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Protein

Basal cell adhesion molecule

Gene

Bcam

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Laminin alpha-5 receptor. May mediate intracellular signaling (By similarity).By similarity

GO - Molecular functioni

  • laminin binding Source: MGI
  • laminin receptor activity Source: MGI
  • protein C-terminus binding Source: MGI

GO - Biological processi

  • cell adhesion Source: MGI
  • cell-matrix adhesion Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Basal cell adhesion molecule
Alternative name(s):
B-CAM cell surface glycoprotein
Lutheran antigen
CD_antigen: CD239
Gene namesi
Name:Bcam
Synonyms:Gplu, Lu
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1929940. Bcam.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini26 – 541ExtracellularSequence analysisAdd BLAST516
Transmembranei542 – 562HelicalSequence analysisAdd BLAST21
Topological domaini563 – 622CytoplasmicSequence analysisAdd BLAST60

GO - Cellular componenti

  • cell surface Source: MGI
  • extracellular exosome Source: MGI
  • integral component of plasma membrane Source: MGI
  • plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000038333826 – 622Basal cell adhesion moleculeAdd BLAST597

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi47 ↔ 118PROSITE-ProRule annotation
Disulfide bondi165 ↔ 230PROSITE-ProRule annotation
Disulfide bondi284 ↔ 330PROSITE-ProRule annotation
Glycosylationi314N-linked (GlcNAc...)Sequence analysis1
Glycosylationi323N-linked (GlcNAc...)Sequence analysis1
Glycosylationi370N-linked (GlcNAc...)Sequence analysis1
Glycosylationi377N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi378 ↔ 418PROSITE-ProRule annotation
Disulfide bondi467 ↔ 516PROSITE-ProRule annotation
Modified residuei590PhosphoserineBy similarity1
Modified residuei592PhosphoserineBy similarity1
Modified residuei594PhosphoserineBy similarity1
Modified residuei615PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ9R069.
PaxDbiQ9R069.
PRIDEiQ9R069.

PTM databases

iPTMnetiQ9R069.
PhosphoSitePlusiQ9R069.

Expressioni

Gene expression databases

BgeeiENSMUSG00000002980.
ExpressionAtlasiQ9R069. baseline and differential.
GenevisibleiQ9R069. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ9R069. 1 interactor.
MINTiMINT-4130729.
STRINGi10090.ENSMUSP00000003061.

Structurei

3D structure databases

ProteinModelPortaliQ9R069.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 135Ig-like V-type 1Add BLAST110
Domaini140 – 250Ig-like V-type 2Add BLAST111
Domaini267 – 342Ig-like C2-type 1Add BLAST76
Domaini356 – 435Ig-like C2-type 2Add BLAST80
Domaini442 – 532Ig-like C2-type 3Add BLAST91

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJIS. Eukaryota.
ENOG4111XZT. LUCA.
GeneTreeiENSGT00530000063457.
InParanoidiQ9R069.
KOiK06578.
OMAiWFLTDRS.
OrthoDBiEOG091G05IA.
PhylomeDBiQ9R069.
TreeFamiTF330534.

Family and domain databases

Gene3Di2.60.40.10. 5 hits.
InterProiIPR013162. CD80_C2-set.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF08205. C2-set_2. 1 hit.
PF13895. Ig_2. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 5 hits.
SM00408. IGc2. 3 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 5 hits.
PROSITEiPS50835. IG_LIKE. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9R069-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPPDARAGL LWLTFLLSGY SGAQAELHVS VPPRVEVMRG EQVALDCTPR
60 70 80 90 100
EHPEHYVLEW FLVDGTGARH RLASVEPQGS EFLGTVHSLG RVPPYEVDSR
110 120 130 140 150
GRLVIAKVQV GDGRDYVCVV KAGAAGTSEA TSSVRVFATP EDTEVSPNKG
160 170 180 190 200
TLSVMDQFAQ EIATCSSNNG NPVPRITWYR NGQRLEVPME VNQKGYITIR
210 220 230 240 250
TVREASGLYS LTSTLYLRLH KDDRDANFHC AAHYDLPSGQ HGRLDSHTFR
260 270 280 290 300
LTLHYPTEHV EFWVGSPSTT EGWVREGDAV QLLCQGDGSP SPEYSFFRQQ
310 320 330 340 350
GTQEEQLNVN LKGNLTLERV HRNQSGIYGC RVEDYDADEE VQLVKKLKLH
360 370 380 390 400
VAYLDPLELS VPEELFVFLN SSSTVVNCSA RGLPTPTVRW TKDSVTLADG
410 420 430 440 450
PMLSLQSVTF DSAGTYTCEA STPTVPLLSR TQSFQLIVQG APELKPNEIM
460 470 480 490 500
PKSGNSWTEG DEVMLTCSAR GFPEPKLTWS QRGDTPAEPP FEGRGWKSSS
510 520 530 540 550
LMVKVTSALS REGVSCEASN IHGKKGHVFH FGSVAPQTAQ AGVAVMAVAV
560 570 580 590 600
SVGLLLLVVA AFYCMRRKGR PGCCRRAEKG APPAREPELS HSGSERPEHT
610 620
GLLMGGPSGG GRGGSGGFGD EC
Length:622
Mass (Da):67,670
Last modified:May 1, 2000 - v1
Checksum:i257903F08D47EB4A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti227N → D in AAF61742 (Ref. 5) Curated1
Sequence conflicti319R → G in BAB16053 (Ref. 3) Curated1
Sequence conflicti319R → G in AAF61742 (Ref. 5) Curated1
Sequence conflicti361V → A in AAF61742 (Ref. 5) Curated1
Sequence conflicti388V → A in BAB16053 (Ref. 3) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF109160 mRNA. Translation: AAF14226.1.
AF346663 mRNA. Translation: AAK83237.1.
AB035511 mRNA. Translation: BAB16053.1.
AF221507 mRNA. Translation: AAF34657.1.
AF246667 Genomic DNA. Translation: AAF61742.1.
AK075704 mRNA. Translation: BAC35900.1.
CCDSiCCDS39803.1.
RefSeqiNP_065232.1. NM_020486.2.
UniGeneiMm.29236.

Genome annotation databases

EnsembliENSMUST00000003061; ENSMUSP00000003061; ENSMUSG00000002980.
GeneIDi57278.
KEGGimmu:57278.
UCSCiuc009fnf.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF109160 mRNA. Translation: AAF14226.1.
AF346663 mRNA. Translation: AAK83237.1.
AB035511 mRNA. Translation: BAB16053.1.
AF221507 mRNA. Translation: AAF34657.1.
AF246667 Genomic DNA. Translation: AAF61742.1.
AK075704 mRNA. Translation: BAC35900.1.
CCDSiCCDS39803.1.
RefSeqiNP_065232.1. NM_020486.2.
UniGeneiMm.29236.

3D structure databases

ProteinModelPortaliQ9R069.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9R069. 1 interactor.
MINTiMINT-4130729.
STRINGi10090.ENSMUSP00000003061.

PTM databases

iPTMnetiQ9R069.
PhosphoSitePlusiQ9R069.

Proteomic databases

MaxQBiQ9R069.
PaxDbiQ9R069.
PRIDEiQ9R069.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000003061; ENSMUSP00000003061; ENSMUSG00000002980.
GeneIDi57278.
KEGGimmu:57278.
UCSCiuc009fnf.1. mouse.

Organism-specific databases

CTDi4059.
MGIiMGI:1929940. Bcam.

Phylogenomic databases

eggNOGiENOG410IJIS. Eukaryota.
ENOG4111XZT. LUCA.
GeneTreeiENSGT00530000063457.
InParanoidiQ9R069.
KOiK06578.
OMAiWFLTDRS.
OrthoDBiEOG091G05IA.
PhylomeDBiQ9R069.
TreeFamiTF330534.

Miscellaneous databases

ChiTaRSiBcam. mouse.
PROiQ9R069.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000002980.
ExpressionAtlasiQ9R069. baseline and differential.
GenevisibleiQ9R069. MM.

Family and domain databases

Gene3Di2.60.40.10. 5 hits.
InterProiIPR013162. CD80_C2-set.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF08205. C2-set_2. 1 hit.
PF13895. Ig_2. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 5 hits.
SM00408. IGc2. 3 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 5 hits.
PROSITEiPS50835. IG_LIKE. 5 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBCAM_MOUSE
AccessioniPrimary (citable) accession number: Q9R069
Secondary accession number(s): Q9ESS5, Q9JKB2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 1, 2009
Last sequence update: May 1, 2000
Last modified: November 2, 2016
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.