Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9QZZ6

- DERM_MOUSE

UniProt

Q9QZZ6 - DERM_MOUSE

Protein

Dermatopontin

Gene

Dpt

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Seems to mediate adhesion by cell surface integrin binding. May serve as a communication link between the dermal fibroblast cell surface and its extracellular matrix environment. Enhances TGFB1 activity By similarity. Inhibits cell proliferation. Accelerates collagen fibril formation, and stabilizes collagen fibrils against low-temperature dissociation.By similarity2 Publications

    GO - Biological processi

    1. cell adhesion Source: UniProtKB-KW
    2. collagen fibril organization Source: MGI
    3. negative regulation of cell proliferation Source: MGI

    Keywords - Biological processi

    Cell adhesion

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Dermatopontin
    Alternative name(s):
    Early quiescence protein 1
    Short name:
    EQ-1
    Tyrosine-rich acidic matrix protein
    Short name:
    TRAMP
    Gene namesi
    Name:Dpt
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 1

    Organism-specific databases

    MGIiMGI:1928392. Dpt.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: Ensembl
    2. proteinaceous extracellular matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Extracellular matrix, Secreted

    Pathology & Biotechi

    Disruption phenotypei

    Mice have reduced skin elasticity, a decrease in skin-thickness, and lower collagen content in the skin.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818By similarityAdd
    BLAST
    Chaini19 – 201183DermatopontinPRO_0000007369Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei19 – 191Pyrrolidone carboxylic acidBy similarity
    Modified residuei23 – 231SulfotyrosineSequence Analysis
    Disulfide bondi50 ↔ 77By similarity
    Disulfide bondi90 ↔ 132Or C-90 with C-133By similarity
    Disulfide bondi106 ↔ 133Or C-106 with C-132By similarity
    Disulfide bondi139 ↔ 196By similarity
    Disulfide bondi143 ↔ 189Sequence Analysis
    Modified residuei162 – 1621SulfotyrosineSequence Analysis
    Modified residuei164 – 1641SulfotyrosineSequence Analysis
    Modified residuei167 – 1671SulfotyrosineSequence Analysis
    Modified residuei194 – 1941SulfotyrosineSequence Analysis

    Post-translational modificationi

    Sulfated on tyrosine residue(s).By similarity

    Keywords - PTMi

    Disulfide bond, Pyrrolidone carboxylic acid, Sulfation

    Proteomic databases

    PaxDbiQ9QZZ6.
    PRIDEiQ9QZZ6.

    PTM databases

    PhosphoSiteiQ9QZZ6.

    Expressioni

    Inductioni

    Induced by cell quiescence.1 Publication

    Gene expression databases

    BgeeiQ9QZZ6.
    CleanExiMM_DPT.
    GenevestigatoriQ9QZZ6.

    Interactioni

    Subunit structurei

    Interacts with TGFB1, DCN and collagen.By similarity

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati26 – 79541-1Add
    BLAST
    Repeati70 – 7562-1
    Repeati80 – 135561-2Add
    BLAST
    Repeati125 – 13062-2
    Repeati181 – 18662-3

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni19 – 1861682 X 53-55 AA tandem repeatsAdd
    BLAST
    Regioni70 – 1861173 X 6 AA tandem repeats of D-R-[EQ]-W-[NQK]-[FY]Add
    BLAST

    Sequence similaritiesi

    Belongs to the dermatopontin family.Curated

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG39338.
    GeneTreeiENSGT00390000010760.
    HOGENOMiHOG000013186.
    HOVERGENiHBG005473.
    InParanoidiQ9QZZ6.
    OMAiIMCRMTD.
    OrthoDBiEOG75J0PB.
    PhylomeDBiQ9QZZ6.
    TreeFamiTF328602.

    Family and domain databases

    InterProiIPR026645. Dermatopontin_fam.
    [Graphical view]
    PANTHERiPTHR15040. PTHR15040. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9QZZ6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDLTLLWVLL PLVTTAWGQY GGYGYPYQQY QDYGDDGWVN LNRQGFSYQC    50
    PHGQVVVAVR SIFSKKEGSD RQWNYACMPT PQSLGEPTEC WWEEINRAGM 100
    EWYQKCSNNG LVAGFQSRYF ESVLDREWQF YCCRYSKRCP YSCWMTTEYP 150
    SHYGEDMDMI SYDYDFYMRG ATTTFSAVER DRQWKFIMCR MTDYDCEFEN 200
    V 201
    Length:201
    Mass (Da):23,995
    Last modified:May 1, 2000 - v1
    Checksum:iDA64550025B9C98E
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti64 – 641S → T in BAB31905. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF143374 mRNA. Translation: AAD54221.1.
    AK019890 mRNA. Translation: BAB31905.1.
    BC046420 mRNA. Translation: AAH46420.1.
    CCDSiCCDS15437.1.
    RefSeqiNP_062733.1. NM_019759.2.
    UniGeneiMm.28935.

    Genome annotation databases

    EnsembliENSMUST00000027861; ENSMUSP00000027861; ENSMUSG00000026574.
    GeneIDi56429.
    KEGGimmu:56429.
    UCSCiuc007diq.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF143374 mRNA. Translation: AAD54221.1 .
    AK019890 mRNA. Translation: BAB31905.1 .
    BC046420 mRNA. Translation: AAH46420.1 .
    CCDSi CCDS15437.1.
    RefSeqi NP_062733.1. NM_019759.2.
    UniGenei Mm.28935.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q9QZZ6.

    Proteomic databases

    PaxDbi Q9QZZ6.
    PRIDEi Q9QZZ6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000027861 ; ENSMUSP00000027861 ; ENSMUSG00000026574 .
    GeneIDi 56429.
    KEGGi mmu:56429.
    UCSCi uc007diq.1. mouse.

    Organism-specific databases

    CTDi 1805.
    MGIi MGI:1928392. Dpt.

    Phylogenomic databases

    eggNOGi NOG39338.
    GeneTreei ENSGT00390000010760.
    HOGENOMi HOG000013186.
    HOVERGENi HBG005473.
    InParanoidi Q9QZZ6.
    OMAi IMCRMTD.
    OrthoDBi EOG75J0PB.
    PhylomeDBi Q9QZZ6.
    TreeFami TF328602.

    Miscellaneous databases

    NextBioi 312598.
    PROi Q9QZZ6.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9QZZ6.
    CleanExi MM_DPT.
    Genevestigatori Q9QZZ6.

    Family and domain databases

    InterProi IPR026645. Dermatopontin_fam.
    [Graphical view ]
    PANTHERi PTHR15040. PTHR15040. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of murine early quiescence-1 gene: the murine counterpart of dermatopontin gene can induce and be induced by cell quiescence."
      Tzen C.-Y., Huang Y.-W.
      Exp. Cell Res. 294:30-38(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INDUCTION.
      Strain: BALB/c.
      Tissue: Mesenchymal stem cell.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Ovary and Uterus.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Salivary gland.
    4. "Targeted disruption of dermatopontin causes abnormal collagen fibrillogenesis."
      Takeda U., Utani A., Wu J., Adachi E., Koseki H., Taniguchi M., Matsumoto T., Ohashi T., Sato M., Shinkai H.
      J. Invest. Dermatol. 119:678-683(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, DISRUPTION PHENOTYPE.

    Entry informationi

    Entry nameiDERM_MOUSE
    AccessioniPrimary (citable) accession number: Q9QZZ6
    Secondary accession number(s): Q9D2B6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 11, 2001
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 101 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3