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Q9R069 (BCAM_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Basal cell adhesion molecule
Alternative name(s):
B-CAM cell surface glycoprotein
Lutheran antigen
CD_antigen=CD239
Gene names
Name:Bcam
Synonyms:Gplu, Lu
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length622 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Laminin alpha-5 receptor. May mediate intracellular signaling By similarity.

Subcellular location

Membrane; Single-pass type I membrane protein By similarity.

Sequence similarities

Contains 3 Ig-like C2-type (immunoglobulin-like) domains.

Contains 2 Ig-like V-type (immunoglobulin-like) domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2525 Potential
Chain26 – 622597Basal cell adhesion molecule
PRO_0000383338

Regions

Topological domain26 – 541516Extracellular Potential
Transmembrane542 – 56221Helical; Potential
Topological domain563 – 62260Cytoplasmic Potential
Domain26 – 135110Ig-like V-type 1
Domain140 – 250111Ig-like V-type 2
Domain267 – 34276Ig-like C2-type 1
Domain356 – 43580Ig-like C2-type 2
Domain442 – 53291Ig-like C2-type 3

Amino acid modifications

Modified residue5901Phosphoserine By similarity
Modified residue5921Phosphoserine By similarity
Modified residue6151Phosphoserine By similarity
Glycosylation3141N-linked (GlcNAc...) Potential
Glycosylation3231N-linked (GlcNAc...) Potential
Glycosylation3701N-linked (GlcNAc...) Potential
Glycosylation3771N-linked (GlcNAc...) Potential
Disulfide bond47 ↔ 118 By similarity
Disulfide bond165 ↔ 230 By similarity
Disulfide bond284 ↔ 330 By similarity
Disulfide bond378 ↔ 418 By similarity
Disulfide bond467 ↔ 516 By similarity

Experimental info

Sequence conflict2271N → D in AAF61742. Ref.5
Sequence conflict3191R → G in BAB16053. Ref.3
Sequence conflict3191R → G in AAF61742. Ref.5
Sequence conflict3611V → A in AAF61742. Ref.5
Sequence conflict3881V → A in BAB16053. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q9R069 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 257903F08D47EB4A

FASTA62267,670
        10         20         30         40         50         60 
MEPPDARAGL LWLTFLLSGY SGAQAELHVS VPPRVEVMRG EQVALDCTPR EHPEHYVLEW 

        70         80         90        100        110        120 
FLVDGTGARH RLASVEPQGS EFLGTVHSLG RVPPYEVDSR GRLVIAKVQV GDGRDYVCVV 

       130        140        150        160        170        180 
KAGAAGTSEA TSSVRVFATP EDTEVSPNKG TLSVMDQFAQ EIATCSSNNG NPVPRITWYR 

       190        200        210        220        230        240 
NGQRLEVPME VNQKGYITIR TVREASGLYS LTSTLYLRLH KDDRDANFHC AAHYDLPSGQ 

       250        260        270        280        290        300 
HGRLDSHTFR LTLHYPTEHV EFWVGSPSTT EGWVREGDAV QLLCQGDGSP SPEYSFFRQQ 

       310        320        330        340        350        360 
GTQEEQLNVN LKGNLTLERV HRNQSGIYGC RVEDYDADEE VQLVKKLKLH VAYLDPLELS 

       370        380        390        400        410        420 
VPEELFVFLN SSSTVVNCSA RGLPTPTVRW TKDSVTLADG PMLSLQSVTF DSAGTYTCEA 

       430        440        450        460        470        480 
STPTVPLLSR TQSFQLIVQG APELKPNEIM PKSGNSWTEG DEVMLTCSAR GFPEPKLTWS 

       490        500        510        520        530        540 
QRGDTPAEPP FEGRGWKSSS LMVKVTSALS REGVSCEASN IHGKKGHVFH FGSVAPQTAQ 

       550        560        570        580        590        600 
AGVAVMAVAV SVGLLLLVVA AFYCMRRKGR PGCCRRAEKG APPAREPELS HSGSERPEHT 

       610        620 
GLLMGGPSGG GRGGSGGFGD EC

« Hide

References

« Hide 'large scale' references
[1]"Characterization of a mouse laminin receptor gene homologous to the human blood group Lutheran gene."
Rahuel C., Colin Y., Goossens D., Gane P., El Nemer W., Cartron J.-P., Le Van Kim C.
Immunogenetics 50:271-277(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Localization of Lutheran, a novel laminin receptor, in normal, knockout, and transgenic mice suggests an interaction with laminin alpha5 in vivo."
Moulson C.L., Li C., Miner J.H.
Dev. Dyn. 222:101-114(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"Mouse Lutheran antigen."
Taira E., Okumura S., Miki N.
Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: BALB/c.
[4]"Mouse Lutheran glycoprotein."
Parsons S.F., Lee G., Chasis J.A., Tanner M.J.A., Anstee D.J.
Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[5]"Mouse Lutheran glycoprotein gene."
Lee G., Willig T.-N., Parsons S.F., Anstee D.J., Mohandas N., Chasis J.A.
Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 129/Sv.
[6]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Lung.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF109160 mRNA. Translation: AAF14226.1.
AF346663 mRNA. Translation: AAK83237.1.
AB035511 mRNA. Translation: BAB16053.1.
AF221507 mRNA. Translation: AAF34657.1.
AF246667 Genomic DNA. Translation: AAF61742.1.
AK075704 mRNA. Translation: BAC35900.1.
IPIIPI00279010.
RefSeqNP_065232.1. NM_020486.2.
UniGeneMm.29236.

3D structure databases

ProteinModelPortalQ9R069.
SMRQ9R069. Positions 26-536.
ModBaseSearch...

PTM databases

PhosphoSiteQ9R069.

Proteomic databases

PaxDbQ9R069.
PRIDEQ9R069.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000003061; ENSMUSP00000003061; ENSMUSG00000002980.
GeneID57278.
KEGGmmu:57278.
UCSCuc009fnf.1. mouse.

Organism-specific databases

CTD4059.
MGIMGI:1929940. Bcam.

Phylogenomic databases

eggNOGNOG150030.
GeneTreeENSGT00530000063457.
InParanoidQ9R069.
KOK06578.
OMAHYPTEHV.
OrthoDBEOG4P5KB5.

Gene expression databases

ArrayExpressQ9R069.
BgeeQ9R069.
GenevestigatorQ9R069.

Family and domain databases

Gene3D2.60.40.10. 5 hits.
InterProIPR013162. CD80_C2-set.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamPF08205. C2-set_2. 1 hit.
[Graphical view]
SMARTSM00409. IG. 1 hit.
SM00408. IGc2. 2 hits.
[Graphical view]
PROSITEPS50835. IG_LIKE. 5 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSBCAM. mouse.
NextBio313639.
SOURCESearch...

Entry information

Entry nameBCAM_MOUSE
AccessionPrimary (citable) accession number: Q9R069
Secondary accession number(s): Q9ESS5, Q9JKB2
Entry history
Integrated into UniProtKB/Swiss-Prot: September 1, 2009
Last sequence update: May 1, 2000
Last modified: May 1, 2013
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents