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Protein

Glycogenin-1

Gene

Gyg1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Self-glucosylates, via an inter-subunit mechanism, to form an oligosaccharide primer that serves as substrate for glycogen synthase.

Catalytic activityi

UDP-alpha-D-glucose + glycogenin = UDP + alpha-D-glucosylglycogenin.

Cofactori

Mn2+By similarityNote: Divalent metal ions. Required for self-glucosylation. Manganese is the most effective.By similarity

Pathwayi: glycogen biosynthesis

This protein is involved in the pathway glycogen biosynthesis, which is part of Glycan biosynthesis.
View all proteins of this organism that are known to be involved in the pathway glycogen biosynthesis and in Glycan biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei86By similarity1
Metal bindingi102ManganeseBy similarity1
Metal bindingi104ManganeseBy similarity1
Sitei160Important for catalytic activityBy similarity1
Sitei163Important for catalytic activityBy similarity1
Metal bindingi212ManganeseBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processGlycogen biosynthesis
LigandManganese, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-3322077 Glycogen synthesis
R-MMU-6798695 Neutrophil degranulation
R-MMU-70221 Glycogen breakdown (glycogenolysis)
UniPathwayiUPA00164

Protein family/group databases

CAZyiGT8 Glycosyltransferase Family 8

Names & Taxonomyi

Protein namesi
Recommended name:
Glycogenin-1 (EC:2.4.1.186)
Short name:
GN-1
Short name:
GN1
Gene namesi
Name:Gyg1
Synonyms:Gyg
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1351614 Gyg

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi305K → A: No loss of interaction with GYS2. 1 Publication1
Mutagenesisi308W → A: No loss of interaction with GYS2. 1 Publication1
Mutagenesisi315Y → A: Severe loss of interaction with GYS2. 1 Publication1
Mutagenesisi321F → A: Severe loss of interaction with GYS2. 1 Publication1
Mutagenesisi324I → A: Severe loss of interaction with GYS2. 1 Publication1
Mutagenesisi328L → A: Severe loss of interaction with GYS2. 1 Publication1
Mutagenesisi332L → A: No loss of interaction with GYS2. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002151772 – 333Glycogenin-1CuratedAdd BLAST332

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylthreonineBy similarity1
Modified residuei44PhosphoserineBy similarity1
Glycosylationi195O-linked (Glc...) tyrosineBy similarity1

Post-translational modificationi

Self-glycosylated by the transfer of glucose residues from UDP-glucose to itself, forming an alpha-1,4-glycan of around 10 residues attached to Tyr-195.
Phosphorylated.By similarity

Keywords - PTMi

Acetylation, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ9R062
MaxQBiQ9R062
PaxDbiQ9R062
PeptideAtlasiQ9R062
PRIDEiQ9R062

2D gel databases

REPRODUCTION-2DPAGEQ9R062

PTM databases

iPTMnetiQ9R062
PhosphoSitePlusiQ9R062

Expressioni

Tissue specificityi

Skeletal muscle, heart, to a lesser extent in kidney, lung and brain.

Gene expression databases

BgeeiENSMUSG00000019528
CleanExiMM_GYG
ExpressionAtlasiQ9R062 baseline and differential
GenevisibleiQ9R062 MM

Interactioni

Subunit structurei

Homodimer tightly complexed to the 86 kDa catalytic subunit of glycogen synthase GYS1 (By similarity). Interacts (via C-terminus) with GYS2; required for GYS2-mediated glycogen synthesis (PubMed:24982189).By similarity1 Publication

Protein-protein interaction databases

IntActiQ9R062, 2 interactors
MINTiQ9R062
STRINGi10090.ENSMUSP00000136035

Structurei

3D structure databases

ProteinModelPortaliQ9R062
SMRiQ9R062
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni284 – 316Interaction with GYS1By similarityAdd BLAST33

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1950 Eukaryota
COG5597 LUCA
GeneTreeiENSGT00390000004721
HOGENOMiHOG000008282
HOVERGENiHBG000681
InParanoidiQ9R062
KOiK00750
PhylomeDBiQ9R062

Family and domain databases

Gene3Di3.90.550.10, 1 hit
InterProiView protein in InterPro
IPR002495 Glyco_trans_8
IPR029044 Nucleotide-diphossugar_trans
PfamiView protein in Pfam
PF01501 Glyco_transf_8, 1 hit
SUPFAMiSSF53448 SSF53448, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9R062-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDQAFVTLT TNDAYAKGAL VLGSSLKQHR TTRRMVVLTS PQVSDSMRKV
60 70 80 90 100
LETVFDDVIM VDVLDSGDSA HLTLMKRPEL GITLTKLHCW SLTQYSKCVF
110 120 130 140 150
MDADTLVLSN IDDLFEREEL SAAPDPGWPD CFNSGVFVYQ PSIETYNQLL
160 170 180 190 200
HLASEQGSFD GGDQGLLNTY FSGWATTDIT KHLPFVYNLS SISIYSYLPA
210 220 230 240 250
FKAFGKNAKV VHFLGRTKPW NYTYNPQTKS VNCDSQDPTV SHPEFLNLWW
260 270 280 290 300
DTFTTNVLPL LQHHGLVKDA SSYLMMEHVS GALSDLSFGE APAAPQPSMS
310 320 330
SEERKERWEQ GQADYMGADS FDNIKRKLDT YLQ
Length:333
Mass (Da):37,402
Last modified:January 23, 2007 - v3
Checksum:i2CE3F0C23166F2CB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF114031 mRNA Translation: AAD48901.1
AK159576 mRNA Translation: BAE35197.1
CH466530 Genomic DNA Translation: EDL34894.1
BC029903 mRNA Translation: AAH29903.1
CCDSiCCDS50873.1
RefSeqiNP_038783.1, NM_013755.3
UniGeneiMm.6375

Genome annotation databases

EnsembliENSMUST00000178328; ENSMUSP00000136035; ENSMUSG00000019528
GeneIDi27357
KEGGimmu:27357
UCSCiuc056zrp.1 mouse

Similar proteinsi

Entry informationi

Entry nameiGLYG_MOUSE
AccessioniPrimary (citable) accession number: Q9R062
Secondary accession number(s): Q3TWR9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 129 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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