sequence conflicti319 – 3191R → G in BAB16053 (Ref. 3) Curated
Sequence conflicti319 – 3191R → G in AAF61742 (Ref. 5) Curated
Sequence conflicti361 – 3611V → A in AAF61742 (Ref. 5) Curated
Sequence conflicti388 – 3881V → A in BAB16053 (Ref. 3) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF109160 mRNA. Translation: AAF14226.1.
AF346663 mRNA. Translation: AAK83237.1.
AB035511 mRNA. Translation: BAB16053.1.
AF221507 mRNA. Translation: AAF34657.1.
AF246667 Genomic DNA. Translation: AAF61742.1.
AK075704 mRNA. Translation: BAC35900.1.
CCDSiCCDS39803.1.
RefSeqiNP_065232.1. NM_020486.2.
UniGeneiMm.29236.

Genome annotation databases

EnsembliENSMUST00000003061; ENSMUSP00000003061; ENSMUSG00000002980.
GeneIDi57278.
KEGGimmu:57278.
UCSCiuc009fnf.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF109160 mRNA. Translation: AAF14226.1.
AF346663 mRNA. Translation: AAK83237.1.
AB035511 mRNA. Translation: BAB16053.1.
AF221507 mRNA. Translation: AAF34657.1.
AF246667 Genomic DNA. Translation: AAF61742.1.
AK075704 mRNA. Translation: BAC35900.1.
CCDSiCCDS39803.1.
RefSeqiNP_065232.1. NM_020486.2.
UniGeneiMm.29236.

3D structure databases

ProteinModelPortaliQ9R069.
SMRiQ9R069. Positions 26-536.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9R069. 1 interaction.
MINTiMINT-4130729.

PTM databases

PhosphoSiteiQ9R069.

Proteomic databases

MaxQBiQ9R069.
PaxDbiQ9R069.
PRIDEiQ9R069.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000003061; ENSMUSP00000003061; ENSMUSG00000002980.
GeneIDi57278.
KEGGimmu:57278.
UCSCiuc009fnf.1. mouse.

Organism-specific databases

CTDi4059.
MGIiMGI:1929940. Bcam.

Phylogenomic databases

eggNOGiNOG150030.
GeneTreeiENSGT00530000063457.
InParanoidiQ9R069.
KOiK06578.
OMAiHYPTEHV.
OrthoDBiEOG7GBFWH.
PhylomeDBiQ9R069.
TreeFamiTF330534.

Miscellaneous databases

ChiTaRSiBcam. mouse.
NextBioi313639.
PROiQ9R069.
SOURCEiSearch...

Gene expression databases

BgeeiQ9R069.
ExpressionAtlasiQ9R069. baseline and differential.
GenevestigatoriQ9R069.

Family and domain databases

Gene3Di2.60.40.10. 5 hits.
InterProiIPR013162. CD80_C2-set.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF08205. C2-set_2. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
SM00408. IGc2. 2 hits.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 5 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of a mouse laminin receptor gene homologous to the human blood group Lutheran gene."
    Rahuel C., Colin Y., Goossens D., Gane P., El Nemer W., Cartron J.-P., Le Van Kim C.
    Immunogenetics 50:271-277(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Localization of Lutheran, a novel laminin receptor, in normal, knockout, and transgenic mice suggests an interaction with laminin alpha5 in vivo."
    Moulson C.L., Li C., Miner J.H.
    Dev. Dyn. 222:101-114(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Mouse Lutheran antigen."
    Taira E., Okumura S., Miki N.
    Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
  4. "Mouse Lutheran glycoprotein."
    Parsons S.F., Lee G., Chasis J.A., Tanner M.J.A., Anstee D.J.
    Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  5. "Mouse Lutheran glycoprotein gene."
    Lee G., Willig T.-N., Parsons S.F., Anstee D.J., Mohandas N., Chasis J.A.
    Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/Sv.
  6. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Lung.

Entry informationi

Entry nameiBCAM_MOUSE
AccessioniPrimary (citable) accession number: Q9R069
Secondary accession number(s): Q9ESS5, Q9JKB2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 1, 2009
Last sequence update: May 1, 2000
Last modified: March 4, 2015
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.