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Protein

WD repeat-containing protein 44

Gene

Wdr44

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Downstream effector for RAB11. May be involved in vesicle recycling.1 Publication

GO - Molecular functioni

  • Rab GTPase binding Source: RGD

GO - Biological processi

  • regulation of cell migration Source: RGD
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat-containing protein 44
Alternative name(s):
Rabphilin-11
Gene namesi
Name:Wdr44
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi727965. Wdr44.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: UniProtKB-SubCell
  • endosome membrane Source: UniProtKB-SubCell
  • Golgi apparatus Source: UniProtKB-SubCell
  • microtubule Source: RGD
  • perinuclear region of cytoplasm Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Endosome, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 908908WD repeat-containing protein 44PRO_0000262771Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei17 – 171PhosphoserineBy similarity
Modified residuei40 – 401PhosphoserineCombined sources
Modified residuei61 – 611PhosphoserineBy similarity
Modified residuei71 – 711PhosphoserineBy similarity
Modified residuei86 – 861PhosphoserineBy similarity
Modified residuei116 – 1161PhosphoserineBy similarity
Modified residuei151 – 1511PhosphothreonineBy similarity
Modified residuei211 – 2111PhosphothreonineBy similarity
Modified residuei254 – 2541PhosphoserineBy similarity
Modified residuei263 – 2631PhosphothreonineBy similarity
Modified residuei334 – 3341PhosphoserineBy similarity
Modified residuei336 – 3361PhosphoserineBy similarity
Modified residuei341 – 3411PhosphothreonineBy similarity
Modified residuei396 – 3961PhosphothreonineCombined sources
Modified residuei398 – 3981PhosphoserineCombined sources
Modified residuei465 – 4651PhosphoserineCombined sources
Modified residuei466 – 4661PhosphoserineCombined sources
Modified residuei467 – 4671PhosphoserineCombined sources
Modified residuei474 – 4741PhosphotyrosineBy similarity
Modified residuei556 – 5561PhosphoserineCombined sources
Modified residuei560 – 5601PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9R037.
PRIDEiQ9R037.

PTM databases

iPTMnetiQ9R037.
PhosphoSiteiQ9R037.

Expressioni

Tissue specificityi

Expressed in heart; brain; spleen; lung; liver; muscle and kidney.1 Publication

Interactioni

Subunit structurei

Interacts with the GTP-bound form of RAB11 when membrane-associated. Does not bind to other Rab and Rho small G proteins (By similarity).By similarity

GO - Molecular functioni

  • Rab GTPase binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000047275.

Structurei

3D structure databases

ProteinModelPortaliQ9R037.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati504 – 54340WD 1Add
BLAST
Repeati600 – 63839WD 2Add
BLAST
Repeati640 – 68041WD 3Add
BLAST
Repeati685 – 72440WD 4Add
BLAST
Repeati735 – 77440WD 5Add
BLAST
Repeati779 – 81840WD 6Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 163163Binding activityAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi203 – 24947Pro-richAdd
BLAST

Sequence similaritiesi

Contains 6 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0283. Eukaryota.
ENOG410XQPJ. LUCA.
HOGENOMiHOG000267152.
HOVERGENiHBG080376.
InParanoidiQ9R037.
PhylomeDBiQ9R037.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 4 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 2 hits.
PROSITEiPS50082. WD_REPEATS_2. 4 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9R037-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMPLKMCTWG GSYPVGSPGK VGLLSFKETK NTGNKAGNES PVQELRQDVS
60 70 80 90 100
KKIIECIIEE SQKVLQLEDD SLDSKGKGLS DQATASHSVA GTEFSNIPGL
110 120 130 140 150
LAIQHELQQG SRKADSQNAA EETELETQKC FPSDNNCEKS EKTEDETNNL
160 170 180 190 200
TEVSSADQLD ASKLETEILN KEAVEVKEGD VVNPASSDAL STKDFAAVEE
210 220 230 240 250
VAPAKPPRHL TPEPDIVAST KKPVPARPPP PTNFPPPRPP PPSRPAPPPR
260 270 280 290 300
KKKSDLEFEA LKTPDLDVPK DNIASDSLLT TNMASESTVR DSLPSLDLAS
310 320 330 340 350
ATSGDKIVTA QENGKAPDVQ TVAGEVMGPQ RPRSNSGREL TDEEILASVM
360 370 380 390 400
IKNLDTGEEI PLSLAEEKLP TGINPLTPLT LHIMRRTKEY VSNDATQSDD
410 420 430 440 450
EEKLQSQQTD TDGGRLKQKT TQLKKFLGKS VKRAKHLAEE YGERAINKVK
460 470 480 490 500
SVRDEVFHTD QDDPSSSDDE GMPYTRPVKF KAAHGFKGPY DFDQIKVVQD
510 520 530 540 550
LSGEHMGAVW TMKFSHCGRL LASAGQDNIV RIWALKNAFD YFNNMRMKYN
560 570 580 590 600
TEGRVSPSPS QESLSSSKSD TDMGVCSGTD EDPDDKNAPF RQRPFCKYKG
610 620 630 640 650
HTADLLDLSW SKNYFLLSSS MDKTVRLWHI SRRECLCCFQ HIDFVTAIAF
660 670 680 690 700
HPRDDRYFLS GSLDGKLRLW NIPDKKVALW NEVDGQTKLI TAANFCQNGK
710 720 730 740 750
YAVIGTYDGR CIFYDTEHLK YHTQIHVRST RGRNKVGRKI TGIEPLPGEN
760 770 780 790 800
KILVTSNDSR IRLYDLRDLS LSMKYKGYVN SSSQIKASFS HDFTYLVSGS
810 820 830 840 850
EDKYVYIWST YHDLSKFTSV RRDRNDFWEG IKAHNAVVTS AIFAPNPSLM
860 870 880 890 900
LSLDVQSEKL EGIDKYEDAE VLDNTSTGIV KTDNTEVLLS ADFTGAQCFY

VKNSFLYP
Length:908
Mass (Da):100,948
Last modified:May 1, 2000 - v1
Checksum:iE5F45471D10DD2CA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF130121 mRNA. Translation: AAF02478.1.
UniGeneiRn.79380.

Genome annotation databases

UCSCiRGD:727965. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF130121 mRNA. Translation: AAF02478.1.
UniGeneiRn.79380.

3D structure databases

ProteinModelPortaliQ9R037.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000047275.

PTM databases

iPTMnetiQ9R037.
PhosphoSiteiQ9R037.

Proteomic databases

PaxDbiQ9R037.
PRIDEiQ9R037.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiRGD:727965. rat.

Organism-specific databases

RGDi727965. Wdr44.

Phylogenomic databases

eggNOGiKOG0283. Eukaryota.
ENOG410XQPJ. LUCA.
HOGENOMiHOG000267152.
HOVERGENiHBG080376.
InParanoidiQ9R037.
PhylomeDBiQ9R037.

Miscellaneous databases

PROiQ9R037.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 4 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 2 hits.
PROSITEiPS50082. WD_REPEATS_2. 4 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiWDR44_RAT
AccessioniPrimary (citable) accession number: Q9R037
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: May 1, 2000
Last modified: July 6, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.