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Q9R053

- SCNBA_MOUSE

UniProt

Q9R053 - SCNBA_MOUSE

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Protein

Sodium channel protein type 11 subunit alpha

Gene

Scn11a

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant sodium channel isoform. Also involved, with the contribution of the receptor tyrosine kinase NTRK2, in rapid BDNF-evoked neuronal depolarization (By similarity).By similarity

GO - Molecular functioni

  1. voltage-gated sodium channel activity Source: MGI

GO - Biological processi

  1. membrane depolarization during action potential Source: RefGenome
  2. neuronal action potential Source: RefGenome
  3. regulation of sensory perception of pain Source: UniProtKB
  4. sodium ion transmembrane transport Source: GOC
  5. sodium ion transport Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Sodium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Sodium transport, Transport

Keywords - Ligandi

Sodium

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium channel protein type 11 subunit alpha
Alternative name(s):
NaN
Sensory neuron sodium channel 2
Sodium channel protein type XI subunit alpha
Voltage-gated sodium channel subunit alpha Nav1.9
Gene namesi
Name:Scn11a
Synonyms:Nan, Nat, Sns2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 9

Organism-specific databases

MGIiMGI:1345149. Scn11a.

Subcellular locationi

Membrane By similarity; Multi-pass membrane protein By similarity

GO - Cellular componenti

  1. axon Source: MGI
  2. C-fiber Source: MGI
  3. extracellular vesicular exosome Source: Ensembl
  4. plasma membrane Source: MGI
  5. voltage-gated sodium channel complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 17651765Sodium channel protein type 11 subunit alphaPRO_0000048511Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi149 – 1491N-linked (GlcNAc...)Sequence Analysis
Glycosylationi217 – 2171N-linked (GlcNAc...)Sequence Analysis
Glycosylationi303 – 3031N-linked (GlcNAc...)Sequence Analysis
Glycosylationi327 – 3271N-linked (GlcNAc...)Sequence Analysis
Glycosylationi336 – 3361N-linked (GlcNAc...)Sequence Analysis
Glycosylationi662 – 6621N-linked (GlcNAc...)Sequence Analysis
Glycosylationi725 – 7251N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1188 – 11881N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1197 – 11971N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1203 – 12031N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1211 – 12111N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1676 – 16761N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9R053.
PRIDEiQ9R053.

PTM databases

PhosphoSiteiQ9R053.

Expressioni

Tissue specificityi

Expressed in the dorsal root ganglia (C-fiber neurons), spinal cord, trigeminal ganglia, testis, ovary, uterus and small intestine.1 Publication

Developmental stagei

Expressed in embryo at 15 dpc onwards.1 Publication

Gene expression databases

BgeeiQ9R053.
CleanExiMM_SCN11A.
GenevestigatoriQ9R053.

Interactioni

Subunit structurei

The voltage-resistant sodium channel consists of an ion conducting pore forming alpha-subunit regulated by one or more auxiliary subunits SCN1B, SCN2B and SCN3B.

Protein-protein interaction databases

BioGridi204861. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ9R053.
SMRiQ9R053. Positions 1585-1728.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei127 – 14822Helical; Name=S1 of repeat IBy similarityAdd
BLAST
Transmembranei160 – 17920Helical; Name=S2 of repeat IBy similarityAdd
BLAST
Transmembranei192 – 21120Helical; Name=S3 of repeat IBy similarityAdd
BLAST
Transmembranei220 – 23920Helical; Voltage-sensor; Name=S4 of repeat IBy similarityAdd
BLAST
Transmembranei256 – 26914Helical; Name=S5 of repeat IBy similarityAdd
BLAST
Transmembranei375 – 40026Helical; Name=S6 of repeat IBy similarityAdd
BLAST
Transmembranei571 – 59424Helical; Name=S1 of repeat IIBy similarityAdd
BLAST
Transmembranei606 – 62924Helical; Name=S2 of repeat IIBy similarityAdd
BLAST
Transmembranei638 – 65922Helical; Name=S3 of repeat IIBy similarityAdd
BLAST
Transmembranei665 – 68420Helical; Voltage-sensor; Name=S4 of repeat IIBy similarityAdd
BLAST
Transmembranei700 – 72223Helical; Name=S5 of repeat IIBy similarityAdd
BLAST
Transmembranei774 – 79926Helical; Name=S6 of repeat IIBy similarityAdd
BLAST
Transmembranei1031 – 105323Helical; Name=S1 of repeat IIIBy similarityAdd
BLAST
Transmembranei1068 – 109326Helical; Name=S2 of repeat IIIBy similarityAdd
BLAST
Transmembranei1100 – 111718Helical; Name=S3 of repeat IIIBy similarityAdd
BLAST
Transmembranei1119 – 114022Helical; Voltage-sensor; Name=S4 of repeat IIIBy similarityAdd
BLAST
Transmembranei1160 – 118122Helical; Name=S5 of repeat IIIBy similarityAdd
BLAST
Transmembranei1263 – 128927Helical; Name=S6 of repeat IIIBy similarityAdd
BLAST
Transmembranei1343 – 136624Helical; Name=S1 of repeat IVBy similarityAdd
BLAST
Transmembranei1378 – 140124Helical; Name=S2 of repeat IVBy similarityAdd
BLAST
Transmembranei1408 – 143124Helical; Name=S3 of repeat IVBy similarityAdd
BLAST
Transmembranei1441 – 146323Helical; Voltage-sensor; Name=S4 of repeat IVBy similarityAdd
BLAST
Transmembranei1479 – 150123Helical; Name=S5 of repeat IVBy similarityAdd
BLAST
Transmembranei1560 – 158425Helical; Name=S6 of repeat IVBy similarityAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati126 – 401276IAdd
BLAST
Repeati570 – 800231IIAdd
BLAST
Repeati1030 – 1290261IIIAdd
BLAST
Repeati1342 – 1585244IVAdd
BLAST

Domaini

The sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1,S2,S3,S5,S6) and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position.

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1226.
GeneTreeiENSGT00760000118827.
HOGENOMiHOG000231755.
HOVERGENiHBG053100.
InParanoidiQ9R053.
KOiK04843.
OMAiLENFNTA.
OrthoDBiEOG7DJSK9.
TreeFamiTF323985.

Family and domain databases

Gene3Di1.20.120.350. 4 hits.
InterProiIPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR028821. Na_channel_a11su.
IPR001696. Na_channel_asu.
IPR010526. Na_trans_assoc.
[Graphical view]
PANTHERiPTHR10037:SF22. PTHR10037:SF22. 1 hit.
PfamiPF00520. Ion_trans. 4 hits.
PF06512. Na_trans_assoc. 1 hit.
[Graphical view]
PRINTSiPR00170. NACHANNEL.

Sequencei

Sequence statusi: Complete.

Q9R053-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEERYYPVIF PDERNFRPFT FDSLAAIEKR ITIQKEKKKS KDKAATEPQP
60 70 80 90 100
RPQLDLKASR KLPKLYGDVP PDLIAKPLED LDPFYKDHKT FMVLNKKRTI
110 120 130 140 150
YRFSAKRALF ILGPFNPIRS FMIRISVHSV FSMFIICTVI INCMFMANNS
160 170 180 190 200
SVDSRPSSNI PEYVFIGIYV LEAVIKILAR GFIVDEFSYL RDPWNWLDFI
210 220 230 240 250
VIGTAIAPCF LGNKVNNLST LRTFRVLRAL KAISVISGLK VIVGALLRSV
260 270 280 290 300
KKLVDVMVLT LFCLSIFALV GQQLFMGILS QKCIKDDCGP NAFSNKDCFV
310 320 330 340 350
KENDSEDFIM CGNWLGRRSC PDGSTCNKTT FNPDYNYTNF DSFGWSFLAM
360 370 380 390 400
FRVMTQDSWE KLYRQILRTS GIYFVFFFVV VIFLGSFYLL NLTLAVVTMA
410 420 430 440 450
YEEQNRNVAA ETEAKEKMFQ EAQQLLREEK EALVAMGIDR TSLNSLQASS
460 470 480 490 500
FSPKKRKFFG SKTRKSFFMR GSKTARASAS DSEDDASKNP QLLEQTKRLS
510 520 530 540 550
QNLPVELFDE HVDPLHRQRA LSAVSILTIT MQEQEKSQEP CFPCGKNLAS
560 570 580 590 600
KYLVWECSPP WLCIKKVLQT IMTDPFTELA ITICIIVNTV FLAMEHHNMD
610 620 630 640 650
NSLKDILKIG NWVFTGIFIA EMCLKIIALD PYHYFRHGWN IFDSIVALVS
660 670 680 690 700
LADVLFHKLS KNLSFLASLR VLRVFKLAKS WPTLNTLIKI IGHSVGALGN
710 720 730 740 750
LTVVLTIVVF IFSVVGMRLF GAKFNKTCST SPESLRRWHM GDFYHSFLVV
760 770 780 790 800
FRILCGEWIE NMWECMQEME GSPLCVIVFV LIMVVGKLVV LNLFIALLLN
810 820 830 840 850
SFSNEEKDGN PEGETRKTKV QLALDRFSRA FYFMARALQN FCCKRCRRQN
860 870 880 890 900
SPKPNEATES FAGESRDTAT LDTRSWKEYD SEMTLYTGQA GAPLAPLAKE
910 920 930 940 950
EDDMECCGEC DASPTSQPSE EAQACDLPLK TKRLPSPDDH GVEMEVFSEE
960 970 980 990 1000
DPNLTIQSAR KKSDAASMLS ECSTIDLNDI FRNLQKTVSP QKQPDRCFPK
1010 1020 1030 1040 1050
GLSCIFLCCK TIKKKSPWVL WWNLRKTCYQ IVKHSWFESF IIFVILLSSG
1060 1070 1080 1090 1100
ALIFEDVNLP SRPQVEKLLK CTDNIFTFIF LLEMILKWVA FGFRKYFTSA
1110 1120 1130 1140 1150
WCWLDFLIVV VSGLSLTNLP NLKSFRNLRA LRPLRALSQF EGMKVVVNAL
1160 1170 1180 1190 1200
MSAIPAILNV LLVCLIFWLI FCILGVNFFS GKFGRCINGT DINKYFNASN
1210 1220 1230 1240 1250
VPNQSQCLVS NYTWKVPNVN FDNVGNAYLA LLQVATYKGW LDIMNAAVDS
1260 1270 1280 1290 1300
RGKDEQPAFE ANLYAYLYFV VFIIFGSFFT LNLFIGVIID NFNQQQKKLG
1310 1320 1330 1340 1350
GQDIFMTEEQ KKYYNAMKKL GTKKPQKPIP RPLNKCQAFV FDLVTSQVFD
1360 1370 1380 1390 1400
VIILGLIVTN MIIMMAESEG QPNEVKKIFD ILNIVFVVIF TVECLIKVFA
1410 1420 1430 1440 1450
LRQHYFTNGW NLFDCVVVVL SIISTLVSGL ENSNVFPPTL FRIVRLARIG
1460 1470 1480 1490 1500
RILRLVRAAR GIRTLLFALM MSLPSLFNIG LLLFLVMFIY AIFGMNWFSK
1510 1520 1530 1540 1550
VKRGSGIDDI FNFDTFSGSM LCLFQITTSA GWDALLNPML ESKASCNSSS
1560 1570 1580 1590 1600
QESCQQPQIA IVYFVSYIII SFLIVVNMYI AVILENFNTA TEESEDPLGE
1610 1620 1630 1640 1650
DDFEIFYEIW EKFDPEATQF IQYSSLSDFA DALPEPLRVA KPNRFQFLMM
1660 1670 1680 1690 1700
DLPMVMGDRL HCMDVLFAFT TRVLGNSSGL DTMKAMMEEK FMEANPFKKL
1710 1720 1730 1740 1750
YEPIVTTTKR KEEEECAAVI QRAYRRHMEK MIKLKLKGRS SSSLQVFCNG
1760
DLSSLDVPKI KVHCD
Length:1,765
Mass (Da):201,385
Last modified:July 27, 2011 - v2
Checksum:i0A17EA3B9D86FB9C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti400 – 4001A → G in BAA92154. (PubMed:10623609)Curated
Sequence conflicti427 – 4271R → K in BAA92154. (PubMed:10623609)Curated
Sequence conflicti489 – 4891N → K in BAA92154. (PubMed:10623609)Curated
Sequence conflicti738 – 7381W → R in BAA92154. (PubMed:10623609)Curated
Sequence conflicti761 – 7611N → T in BAA92154. (PubMed:10623609)Curated
Sequence conflicti764 – 7641E → D in BAA92154. (PubMed:10623609)Curated
Sequence conflicti843 – 8431C → R in BAA92154. (PubMed:10623609)Curated
Sequence conflicti1023 – 10242NL → IF in BAA92154. (PubMed:10623609)Curated
Sequence conflicti1054 – 10541F → L in BAA92154. (PubMed:10623609)Curated
Sequence conflicti1113 – 11131G → V in AAD53403. (PubMed:10444332)Curated
Sequence conflicti1113 – 11131G → V in BAA92154. (PubMed:10623609)Curated
Sequence conflicti1212 – 12121Y → H in BAA92154. (PubMed:10623609)Curated
Sequence conflicti1376 – 13761K → Q in BAA92154. (PubMed:10623609)Curated
Sequence conflicti1496 – 14961N → S in BAA92154. (PubMed:10623609)Curated
Sequence conflicti1572 – 15721F → L in BAA92154. (PubMed:10623609)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF118044 mRNA. Translation: AAD53403.1.
AB031389 mRNA. Translation: BAA92154.1.
AC124662 Genomic DNA. No translation available.
AC162937 Genomic DNA. No translation available.
CCDSiCCDS40804.1.
RefSeqiNP_036017.3. NM_011887.3.
UniGeneiMm.469833.
Mm.89981.

Genome annotation databases

EnsembliENSMUST00000070617; ENSMUSP00000065466; ENSMUSG00000034115.
GeneIDi24046.
KEGGimmu:24046.
UCSCiuc009sbk.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF118044 mRNA. Translation: AAD53403.1 .
AB031389 mRNA. Translation: BAA92154.1 .
AC124662 Genomic DNA. No translation available.
AC162937 Genomic DNA. No translation available.
CCDSi CCDS40804.1.
RefSeqi NP_036017.3. NM_011887.3.
UniGenei Mm.469833.
Mm.89981.

3D structure databases

ProteinModelPortali Q9R053.
SMRi Q9R053. Positions 1585-1728.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 204861. 1 interaction.

PTM databases

PhosphoSitei Q9R053.

Proteomic databases

PaxDbi Q9R053.
PRIDEi Q9R053.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000070617 ; ENSMUSP00000065466 ; ENSMUSG00000034115 .
GeneIDi 24046.
KEGGi mmu:24046.
UCSCi uc009sbk.1. mouse.

Organism-specific databases

CTDi 11280.
MGIi MGI:1345149. Scn11a.

Phylogenomic databases

eggNOGi COG1226.
GeneTreei ENSGT00760000118827.
HOGENOMi HOG000231755.
HOVERGENi HBG053100.
InParanoidi Q9R053.
KOi K04843.
OMAi LENFNTA.
OrthoDBi EOG7DJSK9.
TreeFami TF323985.

Miscellaneous databases

ChiTaRSi SCN11A. mouse.
NextBioi 303975.
PROi Q9R053.
SOURCEi Search...

Gene expression databases

Bgeei Q9R053.
CleanExi MM_SCN11A.
Genevestigatori Q9R053.

Family and domain databases

Gene3Di 1.20.120.350. 4 hits.
InterProi IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR028821. Na_channel_a11su.
IPR001696. Na_channel_asu.
IPR010526. Na_trans_assoc.
[Graphical view ]
PANTHERi PTHR10037:SF22. PTHR10037:SF22. 1 hit.
Pfami PF00520. Ion_trans. 4 hits.
PF06512. Na_trans_assoc. 1 hit.
[Graphical view ]
PRINTSi PR00170. NACHANNEL.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Coding sequence, genomic organization, and conserved chromosomal localization of the mouse gene Scn11a encoding the sodium channel NaN."
    Dib-Hajj S.D., Tyrrell L., Escayg A., Wood P.M., Meisler M.H., Waxman S.G.
    Genomics 59:309-318(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: ICR.
    Tissue: Trigeminal ganglion.
  2. "Cloning and expression study of the mouse tetrodotoxin-resistant voltage-gated sodium channel alpha subunit NaT/Scn11a."
    Ogata K., Jeong S.-Y., Murakami H., Hashida H., Suzuki T., Masuda N., Hirai M., Isahara K., Uchiyama Y., Goto J., Kanazawa I.
    Biochem. Biophys. Res. Commun. 267:271-277(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    Tissue: Testis.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. "Patterned electrical activity modulates sodium channel expression in sensory neurons."
    Klein J.P., Tendi E.A., Dib-Hajj S.D., Fields R.D., Waxman S.G.
    J. Neurosci. Res. 74:192-198(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  5. "Na+ channel Nav1.9: in search of a gating mechanism."
    Delmas P., Coste B.
    Trends Neurosci. 26:55-57(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.

Entry informationi

Entry nameiSCNBA_MOUSE
AccessioniPrimary (citable) accession number: Q9R053
Secondary accession number(s): E9QM88, Q9JMD4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: July 27, 2011
Last modified: October 29, 2014
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3