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Protein

Mevalonate kinase

Gene

Mvk

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be a regulatory site in cholesterol biosynthetic pathway.

Catalytic activityi

ATP + (R)-mevalonate = ADP + (R)-5-phosphomevalonate.

Enzyme regulationi

Farnesyl- and geranyl-pyrophosphates are competitive inhibitors.By similarity

Pathwayi: isopentenyl diphosphate biosynthesis via mevalonate pathway

This protein is involved in step 1 of the subpathway that synthesizes isopentenyl diphosphate from (R)-mevalonate.
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Mevalonate kinase (Mvk)
  2. Phosphomevalonate kinase (Pmvk), Phosphomevalonate kinase (Pmvk), Phosphomevalonate kinase (Pmvk)
  3. no protein annotated in this organism
This subpathway is part of the pathway isopentenyl diphosphate biosynthesis via mevalonate pathway, which is itself part of Isoprenoid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes isopentenyl diphosphate from (R)-mevalonate, the pathway isopentenyl diphosphate biosynthesis via mevalonate pathway and in Isoprenoid biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei55 – 551ATPBy similarity
Binding sitei135 – 1351ATPBy similarity
Active sitei204 – 2041Proton acceptorBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi138 – 14811ATPBy similarityAdd
BLAST

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • identical protein binding Source: MGI
  • mevalonate kinase activity Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Cholesterol biosynthesis, Cholesterol metabolism, Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesis, Sterol metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.1.36. 3474.
ReactomeiR-MMU-191273. Cholesterol biosynthesis.
R-MMU-2426168. Activation of gene expression by SREBF (SREBP).
UniPathwayiUPA00057; UER00098.

Names & Taxonomyi

Protein namesi
Recommended name:
Mevalonate kinase (EC:2.7.1.36)
Short name:
MK
Gene namesi
Name:Mvk
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:107624. Mvk.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 395395Mevalonate kinasePRO_0000156658Add
BLAST

Proteomic databases

EPDiQ9R008.
MaxQBiQ9R008.
PaxDbiQ9R008.
PRIDEiQ9R008.

PTM databases

PhosphoSiteiQ9R008.

Expressioni

Gene expression databases

BgeeiQ9R008.
CleanExiMM_MVK.
ExpressionAtlasiQ9R008. baseline and differential.
GenevisibleiQ9R008. MM.

Interactioni

Subunit structurei

Homodimer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ9R008. 1 interaction.
MINTiMINT-4099820.
STRINGi10090.ENSMUSP00000036971.

Structurei

3D structure databases

ProteinModelPortaliQ9R008.
SMRiQ9R008. Positions 1-395.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1511. Eukaryota.
COG1577. LUCA.
GeneTreeiENSGT00390000011860.
HOGENOMiHOG000188934.
HOVERGENiHBG000402.
InParanoidiQ9R008.
KOiK00869.
OrthoDBiEOG7G1V6N.
PhylomeDBiQ9R008.
TreeFamiTF313775.

Family and domain databases

Gene3Di3.30.230.10. 1 hit.
3.30.70.890. 1 hit.
InterProiIPR013750. GHMP_kinase_C_dom.
IPR006204. GHMP_kinase_N_dom.
IPR006203. GHMP_knse_ATP-bd_CS.
IPR006205. Mev_gal_kin.
IPR006206. Mevalonate/galactokinase.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view]
PANTHERiPTHR10457. PTHR10457. 1 hit.
PTHR10457:SF4. PTHR10457:SF4. 1 hit.
PfamiPF08544. GHMP_kinases_C. 1 hit.
PF00288. GHMP_kinases_N. 1 hit.
[Graphical view]
PRINTSiPR00959. MEVGALKINASE.
SUPFAMiSSF54211. SSF54211. 1 hit.
SSF55060. SSF55060. 1 hit.
TIGRFAMsiTIGR00549. mevalon_kin. 1 hit.
PROSITEiPS00627. GHMP_KINASES_ATP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9R008-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSEALLVSA PGKVILHGEH AVVHGKVALA AALNLRTFLL LRPQSNGKVS
60 70 80 90 100
VNLPNIGIKQ VWDVGMLQRL DTSFLEQGDV SVPTLEQLEK LKKMGDLPRD
110 120 130 140 150
RAGNEGMALL AFLYLYLAIC RKQRTLPSLD MVVWSELPPG AGLGSSAAYS
160 170 180 190 200
VCLAAALLTA CEEVSNPLKD GVSVSRWPEE DLKSINKWAF EGERVIHGNP
210 220 230 240 250
SGVDNAVSTW GGALRFQQGT MSSLKSLPSL QILLTNTKVP RSTKALVAAV
260 270 280 290 300
RSRLTKFPEI VAPLLTSIDA ISLECERVLG EMVAAPVPEQ YLVLEELIDM
310 320 330 340 350
NQHHLNALGV GHNSLDQLCQ VTAAHGLHSK LTGAGGGGCG ITLLKPGLEQ
360 370 380 390
ATVEAAKQAL TSCGFDCWET SIGAPGVSTH SAAAVGDPVR QALGL
Length:395
Mass (Da):41,877
Last modified:May 1, 2000 - v1
Checksum:i953DB1C89403A3F8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF137598 mRNA. Translation: AAF00700.1.
BC005606 mRNA. Translation: AAH05606.1.
CCDSiCCDS19566.1.
RefSeqiNP_076045.1. NM_023556.3.
XP_006530248.1. XM_006530185.2.
UniGeneiMm.28088.

Genome annotation databases

EnsembliENSMUST00000043760; ENSMUSP00000036971; ENSMUSG00000041939.
GeneIDi17855.
KEGGimmu:17855.
UCSCiuc008yzq.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF137598 mRNA. Translation: AAF00700.1.
BC005606 mRNA. Translation: AAH05606.1.
CCDSiCCDS19566.1.
RefSeqiNP_076045.1. NM_023556.3.
XP_006530248.1. XM_006530185.2.
UniGeneiMm.28088.

3D structure databases

ProteinModelPortaliQ9R008.
SMRiQ9R008. Positions 1-395.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9R008. 1 interaction.
MINTiMINT-4099820.
STRINGi10090.ENSMUSP00000036971.

PTM databases

PhosphoSiteiQ9R008.

Proteomic databases

EPDiQ9R008.
MaxQBiQ9R008.
PaxDbiQ9R008.
PRIDEiQ9R008.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000043760; ENSMUSP00000036971; ENSMUSG00000041939.
GeneIDi17855.
KEGGimmu:17855.
UCSCiuc008yzq.1. mouse.

Organism-specific databases

CTDi4598.
MGIiMGI:107624. Mvk.

Phylogenomic databases

eggNOGiKOG1511. Eukaryota.
COG1577. LUCA.
GeneTreeiENSGT00390000011860.
HOGENOMiHOG000188934.
HOVERGENiHBG000402.
InParanoidiQ9R008.
KOiK00869.
OrthoDBiEOG7G1V6N.
PhylomeDBiQ9R008.
TreeFamiTF313775.

Enzyme and pathway databases

UniPathwayiUPA00057; UER00098.
BRENDAi2.7.1.36. 3474.
ReactomeiR-MMU-191273. Cholesterol biosynthesis.
R-MMU-2426168. Activation of gene expression by SREBF (SREBP).

Miscellaneous databases

PROiQ9R008.
SOURCEiSearch...

Gene expression databases

BgeeiQ9R008.
CleanExiMM_MVK.
ExpressionAtlasiQ9R008. baseline and differential.
GenevisibleiQ9R008. MM.

Family and domain databases

Gene3Di3.30.230.10. 1 hit.
3.30.70.890. 1 hit.
InterProiIPR013750. GHMP_kinase_C_dom.
IPR006204. GHMP_kinase_N_dom.
IPR006203. GHMP_knse_ATP-bd_CS.
IPR006205. Mev_gal_kin.
IPR006206. Mevalonate/galactokinase.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view]
PANTHERiPTHR10457. PTHR10457. 1 hit.
PTHR10457:SF4. PTHR10457:SF4. 1 hit.
PfamiPF08544. GHMP_kinases_C. 1 hit.
PF00288. GHMP_kinases_N. 1 hit.
[Graphical view]
PRINTSiPR00959. MEVGALKINASE.
SUPFAMiSSF54211. SSF54211. 1 hit.
SSF55060. SSF55060. 1 hit.
TIGRFAMsiTIGR00549. mevalon_kin. 1 hit.
PROSITEiPS00627. GHMP_KINASES_ATP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and characterization of three novel missense mutations in mevalonate kinase cDNA causing mevalonic aciduria, a disorder of isoprene biosynthesis."
    Houten S.M., Romeijn G.J., Koster J., Gray R.G.F., Darbyshire P., Smit G.P.A., de Klerk J.B.C., Duran R., Gibson K.M., Wanders R.J.A., Waterham H.R.
    Hum. Mol. Genet. 8:1523-1528(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary gland.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Liver, Lung, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiKIME_MOUSE
AccessioniPrimary (citable) accession number: Q9R008
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: June 8, 2016
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.