UniProtKB - Q9R014 (CATJ_MOUSE)
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Protein
Cathepsin J
Gene
Ctsj
Organism
Mus musculus (Mouse)
Status
Functioni
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 138 | By similarity | 1 | |
Active sitei | 276 | By similarity | 1 | |
Active sitei | 300 | By similarity | 1 |
GO - Molecular functioni
- cysteine-type endopeptidase activity Source: GO_Central
- cysteine-type peptidase activity Source: MGI
GO - Biological processi
- proteolysis involved in cellular protein catabolic process Source: GO_Central
Keywordsi
Molecular function | Hydrolase, Protease, Thiol protease |
Enzyme and pathway databases
BRENDAi | 3.4.22.B65. 3474. |
Reactomei | R-MMU-1442490. Collagen degradation. R-MMU-1474228. Degradation of the extracellular matrix. R-MMU-1679131. Trafficking and processing of endosomal TLR. R-MMU-2022090. Assembly of collagen fibrils and other multimeric structures. R-MMU-2132295. MHC class II antigen presentation. R-MMU-8939242. RUNX1 regulates transcription of genes involved in differentiation of keratinocytes. |
Protein family/group databases
MEROPSi | C01.038. |
Names & Taxonomyi
Protein namesi | Recommended name: Cathepsin J (EC:3.4.22.-)Alternative name(s): Cathepsin L-related protein Cathepsin P Catlrp-p |
Gene namesi | Name:Ctsj Synonyms:Ctsp |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1349426. Ctsj. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 17 | Sequence analysisAdd BLAST | 17 | |
PropeptideiPRO_0000026230 | 18 – 113 | Activation peptideAdd BLAST | 96 | |
ChainiPRO_0000026231 | 114 – 334 | Cathepsin JAdd BLAST | 221 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 72 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 135 ↔ 178 | By similarity | ||
Disulfide bondi | 169 ↔ 211 | By similarity | ||
Glycosylationi | 217 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 221 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 268 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 269 ↔ 322 | By similarity |
Keywords - PTMi
Disulfide bond, Glycoprotein, ZymogenProteomic databases
PaxDbi | Q9R014. |
PeptideAtlasi | Q9R014. |
PRIDEi | Q9R014. |
Expressioni
Tissue specificityi
Expressed specifically in placenta.1 Publication
Gene expression databases
CleanExi | MM_CTSJ. |
ExpressionAtlasi | Q9R014. baseline and differential. |
Structurei
3D structure databases
ProteinModelPortali | Q9R014. |
SMRi | Q9R014. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the peptidase C1 family.PROSITE-ProRule annotation
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | KOG1543. Eukaryota. COG4870. LUCA. |
GeneTreei | ENSGT00900000140823. |
HOGENOMi | HOG000230774. |
HOVERGENi | HBG011513. |
InParanoidi | Q9R014. |
KOi | K09599. |
PhylomeDBi | Q9R014. |
TreeFami | TF313739. |
Family and domain databases
InterProi | View protein in InterPro IPR025661. Pept_asp_AS. IPR000169. Pept_cys_AS. IPR025660. Pept_his_AS. IPR013128. Peptidase_C1A. IPR000668. Peptidase_C1A_C. IPR013201. Prot_inhib_I29. |
PANTHERi | PTHR12411. PTHR12411. 1 hit. |
Pfami | View protein in Pfam PF08246. Inhibitor_I29. 1 hit. PF00112. Peptidase_C1. 1 hit. |
PRINTSi | PR00705. PAPAIN. |
SMARTi | View protein in SMART SM00848. Inhibitor_I29. 1 hit. SM00645. Pept_C1. 1 hit. |
PROSITEi | View protein in PROSITE PS00640. THIOL_PROTEASE_ASN. 1 hit. PS00139. THIOL_PROTEASE_CYS. 1 hit. PS00639. THIOL_PROTEASE_HIS. 1 hit. |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q9R014-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTPTVLLLIL CFGVASGAQA HDPKLDAEWK DWKTKYAKSY SPKEEALRRA
60 70 80 90 100
VWEENMRMIK LHNKENSLGK NNFTMKMNKF GDQTSEEFRK SIDNIPIPAA
110 120 130 140 150
MTDPHAQNHV SIGLPDYKDW REEGYVTPVR NQGKCGSCWA FAAAGAIEGQ
160 170 180 190 200
MFWKTGNLTP LSVQNLLDCS KTVGNKGCQS GTAHQAFEYV LKNKGLEAEA
210 220 230 240 250
TYPYEGKDGP CRYRSENASA NITDYVNLPP NELYLWVAVA SIGPVSAAID
260 270 280 290 300
ASHDSFRFYN GGIYYEPNCS SYFVNHAVLV VGYGSEGDVK DGNNYWLIKN
310 320 330
SWGEEWGMNG YMQIAKDHNN HCGIASLASY PNIF
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural varianti | 43 | Missing 2 Publications | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF136272 mRNA. Translation: AAF13142.1. AF158182 mRNA. Translation: AAD41898.1. AY034579 Genomic DNA. Translation: AAK58455.1. AK005526 mRNA. Translation: BAB24099.1. AK131661 mRNA. Translation: BAE20748.1. BC103769 mRNA. Translation: AAI03770.1. |
RefSeqi | NP_036137.1. NM_012007.1. XP_006517318.1. XM_006517255.1. |
UniGenei | Mm.31948. |
Genome annotation databases
Ensembli | ENSMUST00000224224; ENSMUSP00000153389; ENSMUSG00000055298. |
GeneIDi | 26898. |
KEGGi | mmu:26898. |
UCSCi | uc007qwa.1. mouse. |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Entry informationi
Entry namei | CATJ_MOUSE | |
Accessioni | Q9R014Primary (citable) accession number: Q9R014 Secondary accession number(s): Q564D9, Q91XK6, Q9WV51 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 24, 2001 |
Last sequence update: | December 20, 2005 | |
Last modified: | February 28, 2018 | |
This is version 122 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |