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Protein
Submitted name:

CHK2 checkpoint homolog (S. pombe), isoform CRA_a

Gene

Chek2

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • kinase activity Source: RGD
  • protein kinase activity Source: RGD
  • protein serine/threonine kinase activity Source: RGD

GO - Biological processi

  • cellular protein catabolic process Source: Ensembl
  • cellular response to bisphenol A Source: RGD
  • cellular response to drug Source: RGD
  • DNA damage checkpoint Source: RGD
  • DNA damage induced protein phosphorylation Source: Ensembl
  • double-strand break repair Source: Ensembl
  • G2/M transition of mitotic cell cycle Source: Ensembl
  • intrinsic apoptotic signaling pathway in response to DNA damage Source: Ensembl
  • mitotic spindle assembly Source: Ensembl
  • negative regulation of cell cycle arrest Source: RGD
  • negative regulation of DNA damage checkpoint Source: RGD
  • peptidyl-serine phosphorylation Source: RGD
  • positive regulation of anoikis Source: RGD
  • positive regulation of protein phosphorylation Source: RGD
  • positive regulation of transcription, DNA-templated Source: Ensembl
  • protein autophosphorylation Source: Ensembl
  • protein phosphorylation Source: RGD
  • protein stabilization Source: Ensembl
  • regulation of protein catabolic process Source: Ensembl
  • replicative cell aging Source: Ensembl
  • response to gamma radiation Source: Ensembl
  • signal transduction involved in intra-S DNA damage checkpoint Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinaseSAAS annotation, Transferase

Keywords - Ligandi

ATP-bindingSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-RNO-5693565. Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks.
R-RNO-6804756. Regulation of TP53 Activity through Phosphorylation.
R-RNO-6804757. Regulation of TP53 Degradation.
R-RNO-6804760. Regulation of TP53 Activity through Methylation.
R-RNO-69473. G2/M DNA damage checkpoint.
R-RNO-69541. Stabilization of p53.
R-RNO-69601. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.

Names & Taxonomyi

Protein namesi
Submitted name:
CHK2 checkpoint homolog (S. pombe), isoform CRA_aImported
Submitted name:
Checkpoint kinase Chk2Imported
Submitted name:
Protein Chek2Imported
Gene namesi
Name:Chek2Imported
ORF Names:rCG_21791Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 12

Organism-specific databases

RGDi621543. Chek2.

Subcellular locationi

GO - Cellular componenti

  • chromosome, telomeric region Source: Ensembl
  • Golgi apparatus Source: Ensembl
  • nucleus Source: RGD
  • PML body Source: Ensembl
Complete GO annotation...

PTM / Processingi

PTM databases

PhosphoSiteiQ9R019.

Expressioni

Gene expression databases

BgeeiENSRNOG00000037509.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000053643.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini116 – 17863FHAInterPro annotationAdd
BLAST
Domaini223 – 489267Protein kinaseInterPro annotationAdd
BLAST

Sequence similaritiesi

Contains protein kinase domain.SAAS annotation

Phylogenomic databases

eggNOGiKOG0615. Eukaryota.
ENOG410YA63. LUCA.
GeneTreeiENSGT00800000124190.
HOGENOMiHOG000233016.
HOVERGENiHBG108055.
KOiK06641.
OMAiSRAVDCW.
OrthoDBiEOG091G0DVW.
TreeFamiTF101082.

Family and domain databases

Gene3Di2.60.200.20. 1 hit.
InterProiIPR020636. Ca/CaM-dep_Ca-dep_prot_Kinase.
IPR000253. FHA_dom.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
IPR008984. SMAD_FHA_domain.
[Graphical view]
PANTHERiPTHR24347. PTHR24347. 1 hit.
PfamiPF00498. FHA. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00240. FHA. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF49879. SSF49879. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50006. FHA_DOMAIN. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9R019-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSHQSHGST SSKAHDSASC SQSQGGFSQS QGTPSQLHDL SQYQGASSSS
60 70 80 90 100
TSTVPSSSQS SHSSSGTLSS LETVSTQELC SIPEDQEPEE PGPTPWARLW
110 120 130 140 150
ALQDGFSNLD CVNDNYWFGR DKSCEYCFDG PLLKRTDKYR TYSKKHFRIF
160 170 180 190 200
REMGPKNCYI VYLEDHSGNG TFVNTELIGK GKRCPLSNNS EIALSLCRNK
210 220 230 240 250
VFVFFDLTVD DQSVYPKELR DEYIMSKTLG SGACGEVKMA FERKTCKKVA
260 270 280 290 300
IKIISKRRFA LGSSREADTA PSVETEIEIL KKLNHPCIIK IKDVFDVEDY
310 320 330 340 350
YIVLELMEGG ELFDRVVGNK RLKEATCKLY FYQMLLAVQY LHENGIIHRD
360 370 380 390 400
LKPENVLLSS QEEDCLIKIT DFGQSKILGE TSLMRTLCGT PTYLAPEVLI
410 420 430 440 450
SNGTAGYSRA VDCWSLGVIL FICLSGYPPF SEHKTQVSLK DQITSGKYNL
460 470 480 490 500
IPEVWTDVSE KALDLVKKLL VVDPKARLTT EEALSHPWLQ DEHMKKKFQD
510 520 530 540
LLVQEKNLVP LPLAPAQTSG QKRPLELEAE DAESSKRLAV CKAVL
Length:545
Mass (Da):60,930
Last modified:May 1, 2000 - v1
Checksum:iCE532BAD08608873
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC095390 Genomic DNA. No translation available.
AF134054 mRNA. Translation: AAD55890.1.
CH473973 Genomic DNA. Translation: EDM14023.1.
RefSeqiNP_446129.1. NM_053677.1.
XP_006249580.1. XM_006249518.2.
XP_006249581.1. XM_006249519.2.
XP_006249582.1. XM_006249520.2.
XP_006249583.1. XM_006249521.2.
UniGeneiRn.163213.

Genome annotation databases

EnsembliENSRNOT00000056800; ENSRNOP00000053643; ENSRNOG00000037509.
ENSRNOT00000085591; ENSRNOP00000074651; ENSRNOG00000037509.
GeneIDi114212.
KEGGirno:114212.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC095390 Genomic DNA. No translation available.
AF134054 mRNA. Translation: AAD55890.1.
CH473973 Genomic DNA. Translation: EDM14023.1.
RefSeqiNP_446129.1. NM_053677.1.
XP_006249580.1. XM_006249518.2.
XP_006249581.1. XM_006249519.2.
XP_006249582.1. XM_006249520.2.
XP_006249583.1. XM_006249521.2.
UniGeneiRn.163213.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000053643.

PTM databases

PhosphoSiteiQ9R019.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000056800; ENSRNOP00000053643; ENSRNOG00000037509.
ENSRNOT00000085591; ENSRNOP00000074651; ENSRNOG00000037509.
GeneIDi114212.
KEGGirno:114212.

Organism-specific databases

CTDi11200.
RGDi621543. Chek2.

Phylogenomic databases

eggNOGiKOG0615. Eukaryota.
ENOG410YA63. LUCA.
GeneTreeiENSGT00800000124190.
HOGENOMiHOG000233016.
HOVERGENiHBG108055.
KOiK06641.
OMAiSRAVDCW.
OrthoDBiEOG091G0DVW.
TreeFamiTF101082.

Enzyme and pathway databases

ReactomeiR-RNO-5693565. Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks.
R-RNO-6804756. Regulation of TP53 Activity through Phosphorylation.
R-RNO-6804757. Regulation of TP53 Degradation.
R-RNO-6804760. Regulation of TP53 Activity through Methylation.
R-RNO-69473. G2/M DNA damage checkpoint.
R-RNO-69541. Stabilization of p53.
R-RNO-69601. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.

Gene expression databases

BgeeiENSRNOG00000037509.

Family and domain databases

Gene3Di2.60.200.20. 1 hit.
InterProiIPR020636. Ca/CaM-dep_Ca-dep_prot_Kinase.
IPR000253. FHA_dom.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
IPR008984. SMAD_FHA_domain.
[Graphical view]
PANTHERiPTHR24347. PTHR24347. 1 hit.
PfamiPF00498. FHA. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00240. FHA. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF49879. SSF49879. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50006. FHA_DOMAIN. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ9R019_RAT
AccessioniPrimary (citable) accession number: Q9R019
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: September 7, 2016
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.