Ctsj

Functionⁱ

Sites

Feature key	Position(s)	DescriptionActions	Length
Active siteⁱ	138	By similarity	1
Active siteⁱ	276	By similarity	1
Active siteⁱ	300	By similarity	1

GO - Molecular functionⁱ

cysteine-type endopeptidase activity Source: GO_Central
cysteine-type peptidase activity
Source: MGI
Inferred from sequence orthologyⁱ
- 10526153

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

proteolysis involved in cellular protein catabolic process Source: GO_Central

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Hydrolase, Protease, Thiol protease

Molecular function

Hydrolase, Protease, Thiol protease

Enzyme and pathway databases

BRENDAⁱ	3.4.22.B65. 3474.
Reactomeⁱ	R-MMU-1442490. Collagen degradation. R-MMU-1474228. Degradation of the extracellular matrix. R-MMU-1679131. Trafficking and processing of endosomal TLR. R-MMU-2022090. Assembly of collagen fibrils and other multimeric structures. R-MMU-2132295. MHC class II antigen presentation. R-MMU-8939242. RUNX1 regulates transcription of genes involved in differentiation of keratinocytes.

Protein family/group databases

MEROPS protease database More...MEROPSⁱ	C01.038.

MEROPSⁱ

C01.038.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Cathepsin J (EC:3.4.22.-) Alternative name(s): Cathepsin L-related protein Cathepsin P Catlrp-p
Gene namesⁱ	Name:Ctsj Synonyms:Ctsp
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 13

Organism-specific databases

MGIⁱ	MGI:1349426. Ctsj.

Keywords - Cellular componentⁱ

Lysosome

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Length
Signal peptideⁱ	1 – 17	Sequence analysisAdd BLAST	17
PropeptideⁱPRO_0000026230	18 – 113	Activation peptideAdd BLAST	96
ChainⁱPRO_0000026231	114 – 334	Cathepsin JAdd BLAST	221

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	72	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	135 ↔ 178	By similarity
Disulfide bondⁱ	169 ↔ 211	By similarity
Glycosylationⁱ	217	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	221	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	268	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	269 ↔ 322	By similarity

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

PaxDbⁱ	Q9R014.
PeptideAtlas More...PeptideAtlasⁱ	Q9R014.
PRIDEⁱ	Q9R014.

Expressionⁱ

Tissue specificityⁱ

Expressed specifically in placenta.1 Publication

Gene expression databases

CleanExⁱ	MM_CTSJ.
ExpressionAtlasⁱ	Q9R014. baseline and differential.

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000071457.

STRINGⁱ

10090.ENSMUSP00000071457.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9R014.
SMRⁱ	Q9R014.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the peptidase C1 family.PROSITE-ProRule annotation

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	KOG1543. Eukaryota. COG4870. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00900000140823.
HOGENOMⁱ	HOG000230774.
HOVERGENⁱ	HBG011513.
InParanoidⁱ	Q9R014.
KEGG Orthology (KO) More...KOⁱ	K09599.
PhylomeDBⁱ	Q9R014.
TreeFamⁱ	TF313739.

Family and domain databases

InterProⁱ	View protein in InterPro IPR025661. Pept_asp_AS. IPR000169. Pept_cys_AS. IPR025660. Pept_his_AS. IPR013128. Peptidase_C1A. IPR000668. Peptidase_C1A_C. IPR013201. Prot_inhib_I29.
PANTHERⁱ	PTHR12411. PTHR12411. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF08246. Inhibitor_I29. 1 hit. PF00112. Peptidase_C1. 1 hit.
PRINTSⁱ	PR00705. PAPAIN.
SMARTⁱ	View protein in SMART SM00848. Inhibitor_I29. 1 hit. SM00645. Pept_C1. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00640. THIOL_PROTEASE_ASN. 1 hit. PS00139. THIOL_PROTEASE_CYS. 1 hit. PS00639. THIOL_PROTEASE_HIS. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

Q9R014-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MTPTVLLLIL CFGVASGAQA HDPKLDAEWK DWKTKYAKSY SPKEEALRRA 
        60         70         80         90        100
VWEENMRMIK LHNKENSLGK NNFTMKMNKF GDQTSEEFRK SIDNIPIPAA 
       110        120        130        140        150
MTDPHAQNHV SIGLPDYKDW REEGYVTPVR NQGKCGSCWA FAAAGAIEGQ 
       160        170        180        190        200
MFWKTGNLTP LSVQNLLDCS KTVGNKGCQS GTAHQAFEYV LKNKGLEAEA 
       210        220        230        240        250
TYPYEGKDGP CRYRSENASA NITDYVNLPP NELYLWVAVA SIGPVSAAID 
       260        270        280        290        300
ASHDSFRFYN GGIYYEPNCS SYFVNHAVLV VGYGSEGDVK DGNNYWLIKN 
       310        320        330 
SWGEEWGMNG YMQIAKDHNN HCGIASLASY PNIF

Length:334

Mass (Da):37,276

Last modified:December 20, 2005 - v2

Checksum:ⁱA422B7679E76DD7C

GO

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱ	43	Missing 2 Publications		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF136272 mRNA. Translation: AAF13142.1. AF158182 mRNA. Translation: AAD41898.1. AY034579 Genomic DNA. Translation: AAK58455.1. AK005526 mRNA. Translation: BAB24099.1. AK131661 mRNA. Translation: BAE20748.1. BC103769 mRNA. Translation: AAI03770.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_036137.1. NM_012007.1. XP_006517318.1. XM_006517255.1.
UniGeneⁱ	Mm.31948.

Genome annotation databases

Ensemblⁱ	ENSMUST00000224224; ENSMUSP00000153389; ENSMUSG00000055298.
GeneIDⁱ	26898.
KEGGⁱ	mmu:26898.
UCSC genome browser More...UCSCⁱ	uc007qwa.1. mouse.

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q9R014	A0A0R4J0V8 UPI000A31A405 UPI000A31A63B	Mus musculus (Mouse) Mus caroli (Ryukyu mouse) (Ricefield mouse)	334	UniRef90_Q9R014	Cluster: Cathepsin J	4

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q9R014	A0A0R4J0V8 UPI000A31A405 UPI000A31A63B UPI000A311D25 UPI000A314FB3 UPI000B4FC909 UPI00038BDCE7 UPI00038C05C0	Mus musculus (Mouse) Mus caroli (Ryukyu mouse) (Ricefield mouse) Mus pahari (Gairdner's shrew-mouse) (Coelomys pahari) Meriones unguiculatus (Mongolian jird) (Mongolian gerbil) Microtus ochrogaster (Prairie vole)	334	UniRef50_Q9R014	Cluster: Cathepsin J	9

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF136272 mRNA. Translation: AAF13142.1. AF158182 mRNA. Translation: AAD41898.1. AY034579 Genomic DNA. Translation: AAK58455.1. AK005526 mRNA. Translation: BAB24099.1. AK131661 mRNA. Translation: BAE20748.1. BC103769 mRNA. Translation: AAI03770.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_036137.1. NM_012007.1. XP_006517318.1. XM_006517255.1.
UniGeneⁱ	Mm.31948.

3D structure databases

ProteinModelPortalⁱ	Q9R014.
SMRⁱ	Q9R014.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000071457.

STRINGⁱ

10090.ENSMUSP00000071457.

Protein family/group databases

MEROPS protease database More...MEROPSⁱ	C01.038.

MEROPSⁱ

C01.038.

Proteomic databases

PaxDbⁱ	Q9R014.
PeptideAtlas More...PeptideAtlasⁱ	Q9R014.
PRIDEⁱ	Q9R014.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000224224; ENSMUSP00000153389; ENSMUSG00000055298.
GeneIDⁱ	26898.
KEGGⁱ	mmu:26898.
UCSC genome browser More...UCSCⁱ	uc007qwa.1. mouse.

Organism-specific databases

CTDⁱ	26898.
MGIⁱ	MGI:1349426. Ctsj.

Phylogenomic databases

eggNOGⁱ	KOG1543. Eukaryota. COG4870. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00900000140823.
HOGENOMⁱ	HOG000230774.
HOVERGENⁱ	HBG011513.
InParanoidⁱ	Q9R014.
KEGG Orthology (KO) More...KOⁱ	K09599.
PhylomeDBⁱ	Q9R014.
TreeFamⁱ	TF313739.

Enzyme and pathway databases

BRENDAⁱ	3.4.22.B65. 3474.
Reactomeⁱ	R-MMU-1442490. Collagen degradation. R-MMU-1474228. Degradation of the extracellular matrix. R-MMU-1679131. Trafficking and processing of endosomal TLR. R-MMU-2022090. Assembly of collagen fibrils and other multimeric structures. R-MMU-2132295. MHC class II antigen presentation. R-MMU-8939242. RUNX1 regulates transcription of genes involved in differentiation of keratinocytes.

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q9R014.
SOURCEⁱ	Search...

Gene expression databases

CleanExⁱ	MM_CTSJ.
ExpressionAtlasⁱ	Q9R014. baseline and differential.

Family and domain databases

InterProⁱ	View protein in InterPro IPR025661. Pept_asp_AS. IPR000169. Pept_cys_AS. IPR025660. Pept_his_AS. IPR013128. Peptidase_C1A. IPR000668. Peptidase_C1A_C. IPR013201. Prot_inhib_I29.
PANTHERⁱ	PTHR12411. PTHR12411. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF08246. Inhibitor_I29. 1 hit. PF00112. Peptidase_C1. 1 hit.
PRINTSⁱ	PR00705. PAPAIN.
SMARTⁱ	View protein in SMART SM00848. Inhibitor_I29. 1 hit. SM00645. Pept_C1. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00640. THIOL_PROTEASE_ASN. 1 hit. PS00139. THIOL_PROTEASE_CYS. 1 hit. PS00639. THIOL_PROTEASE_HIS. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CATJ_MOUSE
Accessionⁱ	Q9R014Primary (citable) accession number: Q9R014 Secondary accession number(s): Q564D9, Q91XK6, Q9WV51
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 24, 2001
	Last sequence update:	December 20, 2005
	Last modified:	February 28, 2018
	This is version 122 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9R014 (CATJ_MOUSE)

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Cathepsin J

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Lysosome

Extracellular region or secreted

Lysosome

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Natural variant

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ