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Q9R053

- SCNBA_MOUSE

UniProt

Q9R053 - SCNBA_MOUSE

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Protein

Sodium channel protein type 11 subunit alpha

Gene
Scn11a, Nan, Nat, Sns2
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant sodium channel isoform. Also involved, with the contribution of the receptor tyrosine kinase NTRK2, in rapid BDNF-evoked neuronal depolarization By similarity.

GO - Molecular functioni

  1. protein binding Source: MGI
  2. voltage-gated sodium channel activity Source: MGI

GO - Biological processi

  1. membrane depolarization during action potential Source: RefGenome
  2. neuronal action potential Source: RefGenome
  3. regulation of sensory perception of pain Source: UniProtKB
  4. sodium ion transmembrane transport Source: GOC
  5. sodium ion transport Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Sodium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Sodium transport, Transport

Keywords - Ligandi

Sodium

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium channel protein type 11 subunit alpha
Alternative name(s):
NaN
Sensory neuron sodium channel 2
Sodium channel protein type XI subunit alpha
Voltage-gated sodium channel subunit alpha Nav1.9
Gene namesi
Name:Scn11a
Synonyms:Nan, Nat, Sns2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 9

Organism-specific databases

MGIiMGI:1345149. Scn11a.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei127 – 14822Helical; Name=S1 of repeat I; By similarityAdd
BLAST
Transmembranei160 – 17920Helical; Name=S2 of repeat I; By similarityAdd
BLAST
Transmembranei192 – 21120Helical; Name=S3 of repeat I; By similarityAdd
BLAST
Transmembranei220 – 23920Helical; Voltage-sensor; Name=S4 of repeat I; By similarityAdd
BLAST
Transmembranei256 – 26914Helical; Name=S5 of repeat I; By similarityAdd
BLAST
Transmembranei375 – 40026Helical; Name=S6 of repeat I; By similarityAdd
BLAST
Transmembranei571 – 59424Helical; Name=S1 of repeat II; By similarityAdd
BLAST
Transmembranei606 – 62924Helical; Name=S2 of repeat II; By similarityAdd
BLAST
Transmembranei638 – 65922Helical; Name=S3 of repeat II; By similarityAdd
BLAST
Transmembranei665 – 68420Helical; Voltage-sensor; Name=S4 of repeat II; By similarityAdd
BLAST
Transmembranei700 – 72223Helical; Name=S5 of repeat II; By similarityAdd
BLAST
Transmembranei774 – 79926Helical; Name=S6 of repeat II; By similarityAdd
BLAST
Transmembranei1031 – 105323Helical; Name=S1 of repeat III; By similarityAdd
BLAST
Transmembranei1068 – 109326Helical; Name=S2 of repeat III; By similarityAdd
BLAST
Transmembranei1100 – 111718Helical; Name=S3 of repeat III; By similarityAdd
BLAST
Transmembranei1119 – 114022Helical; Voltage-sensor; Name=S4 of repeat III; By similarityAdd
BLAST
Transmembranei1160 – 118122Helical; Name=S5 of repeat III; By similarityAdd
BLAST
Transmembranei1263 – 128927Helical; Name=S6 of repeat III; By similarityAdd
BLAST
Transmembranei1343 – 136624Helical; Name=S1 of repeat IV; By similarityAdd
BLAST
Transmembranei1378 – 140124Helical; Name=S2 of repeat IV; By similarityAdd
BLAST
Transmembranei1408 – 143124Helical; Name=S3 of repeat IV; By similarityAdd
BLAST
Transmembranei1441 – 146323Helical; Voltage-sensor; Name=S4 of repeat IV; By similarityAdd
BLAST
Transmembranei1479 – 150123Helical; Name=S5 of repeat IV; By similarityAdd
BLAST
Transmembranei1560 – 158425Helical; Name=S6 of repeat IV; By similarityAdd
BLAST

GO - Cellular componenti

  1. axon Source: MGI
  2. C-fiber Source: MGI
  3. plasma membrane Source: MGI
  4. voltage-gated sodium channel complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 17651765Sodium channel protein type 11 subunit alphaPRO_0000048511Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi149 – 1491N-linked (GlcNAc...) Reviewed prediction
Glycosylationi217 – 2171N-linked (GlcNAc...) Reviewed prediction
Glycosylationi303 – 3031N-linked (GlcNAc...) Reviewed prediction
Glycosylationi327 – 3271N-linked (GlcNAc...) Reviewed prediction
Glycosylationi336 – 3361N-linked (GlcNAc...) Reviewed prediction
Glycosylationi662 – 6621N-linked (GlcNAc...) Reviewed prediction
Glycosylationi725 – 7251N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1188 – 11881N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1197 – 11971N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1203 – 12031N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1211 – 12111N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1676 – 16761N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9R053.
PRIDEiQ9R053.

PTM databases

PhosphoSiteiQ9R053.

Expressioni

Tissue specificityi

Expressed in the dorsal root ganglia (C-fiber neurons), spinal cord, trigeminal ganglia, testis, ovary, uterus and small intestine.1 Publication

Developmental stagei

Expressed in embryo at 15 dpc onwards.1 Publication

Gene expression databases

BgeeiQ9R053.
CleanExiMM_SCN11A.
GenevestigatoriQ9R053.

Interactioni

Subunit structurei

The voltage-resistant sodium channel consists of an ion conducting pore forming alpha-subunit regulated by one or more auxiliary subunits SCN1B, SCN2B and SCN3B.

Protein-protein interaction databases

BioGridi204861. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ9R053.
SMRiQ9R053. Positions 1585-1728.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati126 – 401276IAdd
BLAST
Repeati570 – 800231IIAdd
BLAST
Repeati1030 – 1290261IIIAdd
BLAST
Repeati1342 – 1585244IVAdd
BLAST

Domaini

The sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1,S2,S3,S5,S6) and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position.

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1226.
GeneTreeiENSGT00750000117555.
HOGENOMiHOG000231755.
HOVERGENiHBG053100.
InParanoidiQ9R053.
KOiK04843.
OMAiLENFNTA.
OrthoDBiEOG7DJSK9.
TreeFamiTF323985.

Family and domain databases

Gene3Di1.20.120.350. 4 hits.
InterProiIPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR028821. Na_channel_a11su.
IPR001696. Na_channel_asu.
IPR010526. Na_trans_assoc.
[Graphical view]
PANTHERiPTHR10037:SF22. PTHR10037:SF22. 1 hit.
PfamiPF00520. Ion_trans. 4 hits.
PF06512. Na_trans_assoc. 1 hit.
[Graphical view]
PRINTSiPR00170. NACHANNEL.

Sequencei

Sequence statusi: Complete.

Q9R053-1 [UniParc]FASTAAdd to Basket

« Hide

MEERYYPVIF PDERNFRPFT FDSLAAIEKR ITIQKEKKKS KDKAATEPQP     50
RPQLDLKASR KLPKLYGDVP PDLIAKPLED LDPFYKDHKT FMVLNKKRTI 100
YRFSAKRALF ILGPFNPIRS FMIRISVHSV FSMFIICTVI INCMFMANNS 150
SVDSRPSSNI PEYVFIGIYV LEAVIKILAR GFIVDEFSYL RDPWNWLDFI 200
VIGTAIAPCF LGNKVNNLST LRTFRVLRAL KAISVISGLK VIVGALLRSV 250
KKLVDVMVLT LFCLSIFALV GQQLFMGILS QKCIKDDCGP NAFSNKDCFV 300
KENDSEDFIM CGNWLGRRSC PDGSTCNKTT FNPDYNYTNF DSFGWSFLAM 350
FRVMTQDSWE KLYRQILRTS GIYFVFFFVV VIFLGSFYLL NLTLAVVTMA 400
YEEQNRNVAA ETEAKEKMFQ EAQQLLREEK EALVAMGIDR TSLNSLQASS 450
FSPKKRKFFG SKTRKSFFMR GSKTARASAS DSEDDASKNP QLLEQTKRLS 500
QNLPVELFDE HVDPLHRQRA LSAVSILTIT MQEQEKSQEP CFPCGKNLAS 550
KYLVWECSPP WLCIKKVLQT IMTDPFTELA ITICIIVNTV FLAMEHHNMD 600
NSLKDILKIG NWVFTGIFIA EMCLKIIALD PYHYFRHGWN IFDSIVALVS 650
LADVLFHKLS KNLSFLASLR VLRVFKLAKS WPTLNTLIKI IGHSVGALGN 700
LTVVLTIVVF IFSVVGMRLF GAKFNKTCST SPESLRRWHM GDFYHSFLVV 750
FRILCGEWIE NMWECMQEME GSPLCVIVFV LIMVVGKLVV LNLFIALLLN 800
SFSNEEKDGN PEGETRKTKV QLALDRFSRA FYFMARALQN FCCKRCRRQN 850
SPKPNEATES FAGESRDTAT LDTRSWKEYD SEMTLYTGQA GAPLAPLAKE 900
EDDMECCGEC DASPTSQPSE EAQACDLPLK TKRLPSPDDH GVEMEVFSEE 950
DPNLTIQSAR KKSDAASMLS ECSTIDLNDI FRNLQKTVSP QKQPDRCFPK 1000
GLSCIFLCCK TIKKKSPWVL WWNLRKTCYQ IVKHSWFESF IIFVILLSSG 1050
ALIFEDVNLP SRPQVEKLLK CTDNIFTFIF LLEMILKWVA FGFRKYFTSA 1100
WCWLDFLIVV VSGLSLTNLP NLKSFRNLRA LRPLRALSQF EGMKVVVNAL 1150
MSAIPAILNV LLVCLIFWLI FCILGVNFFS GKFGRCINGT DINKYFNASN 1200
VPNQSQCLVS NYTWKVPNVN FDNVGNAYLA LLQVATYKGW LDIMNAAVDS 1250
RGKDEQPAFE ANLYAYLYFV VFIIFGSFFT LNLFIGVIID NFNQQQKKLG 1300
GQDIFMTEEQ KKYYNAMKKL GTKKPQKPIP RPLNKCQAFV FDLVTSQVFD 1350
VIILGLIVTN MIIMMAESEG QPNEVKKIFD ILNIVFVVIF TVECLIKVFA 1400
LRQHYFTNGW NLFDCVVVVL SIISTLVSGL ENSNVFPPTL FRIVRLARIG 1450
RILRLVRAAR GIRTLLFALM MSLPSLFNIG LLLFLVMFIY AIFGMNWFSK 1500
VKRGSGIDDI FNFDTFSGSM LCLFQITTSA GWDALLNPML ESKASCNSSS 1550
QESCQQPQIA IVYFVSYIII SFLIVVNMYI AVILENFNTA TEESEDPLGE 1600
DDFEIFYEIW EKFDPEATQF IQYSSLSDFA DALPEPLRVA KPNRFQFLMM 1650
DLPMVMGDRL HCMDVLFAFT TRVLGNSSGL DTMKAMMEEK FMEANPFKKL 1700
YEPIVTTTKR KEEEECAAVI QRAYRRHMEK MIKLKLKGRS SSSLQVFCNG 1750
DLSSLDVPKI KVHCD 1765
Length:1,765
Mass (Da):201,385
Last modified:July 27, 2011 - v2
Checksum:i0A17EA3B9D86FB9C
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti400 – 4001A → G in BAA92154. 1 Publication
Sequence conflicti427 – 4271R → K in BAA92154. 1 Publication
Sequence conflicti489 – 4891N → K in BAA92154. 1 Publication
Sequence conflicti738 – 7381W → R in BAA92154. 1 Publication
Sequence conflicti761 – 7611N → T in BAA92154. 1 Publication
Sequence conflicti764 – 7641E → D in BAA92154. 1 Publication
Sequence conflicti843 – 8431C → R in BAA92154. 1 Publication
Sequence conflicti1023 – 10242NL → IF in BAA92154. 1 Publication
Sequence conflicti1054 – 10541F → L in BAA92154. 1 Publication
Sequence conflicti1113 – 11131G → V in AAD53403. 1 Publication
Sequence conflicti1113 – 11131G → V in BAA92154. 1 Publication
Sequence conflicti1212 – 12121Y → H in BAA92154. 1 Publication
Sequence conflicti1376 – 13761K → Q in BAA92154. 1 Publication
Sequence conflicti1496 – 14961N → S in BAA92154. 1 Publication
Sequence conflicti1572 – 15721F → L in BAA92154. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF118044 mRNA. Translation: AAD53403.1.
AB031389 mRNA. Translation: BAA92154.1.
AC124662 Genomic DNA. No translation available.
AC162937 Genomic DNA. No translation available.
CCDSiCCDS40804.1.
RefSeqiNP_036017.3. NM_011887.3.
UniGeneiMm.469833.
Mm.89981.

Genome annotation databases

EnsembliENSMUST00000070617; ENSMUSP00000065466; ENSMUSG00000034115.
GeneIDi24046.
KEGGimmu:24046.
UCSCiuc009sbk.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF118044 mRNA. Translation: AAD53403.1 .
AB031389 mRNA. Translation: BAA92154.1 .
AC124662 Genomic DNA. No translation available.
AC162937 Genomic DNA. No translation available.
CCDSi CCDS40804.1.
RefSeqi NP_036017.3. NM_011887.3.
UniGenei Mm.469833.
Mm.89981.

3D structure databases

ProteinModelPortali Q9R053.
SMRi Q9R053. Positions 1585-1728.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 204861. 1 interaction.

PTM databases

PhosphoSitei Q9R053.

Proteomic databases

PaxDbi Q9R053.
PRIDEi Q9R053.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000070617 ; ENSMUSP00000065466 ; ENSMUSG00000034115 .
GeneIDi 24046.
KEGGi mmu:24046.
UCSCi uc009sbk.1. mouse.

Organism-specific databases

CTDi 11280.
MGIi MGI:1345149. Scn11a.

Phylogenomic databases

eggNOGi COG1226.
GeneTreei ENSGT00750000117555.
HOGENOMi HOG000231755.
HOVERGENi HBG053100.
InParanoidi Q9R053.
KOi K04843.
OMAi LENFNTA.
OrthoDBi EOG7DJSK9.
TreeFami TF323985.

Miscellaneous databases

ChiTaRSi SCN11A. mouse.
NextBioi 303975.
PROi Q9R053.
SOURCEi Search...

Gene expression databases

Bgeei Q9R053.
CleanExi MM_SCN11A.
Genevestigatori Q9R053.

Family and domain databases

Gene3Di 1.20.120.350. 4 hits.
InterProi IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR028821. Na_channel_a11su.
IPR001696. Na_channel_asu.
IPR010526. Na_trans_assoc.
[Graphical view ]
PANTHERi PTHR10037:SF22. PTHR10037:SF22. 1 hit.
Pfami PF00520. Ion_trans. 4 hits.
PF06512. Na_trans_assoc. 1 hit.
[Graphical view ]
PRINTSi PR00170. NACHANNEL.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Coding sequence, genomic organization, and conserved chromosomal localization of the mouse gene Scn11a encoding the sodium channel NaN."
    Dib-Hajj S.D., Tyrrell L., Escayg A., Wood P.M., Meisler M.H., Waxman S.G.
    Genomics 59:309-318(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: ICR.
    Tissue: Trigeminal ganglion.
  2. "Cloning and expression study of the mouse tetrodotoxin-resistant voltage-gated sodium channel alpha subunit NaT/Scn11a."
    Ogata K., Jeong S.-Y., Murakami H., Hashida H., Suzuki T., Masuda N., Hirai M., Isahara K., Uchiyama Y., Goto J., Kanazawa I.
    Biochem. Biophys. Res. Commun. 267:271-277(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    Tissue: Testis.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. "Patterned electrical activity modulates sodium channel expression in sensory neurons."
    Klein J.P., Tendi E.A., Dib-Hajj S.D., Fields R.D., Waxman S.G.
    J. Neurosci. Res. 74:192-198(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  5. "Na+ channel Nav1.9: in search of a gating mechanism."
    Delmas P., Coste B.
    Trends Neurosci. 26:55-57(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.

Entry informationi

Entry nameiSCNBA_MOUSE
AccessioniPrimary (citable) accession number: Q9R053
Secondary accession number(s): E9QM88, Q9JMD4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi