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Protein

Zinc finger Ran-binding domain-containing protein 2

Gene

Zranb2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Splice factor required for alternative splicing of TRA2B/SFRS10 transcripts. May interfere with constitutive 5'-splice site selection (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri9 – 4032RanBP2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri65 – 9430RanBP2-type 2PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

mRNA processing, mRNA splicing

Keywords - Ligandi

Metal-binding, RNA-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger Ran-binding domain-containing protein 2
Alternative name(s):
Zinc finger protein 265
Zinc finger, splicing
Gene namesi
Name:Zranb2
Synonyms:Zfp265, Zis, Znf265
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1858211. Zranb2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 330330Zinc finger Ran-binding domain-containing protein 2PRO_0000066586Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei9 – 91PhosphoserineBy similarity
Modified residuei18 – 181N6-acetyllysineCombined sources
Modified residuei54 – 541N6-acetyllysineCombined sources
Modified residuei92 – 921N6-acetyllysineCombined sources
Modified residuei120 – 1201PhosphoserineCombined sources
Modified residuei153 – 1531PhosphoserineCombined sources
Modified residuei181 – 1811PhosphoserineBy similarity
Modified residuei188 – 1881PhosphoserineCombined sources
Modified residuei193 – 1931PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9R020.
MaxQBiQ9R020.
PaxDbiQ9R020.
PRIDEiQ9R020.

PTM databases

iPTMnetiQ9R020.
PhosphoSiteiQ9R020.

Expressioni

Gene expression databases

BgeeiENSMUSG00000028180.
CleanExiMM_ZRANB2.
ExpressionAtlasiQ9R020. baseline and differential.

Interactioni

Subunit structurei

Interacts with the C-terminal half of SNRNP70, the Arg/Ser-rich domain of AKAP17A as well as with U2AF1 and CLK1.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000101678.

Structurei

3D structure databases

ProteinModelPortaliQ9R020.
SMRiQ9R020. Positions 1-40, 67-95.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni151 – 324174Required for nuclear targetingBy similarityAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi198 – 26265Arg/Ser-richAdd
BLAST

Domaini

The RanBP2-type zinc fingers mediate binding to RNA.By similarity

Sequence similaritiesi

Belongs to the ZRANB2 family.Curated
Contains 2 RanBP2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri9 – 4032RanBP2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri65 – 9430RanBP2-type 2PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1995. Eukaryota.
ENOG4111QXA. LUCA.
GeneTreeiENSGT00730000111078.
HOGENOMiHOG000008684.
HOVERGENiHBG066285.
InParanoidiQ9R020.
OMAiDLWGDNE.
OrthoDBiEOG091G0MZC.

Family and domain databases

Gene3Di4.10.1060.10. 2 hits.
InterProiIPR017337. UCP037956_Znf_RanB2.
IPR001876. Znf_RanBP2.
[Graphical view]
PfamiPF00641. zf-RanBP. 2 hits.
[Graphical view]
PIRSFiPIRSF037956. UCP037956_ZnF_Ran. 1 hit.
SMARTiSM00547. ZnF_RBZ. 2 hits.
[Graphical view]
SUPFAMiSSF90209. SSF90209. 2 hits.
PROSITEiPS01358. ZF_RANBP2_1. 2 hits.
PS50199. ZF_RANBP2_2. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9R020-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSTKNFRVSD GDWICPDKKC GNVNFARRTS CNRCGREKTT EAKMMKAGGT
60 70 80 90 100
EIGKTLAEKS RGLFSANDWQ CKTCSNVNWA RRSECNMCNT PKYAKLEERT
110 120 130 140 150
GYGGGFNERE NVEYIEREES DGEYDEFGRK KKKYRGKAVG PASILKEVED
160 170 180 190 200
KESEGEEEDE DEDLSKYKLD EDEDEDDADL SKYNLDASEE EDSNKKKSNR
210 220 230 240 250
RSRSKSRSSH SRSSSRSSSP SSSRSRSRSR SRSSSSSQSR SHSGSREHSR
260 270 280 290 300
SRGSKSRSSS RSHRGSSSPR KRSYSSSSSS PERDRKRSRS RPSSPAVRKK
310 320 330
RRTRSRSPER HHRSSSGSTH SGSRSSSKKK
Length:330
Mass (Da):37,350
Last modified:May 1, 2007 - v2
Checksum:i1FD8F01C7C644F21
GO
Isoform 2 (identifier: Q9R020-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     37-73: Missing.

Note: No experimental confirmation available.
Show »
Length:293
Mass (Da):33,321
Checksum:iAAD61B45FF27F2C1
GO

Sequence cautioni

The sequence AAF04474 differs from that shown. Reason: Frameshift at position 263. Curated
The sequence BAE36054 differs from that shown. Reason: Frameshift at position 37. Curated
The sequence BAE38837 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAE39790 differs from that shown. Reason: Frameshift at position 240. Curated
The sequence BAE40017 differs from that shown. Reason: Frameshift at position 240. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti86 – 861N → D in AAF04474 (PubMed:10773668).Curated
Sequence conflicti111 – 1111N → S in AAF04474 (PubMed:10773668).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei37 – 7337Missing in isoform 2. 1 PublicationVSP_024946Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK146275 mRNA. Translation: BAE27034.1.
AK150291 mRNA. Translation: BAE29446.1.
AK152536 mRNA. Translation: BAE31292.1.
AK160862 mRNA. Translation: BAE36054.1. Frameshift.
AK166534 mRNA. Translation: BAE38837.1. Different initiation.
AK167756 mRNA. Translation: BAE39790.1. Frameshift.
AK167766 mRNA. Translation: BAE39799.1.
AK167862 mRNA. Translation: BAE39880.1.
AK167983 mRNA. Translation: BAE39974.1.
AK168033 mRNA. Translation: BAE40017.1. Frameshift.
AK168162 mRNA. Translation: BAE40123.1.
AK168613 mRNA. Translation: BAE40479.1.
AK169114 mRNA. Translation: BAE40895.1.
AK169335 mRNA. Translation: BAE41087.1.
BC132547 mRNA. Translation: AAI32548.1.
AF133818 mRNA. Translation: AAF04474.1. Frameshift.
CCDSiCCDS51100.1. [Q9R020-1]
RefSeqiNP_059077.1. NM_017381.2. [Q9R020-1]
UniGeneiMm.259036.

Genome annotation databases

EnsembliENSMUST00000106058; ENSMUSP00000101673; ENSMUSG00000028180. [Q9R020-1]
GeneIDi53861.
KEGGimmu:53861.
UCSCiuc008rve.1. mouse. [Q9R020-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK146275 mRNA. Translation: BAE27034.1.
AK150291 mRNA. Translation: BAE29446.1.
AK152536 mRNA. Translation: BAE31292.1.
AK160862 mRNA. Translation: BAE36054.1. Frameshift.
AK166534 mRNA. Translation: BAE38837.1. Different initiation.
AK167756 mRNA. Translation: BAE39790.1. Frameshift.
AK167766 mRNA. Translation: BAE39799.1.
AK167862 mRNA. Translation: BAE39880.1.
AK167983 mRNA. Translation: BAE39974.1.
AK168033 mRNA. Translation: BAE40017.1. Frameshift.
AK168162 mRNA. Translation: BAE40123.1.
AK168613 mRNA. Translation: BAE40479.1.
AK169114 mRNA. Translation: BAE40895.1.
AK169335 mRNA. Translation: BAE41087.1.
BC132547 mRNA. Translation: AAI32548.1.
AF133818 mRNA. Translation: AAF04474.1. Frameshift.
CCDSiCCDS51100.1. [Q9R020-1]
RefSeqiNP_059077.1. NM_017381.2. [Q9R020-1]
UniGeneiMm.259036.

3D structure databases

ProteinModelPortaliQ9R020.
SMRiQ9R020. Positions 1-40, 67-95.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000101678.

PTM databases

iPTMnetiQ9R020.
PhosphoSiteiQ9R020.

Proteomic databases

EPDiQ9R020.
MaxQBiQ9R020.
PaxDbiQ9R020.
PRIDEiQ9R020.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000106058; ENSMUSP00000101673; ENSMUSG00000028180. [Q9R020-1]
GeneIDi53861.
KEGGimmu:53861.
UCSCiuc008rve.1. mouse. [Q9R020-1]

Organism-specific databases

CTDi9406.
MGIiMGI:1858211. Zranb2.

Phylogenomic databases

eggNOGiKOG1995. Eukaryota.
ENOG4111QXA. LUCA.
GeneTreeiENSGT00730000111078.
HOGENOMiHOG000008684.
HOVERGENiHBG066285.
InParanoidiQ9R020.
OMAiDLWGDNE.
OrthoDBiEOG091G0MZC.

Miscellaneous databases

ChiTaRSiZranb2. mouse.
PROiQ9R020.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028180.
CleanExiMM_ZRANB2.
ExpressionAtlasiQ9R020. baseline and differential.

Family and domain databases

Gene3Di4.10.1060.10. 2 hits.
InterProiIPR017337. UCP037956_Znf_RanB2.
IPR001876. Znf_RanBP2.
[Graphical view]
PfamiPF00641. zf-RanBP. 2 hits.
[Graphical view]
PIRSFiPIRSF037956. UCP037956_ZnF_Ran. 1 hit.
SMARTiSM00547. ZnF_RBZ. 2 hits.
[Graphical view]
SUPFAMiSSF90209. SSF90209. 2 hits.
PROSITEiPS01358. ZF_RANBP2_1. 2 hits.
PS50199. ZF_RANBP2_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZRAB2_MOUSE
AccessioniPrimary (citable) accession number: Q9R020
Secondary accession number(s): Q3TI29
, Q3TLF5, Q3TUB7, Q3UD16
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: May 1, 2007
Last modified: September 7, 2016
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.