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Q9R019

- Q9R019_RAT

UniProt

Q9R019 - Q9R019_RAT

Protein
Submitted name:

CHK2 checkpoint homolog (S. pombe), isoform CRA_a

Gene

Chek2

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. ATP binding Source: InterPro
    2. kinase activity Source: RGD
    3. protein kinase activity Source: RGD
    4. protein serine/threonine kinase activity Source: RGD

    GO - Biological processi

    1. cellular protein catabolic process Source: Ensembl
    2. DNA damage checkpoint Source: RGD
    3. DNA damage induced protein phosphorylation Source: Ensembl
    4. double-strand break repair Source: Ensembl
    5. G2/M transition of mitotic cell cycle Source: Ensembl
    6. intrinsic apoptotic signaling pathway in response to DNA damage Source: Ensembl
    7. positive regulation of transcription, DNA-templated Source: Ensembl
    8. protein autophosphorylation Source: Ensembl
    9. protein phosphorylation Source: RGD
    10. protein stabilization Source: Ensembl
    11. regulation of protein catabolic process Source: Ensembl
    12. response to gamma radiation Source: Ensembl
    13. signal transduction involved in intra-S DNA damage checkpoint Source: Ensembl
    14. spindle assembly involved in mitosis Source: Ensembl

    Keywords - Molecular functioni

    KinaseImported, Transferase

    Enzyme and pathway databases

    ReactomeiREACT_204983. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.
    REACT_207631. G2/M DNA damage checkpoint.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    CHK2 checkpoint homolog (S. pombe), isoform CRA_aImported
    Submitted name:
    Checkpoint kinase Chk2Imported
    Submitted name:
    Protein Chek2Imported
    Gene namesi
    Name:Chek2Imported
    ORF Names:rCG_21791Imported
    OrganismiRattus norvegicus (Rat)Imported
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 12

    Organism-specific databases

    RGDi621543. Chek2.

    Subcellular locationi

    GO - Cellular componenti

    1. chromosome, telomeric region Source: Ensembl
    2. PML body Source: Ensembl

    Expressioni

    Gene expression databases

    GenevestigatoriQ9R019.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000053643.

    Family & Domainsi

    Phylogenomic databases

    eggNOGiCOG0515.
    GeneTreeiENSGT00710000106821.
    HOGENOMiHOG000233016.
    HOVERGENiHBG108055.
    InParanoidiQ9R019.
    KOiK06641.
    OMAiKFAIGSE.
    OrthoDBiEOG7C5M7Z.
    TreeFamiTF101082.

    Family and domain databases

    Gene3Di2.60.200.20. 1 hit.
    InterProiIPR000253. FHA_dom.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    IPR008984. SMAD_FHA_domain.
    [Graphical view]
    PfamiPF00498. FHA. 1 hit.
    PF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00240. FHA. 1 hit.
    SM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF49879. SSF49879. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEiPS50006. FHA_DOMAIN. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9R019-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKSHQSHGST SSKAHDSASC SQSQGGFSQS QGTPSQLHDL SQYQGASSSS    50
    TSTVPSSSQS SHSSSGTLSS LETVSTQELC SIPEDQEPEE PGPTPWARLW 100
    ALQDGFSNLD CVNDNYWFGR DKSCEYCFDG PLLKRTDKYR TYSKKHFRIF 150
    REMGPKNCYI VYLEDHSGNG TFVNTELIGK GKRCPLSNNS EIALSLCRNK 200
    VFVFFDLTVD DQSVYPKELR DEYIMSKTLG SGACGEVKMA FERKTCKKVA 250
    IKIISKRRFA LGSSREADTA PSVETEIEIL KKLNHPCIIK IKDVFDVEDY 300
    YIVLELMEGG ELFDRVVGNK RLKEATCKLY FYQMLLAVQY LHENGIIHRD 350
    LKPENVLLSS QEEDCLIKIT DFGQSKILGE TSLMRTLCGT PTYLAPEVLI 400
    SNGTAGYSRA VDCWSLGVIL FICLSGYPPF SEHKTQVSLK DQITSGKYNL 450
    IPEVWTDVSE KALDLVKKLL VVDPKARLTT EEALSHPWLQ DEHMKKKFQD 500
    LLVQEKNLVP LPLAPAQTSG QKRPLELEAE DAESSKRLAV CKAVL 545
    Length:545
    Mass (Da):60,930
    Last modified:May 1, 2000 - v1
    Checksum:iCE532BAD08608873
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06072709 Genomic DNA. No translation available.
    AF134054 mRNA. Translation: AAD55890.1.
    CH473973 Genomic DNA. Translation: EDM14023.1.
    RefSeqiNP_446129.1. NM_053677.1.
    XP_006249580.1. XM_006249518.1.
    XP_006249581.1. XM_006249519.1.
    XP_006249582.1. XM_006249520.1.
    XP_006249583.1. XM_006249521.1.
    UniGeneiRn.163213.

    Genome annotation databases

    EnsembliENSRNOT00000056800; ENSRNOP00000053643; ENSRNOG00000037509.
    GeneIDi114212.
    KEGGirno:114212.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06072709 Genomic DNA. No translation available.
    AF134054 mRNA. Translation: AAD55890.1 .
    CH473973 Genomic DNA. Translation: EDM14023.1 .
    RefSeqi NP_446129.1. NM_053677.1.
    XP_006249580.1. XM_006249518.1.
    XP_006249581.1. XM_006249519.1.
    XP_006249582.1. XM_006249520.1.
    XP_006249583.1. XM_006249521.1.
    UniGenei Rn.163213.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000053643.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000056800 ; ENSRNOP00000053643 ; ENSRNOG00000037509 .
    GeneIDi 114212.
    KEGGi rno:114212.

    Organism-specific databases

    CTDi 11200.
    RGDi 621543. Chek2.

    Phylogenomic databases

    eggNOGi COG0515.
    GeneTreei ENSGT00710000106821.
    HOGENOMi HOG000233016.
    HOVERGENi HBG108055.
    InParanoidi Q9R019.
    KOi K06641.
    OMAi KFAIGSE.
    OrthoDBi EOG7C5M7Z.
    TreeFami TF101082.

    Enzyme and pathway databases

    Reactomei REACT_204983. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.
    REACT_207631. G2/M DNA damage checkpoint.

    Miscellaneous databases

    NextBioi 618421.
    PROi Q9R019.

    Gene expression databases

    Genevestigatori Q9R019.

    Family and domain databases

    Gene3Di 2.60.200.20. 1 hit.
    InterProi IPR000253. FHA_dom.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    IPR008984. SMAD_FHA_domain.
    [Graphical view ]
    Pfami PF00498. FHA. 1 hit.
    PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00240. FHA. 1 hit.
    SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49879. SSF49879. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEi PS50006. FHA_DOMAIN. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: ThymusImported.
    2. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
      Rat Genome Sequencing Project Consortium
      Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
      , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
      Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Brown NorwayImported.
    3. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BNImported.
    4. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BNImported.
    5. Ensembl
      Submitted (FEB-2012) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: Brown NorwayImported.

    Entry informationi

    Entry nameiQ9R019_RAT
    AccessioniPrimary (citable) accession number: Q9R019
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 1, 2000
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 104 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3