Q9R019 (Q9R019_RAT) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
CHK2 checkpoint homolog (S. pombe), isoform CRA_a EMBL EDM14023.1

Submitted name:
Checkpoint kinase Chk2 EMBL AAD55890.1
Submitted name:
Protein Chek2 Ensembl ENSRNOP00000053643

Gene names

Name:	Chek2 EMBL EDM14023.1 Ensembl ENSRNOP00000053643 RGD 621543
ORF Names:	rCG_21791 EMBL EDM14023.1

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	545 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

Ontologies

Keywords
Molecular function	Kinase EMBL AAD55890.1 Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	DNA damage checkpoint Inferred from mutant phenotype Ref.1. Source: RGD DNA damage induced protein phosphorylation Inferred from electronic annotation. Source: Compara G2/M transition of mitotic cell cycle Inferred from electronic annotation. Source: Compara cellular protein catabolic process Inferred from electronic annotation. Source: Compara double-strand break repair Inferred from electronic annotation. Source: Compara intrinsic apoptotic signaling pathway in response to DNA damage Inferred from electronic annotation. Source: Compara positive regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: Compara protein autophosphorylation Inferred from electronic annotation. Source: Compara regulation of protein catabolic process Inferred from electronic annotation. Source: Compara response to gamma radiation Inferred from electronic annotation. Source: Compara signal transduction involved in intra-S DNA damage checkpoint Inferred from electronic annotation. Source: Compara spindle assembly involved in mitosis Inferred from electronic annotation. Source: Compara
Cellular_component	PML body Inferred from electronic annotation. Source: Compara chromosome, telomeric region Inferred from electronic annotation. Source: Compara
Molecular_function	ATP binding Inferred from electronic annotation. Source: InterPro protein serine/threonine kinase activity Inferred from direct assay Ref.1. Source: RGD
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q9R019 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: CE532BAD08608873	FASTA	545	60,930
	10 20 30 40 50 60 MKSHQSHGST SSKAHDSASC SQSQGGFSQS QGTPSQLHDL SQYQGASSSS TSTVPSSSQS 70 80 90 100 110 120 SHSSSGTLSS LETVSTQELC SIPEDQEPEE PGPTPWARLW ALQDGFSNLD CVNDNYWFGR 130 140 150 160 170 180 DKSCEYCFDG PLLKRTDKYR TYSKKHFRIF REMGPKNCYI VYLEDHSGNG TFVNTELIGK 190 200 210 220 230 240 GKRCPLSNNS EIALSLCRNK VFVFFDLTVD DQSVYPKELR DEYIMSKTLG SGACGEVKMA 250 260 270 280 290 300 FERKTCKKVA IKIISKRRFA LGSSREADTA PSVETEIEIL KKLNHPCIIK IKDVFDVEDY 310 320 330 340 350 360 YIVLELMEGG ELFDRVVGNK RLKEATCKLY FYQMLLAVQY LHENGIIHRD LKPENVLLSS 370 380 390 400 410 420 QEEDCLIKIT DFGQSKILGE TSLMRTLCGT PTYLAPEVLI SNGTAGYSRA VDCWSLGVIL 430 440 450 460 470 480 FICLSGYPPF SEHKTQVSLK DQITSGKYNL IPEVWTDVSE KALDLVKKLL VVDPKARLTT 490 500 510 520 530 540 EEALSHPWLQ DEHMKKKFQD LLVQEKNLVP LPLAPAQTSG QKRPLELEAE DAESSKRLAV CKAVL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Mammalian Chk2 is a downstream effector of the ATM-dependent DNA damage checkpoint pathway." Chaturvedi P., Eng W.K., Zhu Y., Mattern M.R., Mishra R., Hurle M.R., Zhang X., Annan R.S., Lu Q., Faucette L.F., Scott G.F., Li X., Carr S.A., Johnson R.K., Winkler J.D., Zhou B.B. Oncogene 18:4047-4054(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Tissue: Thymus EMBL AAD55890.1.
[2]	"Genome sequence of the Brown Norway rat yields insights into mammalian evolution." Rat Genome Sequencing Project Consortium Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M. , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S. Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Brown Norway Ensembl ENSRNOP00000053643.
[3]	"Gene and alternative splicing annotation with AIR." Florea L., Di Francesco V., Miller J., Turner R., Yao A., Harris M., Walenz B., Mobarry C., Merkulov G.V., Charlab R., Dew I., Deng Z., Istrail S., Li P., Sutton G. Genome Res. 15:54-66(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: BN EMBL EDM14023.1.
[4]	Mural R.J., Li P.W., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S.H., Dew I., Evans C.A., Ferriera S., Flanigan M., Fosler C., Glodek A., Gu Z., Holt R.A., Jennings D., Kraft C.L., Lu F. , Nguyen T., Nusskern D.R., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Wang Z., Woodage T., Zheng X.H., Zhong F. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: BN EMBL EDM14023.1.
[5]	Ensembl Submitted (FEB-2012) to UniProtKB Cited for: IDENTIFICATION. Strain: Brown Norway Ensembl ENSRNOP00000053643.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AABR06072709 Genomic DNA. No translation available. AF134054 mRNA. Translation: AAD55890.1. CH473973 Genomic DNA. Translation: EDM14023.1.
IPI	IPI00205562.
RefSeq	NP_446129.1. NM_053677.1.
UniGene	Rn.163213.
3D structure databases
HSSP	HSSP built from PDB template 1GXC based on UniProtKB O96017.
SMR	Q9R019. Positions 95-210, 213-505.
ModBase	Search...
Protein-protein interaction databases
STRING	10116.ENSRNOP00000053643.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000056800; ENSRNOP00000053643; ENSRNOG00000037509.
GeneID	114212.
KEGG	rno:114212.
Organism-specific databases
CTD	11200.
RGD	621543. Chek2.
Phylogenomic databases
eggNOG	COG0515.
GeneTree	ENSGT00680000099894.
HOGENOM	HOG000233016.
HOVERGEN	HBG108055.
InParanoid	Q9R019.
KO	K06641.
OMA	KFAIGSE.
OrthoDB	EOG4M0F1R.
Gene expression databases
Genevestigator	Q9R019.
Family and domain databases
Gene3D	2.60.200.20. 1 hit.
InterPro	IPR000253. FHA_dom. IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR002290. Ser/Thr_dual-sp_kinase_dom. IPR008271. Ser/Thr_kinase_AS. IPR008984. SMAD_FHA_domain. [Graphical view]
Pfam	PF00498. FHA. 1 hit. PF00069. Pkinase. 1 hit. [Graphical view]
SMART	SM00240. FHA. 1 hit. SM00220. S_TKc. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit. SSF49879. SMAD_FHA. 1 hit.
PROSITE	PS50006. FHA_DOMAIN. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	618421.

Entry information

Entry name

Q9R019_RAT

Accession

Primary (citable) accession number: Q9R019

Entry history

Integrated into UniProtKB/TrEMBL:	May 1, 2000
Last sequence update:	May 1, 2000
Last modified:	April 3, 2013
This is version 91 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)