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Protein

Angiopoietin-related protein 2

Gene

Angptl2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Induces sprouting in endothelial cells through an autocrine and paracrine action.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Angiopoietin-related protein 2
Alternative name(s):
Angiopoietin-like protein 2
Gene namesi
Name:Angptl2
Synonyms:Arp2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:1347002. Angptl2.

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular vesicular exosome Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence AnalysisAdd
BLAST
Chaini20 – 493474Angiopoietin-related protein 2PRO_0000009121Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi164 – 1641N-linked (GlcNAc...)Sequence Analysis
Glycosylationi192 – 1921N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi278 ↔ 307PROSITE-ProRule annotation
Disulfide bondi430 ↔ 443PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ9R045.
PaxDbiQ9R045.
PRIDEiQ9R045.

PTM databases

PhosphoSiteiQ9R045.

Expressioni

Tissue specificityi

Widely expressed in heart, tongue, lung and skeletal muscle. Also found in lower levels in kidney, epididymis and testis.

Gene expression databases

BgeeiQ9R045.
CleanExiMM_ANGPTL2.
GenevestigatoriQ9R045.

Interactioni

Protein-protein interaction databases

BioGridi204920. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ9R045.
SMRiQ9R045. Positions 276-487.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini269 – 489221Fibrinogen C-terminalPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili77 – 11539Sequence AnalysisAdd
BLAST
Coiled coili152 – 20251Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Contains 1 fibrinogen C-terminal domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Signal

Phylogenomic databases

eggNOGiNOG251988.
GeneTreeiENSGT00760000118809.
HOGENOMiHOG000037129.
HOVERGENiHBG103336.
InParanoidiQ9R045.
OMAiEEHCQRV.
OrthoDBiEOG7X9G60.
TreeFamiTF336658.

Family and domain databases

Gene3Di3.90.215.10. 1 hit.
4.10.530.10. 1 hit.
InterProiIPR014716. Fibrinogen_a/b/g_C_1.
IPR014715. Fibrinogen_a/b/g_C_2.
IPR002181. Fibrinogen_a/b/g_C_dom.
IPR020837. Fibrinogen_CS.
[Graphical view]
PfamiPF00147. Fibrinogen_C. 1 hit.
[Graphical view]
SMARTiSM00186. FBG. 1 hit.
[Graphical view]
SUPFAMiSSF56496. SSF56496. 1 hit.
PROSITEiPS00514. FIBRINOGEN_C_1. 1 hit.
PS51406. FIBRINOGEN_C_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9R045-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRPLCMTYWW LGLLATVGAA TGPEADVEGT EDGSQREYIY LNRYKRAGES
60 70 80 90 100
PDKCTYTFIV PQQRVTGAIC VNSKEPEVHL ENRVHKQELE LLNNELLKQK
110 120 130 140 150
RQIETLQQLV EVDGGIVSEV KLLRKESRNM NSRVTQLYMQ LLHEIIRKRD
160 170 180 190 200
NALELSQLEN RILNQTADML QLASKYKDLE HKFQHLAMLA HNQSEVIAQL
210 220 230 240 250
EEHCQRVPAA RPMPQPPPAA PPRVYQPPTY NRIINQISTN EIQSDQNLKV
260 270 280 290 300
LPPSLPTMPA LTSLPSSTDK PSGPWRDCLQ ALEDGHSTSS IYLVKPENTN
310 320 330 340 350
RLMQVWCDQR HDPGGWTVIQ RRLDGSVNFF RNWETYKQGF GNIDGEYWLG
360 370 380 390 400
LENIYWLTNQ GNYKLLVTME DWSGRKVFAE YASFRLEPES EYYKLRLGRY
410 420 430 440 450
HGNAGDSFTW HNGKQFTTLD RDHDVYTGNC AHYQKGGWWY NACAHSNLNG
460 470 480 490
VWYRGGHYRS RYQDGVYWAE FRGGSYSLKK VVMMIRPNPN TFH
Length:493
Mass (Da):57,105
Last modified:July 27, 2011 - v2
Checksum:i22884B4010746BF2
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti490 – 4912NT → DI in AAD55358. (PubMed:10473614)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF125176 mRNA. Translation: AAD55358.1.
AK037265 mRNA. Translation: BAC29780.1.
AK155464 mRNA. Translation: BAE33276.1.
AL845277 Genomic DNA. Translation: CAM22212.1.
CH466542 Genomic DNA. Translation: EDL08597.1.
BC138609 mRNA. Translation: AAI38610.1.
BC138610 mRNA. Translation: AAI38611.1.
CCDSiCCDS15940.1.
RefSeqiNP_036053.2. NM_011923.4.
XP_006498114.1. XM_006498051.1.
UniGeneiMm.208919.

Genome annotation databases

EnsembliENSMUST00000004208; ENSMUSP00000004208; ENSMUSG00000004105.
GeneIDi26360.
KEGGimmu:26360.
UCSCiuc008jhq.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF125176 mRNA. Translation: AAD55358.1.
AK037265 mRNA. Translation: BAC29780.1.
AK155464 mRNA. Translation: BAE33276.1.
AL845277 Genomic DNA. Translation: CAM22212.1.
CH466542 Genomic DNA. Translation: EDL08597.1.
BC138609 mRNA. Translation: AAI38610.1.
BC138610 mRNA. Translation: AAI38611.1.
CCDSiCCDS15940.1.
RefSeqiNP_036053.2. NM_011923.4.
XP_006498114.1. XM_006498051.1.
UniGeneiMm.208919.

3D structure databases

ProteinModelPortaliQ9R045.
SMRiQ9R045. Positions 276-487.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204920. 1 interaction.

PTM databases

PhosphoSiteiQ9R045.

Proteomic databases

MaxQBiQ9R045.
PaxDbiQ9R045.
PRIDEiQ9R045.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000004208; ENSMUSP00000004208; ENSMUSG00000004105.
GeneIDi26360.
KEGGimmu:26360.
UCSCiuc008jhq.1. mouse.

Organism-specific databases

CTDi23452.
MGIiMGI:1347002. Angptl2.

Phylogenomic databases

eggNOGiNOG251988.
GeneTreeiENSGT00760000118809.
HOGENOMiHOG000037129.
HOVERGENiHBG103336.
InParanoidiQ9R045.
OMAiEEHCQRV.
OrthoDBiEOG7X9G60.
TreeFamiTF336658.

Miscellaneous databases

NextBioi304215.
PROiQ9R045.
SOURCEiSearch...

Gene expression databases

BgeeiQ9R045.
CleanExiMM_ANGPTL2.
GenevestigatoriQ9R045.

Family and domain databases

Gene3Di3.90.215.10. 1 hit.
4.10.530.10. 1 hit.
InterProiIPR014716. Fibrinogen_a/b/g_C_1.
IPR014715. Fibrinogen_a/b/g_C_2.
IPR002181. Fibrinogen_a/b/g_C_dom.
IPR020837. Fibrinogen_CS.
[Graphical view]
PfamiPF00147. Fibrinogen_C. 1 hit.
[Graphical view]
SMARTiSM00186. FBG. 1 hit.
[Graphical view]
SUPFAMiSSF56496. SSF56496. 1 hit.
PROSITEiPS00514. FIBRINOGEN_C_1. 1 hit.
PS51406. FIBRINOGEN_C_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning, expression, and characterization of angiopoietin-related protein. angiopoietin-related protein induces endothelial cell sprouting."
    Kim I., Moon S.-O., Koh K.N., Kim H., Uhm C.-S., Kwak H.J., Kim N.-G., Koh G.Y.
    J. Biol. Chem. 274:26523-26528(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Heart.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and NOD.
    Tissue: Thymus.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiANGL2_MOUSE
AccessioniPrimary (citable) accession number: Q9R045
Secondary accession number(s): Q8BM09
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: July 27, 2011
Last modified: February 4, 2015
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.