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Q9R019

- Q9R019_RAT

UniProt

Q9R019 - Q9R019_RAT

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Protein
Submitted name:

CHK2 checkpoint homolog (S. pombe), isoform CRA_a

Gene

Chek2

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. ATP binding Source: InterPro
  2. kinase activity Source: RGD
  3. protein kinase activity Source: RGD
  4. protein serine/threonine kinase activity Source: RGD

GO - Biological processi

  1. cellular protein catabolic process Source: Ensembl
  2. DNA damage checkpoint Source: RGD
  3. DNA damage induced protein phosphorylation Source: Ensembl
  4. double-strand break repair Source: Ensembl
  5. G2/M transition of mitotic cell cycle Source: Ensembl
  6. intrinsic apoptotic signaling pathway in response to DNA damage Source: Ensembl
  7. positive regulation of transcription, DNA-templated Source: Ensembl
  8. protein autophosphorylation Source: Ensembl
  9. protein phosphorylation Source: RGD
  10. protein stabilization Source: Ensembl
  11. regulation of protein catabolic process Source: Ensembl
  12. response to gamma radiation Source: Ensembl
  13. signal transduction involved in intra-S DNA damage checkpoint Source: Ensembl
  14. spindle assembly involved in mitosis Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

KinaseImported, Transferase

Enzyme and pathway databases

ReactomeiREACT_204983. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.
REACT_207631. G2/M DNA damage checkpoint.

Names & Taxonomyi

Protein namesi
Submitted name:
CHK2 checkpoint homolog (S. pombe), isoform CRA_aImported
Submitted name:
Checkpoint kinase Chk2Imported
Submitted name:
Protein Chek2Imported
Gene namesi
Name:Chek2Imported
ORF Names:rCG_21791Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 12

Organism-specific databases

RGDi621543. Chek2.

Subcellular locationi

GO - Cellular componenti

  1. chromosome, telomeric region Source: Ensembl
  2. PML body Source: Ensembl
Complete GO annotation...

Expressioni

Gene expression databases

GenevestigatoriQ9R019.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000053643.

Family & Domainsi

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00710000106821.
HOGENOMiHOG000233016.
HOVERGENiHBG108055.
KOiK06641.
OMAiKFAIGSE.
OrthoDBiEOG7C5M7Z.
TreeFamiTF101082.

Family and domain databases

Gene3Di2.60.200.20. 1 hit.
InterProiIPR000253. FHA_dom.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
IPR008984. SMAD_FHA_domain.
[Graphical view]
PfamiPF00498. FHA. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00240. FHA. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF49879. SSF49879. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50006. FHA_DOMAIN. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9R019-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKSHQSHGST SSKAHDSASC SQSQGGFSQS QGTPSQLHDL SQYQGASSSS
60 70 80 90 100
TSTVPSSSQS SHSSSGTLSS LETVSTQELC SIPEDQEPEE PGPTPWARLW
110 120 130 140 150
ALQDGFSNLD CVNDNYWFGR DKSCEYCFDG PLLKRTDKYR TYSKKHFRIF
160 170 180 190 200
REMGPKNCYI VYLEDHSGNG TFVNTELIGK GKRCPLSNNS EIALSLCRNK
210 220 230 240 250
VFVFFDLTVD DQSVYPKELR DEYIMSKTLG SGACGEVKMA FERKTCKKVA
260 270 280 290 300
IKIISKRRFA LGSSREADTA PSVETEIEIL KKLNHPCIIK IKDVFDVEDY
310 320 330 340 350
YIVLELMEGG ELFDRVVGNK RLKEATCKLY FYQMLLAVQY LHENGIIHRD
360 370 380 390 400
LKPENVLLSS QEEDCLIKIT DFGQSKILGE TSLMRTLCGT PTYLAPEVLI
410 420 430 440 450
SNGTAGYSRA VDCWSLGVIL FICLSGYPPF SEHKTQVSLK DQITSGKYNL
460 470 480 490 500
IPEVWTDVSE KALDLVKKLL VVDPKARLTT EEALSHPWLQ DEHMKKKFQD
510 520 530 540
LLVQEKNLVP LPLAPAQTSG QKRPLELEAE DAESSKRLAV CKAVL
Length:545
Mass (Da):60,930
Last modified:May 1, 2000 - v1
Checksum:iCE532BAD08608873
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AABR06072709 Genomic DNA. No translation available.
AF134054 mRNA. Translation: AAD55890.1.
CH473973 Genomic DNA. Translation: EDM14023.1.
RefSeqiNP_446129.1. NM_053677.1.
XP_006249580.1. XM_006249518.2.
XP_006249581.1. XM_006249519.2.
XP_006249582.1. XM_006249520.2.
XP_006249583.1. XM_006249521.2.
UniGeneiRn.163213.

Genome annotation databases

EnsembliENSRNOT00000056800; ENSRNOP00000053643; ENSRNOG00000037509.
GeneIDi114212.
KEGGirno:114212.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AABR06072709 Genomic DNA. No translation available.
AF134054 mRNA. Translation: AAD55890.1 .
CH473973 Genomic DNA. Translation: EDM14023.1 .
RefSeqi NP_446129.1. NM_053677.1.
XP_006249580.1. XM_006249518.2.
XP_006249581.1. XM_006249519.2.
XP_006249582.1. XM_006249520.2.
XP_006249583.1. XM_006249521.2.
UniGenei Rn.163213.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000053643.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000056800 ; ENSRNOP00000053643 ; ENSRNOG00000037509 .
GeneIDi 114212.
KEGGi rno:114212.

Organism-specific databases

CTDi 11200.
RGDi 621543. Chek2.

Phylogenomic databases

eggNOGi COG0515.
GeneTreei ENSGT00710000106821.
HOGENOMi HOG000233016.
HOVERGENi HBG108055.
KOi K06641.
OMAi KFAIGSE.
OrthoDBi EOG7C5M7Z.
TreeFami TF101082.

Enzyme and pathway databases

Reactomei REACT_204983. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.
REACT_207631. G2/M DNA damage checkpoint.

Miscellaneous databases

NextBioi 618421.
PROi Q9R019.

Gene expression databases

Genevestigatori Q9R019.

Family and domain databases

Gene3Di 2.60.200.20. 1 hit.
InterProi IPR000253. FHA_dom.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
IPR008984. SMAD_FHA_domain.
[Graphical view ]
Pfami PF00498. FHA. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00240. FHA. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF49879. SSF49879. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEi PS50006. FHA_DOMAIN. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: ThymusImported.
  2. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Rat Genome Sequencing Project Consortium
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown NorwayImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  4. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  5. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Brown NorwayImported.

Entry informationi

Entry nameiQ9R019_RAT
AccessioniPrimary (citable) accession number: Q9R019
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: October 29, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3