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Protein

Angiopoietin-related protein 2

Gene

Angptl2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Induces sprouting in endothelial cells through an autocrine and paracrine action.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Angiopoietin-related protein 2
Alternative name(s):
Angiopoietin-like protein 2
Gene namesi
Name:Angptl2
Synonyms:Arp2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1347002 Angptl2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000000912120 – 493Angiopoietin-related protein 2Add BLAST474

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi164N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi192N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi278 ↔ 307PROSITE-ProRule annotation
Disulfide bondi430 ↔ 443PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ9R045
PaxDbiQ9R045
PeptideAtlasiQ9R045
PRIDEiQ9R045

PTM databases

iPTMnetiQ9R045
PhosphoSitePlusiQ9R045

Expressioni

Tissue specificityi

Widely expressed in heart, tongue, lung and skeletal muscle. Also found in lower levels in kidney, epididymis and testis.

Gene expression databases

BgeeiENSMUSG00000004105
CleanExiMM_ANGPTL2
ExpressionAtlasiQ9R045 baseline and differential
GenevisibleiQ9R045 MM

Interactioni

Protein-protein interaction databases

BioGridi204920, 1 interactor
STRINGi10090.ENSMUSP00000004208

Structurei

3D structure databases

ProteinModelPortaliQ9R045
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini269 – 489Fibrinogen C-terminalPROSITE-ProRule annotationAdd BLAST221

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili77 – 115Sequence analysisAdd BLAST39
Coiled coili152 – 202Sequence analysisAdd BLAST51

Keywords - Domaini

Coiled coil, Signal

Phylogenomic databases

eggNOGiKOG2579 Eukaryota
ENOG410ZYS4 LUCA
GeneTreeiENSGT00760000118809
HOGENOMiHOG000037129
HOVERGENiHBG103336
InParanoidiQ9R045
OMAiTPPRVYQ
OrthoDBiEOG091G03M1
TreeFamiTF336658

Family and domain databases

CDDicd00087 FReD, 1 hit
InterProiView protein in InterPro
IPR036056 Fibrinogen-like_C
IPR002181 Fibrinogen_a/b/g_C_dom
IPR020837 Fibrinogen_CS
PfamiView protein in Pfam
PF00147 Fibrinogen_C, 1 hit
SMARTiView protein in SMART
SM00186 FBG, 1 hit
SUPFAMiSSF56496 SSF56496, 1 hit
PROSITEiView protein in PROSITE
PS00514 FIBRINOGEN_C_1, 1 hit
PS51406 FIBRINOGEN_C_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9R045-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRPLCMTYWW LGLLATVGAA TGPEADVEGT EDGSQREYIY LNRYKRAGES
60 70 80 90 100
PDKCTYTFIV PQQRVTGAIC VNSKEPEVHL ENRVHKQELE LLNNELLKQK
110 120 130 140 150
RQIETLQQLV EVDGGIVSEV KLLRKESRNM NSRVTQLYMQ LLHEIIRKRD
160 170 180 190 200
NALELSQLEN RILNQTADML QLASKYKDLE HKFQHLAMLA HNQSEVIAQL
210 220 230 240 250
EEHCQRVPAA RPMPQPPPAA PPRVYQPPTY NRIINQISTN EIQSDQNLKV
260 270 280 290 300
LPPSLPTMPA LTSLPSSTDK PSGPWRDCLQ ALEDGHSTSS IYLVKPENTN
310 320 330 340 350
RLMQVWCDQR HDPGGWTVIQ RRLDGSVNFF RNWETYKQGF GNIDGEYWLG
360 370 380 390 400
LENIYWLTNQ GNYKLLVTME DWSGRKVFAE YASFRLEPES EYYKLRLGRY
410 420 430 440 450
HGNAGDSFTW HNGKQFTTLD RDHDVYTGNC AHYQKGGWWY NACAHSNLNG
460 470 480 490
VWYRGGHYRS RYQDGVYWAE FRGGSYSLKK VVMMIRPNPN TFH
Length:493
Mass (Da):57,105
Last modified:July 27, 2011 - v2
Checksum:i22884B4010746BF2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti490 – 491NT → DI in AAD55358 (PubMed:10473614).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF125176 mRNA Translation: AAD55358.1
AK037265 mRNA Translation: BAC29780.1
AK155464 mRNA Translation: BAE33276.1
AL845277 Genomic DNA Translation: CAM22212.1
CH466542 Genomic DNA Translation: EDL08597.1
BC138609 mRNA Translation: AAI38610.1
BC138610 mRNA Translation: AAI38611.1
CCDSiCCDS15940.1
RefSeqiNP_036053.2, NM_011923.4
XP_006498114.1, XM_006498051.1
UniGeneiMm.208919

Genome annotation databases

EnsembliENSMUST00000004208; ENSMUSP00000004208; ENSMUSG00000004105
GeneIDi26360
KEGGimmu:26360
UCSCiuc008jhq.1 mouse

Similar proteinsi

Entry informationi

Entry nameiANGL2_MOUSE
AccessioniPrimary (citable) accession number: Q9R045
Secondary accession number(s): Q8BM09
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: July 27, 2011
Last modified: April 25, 2018
This is version 123 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health