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Protein

Coxsackievirus and adenovirus receptor homolog

Gene

Cxadr

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the epithelial apical junction complex that may function as a homophilic cell adhesion molecule and is essential for tight junction integrity. Also involved in transepithelial migration of leukocytes through adhesive interactions with JAML a transmembrane protein of the plasma membrane of leukocytes. The interaction between both receptors also mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionReceptor
Biological processCell adhesion

Enzyme and pathway databases

ReactomeiR-RNO-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-RNO-202733 Cell surface interactions at the vascular wall

Names & Taxonomyi

Protein namesi
Recommended name:
Coxsackievirus and adenovirus receptor homolog
Short name:
CAR
Short name:
rCAR
Gene namesi
Name:Cxadr
Synonyms:Car
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 11

Organism-specific databases

RGDi619794 Cxadr

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini20 – 238ExtracellularSequence analysisAdd BLAST219
Transmembranei239 – 259HelicalSequence analysisAdd BLAST21
Topological domaini260 – 365CytoplasmicSequence analysisAdd BLAST106

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Tight junction

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000001474220 – 365Coxsackievirus and adenovirus receptor homologAdd BLAST346

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi41 ↔ 120PROSITE-ProRule annotation
Glycosylationi106N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi146 ↔ 223PROSITE-ProRule annotation
Disulfide bondi162 ↔ 212PROSITE-ProRule annotation
Lipidationi259S-palmitoyl cysteineBy similarity1
Lipidationi260S-palmitoyl cysteineBy similarity1
Modified residuei297PhosphoserineBy similarity1
Modified residuei304PhosphoserineBy similarity1
Modified residuei306PhosphoserineBy similarity1
Modified residuei323PhosphoserineCombined sources1
Modified residuei332PhosphoserineCombined sources1
Modified residuei363PhosphoserineBy similarity1

Post-translational modificationi

N-glycosylated.By similarity
Palmitoylated on Cys-259 and/or Cys-260; required for proper localization to the plasma membrane.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PaxDbiQ9R066
PRIDEiQ9R066

PTM databases

iPTMnetiQ9R066
PhosphoSitePlusiQ9R066
SwissPalmiQ9R066

Expressioni

Tissue specificityi

Expressed in heart, brain, spleen, lung, liver, muscle, kidney, testis, spleen and skeletal muscle.1 Publication

Gene expression databases

BgeeiENSRNOG00000001557
GenevisibleiQ9R066 RN

Interactioni

Subunit structurei

Monomer. May form homodimer. Interacts with LNX, BAIAP1, DLG4, PRKCABP, TJP1 and CTNNB1. Interacts with MPDZ; recruits MPDZ to intercellular contact sites. Interacts with JAML (homodimeric form) (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000041873

Structurei

3D structure databases

ProteinModelPortaliQ9R066
SMRiQ9R066
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini20 – 136Ig-like C2-type 1Add BLAST117
Domaini141 – 228Ig-like C2-type 2Add BLAST88

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi360 – 365PDZ-bindingBy similarity6

Domaini

The Ig-like C2-type 1 domain mediates homodimerization and interaction with JAML.By similarity
The PDZ-binding motif mediates interaction with MPDZ and BAIAP1.By similarity

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IGDG Eukaryota
ENOG4110WP1 LUCA
GeneTreeiENSGT00760000119145
HOGENOMiHOG000111222
HOVERGENiHBG105787
InParanoidiQ9R066
KOiK06788
OMAiVGNKKIQ
OrthoDBiEOG091G05PI
PhylomeDBiQ9R066
TreeFamiTF330875

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013106 Ig_V-set
IPR013151 Immunoglobulin
PfamiView protein in Pfam
PF00047 ig, 1 hit
PF07686 V-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 2 hits
SM00408 IGc2, 2 hits
SM00406 IGv, 1 hit
SUPFAMiSSF48726 SSF48726, 2 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 2 hits

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9R066-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MALLLCFVLL CGVADFTSSL SITTPEQRIE KAKGETAYLP CKFTLEPEDQ
60 70 80 90 100
GPLDIEWLIS PSDNQKVDQV IILYSGDKIY DNYYPDLKGR VHFTSNDVKS
110 120 130 140 150
GDASINVTNL QLSDIGTYQC KVKKAPGVAN RKFLLTVLVK PSGTRCFVDG
160 170 180 190 200
SGEIGNDFKL KCEPKEGSLP LQYEWQKLSD SQKMPTPWLA EMTSPVISVK
210 220 230 240 250
NASSEYSGTY SCTVQNRVGS DQCMLRLDVV PPSNRAGTIA GAVIGTLLAL
260 270 280 290 300
VLIGAILFCC HKKRREEKYE KEVHHDIRED VPPPKSRTST ARSYIGSNHS
310 320 330 340 350
SLGSMSPSNM EGYSKTQYNQ VPSEDFERAP QSPTLAPAKV AAPNLSRMGA
360
VPVMIPAQSK DGSIV
Length:365
Mass (Da):39,949
Last modified:July 19, 2005 - v2
Checksum:i66D34B92B7F97363
GO
Isoform 2 (identifier: Q9R066-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     340-352: VAAPNLSRMGAVP → FKYAYLTDGIAVV
     353-365: Missing.

Show »
Length:352
Mass (Da):38,799
Checksum:iAC3A0D35EED8C866
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_014815340 – 352VAAPN…MGAVP → FKYAYLTDGIAVV in isoform 2. CuratedAdd BLAST13
Alternative sequenceiVSP_014816353 – 365Missing in isoform 2. CuratedAdd BLAST13

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03078554 Genomic DNA No translation available.
AABR03079390 Genomic DNA No translation available.
AF109643 mRNA Translation: AAF01254.1
AF109644 mRNA Translation: AAF01255.1
BC088313 mRNA Translation: AAH88313.1
RefSeqiNP_446022.1, NM_053570.1 [Q9R066-2]
XP_006248062.1, XM_006248000.3 [Q9R066-1]
UniGeneiRn.113837

Genome annotation databases

EnsembliENSRNOT00000050701; ENSRNOP00000041873; ENSRNOG00000001557 [Q9R066-2]
GeneIDi89843
KEGGirno:89843
UCSCiRGD:619794 rat [Q9R066-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCXAR_RAT
AccessioniPrimary (citable) accession number: Q9R066
Secondary accession number(s): Q5M817, Q9R067
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 19, 2005
Last modified: May 23, 2018
This is version 132 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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