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Q9R053

- SCNBA_MOUSE

UniProt

Q9R053 - SCNBA_MOUSE

Protein

Sodium channel protein type 11 subunit alpha

Gene

Scn11a

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant sodium channel isoform. Also involved, with the contribution of the receptor tyrosine kinase NTRK2, in rapid BDNF-evoked neuronal depolarization By similarity.By similarity

    GO - Molecular functioni

    1. protein binding Source: MGI
    2. voltage-gated sodium channel activity Source: MGI

    GO - Biological processi

    1. membrane depolarization during action potential Source: RefGenome
    2. neuronal action potential Source: RefGenome
    3. regulation of sensory perception of pain Source: UniProtKB
    4. sodium ion transmembrane transport Source: GOC
    5. sodium ion transport Source: MGI

    Keywords - Molecular functioni

    Ion channel, Sodium channel, Voltage-gated channel

    Keywords - Biological processi

    Ion transport, Sodium transport, Transport

    Keywords - Ligandi

    Sodium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sodium channel protein type 11 subunit alpha
    Alternative name(s):
    NaN
    Sensory neuron sodium channel 2
    Sodium channel protein type XI subunit alpha
    Voltage-gated sodium channel subunit alpha Nav1.9
    Gene namesi
    Name:Scn11a
    Synonyms:Nan, Nat, Sns2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 9

    Organism-specific databases

    MGIiMGI:1345149. Scn11a.

    Subcellular locationi

    Membrane By similarity; Multi-pass membrane protein By similarity

    GO - Cellular componenti

    1. axon Source: MGI
    2. C-fiber Source: MGI
    3. plasma membrane Source: MGI
    4. voltage-gated sodium channel complex Source: InterPro

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 17651765Sodium channel protein type 11 subunit alphaPRO_0000048511Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi149 – 1491N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi217 – 2171N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi303 – 3031N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi327 – 3271N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi336 – 3361N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi662 – 6621N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi725 – 7251N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1188 – 11881N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1197 – 11971N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1203 – 12031N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1211 – 12111N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1676 – 16761N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ9R053.
    PRIDEiQ9R053.

    PTM databases

    PhosphoSiteiQ9R053.

    Expressioni

    Tissue specificityi

    Expressed in the dorsal root ganglia (C-fiber neurons), spinal cord, trigeminal ganglia, testis, ovary, uterus and small intestine.1 Publication

    Developmental stagei

    Expressed in embryo at 15 dpc onwards.1 Publication

    Gene expression databases

    BgeeiQ9R053.
    CleanExiMM_SCN11A.
    GenevestigatoriQ9R053.

    Interactioni

    Subunit structurei

    The voltage-resistant sodium channel consists of an ion conducting pore forming alpha-subunit regulated by one or more auxiliary subunits SCN1B, SCN2B and SCN3B.

    Protein-protein interaction databases

    BioGridi204861. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9R053.
    SMRiQ9R053. Positions 1585-1728.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei127 – 14822Helical; Name=S1 of repeat IBy similarityAdd
    BLAST
    Transmembranei160 – 17920Helical; Name=S2 of repeat IBy similarityAdd
    BLAST
    Transmembranei192 – 21120Helical; Name=S3 of repeat IBy similarityAdd
    BLAST
    Transmembranei220 – 23920Helical; Voltage-sensor; Name=S4 of repeat IBy similarityAdd
    BLAST
    Transmembranei256 – 26914Helical; Name=S5 of repeat IBy similarityAdd
    BLAST
    Transmembranei375 – 40026Helical; Name=S6 of repeat IBy similarityAdd
    BLAST
    Transmembranei571 – 59424Helical; Name=S1 of repeat IIBy similarityAdd
    BLAST
    Transmembranei606 – 62924Helical; Name=S2 of repeat IIBy similarityAdd
    BLAST
    Transmembranei638 – 65922Helical; Name=S3 of repeat IIBy similarityAdd
    BLAST
    Transmembranei665 – 68420Helical; Voltage-sensor; Name=S4 of repeat IIBy similarityAdd
    BLAST
    Transmembranei700 – 72223Helical; Name=S5 of repeat IIBy similarityAdd
    BLAST
    Transmembranei774 – 79926Helical; Name=S6 of repeat IIBy similarityAdd
    BLAST
    Transmembranei1031 – 105323Helical; Name=S1 of repeat IIIBy similarityAdd
    BLAST
    Transmembranei1068 – 109326Helical; Name=S2 of repeat IIIBy similarityAdd
    BLAST
    Transmembranei1100 – 111718Helical; Name=S3 of repeat IIIBy similarityAdd
    BLAST
    Transmembranei1119 – 114022Helical; Voltage-sensor; Name=S4 of repeat IIIBy similarityAdd
    BLAST
    Transmembranei1160 – 118122Helical; Name=S5 of repeat IIIBy similarityAdd
    BLAST
    Transmembranei1263 – 128927Helical; Name=S6 of repeat IIIBy similarityAdd
    BLAST
    Transmembranei1343 – 136624Helical; Name=S1 of repeat IVBy similarityAdd
    BLAST
    Transmembranei1378 – 140124Helical; Name=S2 of repeat IVBy similarityAdd
    BLAST
    Transmembranei1408 – 143124Helical; Name=S3 of repeat IVBy similarityAdd
    BLAST
    Transmembranei1441 – 146323Helical; Voltage-sensor; Name=S4 of repeat IVBy similarityAdd
    BLAST
    Transmembranei1479 – 150123Helical; Name=S5 of repeat IVBy similarityAdd
    BLAST
    Transmembranei1560 – 158425Helical; Name=S6 of repeat IVBy similarityAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati126 – 401276IAdd
    BLAST
    Repeati570 – 800231IIAdd
    BLAST
    Repeati1030 – 1290261IIIAdd
    BLAST
    Repeati1342 – 1585244IVAdd
    BLAST

    Domaini

    The sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1,S2,S3,S5,S6) and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position.

    Sequence similaritiesi

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1226.
    GeneTreeiENSGT00750000117555.
    HOGENOMiHOG000231755.
    HOVERGENiHBG053100.
    InParanoidiQ9R053.
    KOiK04843.
    OMAiLENFNTA.
    OrthoDBiEOG7DJSK9.
    TreeFamiTF323985.

    Family and domain databases

    Gene3Di1.20.120.350. 4 hits.
    InterProiIPR027359. Channel_four-helix_dom.
    IPR005821. Ion_trans_dom.
    IPR028821. Na_channel_a11su.
    IPR001696. Na_channel_asu.
    IPR010526. Na_trans_assoc.
    [Graphical view]
    PANTHERiPTHR10037:SF22. PTHR10037:SF22. 1 hit.
    PfamiPF00520. Ion_trans. 4 hits.
    PF06512. Na_trans_assoc. 1 hit.
    [Graphical view]
    PRINTSiPR00170. NACHANNEL.

    Sequencei

    Sequence statusi: Complete.

    Q9R053-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEERYYPVIF PDERNFRPFT FDSLAAIEKR ITIQKEKKKS KDKAATEPQP     50
    RPQLDLKASR KLPKLYGDVP PDLIAKPLED LDPFYKDHKT FMVLNKKRTI 100
    YRFSAKRALF ILGPFNPIRS FMIRISVHSV FSMFIICTVI INCMFMANNS 150
    SVDSRPSSNI PEYVFIGIYV LEAVIKILAR GFIVDEFSYL RDPWNWLDFI 200
    VIGTAIAPCF LGNKVNNLST LRTFRVLRAL KAISVISGLK VIVGALLRSV 250
    KKLVDVMVLT LFCLSIFALV GQQLFMGILS QKCIKDDCGP NAFSNKDCFV 300
    KENDSEDFIM CGNWLGRRSC PDGSTCNKTT FNPDYNYTNF DSFGWSFLAM 350
    FRVMTQDSWE KLYRQILRTS GIYFVFFFVV VIFLGSFYLL NLTLAVVTMA 400
    YEEQNRNVAA ETEAKEKMFQ EAQQLLREEK EALVAMGIDR TSLNSLQASS 450
    FSPKKRKFFG SKTRKSFFMR GSKTARASAS DSEDDASKNP QLLEQTKRLS 500
    QNLPVELFDE HVDPLHRQRA LSAVSILTIT MQEQEKSQEP CFPCGKNLAS 550
    KYLVWECSPP WLCIKKVLQT IMTDPFTELA ITICIIVNTV FLAMEHHNMD 600
    NSLKDILKIG NWVFTGIFIA EMCLKIIALD PYHYFRHGWN IFDSIVALVS 650
    LADVLFHKLS KNLSFLASLR VLRVFKLAKS WPTLNTLIKI IGHSVGALGN 700
    LTVVLTIVVF IFSVVGMRLF GAKFNKTCST SPESLRRWHM GDFYHSFLVV 750
    FRILCGEWIE NMWECMQEME GSPLCVIVFV LIMVVGKLVV LNLFIALLLN 800
    SFSNEEKDGN PEGETRKTKV QLALDRFSRA FYFMARALQN FCCKRCRRQN 850
    SPKPNEATES FAGESRDTAT LDTRSWKEYD SEMTLYTGQA GAPLAPLAKE 900
    EDDMECCGEC DASPTSQPSE EAQACDLPLK TKRLPSPDDH GVEMEVFSEE 950
    DPNLTIQSAR KKSDAASMLS ECSTIDLNDI FRNLQKTVSP QKQPDRCFPK 1000
    GLSCIFLCCK TIKKKSPWVL WWNLRKTCYQ IVKHSWFESF IIFVILLSSG 1050
    ALIFEDVNLP SRPQVEKLLK CTDNIFTFIF LLEMILKWVA FGFRKYFTSA 1100
    WCWLDFLIVV VSGLSLTNLP NLKSFRNLRA LRPLRALSQF EGMKVVVNAL 1150
    MSAIPAILNV LLVCLIFWLI FCILGVNFFS GKFGRCINGT DINKYFNASN 1200
    VPNQSQCLVS NYTWKVPNVN FDNVGNAYLA LLQVATYKGW LDIMNAAVDS 1250
    RGKDEQPAFE ANLYAYLYFV VFIIFGSFFT LNLFIGVIID NFNQQQKKLG 1300
    GQDIFMTEEQ KKYYNAMKKL GTKKPQKPIP RPLNKCQAFV FDLVTSQVFD 1350
    VIILGLIVTN MIIMMAESEG QPNEVKKIFD ILNIVFVVIF TVECLIKVFA 1400
    LRQHYFTNGW NLFDCVVVVL SIISTLVSGL ENSNVFPPTL FRIVRLARIG 1450
    RILRLVRAAR GIRTLLFALM MSLPSLFNIG LLLFLVMFIY AIFGMNWFSK 1500
    VKRGSGIDDI FNFDTFSGSM LCLFQITTSA GWDALLNPML ESKASCNSSS 1550
    QESCQQPQIA IVYFVSYIII SFLIVVNMYI AVILENFNTA TEESEDPLGE 1600
    DDFEIFYEIW EKFDPEATQF IQYSSLSDFA DALPEPLRVA KPNRFQFLMM 1650
    DLPMVMGDRL HCMDVLFAFT TRVLGNSSGL DTMKAMMEEK FMEANPFKKL 1700
    YEPIVTTTKR KEEEECAAVI QRAYRRHMEK MIKLKLKGRS SSSLQVFCNG 1750
    DLSSLDVPKI KVHCD 1765
    Length:1,765
    Mass (Da):201,385
    Last modified:July 27, 2011 - v2
    Checksum:i0A17EA3B9D86FB9C
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti400 – 4001A → G in BAA92154. (PubMed:10623609)Curated
    Sequence conflicti427 – 4271R → K in BAA92154. (PubMed:10623609)Curated
    Sequence conflicti489 – 4891N → K in BAA92154. (PubMed:10623609)Curated
    Sequence conflicti738 – 7381W → R in BAA92154. (PubMed:10623609)Curated
    Sequence conflicti761 – 7611N → T in BAA92154. (PubMed:10623609)Curated
    Sequence conflicti764 – 7641E → D in BAA92154. (PubMed:10623609)Curated
    Sequence conflicti843 – 8431C → R in BAA92154. (PubMed:10623609)Curated
    Sequence conflicti1023 – 10242NL → IF in BAA92154. (PubMed:10623609)Curated
    Sequence conflicti1054 – 10541F → L in BAA92154. (PubMed:10623609)Curated
    Sequence conflicti1113 – 11131G → V in AAD53403. (PubMed:10444332)Curated
    Sequence conflicti1113 – 11131G → V in BAA92154. (PubMed:10623609)Curated
    Sequence conflicti1212 – 12121Y → H in BAA92154. (PubMed:10623609)Curated
    Sequence conflicti1376 – 13761K → Q in BAA92154. (PubMed:10623609)Curated
    Sequence conflicti1496 – 14961N → S in BAA92154. (PubMed:10623609)Curated
    Sequence conflicti1572 – 15721F → L in BAA92154. (PubMed:10623609)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF118044 mRNA. Translation: AAD53403.1.
    AB031389 mRNA. Translation: BAA92154.1.
    AC124662 Genomic DNA. No translation available.
    AC162937 Genomic DNA. No translation available.
    CCDSiCCDS40804.1.
    RefSeqiNP_036017.3. NM_011887.3.
    UniGeneiMm.469833.
    Mm.89981.

    Genome annotation databases

    EnsembliENSMUST00000070617; ENSMUSP00000065466; ENSMUSG00000034115.
    GeneIDi24046.
    KEGGimmu:24046.
    UCSCiuc009sbk.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF118044 mRNA. Translation: AAD53403.1 .
    AB031389 mRNA. Translation: BAA92154.1 .
    AC124662 Genomic DNA. No translation available.
    AC162937 Genomic DNA. No translation available.
    CCDSi CCDS40804.1.
    RefSeqi NP_036017.3. NM_011887.3.
    UniGenei Mm.469833.
    Mm.89981.

    3D structure databases

    ProteinModelPortali Q9R053.
    SMRi Q9R053. Positions 1585-1728.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 204861. 1 interaction.

    PTM databases

    PhosphoSitei Q9R053.

    Proteomic databases

    PaxDbi Q9R053.
    PRIDEi Q9R053.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000070617 ; ENSMUSP00000065466 ; ENSMUSG00000034115 .
    GeneIDi 24046.
    KEGGi mmu:24046.
    UCSCi uc009sbk.1. mouse.

    Organism-specific databases

    CTDi 11280.
    MGIi MGI:1345149. Scn11a.

    Phylogenomic databases

    eggNOGi COG1226.
    GeneTreei ENSGT00750000117555.
    HOGENOMi HOG000231755.
    HOVERGENi HBG053100.
    InParanoidi Q9R053.
    KOi K04843.
    OMAi LENFNTA.
    OrthoDBi EOG7DJSK9.
    TreeFami TF323985.

    Miscellaneous databases

    ChiTaRSi SCN11A. mouse.
    NextBioi 303975.
    PROi Q9R053.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9R053.
    CleanExi MM_SCN11A.
    Genevestigatori Q9R053.

    Family and domain databases

    Gene3Di 1.20.120.350. 4 hits.
    InterProi IPR027359. Channel_four-helix_dom.
    IPR005821. Ion_trans_dom.
    IPR028821. Na_channel_a11su.
    IPR001696. Na_channel_asu.
    IPR010526. Na_trans_assoc.
    [Graphical view ]
    PANTHERi PTHR10037:SF22. PTHR10037:SF22. 1 hit.
    Pfami PF00520. Ion_trans. 4 hits.
    PF06512. Na_trans_assoc. 1 hit.
    [Graphical view ]
    PRINTSi PR00170. NACHANNEL.
    ProtoNeti Search...

    Publicationsi

    1. "Coding sequence, genomic organization, and conserved chromosomal localization of the mouse gene Scn11a encoding the sodium channel NaN."
      Dib-Hajj S.D., Tyrrell L., Escayg A., Wood P.M., Meisler M.H., Waxman S.G.
      Genomics 59:309-318(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: ICR.
      Tissue: Trigeminal ganglion.
    2. "Cloning and expression study of the mouse tetrodotoxin-resistant voltage-gated sodium channel alpha subunit NaT/Scn11a."
      Ogata K., Jeong S.-Y., Murakami H., Hashida H., Suzuki T., Masuda N., Hirai M., Isahara K., Uchiyama Y., Goto J., Kanazawa I.
      Biochem. Biophys. Res. Commun. 267:271-277(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
      Tissue: Testis.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    4. "Patterned electrical activity modulates sodium channel expression in sensory neurons."
      Klein J.P., Tendi E.A., Dib-Hajj S.D., Fields R.D., Waxman S.G.
      J. Neurosci. Res. 74:192-198(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION.
    5. "Na+ channel Nav1.9: in search of a gating mechanism."
      Delmas P., Coste B.
      Trends Neurosci. 26:55-57(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.

    Entry informationi

    Entry nameiSCNBA_MOUSE
    AccessioniPrimary (citable) accession number: Q9R053
    Secondary accession number(s): E9QM88, Q9JMD4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 21, 2004
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 103 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3