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Protein

Zinc finger Ran-binding domain-containing protein 2

Gene

Zranb2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Splice factor required for alternative splicing of TRA2B/SFRS10 transcripts. May interfere with constitutive 5'-splice site selection (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri9 – 40RanBP2-type 1PROSITE-ProRule annotationAdd BLAST32
Zinc fingeri65 – 94RanBP2-type 2PROSITE-ProRule annotationAdd BLAST30

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRNA-binding
Biological processmRNA processing, mRNA splicing
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger Ran-binding domain-containing protein 2
Alternative name(s):
Zinc finger protein 265
Zinc finger, splicing
Gene namesi
Name:Zranb2
Synonyms:Zfp265, Zis, Znf265
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1858211 Zranb2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000665861 – 330Zinc finger Ran-binding domain-containing protein 2Add BLAST330

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei9PhosphoserineBy similarity1
Modified residuei18N6-acetyllysineCombined sources1
Modified residuei54N6-acetyllysineCombined sources1
Modified residuei92N6-acetyllysineCombined sources1
Modified residuei120PhosphoserineCombined sources1
Modified residuei153PhosphoserineCombined sources1
Modified residuei181PhosphoserineBy similarity1
Modified residuei188PhosphoserineCombined sources1
Modified residuei193PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9R020
PaxDbiQ9R020
PRIDEiQ9R020

PTM databases

iPTMnetiQ9R020
PhosphoSitePlusiQ9R020

Expressioni

Gene expression databases

BgeeiENSMUSG00000028180
CleanExiMM_ZRANB2
ExpressionAtlasiQ9R020 baseline and differential

Interactioni

Subunit structurei

Interacts with the C-terminal half of SNRNP70, the Arg/Ser-rich domain of AKAP17A as well as with U2AF1 and CLK1.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000101678

Structurei

3D structure databases

ProteinModelPortaliQ9R020
SMRiQ9R020
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni151 – 324Required for nuclear targetingBy similarityAdd BLAST174

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi198 – 262Arg/Ser-richAdd BLAST65

Domaini

The RanBP2-type zinc fingers mediate binding to RNA.By similarity

Sequence similaritiesi

Belongs to the ZRANB2 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri9 – 40RanBP2-type 1PROSITE-ProRule annotationAdd BLAST32
Zinc fingeri65 – 94RanBP2-type 2PROSITE-ProRule annotationAdd BLAST30

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1995 Eukaryota
ENOG4111QXA LUCA
GeneTreeiENSGT00730000111078
HOGENOMiHOG000008684
HOVERGENiHBG066285
InParanoidiQ9R020
OMAiDLWGDNE
OrthoDBiEOG091G0MZC

Family and domain databases

InterProiView protein in InterPro
IPR017337 UCP037956_Znf_RanB2
IPR001876 Znf_RanBP2
IPR036443 Znf_RanBP2_sf
PfamiView protein in Pfam
PF00641 zf-RanBP, 2 hits
PIRSFiPIRSF037956 UCP037956_ZnF_Ran, 1 hit
SMARTiView protein in SMART
SM00547 ZnF_RBZ, 2 hits
SUPFAMiSSF90209 SSF90209, 2 hits
PROSITEiView protein in PROSITE
PS01358 ZF_RANBP2_1, 2 hits
PS50199 ZF_RANBP2_2, 2 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9R020-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSTKNFRVSD GDWICPDKKC GNVNFARRTS CNRCGREKTT EAKMMKAGGT
60 70 80 90 100
EIGKTLAEKS RGLFSANDWQ CKTCSNVNWA RRSECNMCNT PKYAKLEERT
110 120 130 140 150
GYGGGFNERE NVEYIEREES DGEYDEFGRK KKKYRGKAVG PASILKEVED
160 170 180 190 200
KESEGEEEDE DEDLSKYKLD EDEDEDDADL SKYNLDASEE EDSNKKKSNR
210 220 230 240 250
RSRSKSRSSH SRSSSRSSSP SSSRSRSRSR SRSSSSSQSR SHSGSREHSR
260 270 280 290 300
SRGSKSRSSS RSHRGSSSPR KRSYSSSSSS PERDRKRSRS RPSSPAVRKK
310 320 330
RRTRSRSPER HHRSSSGSTH SGSRSSSKKK
Length:330
Mass (Da):37,350
Last modified:May 1, 2007 - v2
Checksum:i1FD8F01C7C644F21
GO
Isoform 2 (identifier: Q9R020-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     37-73: Missing.

Note: No experimental confirmation available.
Show »
Length:293
Mass (Da):33,321
Checksum:iAAD61B45FF27F2C1
GO

Sequence cautioni

The sequence AAF04474 differs from that shown. Reason: Frameshift at position 263.Curated
The sequence BAE36054 differs from that shown. Reason: Frameshift at position 37.Curated
The sequence BAE38837 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAE39790 differs from that shown. Reason: Frameshift at position 240.Curated
The sequence BAE40017 differs from that shown. Reason: Frameshift at position 240.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti86N → D in AAF04474 (PubMed:10773668).Curated1
Sequence conflicti111N → S in AAF04474 (PubMed:10773668).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_02494637 – 73Missing in isoform 2. 1 PublicationAdd BLAST37

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK146275 mRNA Translation: BAE27034.1
AK150291 mRNA Translation: BAE29446.1
AK152536 mRNA Translation: BAE31292.1
AK160862 mRNA Translation: BAE36054.1 Frameshift.
AK166534 mRNA Translation: BAE38837.1 Different initiation.
AK167756 mRNA Translation: BAE39790.1 Frameshift.
AK167766 mRNA Translation: BAE39799.1
AK167862 mRNA Translation: BAE39880.1
AK167983 mRNA Translation: BAE39974.1
AK168033 mRNA Translation: BAE40017.1 Frameshift.
AK168162 mRNA Translation: BAE40123.1
AK168613 mRNA Translation: BAE40479.1
AK169114 mRNA Translation: BAE40895.1
AK169335 mRNA Translation: BAE41087.1
BC132547 mRNA Translation: AAI32548.1
AF133818 mRNA Translation: AAF04474.1 Frameshift.
CCDSiCCDS51100.1 [Q9R020-1]
RefSeqiNP_059077.1, NM_017381.2 [Q9R020-1]
XP_017175137.1, XM_017319648.1
UniGeneiMm.259036

Genome annotation databases

EnsembliENSMUST00000106058; ENSMUSP00000101673; ENSMUSG00000028180 [Q9R020-1]
GeneIDi53861
KEGGimmu:53861
UCSCiuc008rve.1 mouse [Q9R020-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiZRAB2_MOUSE
AccessioniPrimary (citable) accession number: Q9R020
Secondary accession number(s): Q3TI29
, Q3TLF5, Q3TUB7, Q3UD16
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: May 1, 2007
Last modified: March 28, 2018
This is version 114 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health