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Q9R045

- ANGL2_MOUSE

UniProt

Q9R045 - ANGL2_MOUSE

Protein

Angiopoietin-related protein 2

Gene

Angptl2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Induces sprouting in endothelial cells through an autocrine and paracrine action.By similarity

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Angiopoietin-related protein 2
    Alternative name(s):
    Angiopoietin-like protein 2
    Gene namesi
    Name:Angptl2
    Synonyms:Arp2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:1347002. Angptl2.

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Sequence AnalysisAdd
    BLAST
    Chaini20 – 493474Angiopoietin-related protein 2PRO_0000009121Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi164 – 1641N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi192 – 1921N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi278 ↔ 307PROSITE-ProRule annotation
    Disulfide bondi430 ↔ 443PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ9R045.
    PRIDEiQ9R045.

    PTM databases

    PhosphoSiteiQ9R045.

    Expressioni

    Tissue specificityi

    Widely expressed in heart, tongue, lung and skeletal muscle. Also found in lower levels in kidney, epididymis and testis.

    Gene expression databases

    BgeeiQ9R045.
    CleanExiMM_ANGPTL2.
    GenevestigatoriQ9R045.

    Interactioni

    Protein-protein interaction databases

    BioGridi204920. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9R045.
    SMRiQ9R045. Positions 248-487.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini269 – 489221Fibrinogen C-terminalPROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili77 – 11539Sequence AnalysisAdd
    BLAST
    Coiled coili152 – 20251Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Contains 1 fibrinogen C-terminal domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil, Signal

    Phylogenomic databases

    eggNOGiNOG251988.
    GeneTreeiENSGT00740000114872.
    HOGENOMiHOG000037129.
    HOVERGENiHBG103336.
    InParanoidiQ8BM09.
    OMAiEEHCQRV.
    OrthoDBiEOG7X9G60.
    TreeFamiTF336658.

    Family and domain databases

    Gene3Di3.90.215.10. 1 hit.
    4.10.530.10. 1 hit.
    InterProiIPR014716. Fibrinogen_a/b/g_C_1.
    IPR014715. Fibrinogen_a/b/g_C_2.
    IPR002181. Fibrinogen_a/b/g_C_dom.
    IPR020837. Fibrinogen_CS.
    [Graphical view]
    PfamiPF00147. Fibrinogen_C. 1 hit.
    [Graphical view]
    SMARTiSM00186. FBG. 1 hit.
    [Graphical view]
    SUPFAMiSSF56496. SSF56496. 1 hit.
    PROSITEiPS00514. FIBRINOGEN_C_1. 1 hit.
    PS51406. FIBRINOGEN_C_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9R045-1 [UniParc]FASTAAdd to Basket

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    MRPLCMTYWW LGLLATVGAA TGPEADVEGT EDGSQREYIY LNRYKRAGES    50
    PDKCTYTFIV PQQRVTGAIC VNSKEPEVHL ENRVHKQELE LLNNELLKQK 100
    RQIETLQQLV EVDGGIVSEV KLLRKESRNM NSRVTQLYMQ LLHEIIRKRD 150
    NALELSQLEN RILNQTADML QLASKYKDLE HKFQHLAMLA HNQSEVIAQL 200
    EEHCQRVPAA RPMPQPPPAA PPRVYQPPTY NRIINQISTN EIQSDQNLKV 250
    LPPSLPTMPA LTSLPSSTDK PSGPWRDCLQ ALEDGHSTSS IYLVKPENTN 300
    RLMQVWCDQR HDPGGWTVIQ RRLDGSVNFF RNWETYKQGF GNIDGEYWLG 350
    LENIYWLTNQ GNYKLLVTME DWSGRKVFAE YASFRLEPES EYYKLRLGRY 400
    HGNAGDSFTW HNGKQFTTLD RDHDVYTGNC AHYQKGGWWY NACAHSNLNG 450
    VWYRGGHYRS RYQDGVYWAE FRGGSYSLKK VVMMIRPNPN TFH 493
    Length:493
    Mass (Da):57,105
    Last modified:July 27, 2011 - v2
    Checksum:i22884B4010746BF2
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti490 – 4912NT → DI in AAD55358. (PubMed:10473614)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF125176 mRNA. Translation: AAD55358.1.
    AK037265 mRNA. Translation: BAC29780.1.
    AK155464 mRNA. Translation: BAE33276.1.
    AL845277 Genomic DNA. Translation: CAM22212.1.
    CH466542 Genomic DNA. Translation: EDL08597.1.
    BC138609 mRNA. Translation: AAI38610.1.
    BC138610 mRNA. Translation: AAI38611.1.
    CCDSiCCDS15940.1.
    RefSeqiNP_036053.2. NM_011923.4.
    XP_006498114.1. XM_006498051.1.
    UniGeneiMm.208919.

    Genome annotation databases

    EnsembliENSMUST00000004208; ENSMUSP00000004208; ENSMUSG00000004105.
    GeneIDi26360.
    KEGGimmu:26360.
    UCSCiuc008jhq.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF125176 mRNA. Translation: AAD55358.1 .
    AK037265 mRNA. Translation: BAC29780.1 .
    AK155464 mRNA. Translation: BAE33276.1 .
    AL845277 Genomic DNA. Translation: CAM22212.1 .
    CH466542 Genomic DNA. Translation: EDL08597.1 .
    BC138609 mRNA. Translation: AAI38610.1 .
    BC138610 mRNA. Translation: AAI38611.1 .
    CCDSi CCDS15940.1.
    RefSeqi NP_036053.2. NM_011923.4.
    XP_006498114.1. XM_006498051.1.
    UniGenei Mm.208919.

    3D structure databases

    ProteinModelPortali Q9R045.
    SMRi Q9R045. Positions 248-487.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 204920. 1 interaction.

    PTM databases

    PhosphoSitei Q9R045.

    Proteomic databases

    PaxDbi Q9R045.
    PRIDEi Q9R045.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000004208 ; ENSMUSP00000004208 ; ENSMUSG00000004105 .
    GeneIDi 26360.
    KEGGi mmu:26360.
    UCSCi uc008jhq.1. mouse.

    Organism-specific databases

    CTDi 23452.
    MGIi MGI:1347002. Angptl2.

    Phylogenomic databases

    eggNOGi NOG251988.
    GeneTreei ENSGT00740000114872.
    HOGENOMi HOG000037129.
    HOVERGENi HBG103336.
    InParanoidi Q8BM09.
    OMAi EEHCQRV.
    OrthoDBi EOG7X9G60.
    TreeFami TF336658.

    Miscellaneous databases

    NextBioi 304215.
    PROi Q9R045.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9R045.
    CleanExi MM_ANGPTL2.
    Genevestigatori Q9R045.

    Family and domain databases

    Gene3Di 3.90.215.10. 1 hit.
    4.10.530.10. 1 hit.
    InterProi IPR014716. Fibrinogen_a/b/g_C_1.
    IPR014715. Fibrinogen_a/b/g_C_2.
    IPR002181. Fibrinogen_a/b/g_C_dom.
    IPR020837. Fibrinogen_CS.
    [Graphical view ]
    Pfami PF00147. Fibrinogen_C. 1 hit.
    [Graphical view ]
    SMARTi SM00186. FBG. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56496. SSF56496. 1 hit.
    PROSITEi PS00514. FIBRINOGEN_C_1. 1 hit.
    PS51406. FIBRINOGEN_C_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning, expression, and characterization of angiopoietin-related protein. angiopoietin-related protein induces endothelial cell sprouting."
      Kim I., Moon S.-O., Koh K.N., Kim H., Uhm C.-S., Kwak H.J., Kim N.-G., Koh G.Y.
      J. Biol. Chem. 274:26523-26528(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Heart.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J and NOD.
      Tissue: Thymus.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiANGL2_MOUSE
    AccessioniPrimary (citable) accession number: Q9R045
    Secondary accession number(s): Q8BM09
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 27, 2001
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 102 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3