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Q9R045

- ANGL2_MOUSE

UniProt

Q9R045 - ANGL2_MOUSE

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Protein

Angiopoietin-related protein 2

Gene
Angptl2, Arp2
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Induces sprouting in endothelial cells through an autocrine and paracrine action By similarity.

Names & Taxonomyi

Protein namesi
Recommended name:
Angiopoietin-related protein 2
Alternative name(s):
Angiopoietin-like protein 2
Gene namesi
Name:Angptl2
Synonyms:Arp2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:1347002. Angptl2.

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919 Reviewed predictionAdd
BLAST
Chaini20 – 493474Angiopoietin-related protein 2PRO_0000009121Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi164 – 1641N-linked (GlcNAc...) Reviewed prediction
Glycosylationi192 – 1921N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi278 ↔ 307 By similarity
Disulfide bondi430 ↔ 443 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9R045.
PRIDEiQ9R045.

PTM databases

PhosphoSiteiQ9R045.

Expressioni

Tissue specificityi

Widely expressed in heart, tongue, lung and skeletal muscle. Also found in lower levels in kidney, epididymis and testis.

Gene expression databases

BgeeiQ9R045.
CleanExiMM_ANGPTL2.
GenevestigatoriQ9R045.

Interactioni

Protein-protein interaction databases

BioGridi204920. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ9R045.
SMRiQ9R045. Positions 248-487.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini269 – 489221Fibrinogen C-terminalAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili77 – 11539 Reviewed predictionAdd
BLAST
Coiled coili152 – 20251 Reviewed predictionAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Coiled coil, Signal

Phylogenomic databases

eggNOGiNOG251988.
GeneTreeiENSGT00740000114872.
HOGENOMiHOG000037129.
HOVERGENiHBG103336.
InParanoidiQ8BM09.
OMAiEEHCQRV.
OrthoDBiEOG7X9G60.
TreeFamiTF336658.

Family and domain databases

Gene3Di3.90.215.10. 1 hit.
4.10.530.10. 1 hit.
InterProiIPR014716. Fibrinogen_a/b/g_C_1.
IPR014715. Fibrinogen_a/b/g_C_2.
IPR002181. Fibrinogen_a/b/g_C_dom.
IPR020837. Fibrinogen_CS.
[Graphical view]
PfamiPF00147. Fibrinogen_C. 1 hit.
[Graphical view]
SMARTiSM00186. FBG. 1 hit.
[Graphical view]
SUPFAMiSSF56496. SSF56496. 1 hit.
PROSITEiPS00514. FIBRINOGEN_C_1. 1 hit.
PS51406. FIBRINOGEN_C_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9R045-1 [UniParc]FASTAAdd to Basket

« Hide

MRPLCMTYWW LGLLATVGAA TGPEADVEGT EDGSQREYIY LNRYKRAGES    50
PDKCTYTFIV PQQRVTGAIC VNSKEPEVHL ENRVHKQELE LLNNELLKQK 100
RQIETLQQLV EVDGGIVSEV KLLRKESRNM NSRVTQLYMQ LLHEIIRKRD 150
NALELSQLEN RILNQTADML QLASKYKDLE HKFQHLAMLA HNQSEVIAQL 200
EEHCQRVPAA RPMPQPPPAA PPRVYQPPTY NRIINQISTN EIQSDQNLKV 250
LPPSLPTMPA LTSLPSSTDK PSGPWRDCLQ ALEDGHSTSS IYLVKPENTN 300
RLMQVWCDQR HDPGGWTVIQ RRLDGSVNFF RNWETYKQGF GNIDGEYWLG 350
LENIYWLTNQ GNYKLLVTME DWSGRKVFAE YASFRLEPES EYYKLRLGRY 400
HGNAGDSFTW HNGKQFTTLD RDHDVYTGNC AHYQKGGWWY NACAHSNLNG 450
VWYRGGHYRS RYQDGVYWAE FRGGSYSLKK VVMMIRPNPN TFH 493
Length:493
Mass (Da):57,105
Last modified:July 27, 2011 - v2
Checksum:i22884B4010746BF2
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti490 – 4912NT → DI in AAD55358. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF125176 mRNA. Translation: AAD55358.1.
AK037265 mRNA. Translation: BAC29780.1.
AK155464 mRNA. Translation: BAE33276.1.
AL845277 Genomic DNA. Translation: CAM22212.1.
CH466542 Genomic DNA. Translation: EDL08597.1.
BC138609 mRNA. Translation: AAI38610.1.
BC138610 mRNA. Translation: AAI38611.1.
CCDSiCCDS15940.1.
RefSeqiNP_036053.2. NM_011923.4.
XP_006498114.1. XM_006498051.1.
UniGeneiMm.208919.

Genome annotation databases

EnsembliENSMUST00000004208; ENSMUSP00000004208; ENSMUSG00000004105.
GeneIDi26360.
KEGGimmu:26360.
UCSCiuc008jhq.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF125176 mRNA. Translation: AAD55358.1 .
AK037265 mRNA. Translation: BAC29780.1 .
AK155464 mRNA. Translation: BAE33276.1 .
AL845277 Genomic DNA. Translation: CAM22212.1 .
CH466542 Genomic DNA. Translation: EDL08597.1 .
BC138609 mRNA. Translation: AAI38610.1 .
BC138610 mRNA. Translation: AAI38611.1 .
CCDSi CCDS15940.1.
RefSeqi NP_036053.2. NM_011923.4.
XP_006498114.1. XM_006498051.1.
UniGenei Mm.208919.

3D structure databases

ProteinModelPortali Q9R045.
SMRi Q9R045. Positions 248-487.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 204920. 1 interaction.

PTM databases

PhosphoSitei Q9R045.

Proteomic databases

PaxDbi Q9R045.
PRIDEi Q9R045.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000004208 ; ENSMUSP00000004208 ; ENSMUSG00000004105 .
GeneIDi 26360.
KEGGi mmu:26360.
UCSCi uc008jhq.1. mouse.

Organism-specific databases

CTDi 23452.
MGIi MGI:1347002. Angptl2.

Phylogenomic databases

eggNOGi NOG251988.
GeneTreei ENSGT00740000114872.
HOGENOMi HOG000037129.
HOVERGENi HBG103336.
InParanoidi Q8BM09.
OMAi EEHCQRV.
OrthoDBi EOG7X9G60.
TreeFami TF336658.

Miscellaneous databases

NextBioi 304215.
PROi Q9R045.
SOURCEi Search...

Gene expression databases

Bgeei Q9R045.
CleanExi MM_ANGPTL2.
Genevestigatori Q9R045.

Family and domain databases

Gene3Di 3.90.215.10. 1 hit.
4.10.530.10. 1 hit.
InterProi IPR014716. Fibrinogen_a/b/g_C_1.
IPR014715. Fibrinogen_a/b/g_C_2.
IPR002181. Fibrinogen_a/b/g_C_dom.
IPR020837. Fibrinogen_CS.
[Graphical view ]
Pfami PF00147. Fibrinogen_C. 1 hit.
[Graphical view ]
SMARTi SM00186. FBG. 1 hit.
[Graphical view ]
SUPFAMi SSF56496. SSF56496. 1 hit.
PROSITEi PS00514. FIBRINOGEN_C_1. 1 hit.
PS51406. FIBRINOGEN_C_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning, expression, and characterization of angiopoietin-related protein. angiopoietin-related protein induces endothelial cell sprouting."
    Kim I., Moon S.-O., Koh K.N., Kim H., Uhm C.-S., Kwak H.J., Kim N.-G., Koh G.Y.
    J. Biol. Chem. 274:26523-26528(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Heart.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and NOD.
    Tissue: Thymus.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiANGL2_MOUSE
AccessioniPrimary (citable) accession number: Q9R045
Secondary accession number(s): Q8BM09
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi