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Q9R019 (Q9R019_RAT) Unreviewed, UniProtKB/TrEMBL

Last modified July 9, 2014. Version 102. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein names

Checkpoint kinase Chk2 EMBL AAD55890.1

Protein Chek2 Ensembl ENSRNOP00000053643
Gene names
Name:Chek2 EMBL EDM14023.1 Ensembl ENSRNOP00000053643 RGD 621543
ORF Names:rCG_21791 EMBL EDM14023.1
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length545 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

Ontologies

Keywords
   Molecular functionKinase EMBL AAD55890.1
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processDNA damage checkpoint

Inferred from mutant phenotype Ref.1. Source: RGD

DNA damage induced protein phosphorylation

Inferred from electronic annotation. Source: Ensembl

G2/M transition of mitotic cell cycle

Inferred from electronic annotation. Source: Ensembl

cellular protein catabolic process

Inferred from electronic annotation. Source: Ensembl

double-strand break repair

Inferred from electronic annotation. Source: Ensembl

intrinsic apoptotic signaling pathway in response to DNA damage

Inferred from electronic annotation. Source: Ensembl

positive regulation of transcription, DNA-templated

Inferred from electronic annotation. Source: Ensembl

protein autophosphorylation

Inferred from electronic annotation. Source: Ensembl

protein phosphorylation

Inferred from direct assay PubMed 11278490. Source: RGD

protein stabilization

Inferred from electronic annotation. Source: Ensembl

regulation of protein catabolic process

Inferred from electronic annotation. Source: Ensembl

response to gamma radiation

Inferred from electronic annotation. Source: Ensembl

signal transduction involved in intra-S DNA damage checkpoint

Inferred from electronic annotation. Source: Ensembl

spindle assembly involved in mitosis

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentPML body

Inferred from electronic annotation. Source: Ensembl

chromosome, telomeric region

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionATP binding

Inferred from electronic annotation. Source: InterPro

kinase activity

Inferred from direct assay Ref.1. Source: RGD

protein kinase activity

Inferred from direct assay PubMed 11278490. Source: RGD

protein serine/threonine kinase activity

Inferred from direct assay Ref.1. Source: RGD

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
Q9R019 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: CE532BAD08608873

FASTA54560,930
        10         20         30         40         50         60 
MKSHQSHGST SSKAHDSASC SQSQGGFSQS QGTPSQLHDL SQYQGASSSS TSTVPSSSQS 

        70         80         90        100        110        120 
SHSSSGTLSS LETVSTQELC SIPEDQEPEE PGPTPWARLW ALQDGFSNLD CVNDNYWFGR 

       130        140        150        160        170        180 
DKSCEYCFDG PLLKRTDKYR TYSKKHFRIF REMGPKNCYI VYLEDHSGNG TFVNTELIGK 

       190        200        210        220        230        240 
GKRCPLSNNS EIALSLCRNK VFVFFDLTVD DQSVYPKELR DEYIMSKTLG SGACGEVKMA 

       250        260        270        280        290        300 
FERKTCKKVA IKIISKRRFA LGSSREADTA PSVETEIEIL KKLNHPCIIK IKDVFDVEDY 

       310        320        330        340        350        360 
YIVLELMEGG ELFDRVVGNK RLKEATCKLY FYQMLLAVQY LHENGIIHRD LKPENVLLSS 

       370        380        390        400        410        420 
QEEDCLIKIT DFGQSKILGE TSLMRTLCGT PTYLAPEVLI SNGTAGYSRA VDCWSLGVIL 

       430        440        450        460        470        480 
FICLSGYPPF SEHKTQVSLK DQITSGKYNL IPEVWTDVSE KALDLVKKLL VVDPKARLTT 

       490        500        510        520        530        540 
EEALSHPWLQ DEHMKKKFQD LLVQEKNLVP LPLAPAQTSG QKRPLELEAE DAESSKRLAV 


CKAVL 

« Hide

References

« Hide 'large scale' references
[1]"Mammalian Chk2 is a downstream effector of the ATM-dependent DNA damage checkpoint pathway."
Chaturvedi P., Eng W.K., Zhu Y., Mattern M.R., Mishra R., Hurle M.R., Zhang X., Annan R.S., Lu Q., Faucette L.F., Scott G.F., Li X., Carr S.A., Johnson R.K., Winkler J.D., Zhou B.B.
Oncogene 18:4047-4054(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Tissue: Thymus EMBL AAD55890.1.
[2]"Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
Rat Genome Sequencing Project Consortium
Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M. expand/collapse author list , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Brown Norway Ensembl ENSRNOP00000053643.
[3]"Gene and alternative splicing annotation with AIR."
Florea L., Di Francesco V., Miller J., Turner R., Yao A., Harris M., Walenz B., Mobarry C., Merkulov G.V., Charlab R., Dew I., Deng Z., Istrail S., Li P., Sutton G.
Genome Res. 15:54-66(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: BN EMBL EDM14023.1.
[4]Mural R.J., Li P.W., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S.H., Dew I., Evans C.A., Ferriera S., Flanigan M., Fosler C., Glodek A., Gu Z., Holt R.A., Jennings D., Kraft C.L., Lu F. expand/collapse author list , Nguyen T., Nusskern D.R., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Wang Z., Woodage T., Zheng X.H., Zhong F.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: BN EMBL EDM14023.1.
[5]Ensembl
Submitted (FEB-2012) to UniProtKB
Cited for: IDENTIFICATION.
Strain: Brown Norway Ensembl ENSRNOP00000053643.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AABR06072709 Genomic DNA. No translation available.
AF134054 mRNA. Translation: AAD55890.1.
CH473973 Genomic DNA. Translation: EDM14023.1.
RefSeqNP_446129.1. NM_053677.1.
XP_006249580.1. XM_006249518.1.
XP_006249581.1. XM_006249519.1.
XP_006249582.1. XM_006249520.1.
XP_006249583.1. XM_006249521.1.
UniGeneRn.163213.

3D structure databases

ProteinModelPortalQ9R019.
SMRQ9R019. Positions 95-210, 213-505.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000053643.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000056800; ENSRNOP00000053643; ENSRNOG00000037509.
GeneID114212.
KEGGrno:114212.

Organism-specific databases

CTD11200.
RGD621543. Chek2.

Phylogenomic databases

eggNOGCOG0515.
GeneTreeENSGT00710000106821.
HOGENOMHOG000233016.
HOVERGENHBG108055.
InParanoidQ9R019.
KOK06641.
OMAKFAIGSE.
OrthoDBEOG7C5M7Z.
PhylomeDBQ9R019.
TreeFamTF101082.

Gene expression databases

GenevestigatorQ9R019.

Family and domain databases

Gene3D2.60.200.20. 1 hit.
InterProIPR000253. FHA_dom.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
IPR008984. SMAD_FHA_domain.
[Graphical view]
PfamPF00498. FHA. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
SMARTSM00240. FHA. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF49879. SSF49879. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEPS50006. FHA_DOMAIN. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio618421.
PROQ9R019.

Entry information

Entry nameQ9R019_RAT
AccessionPrimary (citable) accession number: Q9R019
Entry history
Integrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: July 9, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)