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Q9R059 (FHL3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 97. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Four and a half LIM domains protein 3

Short name=FHL-3
Alternative name(s):
Skeletal muscle LIM-protein 2
Short name=SLIM-2
Gene names
Name:Fhl3
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length289 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Tissue specificity

In the adult, expressed at high levels in skeletal muscle and, to a lesser extent, in heart, lung, skin and kidney. During embryonic development, expressed ubiquitously at low levels. Ref.1 Ref.2

Sequence similarities

Contains 4 LIM zinc-binding domains.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Sox15P432677EBI-7332617,EBI-7332587

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 289288Four and a half LIM domains protein 3
PRO_0000075741

Regions

Domain40 – 9253LIM zinc-binding 1
Domain101 – 15353LIM zinc-binding 2
Domain162 – 21251LIM zinc-binding 3
Domain221 – 27555LIM zinc-binding 4
Zinc finger7 – 3125C4-type Potential

Amino acid modifications

Modified residue21N-acetylserine By similarity
Modified residue1571N6-acetyllysine Ref.6
Modified residue2441N6-acetyllysine Ref.6

Experimental info

Sequence conflict771D → G in AAD32623. Ref.1
Sequence conflict911E → D in AAD32623. Ref.1
Sequence conflict951T → S in AAD32623. Ref.1
Sequence conflict1371G → A in AAD53231. Ref.2
Sequence conflict157 – 1593KFA → NLT in AAF73159. Ref.5
Sequence conflict1921K → Q in AAD32623. Ref.1
Sequence conflict1991Q → H in AAD53231. Ref.2
Sequence conflict2051D → E in AAD32623. Ref.1
Sequence conflict2251K → N in AAD53231. Ref.2
Sequence conflict229 – 23810TGGSGGGEGA → V in AAD32623. Ref.1
Sequence conflict2351G → A in AAD53231. Ref.2
Sequence conflict2561S → N in AAD32623. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q9R059 [UniParc].

Last modified October 3, 2012. Version 2.
Checksum: 38168919F5303237

FASTA28931,795
        10         20         30         40         50         60 
MSEAFDCAKC NESLYGRKYI QTDSGPYCVP CYDNTFANTC AECQQLIGHD SRELFYEDRH 

        70         80         90        100        110        120 
FHEGCFRCCR CQRSLADEPF TCQDSELLCN ECYCTAFSSQ CSACGETVMP GSRKLEYGGQ 

       130        140        150        160        170        180 
TWHEHCFLCS GCEQPLGSRS FVPDKGAHYC VPCYENKFAP RCARCSKTLT QGGVTYRDQP 

       190        200        210        220        230        240 
WHRECLVCTG CKTPLAGQQF TSRDDDPYCV ACFGELFAPK CSSCKRPITG GSGGGEGAGL 

       250        260        270        280 
GGGKYVSFED RHWHHSCFSC ARCSTSLVGQ GFVPDGDQVL CQGCSQAGP 

« Hide

References

« Hide 'large scale' references
[1]"The LIM proteins FHL1 and FHL3 are expressed differently in skeletal muscle."
Morgan M.J., Madgwick A.J.A.
Biochem. Biophys. Res. Commun. 255:245-250(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
[2]"Expression patterns of FHL/SLIM family members suggest important functional roles in skeletal muscle and cardiovascular system."
Chu P.-H., Ruiz-Lozano P., Zhou Q., Cai C., Chen J.
Mech. Dev. 95:259-265(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
[3]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[5]"The cloning, sequencing and characterization of a mouse FHL3, which contains four and a half LIM domains."
Li H.Y., Lee S.M.Y., Tsui S.K.W., Chan K.K., Kotaka M., Chim S.S.C., Lee C.Y., Fung K.P., Waye M.M.Y.
Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 11-228.
[6]"SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-157 AND LYS-244, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Embryonic fibroblast.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF134772 mRNA. Translation: AAD32623.1.
AF114382 mRNA. Translation: AAD53231.1.
AL606907 Genomic DNA. No translation available.
BC144903 mRNA. Translation: AAI44904.1.
BC145939 mRNA. Translation: AAI45940.1.
AF149826 mRNA. Translation: AAF73159.1.
CCDSCCDS38874.1.
RefSeqNP_034343.2. NM_010213.3.
XP_006502831.1. XM_006502768.1.
UniGeneMm.331856.

3D structure databases

ProteinModelPortalQ9R059.
SMRQ9R059. Positions 1-286.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ9R059. 1 interaction.
MINTMINT-4788495.

PTM databases

PhosphoSiteQ9R059.

Proteomic databases

MaxQBQ9R059.
PaxDbQ9R059.
PRIDEQ9R059.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000038684; ENSMUSP00000040150; ENSMUSG00000032643.
GeneID14201.
KEGGmmu:14201.
UCSCuc008uqv.2. mouse.

Organism-specific databases

CTD2275.
MGIMGI:1341092. Fhl3.

Phylogenomic databases

eggNOGNOG314122.
GeneTreeENSGT00740000115292.
HOGENOMHOG000231075.
HOVERGENHBG074526.
InParanoidQ9R059.
OMARDDDPYC.
PhylomeDBQ9R059.
TreeFamTF314113.

Gene expression databases

CleanExMM_FHL3.
GenevestigatorQ9R059.

Family and domain databases

Gene3D2.10.110.10. 5 hits.
InterProIPR001781. Znf_LIM.
[Graphical view]
PfamPF00412. LIM. 4 hits.
[Graphical view]
SMARTSM00132. LIM. 4 hits.
[Graphical view]
PROSITEPS00478. LIM_DOMAIN_1. 3 hits.
PS50023. LIM_DOMAIN_2. 4 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio13895005.
PROQ9R059.
SOURCESearch...

Entry information

Entry nameFHL3_MOUSE
AccessionPrimary (citable) accession number: Q9R059
Secondary accession number(s): A6H6N4, Q9JLP5, Q9WUH3
Entry history
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: October 3, 2012
Last modified: July 9, 2014
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot