ID   ANGL2_MOUSE             Reviewed;         493 AA.
AC   Q9R045; Q8BM09;
DT   27-APR-2001, integrated into UniProtKB/Swiss-Prot.
DT   27-JUL-2011, sequence version 2.
DT   24-JAN-2024, entry version 152.
DE   RecName: Full=Angiopoietin-related protein 2;
DE   AltName: Full=Angiopoietin-like protein 2;
DE   Flags: Precursor;
GN   Name=Angptl2; Synonyms=Arp2;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Heart;
RX   PubMed=10473614; DOI=10.1074/jbc.274.37.26523;
RA   Kim I., Moon S.-O., Koh K.N., Kim H., Uhm C.-S., Kwak H.J., Kim N.-G.,
RA   Koh G.Y.;
RT   "Molecular cloning, expression, and characterization of angiopoietin-
RT   related protein. angiopoietin-related protein induces endothelial cell
RT   sprouting.";
RL   J. Biol. Chem. 274:26523-26528(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J, and NOD; TISSUE=Thymus;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Induces sprouting in endothelial cells through an autocrine
CC       and paracrine action. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Widely expressed in heart, tongue, lung and
CC       skeletal muscle. Also found in lower levels in kidney, epididymis and
CC       testis.
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DR   EMBL; AF125176; AAD55358.1; -; mRNA.
DR   EMBL; AK037265; BAC29780.1; -; mRNA.
DR   EMBL; AK155464; BAE33276.1; -; mRNA.
DR   EMBL; AL845277; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH466542; EDL08597.1; -; Genomic_DNA.
DR   EMBL; BC138609; AAI38610.1; -; mRNA.
DR   EMBL; BC138610; AAI38611.1; -; mRNA.
DR   CCDS; CCDS15940.1; -.
DR   RefSeq; NP_036053.2; NM_011923.4.
DR   RefSeq; XP_006498114.1; XM_006498051.1.
DR   AlphaFoldDB; Q9R045; -.
DR   SMR; Q9R045; -.
DR   BioGRID; 204920; 3.
DR   STRING; 10090.ENSMUSP00000004208; -.
DR   GlyCosmos; Q9R045; 2 sites, No reported glycans.
DR   GlyGen; Q9R045; 2 sites.
DR   iPTMnet; Q9R045; -.
DR   PhosphoSitePlus; Q9R045; -.
DR   MaxQB; Q9R045; -.
DR   PaxDb; 10090-ENSMUSP00000004208; -.
DR   PeptideAtlas; Q9R045; -.
DR   ProteomicsDB; 282104; -.
DR   Pumba; Q9R045; -.
DR   Antibodypedia; 30639; 326 antibodies from 31 providers.
DR   DNASU; 26360; -.
DR   Ensembl; ENSMUST00000004208.7; ENSMUSP00000004208.6; ENSMUSG00000004105.9.
DR   GeneID; 26360; -.
DR   KEGG; mmu:26360; -.
DR   UCSC; uc008jhq.1; mouse.
DR   AGR; MGI:1347002; -.
DR   CTD; 23452; -.
DR   MGI; MGI:1347002; Angptl2.
DR   VEuPathDB; HostDB:ENSMUSG00000004105; -.
DR   eggNOG; KOG2579; Eukaryota.
DR   GeneTree; ENSGT00940000155946; -.
DR   HOGENOM; CLU_038628_0_0_1; -.
DR   InParanoid; Q9R045; -.
DR   OMA; CVTYWWL; -.
DR   OrthoDB; 3134470at2759; -.
DR   PhylomeDB; Q9R045; -.
DR   TreeFam; TF336658; -.
DR   BioGRID-ORCS; 26360; 2 hits in 78 CRISPR screens.
DR   PRO; PR:Q9R045; -.
DR   Proteomes; UP000000589; Chromosome 2.
DR   RNAct; Q9R045; Protein.
DR   Bgee; ENSMUSG00000004105; Expressed in tarsal region and 233 other cell types or tissues.
DR   ExpressionAtlas; Q9R045; baseline and differential.
DR   GO; GO:0062023; C:collagen-containing extracellular matrix; IBA:GO_Central.
DR   GO; GO:0005615; C:extracellular space; HDA:BHF-UCL.
DR   GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central.
DR   CDD; cd00087; FReD; 1.
DR   Gene3D; 3.90.215.10; Gamma Fibrinogen, chain A, domain 1; 1.
DR   InterPro; IPR036056; Fibrinogen-like_C.
DR   InterPro; IPR014716; Fibrinogen_a/b/g_C_1.
DR   InterPro; IPR002181; Fibrinogen_a/b/g_C_dom.
DR   InterPro; IPR020837; Fibrinogen_CS.
DR   NCBIfam; NF040941; GGGWT_bact; 1.
DR   PANTHER; PTHR19143:SF24; ANGIOPOIETIN-RELATED PROTEIN 2; 1.
DR   PANTHER; PTHR19143; FIBRINOGEN/TENASCIN/ANGIOPOEITIN; 1.
DR   Pfam; PF00147; Fibrinogen_C; 1.
DR   SMART; SM00186; FBG; 1.
DR   SUPFAM; SSF56496; Fibrinogen C-terminal domain-like; 1.
DR   PROSITE; PS00514; FIBRINOGEN_C_1; 1.
DR   PROSITE; PS51406; FIBRINOGEN_C_2; 1.
DR   Genevisible; Q9R045; MM.
PE   2: Evidence at transcript level;
KW   Coiled coil; Disulfide bond; Glycoprotein; Reference proteome; Secreted;
KW   Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..493
FT                   /note="Angiopoietin-related protein 2"
FT                   /id="PRO_0000009121"
FT   DOMAIN          269..489
FT                   /note="Fibrinogen C-terminal"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00739"
FT   COILED          77..115
FT                   /evidence="ECO:0000255"
FT   COILED          152..202
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        164
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        192
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        278..307
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00739"
FT   DISULFID        430..443
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00739"
FT   CONFLICT        490..491
FT                   /note="NT -> DI (in Ref. 1; AAD55358)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   493 AA;  57105 MW;  22884B4010746BF2 CRC64;
     MRPLCMTYWW LGLLATVGAA TGPEADVEGT EDGSQREYIY LNRYKRAGES PDKCTYTFIV
     PQQRVTGAIC VNSKEPEVHL ENRVHKQELE LLNNELLKQK RQIETLQQLV EVDGGIVSEV
     KLLRKESRNM NSRVTQLYMQ LLHEIIRKRD NALELSQLEN RILNQTADML QLASKYKDLE
     HKFQHLAMLA HNQSEVIAQL EEHCQRVPAA RPMPQPPPAA PPRVYQPPTY NRIINQISTN
     EIQSDQNLKV LPPSLPTMPA LTSLPSSTDK PSGPWRDCLQ ALEDGHSTSS IYLVKPENTN
     RLMQVWCDQR HDPGGWTVIQ RRLDGSVNFF RNWETYKQGF GNIDGEYWLG LENIYWLTNQ
     GNYKLLVTME DWSGRKVFAE YASFRLEPES EYYKLRLGRY HGNAGDSFTW HNGKQFTTLD
     RDHDVYTGNC AHYQKGGWWY NACAHSNLNG VWYRGGHYRS RYQDGVYWAE FRGGSYSLKK
     VVMMIRPNPN TFH
//