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Q9QZZ6

- DERM_MOUSE

UniProt

Q9QZZ6 - DERM_MOUSE

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Protein

Dermatopontin

Gene
Dpt
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Seems to mediate adhesion by cell surface integrin binding. May serve as a communication link between the dermal fibroblast cell surface and its extracellular matrix environment. Enhances TGFB1 activity By similarity. Inhibits cell proliferation. Accelerates collagen fibril formation, and stabilizes collagen fibrils against low-temperature dissociation.2 Publications

GO - Biological processi

  1. cell adhesion Source: UniProtKB-KW
  2. collagen fibril organization Source: MGI
  3. negative regulation of cell proliferation Source: MGI
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Dermatopontin
Alternative name(s):
Early quiescence protein 1
Short name:
EQ-1
Tyrosine-rich acidic matrix protein
Short name:
TRAMP
Gene namesi
Name:Dpt
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:1928392. Dpt.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: Ensembl
  2. proteinaceous extracellular matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Disruption phenotypei

Mice have reduced skin elasticity, a decrease in skin-thickness, and lower collagen content in the skin.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818 By similarityAdd
BLAST
Chaini19 – 201183DermatopontinPRO_0000007369Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei19 – 191Pyrrolidone carboxylic acid By similarity
Modified residuei23 – 231Sulfotyrosine Reviewed prediction
Disulfide bondi50 ↔ 77 By similarity
Disulfide bondi90 ↔ 132Or C-90 with C-133 By similarity
Disulfide bondi106 ↔ 133Or C-106 with C-132 By similarity
Disulfide bondi139 ↔ 196 By similarity
Disulfide bondi143 ↔ 189 Reviewed prediction
Modified residuei162 – 1621Sulfotyrosine Reviewed prediction
Modified residuei164 – 1641Sulfotyrosine Reviewed prediction
Modified residuei167 – 1671Sulfotyrosine Reviewed prediction
Modified residuei194 – 1941Sulfotyrosine Reviewed prediction

Post-translational modificationi

Sulfated on tyrosine residue(s) By similarity.

Keywords - PTMi

Disulfide bond, Pyrrolidone carboxylic acid, Sulfation

Proteomic databases

PaxDbiQ9QZZ6.
PRIDEiQ9QZZ6.

PTM databases

PhosphoSiteiQ9QZZ6.

Expressioni

Inductioni

Induced by cell quiescence.1 Publication

Gene expression databases

BgeeiQ9QZZ6.
CleanExiMM_DPT.
GenevestigatoriQ9QZZ6.

Interactioni

Subunit structurei

Interacts with TGFB1, DCN and collagen By similarity.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati26 – 79541-1Add
BLAST
Repeati70 – 7562-1
Repeati80 – 135561-2Add
BLAST
Repeati125 – 13062-2
Repeati181 – 18662-3

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni19 – 1861682 X 53-55 AA tandem repeatsAdd
BLAST
Regioni70 – 1861173 X 6 AA tandem repeats of D-R-[EQ]-W-[NQK]-[FY]Add
BLAST

Sequence similaritiesi

Belongs to the dermatopontin family.

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiNOG39338.
GeneTreeiENSGT00390000010760.
HOGENOMiHOG000013186.
HOVERGENiHBG005473.
InParanoidiQ9QZZ6.
OMAiIMCRMTD.
OrthoDBiEOG75J0PB.
PhylomeDBiQ9QZZ6.
TreeFamiTF328602.

Family and domain databases

InterProiIPR026645. Dermatopontin_fam.
[Graphical view]
PANTHERiPTHR15040. PTHR15040. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9QZZ6-1 [UniParc]FASTAAdd to Basket

« Hide

MDLTLLWVLL PLVTTAWGQY GGYGYPYQQY QDYGDDGWVN LNRQGFSYQC    50
PHGQVVVAVR SIFSKKEGSD RQWNYACMPT PQSLGEPTEC WWEEINRAGM 100
EWYQKCSNNG LVAGFQSRYF ESVLDREWQF YCCRYSKRCP YSCWMTTEYP 150
SHYGEDMDMI SYDYDFYMRG ATTTFSAVER DRQWKFIMCR MTDYDCEFEN 200
V 201
Length:201
Mass (Da):23,995
Last modified:May 1, 2000 - v1
Checksum:iDA64550025B9C98E
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti64 – 641S → T in BAB31905. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF143374 mRNA. Translation: AAD54221.1.
AK019890 mRNA. Translation: BAB31905.1.
BC046420 mRNA. Translation: AAH46420.1.
CCDSiCCDS15437.1.
RefSeqiNP_062733.1. NM_019759.2.
UniGeneiMm.28935.

Genome annotation databases

EnsembliENSMUST00000027861; ENSMUSP00000027861; ENSMUSG00000026574.
GeneIDi56429.
KEGGimmu:56429.
UCSCiuc007diq.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF143374 mRNA. Translation: AAD54221.1 .
AK019890 mRNA. Translation: BAB31905.1 .
BC046420 mRNA. Translation: AAH46420.1 .
CCDSi CCDS15437.1.
RefSeqi NP_062733.1. NM_019759.2.
UniGenei Mm.28935.

3D structure databases

ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q9QZZ6.

Proteomic databases

PaxDbi Q9QZZ6.
PRIDEi Q9QZZ6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000027861 ; ENSMUSP00000027861 ; ENSMUSG00000026574 .
GeneIDi 56429.
KEGGi mmu:56429.
UCSCi uc007diq.1. mouse.

Organism-specific databases

CTDi 1805.
MGIi MGI:1928392. Dpt.

Phylogenomic databases

eggNOGi NOG39338.
GeneTreei ENSGT00390000010760.
HOGENOMi HOG000013186.
HOVERGENi HBG005473.
InParanoidi Q9QZZ6.
OMAi IMCRMTD.
OrthoDBi EOG75J0PB.
PhylomeDBi Q9QZZ6.
TreeFami TF328602.

Miscellaneous databases

NextBioi 312598.
PROi Q9QZZ6.
SOURCEi Search...

Gene expression databases

Bgeei Q9QZZ6.
CleanExi MM_DPT.
Genevestigatori Q9QZZ6.

Family and domain databases

InterProi IPR026645. Dermatopontin_fam.
[Graphical view ]
PANTHERi PTHR15040. PTHR15040. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of murine early quiescence-1 gene: the murine counterpart of dermatopontin gene can induce and be induced by cell quiescence."
    Tzen C.-Y., Huang Y.-W.
    Exp. Cell Res. 294:30-38(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INDUCTION.
    Strain: BALB/c.
    Tissue: Mesenchymal stem cell.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Ovary and Uterus.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Salivary gland.
  4. "Targeted disruption of dermatopontin causes abnormal collagen fibrillogenesis."
    Takeda U., Utani A., Wu J., Adachi E., Koseki H., Taniguchi M., Matsumoto T., Ohashi T., Sato M., Shinkai H.
    J. Invest. Dermatol. 119:678-683(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiDERM_MOUSE
AccessioniPrimary (citable) accession number: Q9QZZ6
Secondary accession number(s): Q9D2B6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2001
Last sequence update: May 1, 2000
Last modified: July 9, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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