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Q9R069

- BCAM_MOUSE

UniProt

Q9R069 - BCAM_MOUSE

Protein

Basal cell adhesion molecule

Gene

Bcam

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Laminin alpha-5 receptor. May mediate intracellular signaling By similarity.By similarity

    GO - Molecular functioni

    1. laminin receptor activity Source: MGI

    GO - Biological processi

    1. cell adhesion Source: MGI
    2. cell-matrix adhesion Source: Ensembl

    Keywords - Molecular functioni

    Receptor

    Keywords - Biological processi

    Cell adhesion

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Basal cell adhesion molecule
    Alternative name(s):
    B-CAM cell surface glycoprotein
    Lutheran antigen
    CD_antigen: CD239
    Gene namesi
    Name:Bcam
    Synonyms:Gplu, Lu
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:1929940. Bcam.

    Subcellular locationi

    Membrane By similarity; Single-pass type I membrane protein By similarity

    GO - Cellular componenti

    1. cell surface Source: MGI
    2. integral component of plasma membrane Source: MGI
    3. plasma membrane Source: MGI

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2525Sequence AnalysisAdd
    BLAST
    Chaini26 – 622597Basal cell adhesion moleculePRO_0000383338Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi47 ↔ 118PROSITE-ProRule annotation
    Disulfide bondi165 ↔ 230PROSITE-ProRule annotation
    Disulfide bondi284 ↔ 330PROSITE-ProRule annotation
    Glycosylationi314 – 3141N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi323 – 3231N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi370 – 3701N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi377 – 3771N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi378 ↔ 418PROSITE-ProRule annotation
    Disulfide bondi467 ↔ 516PROSITE-ProRule annotation
    Modified residuei590 – 5901PhosphoserineBy similarity
    Modified residuei592 – 5921PhosphoserineBy similarity
    Modified residuei615 – 6151PhosphoserineBy similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    Proteomic databases

    MaxQBiQ9R069.
    PaxDbiQ9R069.
    PRIDEiQ9R069.

    PTM databases

    PhosphoSiteiQ9R069.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9R069.
    BgeeiQ9R069.
    GenevestigatoriQ9R069.

    Interactioni

    Protein-protein interaction databases

    IntActiQ9R069. 1 interaction.
    MINTiMINT-4130729.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9R069.
    SMRiQ9R069. Positions 26-536.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini26 – 541516ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini563 – 62260CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei542 – 56221HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini26 – 135110Ig-like V-type 1Add
    BLAST
    Domaini140 – 250111Ig-like V-type 2Add
    BLAST
    Domaini267 – 34276Ig-like C2-type 1Add
    BLAST
    Domaini356 – 43580Ig-like C2-type 2Add
    BLAST
    Domaini442 – 53291Ig-like C2-type 3Add
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG150030.
    GeneTreeiENSGT00530000063457.
    InParanoidiQ9R069.
    KOiK06578.
    OMAiHYPTEHV.
    OrthoDBiEOG7GBFWH.
    PhylomeDBiQ9R069.
    TreeFamiTF330534.

    Family and domain databases

    Gene3Di2.60.40.10. 5 hits.
    InterProiIPR013162. CD80_C2-set.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR003598. Ig_sub2.
    [Graphical view]
    PfamiPF08205. C2-set_2. 1 hit.
    [Graphical view]
    SMARTiSM00409. IG. 1 hit.
    SM00408. IGc2. 2 hits.
    [Graphical view]
    PROSITEiPS50835. IG_LIKE. 5 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9R069-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEPPDARAGL LWLTFLLSGY SGAQAELHVS VPPRVEVMRG EQVALDCTPR    50
    EHPEHYVLEW FLVDGTGARH RLASVEPQGS EFLGTVHSLG RVPPYEVDSR 100
    GRLVIAKVQV GDGRDYVCVV KAGAAGTSEA TSSVRVFATP EDTEVSPNKG 150
    TLSVMDQFAQ EIATCSSNNG NPVPRITWYR NGQRLEVPME VNQKGYITIR 200
    TVREASGLYS LTSTLYLRLH KDDRDANFHC AAHYDLPSGQ HGRLDSHTFR 250
    LTLHYPTEHV EFWVGSPSTT EGWVREGDAV QLLCQGDGSP SPEYSFFRQQ 300
    GTQEEQLNVN LKGNLTLERV HRNQSGIYGC RVEDYDADEE VQLVKKLKLH 350
    VAYLDPLELS VPEELFVFLN SSSTVVNCSA RGLPTPTVRW TKDSVTLADG 400
    PMLSLQSVTF DSAGTYTCEA STPTVPLLSR TQSFQLIVQG APELKPNEIM 450
    PKSGNSWTEG DEVMLTCSAR GFPEPKLTWS QRGDTPAEPP FEGRGWKSSS 500
    LMVKVTSALS REGVSCEASN IHGKKGHVFH FGSVAPQTAQ AGVAVMAVAV 550
    SVGLLLLVVA AFYCMRRKGR PGCCRRAEKG APPAREPELS HSGSERPEHT 600
    GLLMGGPSGG GRGGSGGFGD EC 622
    Length:622
    Mass (Da):67,670
    Last modified:May 1, 2000 - v1
    Checksum:i257903F08D47EB4A
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti227 – 2271N → D in AAF61742. 1 PublicationCurated
    Sequence conflicti319 – 3191R → G in BAB16053. 1 PublicationCurated
    Sequence conflicti319 – 3191R → G in AAF61742. 1 PublicationCurated
    Sequence conflicti361 – 3611V → A in AAF61742. 1 PublicationCurated
    Sequence conflicti388 – 3881V → A in BAB16053. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF109160 mRNA. Translation: AAF14226.1.
    AF346663 mRNA. Translation: AAK83237.1.
    AB035511 mRNA. Translation: BAB16053.1.
    AF221507 mRNA. Translation: AAF34657.1.
    AF246667 Genomic DNA. Translation: AAF61742.1.
    AK075704 mRNA. Translation: BAC35900.1.
    CCDSiCCDS39803.1.
    RefSeqiNP_065232.1. NM_020486.2.
    UniGeneiMm.29236.

    Genome annotation databases

    EnsembliENSMUST00000003061; ENSMUSP00000003061; ENSMUSG00000002980.
    GeneIDi57278.
    KEGGimmu:57278.
    UCSCiuc009fnf.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF109160 mRNA. Translation: AAF14226.1 .
    AF346663 mRNA. Translation: AAK83237.1 .
    AB035511 mRNA. Translation: BAB16053.1 .
    AF221507 mRNA. Translation: AAF34657.1 .
    AF246667 Genomic DNA. Translation: AAF61742.1 .
    AK075704 mRNA. Translation: BAC35900.1 .
    CCDSi CCDS39803.1.
    RefSeqi NP_065232.1. NM_020486.2.
    UniGenei Mm.29236.

    3D structure databases

    ProteinModelPortali Q9R069.
    SMRi Q9R069. Positions 26-536.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q9R069. 1 interaction.
    MINTi MINT-4130729.

    PTM databases

    PhosphoSitei Q9R069.

    Proteomic databases

    MaxQBi Q9R069.
    PaxDbi Q9R069.
    PRIDEi Q9R069.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000003061 ; ENSMUSP00000003061 ; ENSMUSG00000002980 .
    GeneIDi 57278.
    KEGGi mmu:57278.
    UCSCi uc009fnf.1. mouse.

    Organism-specific databases

    CTDi 4059.
    MGIi MGI:1929940. Bcam.

    Phylogenomic databases

    eggNOGi NOG150030.
    GeneTreei ENSGT00530000063457.
    InParanoidi Q9R069.
    KOi K06578.
    OMAi HYPTEHV.
    OrthoDBi EOG7GBFWH.
    PhylomeDBi Q9R069.
    TreeFami TF330534.

    Miscellaneous databases

    ChiTaRSi BCAM. mouse.
    NextBioi 313639.
    PROi Q9R069.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9R069.
    Bgeei Q9R069.
    Genevestigatori Q9R069.

    Family and domain databases

    Gene3Di 2.60.40.10. 5 hits.
    InterProi IPR013162. CD80_C2-set.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR003598. Ig_sub2.
    [Graphical view ]
    Pfami PF08205. C2-set_2. 1 hit.
    [Graphical view ]
    SMARTi SM00409. IG. 1 hit.
    SM00408. IGc2. 2 hits.
    [Graphical view ]
    PROSITEi PS50835. IG_LIKE. 5 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of a mouse laminin receptor gene homologous to the human blood group Lutheran gene."
      Rahuel C., Colin Y., Goossens D., Gane P., El Nemer W., Cartron J.-P., Le Van Kim C.
      Immunogenetics 50:271-277(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Localization of Lutheran, a novel laminin receptor, in normal, knockout, and transgenic mice suggests an interaction with laminin alpha5 in vivo."
      Moulson C.L., Li C., Miner J.H.
      Dev. Dyn. 222:101-114(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Mouse Lutheran antigen."
      Taira E., Okumura S., Miki N.
      Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: BALB/c.
    4. "Mouse Lutheran glycoprotein."
      Parsons S.F., Lee G., Chasis J.A., Tanner M.J.A., Anstee D.J.
      Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    5. "Mouse Lutheran glycoprotein gene."
      Lee G., Willig T.-N., Parsons S.F., Anstee D.J., Mohandas N., Chasis J.A.
      Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 129/Sv.
    6. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Lung.

    Entry informationi

    Entry nameiBCAM_MOUSE
    AccessioniPrimary (citable) accession number: Q9R069
    Secondary accession number(s): Q9ESS5, Q9JKB2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 1, 2009
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 107 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3