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Protein

Mevalonate kinase

Gene

Mvk

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the phosphorylation of mevalonate to mevalonate 5-phosphate, a key step in isoprenoid and cholesterol biosynthesis.By similarity

Catalytic activityi

ATP + (R)-mevalonate = ADP + (R)-5-phosphomevalonate.By similarity

Cofactori

Mg2+By similarity

Pathwayi: isopentenyl diphosphate biosynthesis via mevalonate pathway

This protein is involved in step 1 of the subpathway that synthesizes isopentenyl diphosphate from (R)-mevalonate.
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Mevalonate kinase (Mvk), Mevalonate kinase (Mvk)
  2. Phosphomevalonate kinase (Pmvk), Phosphomevalonate kinase (Pmvk), Phosphomevalonate kinase (Pmvk)
  3. no protein annotated in this organism
This subpathway is part of the pathway isopentenyl diphosphate biosynthesis via mevalonate pathway, which is itself part of Isoprenoid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes isopentenyl diphosphate from (R)-mevalonate, the pathway isopentenyl diphosphate biosynthesis via mevalonate pathway and in Isoprenoid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei13ATPBy similarity1
Binding sitei55ATPBy similarity1
Binding sitei104ATP; via carbonyl oxygenBy similarity1
Binding sitei135ATPBy similarity1
Metal bindingi146MagnesiumBy similarity1
Metal bindingi193MagnesiumBy similarity1
Active sitei204Proton acceptorBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi140 – 146ATPBy similarity7

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • identical protein binding Source: MGI
  • mevalonate kinase activity Source: MGI

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processCholesterol biosynthesis, Cholesterol metabolism, Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesis, Sterol metabolism
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.1.36 3474
ReactomeiR-MMU-191273 Cholesterol biosynthesis
UniPathwayiUPA00057; UER00098

Names & Taxonomyi

Protein namesi
Recommended name:
Mevalonate kinaseCurated (EC:2.7.1.36By similarity)
Short name:
MK
Gene namesi
Name:MvkImported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:107624 Mvk

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001566581 – 395Mevalonate kinaseAdd BLAST395

Proteomic databases

EPDiQ9R008
MaxQBiQ9R008
PaxDbiQ9R008
PeptideAtlasiQ9R008
PRIDEiQ9R008

PTM databases

PhosphoSitePlusiQ9R008

Expressioni

Gene expression databases

BgeeiENSMUSG00000041939
CleanExiMM_MVK
ExpressionAtlasiQ9R008 baseline and differential
GenevisibleiQ9R008 MM

Interactioni

Subunit structurei

Homodimer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ9R008, 1 interactor
MINTiQ9R008
STRINGi10090.ENSMUSP00000036971

Structurei

3D structure databases

ProteinModelPortaliQ9R008
SMRiQ9R008
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1511 Eukaryota
COG1577 LUCA
GeneTreeiENSGT00390000011860
HOGENOMiHOG000188934
HOVERGENiHBG000402
InParanoidiQ9R008
KOiK00869
PhylomeDBiQ9R008
TreeFamiTF313775

Family and domain databases

Gene3Di3.30.230.10, 2 hits
3.30.70.890, 1 hit
InterProiView protein in InterPro
IPR013750 GHMP_kinase_C_dom
IPR036554 GHMP_kinase_C_sf
IPR006204 GHMP_kinase_N_dom
IPR006203 GHMP_knse_ATP-bd_CS
IPR006205 Mev_gal_kin
IPR020568 Ribosomal_S5_D2-typ_fold
IPR014721 Ribosomal_S5_D2-typ_fold_subgr
PfamiView protein in Pfam
PF08544 GHMP_kinases_C, 1 hit
PF00288 GHMP_kinases_N, 1 hit
SUPFAMiSSF54211 SSF54211, 1 hit
SSF55060 SSF55060, 1 hit
TIGRFAMsiTIGR00549 mevalon_kin, 1 hit
PROSITEiView protein in PROSITE
PS00627 GHMP_KINASES_ATP, 1 hit

Sequencei

Sequence statusi: Complete.

Q9R008-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSEALLVSA PGKVILHGEH AVVHGKVALA AALNLRTFLL LRPQSNGKVS
60 70 80 90 100
VNLPNIGIKQ VWDVGMLQRL DTSFLEQGDV SVPTLEQLEK LKKMGDLPRD
110 120 130 140 150
RAGNEGMALL AFLYLYLAIC RKQRTLPSLD MVVWSELPPG AGLGSSAAYS
160 170 180 190 200
VCLAAALLTA CEEVSNPLKD GVSVSRWPEE DLKSINKWAF EGERVIHGNP
210 220 230 240 250
SGVDNAVSTW GGALRFQQGT MSSLKSLPSL QILLTNTKVP RSTKALVAAV
260 270 280 290 300
RSRLTKFPEI VAPLLTSIDA ISLECERVLG EMVAAPVPEQ YLVLEELIDM
310 320 330 340 350
NQHHLNALGV GHNSLDQLCQ VTAAHGLHSK LTGAGGGGCG ITLLKPGLEQ
360 370 380 390
ATVEAAKQAL TSCGFDCWET SIGAPGVSTH SAAAVGDPVR QALGL
Length:395
Mass (Da):41,877
Last modified:May 1, 2000 - v1
Checksum:i953DB1C89403A3F8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF137598 mRNA Translation: AAF00700.1
BC005606 mRNA Translation: AAH05606.1
CCDSiCCDS19566.1
RefSeqiNP_076045.1, NM_023556.3
XP_006530248.1, XM_006530185.3
UniGeneiMm.28088

Genome annotation databases

EnsembliENSMUST00000043760; ENSMUSP00000036971; ENSMUSG00000041939
GeneIDi17855
KEGGimmu:17855
UCSCiuc008yzq.1 mouse

Similar proteinsi

Entry informationi

Entry nameiKIME_MOUSE
AccessioniPrimary (citable) accession number: Q9R008
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: May 23, 2018
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

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