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Protein

Cathepsin J

Gene

Ctsj

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei138By similarity1
Active sitei276By similarity1
Active sitei300By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Thiol protease

Enzyme and pathway databases

BRENDAi3.4.22.B65. 3474.

Protein family/group databases

MEROPSiC01.038.

Names & Taxonomyi

Protein namesi
Recommended name:
Cathepsin J (EC:3.4.22.-)
Alternative name(s):
Cathepsin L-related protein
Cathepsin P
Catlrp-p
Gene namesi
Name:Ctsj
Synonyms:Ctsp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1349426. Ctsj.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Lysosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
PropeptideiPRO_000002623018 – 113Activation peptideAdd BLAST96
ChainiPRO_0000026231114 – 334Cathepsin JAdd BLAST221

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi72N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi135 ↔ 178By similarity
Disulfide bondi169 ↔ 211By similarity
Glycosylationi217N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi221N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi268N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi269 ↔ 322By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

PaxDbiQ9R014.
PeptideAtlasiQ9R014.
PRIDEiQ9R014.

Expressioni

Tissue specificityi

Expressed specifically in placenta.1 Publication

Gene expression databases

BgeeiENSMUSG00000055298.
CleanExiMM_CTSJ.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000071457.

Structurei

3D structure databases

ProteinModelPortaliQ9R014.
SMRiQ9R014.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase C1 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1543. Eukaryota.
COG4870. LUCA.
HOGENOMiHOG000230774.
HOVERGENiHBG011513.
InParanoidiQ9R014.
KOiK09599.
PhylomeDBiQ9R014.
TreeFamiTF313739.

Family and domain databases

InterProiView protein in InterPro
IPR025661. Pept_asp_AS.
IPR000169. Pept_cys_AS.
IPR025660. Pept_his_AS.
IPR013128. Peptidase_C1A.
IPR000668. Peptidase_C1A_C.
IPR013201. Prot_inhib_I29.
PANTHERiPTHR12411. PTHR12411. 1 hit.
PfamiView protein in Pfam
PF08246. Inhibitor_I29. 1 hit.
PF00112. Peptidase_C1. 1 hit.
PRINTSiPR00705. PAPAIN.
SMARTiView protein in SMART
SM00848. Inhibitor_I29. 1 hit.
SM00645. Pept_C1. 1 hit.
PROSITEiView protein in PROSITE
PS00640. THIOL_PROTEASE_ASN. 1 hit.
PS00139. THIOL_PROTEASE_CYS. 1 hit.
PS00639. THIOL_PROTEASE_HIS. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9R014-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTPTVLLLIL CFGVASGAQA HDPKLDAEWK DWKTKYAKSY SPKEEALRRA
60 70 80 90 100
VWEENMRMIK LHNKENSLGK NNFTMKMNKF GDQTSEEFRK SIDNIPIPAA
110 120 130 140 150
MTDPHAQNHV SIGLPDYKDW REEGYVTPVR NQGKCGSCWA FAAAGAIEGQ
160 170 180 190 200
MFWKTGNLTP LSVQNLLDCS KTVGNKGCQS GTAHQAFEYV LKNKGLEAEA
210 220 230 240 250
TYPYEGKDGP CRYRSENASA NITDYVNLPP NELYLWVAVA SIGPVSAAID
260 270 280 290 300
ASHDSFRFYN GGIYYEPNCS SYFVNHAVLV VGYGSEGDVK DGNNYWLIKN
310 320 330
SWGEEWGMNG YMQIAKDHNN HCGIASLASY PNIF
Length:334
Mass (Da):37,276
Last modified:December 20, 2005 - v2
Checksum:iA422B7679E76DD7C
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti43Missing 2 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF136272 mRNA. Translation: AAF13142.1.
AF158182 mRNA. Translation: AAD41898.1.
AY034579 Genomic DNA. Translation: AAK58455.1.
AK005526 mRNA. Translation: BAB24099.1.
AK131661 mRNA. Translation: BAE20748.1.
BC103769 mRNA. Translation: AAI03770.1.
RefSeqiNP_036137.1. NM_012007.1.
XP_006517318.1. XM_006517255.1.
UniGeneiMm.31948.

Genome annotation databases

GeneIDi26898.
KEGGimmu:26898.
UCSCiuc007qwa.1. mouse.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF136272 mRNA. Translation: AAF13142.1.
AF158182 mRNA. Translation: AAD41898.1.
AY034579 Genomic DNA. Translation: AAK58455.1.
AK005526 mRNA. Translation: BAB24099.1.
AK131661 mRNA. Translation: BAE20748.1.
BC103769 mRNA. Translation: AAI03770.1.
RefSeqiNP_036137.1. NM_012007.1.
XP_006517318.1. XM_006517255.1.
UniGeneiMm.31948.

3D structure databases

ProteinModelPortaliQ9R014.
SMRiQ9R014.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000071457.

Protein family/group databases

MEROPSiC01.038.

Proteomic databases

PaxDbiQ9R014.
PeptideAtlasiQ9R014.
PRIDEiQ9R014.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi26898.
KEGGimmu:26898.
UCSCiuc007qwa.1. mouse.

Organism-specific databases

CTDi26898.
MGIiMGI:1349426. Ctsj.

Phylogenomic databases

eggNOGiKOG1543. Eukaryota.
COG4870. LUCA.
HOGENOMiHOG000230774.
HOVERGENiHBG011513.
InParanoidiQ9R014.
KOiK09599.
PhylomeDBiQ9R014.
TreeFamiTF313739.

Enzyme and pathway databases

BRENDAi3.4.22.B65. 3474.

Miscellaneous databases

PROiPR:Q9R014.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000055298.
CleanExiMM_CTSJ.

Family and domain databases

InterProiView protein in InterPro
IPR025661. Pept_asp_AS.
IPR000169. Pept_cys_AS.
IPR025660. Pept_his_AS.
IPR013128. Peptidase_C1A.
IPR000668. Peptidase_C1A_C.
IPR013201. Prot_inhib_I29.
PANTHERiPTHR12411. PTHR12411. 1 hit.
PfamiView protein in Pfam
PF08246. Inhibitor_I29. 1 hit.
PF00112. Peptidase_C1. 1 hit.
PRINTSiPR00705. PAPAIN.
SMARTiView protein in SMART
SM00848. Inhibitor_I29. 1 hit.
SM00645. Pept_C1. 1 hit.
PROSITEiView protein in PROSITE
PS00640. THIOL_PROTEASE_ASN. 1 hit.
PS00139. THIOL_PROTEASE_CYS. 1 hit.
PS00639. THIOL_PROTEASE_HIS. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCATJ_MOUSE
AccessioniPrimary (citable) accession number: Q9R014
Secondary accession number(s): Q564D9, Q91XK6, Q9WV51
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: December 20, 2005
Last modified: May 10, 2017
This is version 118 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.