Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Dermatopontin

Gene

Dpt

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Seems to mediate adhesion by cell surface integrin binding. May serve as a communication link between the dermal fibroblast cell surface and its extracellular matrix environment. Enhances TGFB1 activity (By similarity). Inhibits cell proliferation. Accelerates collagen fibril formation, and stabilizes collagen fibrils against low-temperature dissociation.By similarity2 Publications

GO - Biological processi

  • cell adhesion Source: UniProtKB-KW
  • collagen fibril organization Source: MGI
  • negative regulation of cell proliferation Source: MGI

Keywordsi

Biological processCell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Dermatopontin
Alternative name(s):
Early quiescence protein 1
Short name:
EQ-1
Tyrosine-rich acidic matrix protein
Short name:
TRAMP
Gene namesi
Name:Dpt
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1928392 Dpt

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Disruption phenotypei

Mice have reduced skin elasticity, a decrease in skin-thickness, and lower collagen content in the skin.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18By similarityAdd BLAST18
ChainiPRO_000000736919 – 201DermatopontinAdd BLAST183

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei19Pyrrolidone carboxylic acidBy similarity1
Modified residuei23SulfotyrosineSequence analysis1
Disulfide bondi50 ↔ 77By similarity
Disulfide bondi90 ↔ 132Or C-90 with C-133By similarity
Disulfide bondi106 ↔ 133Or C-106 with C-132By similarity
Disulfide bondi139 ↔ 196By similarity
Disulfide bondi143 ↔ 189Sequence analysis
Modified residuei162SulfotyrosineSequence analysis1
Modified residuei164SulfotyrosineSequence analysis1
Modified residuei167SulfotyrosineSequence analysis1
Modified residuei194SulfotyrosineSequence analysis1

Post-translational modificationi

Sulfated on tyrosine residue(s).By similarity

Keywords - PTMi

Disulfide bond, Pyrrolidone carboxylic acid, Sulfation

Proteomic databases

MaxQBiQ9QZZ6
PaxDbiQ9QZZ6
PRIDEiQ9QZZ6

PTM databases

PhosphoSitePlusiQ9QZZ6

Expressioni

Inductioni

Induced by cell quiescence.1 Publication

Gene expression databases

BgeeiENSMUSG00000026574
CleanExiMM_DPT
GenevisibleiQ9QZZ6 MM

Interactioni

Subunit structurei

Interacts with TGFB1, DCN and collagen.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027861

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati26 – 791-1Add BLAST54
Repeati70 – 752-16
Repeati80 – 1351-2Add BLAST56
Repeati125 – 1302-26
Repeati181 – 1862-36

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni19 – 1862 X 53-55 AA tandem repeatsAdd BLAST168
Regioni70 – 1863 X 6 AA tandem repeats of D-R-[EQ]-W-[NQK]-[FY]Add BLAST117

Sequence similaritiesi

Belongs to the dermatopontin family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IGCN Eukaryota
ENOG4111HSK LUCA
GeneTreeiENSGT00390000010760
HOGENOMiHOG000013186
HOVERGENiHBG005473
InParanoidiQ9QZZ6
OMAiGFNFQCP
OrthoDBiEOG091G0L6V
PhylomeDBiQ9QZZ6
TreeFamiTF328602

Family and domain databases

InterProiView protein in InterPro
IPR026645 Dermatopontin_fam
PANTHERiPTHR15040 PTHR15040, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9QZZ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLTLLWVLL PLVTTAWGQY GGYGYPYQQY QDYGDDGWVN LNRQGFSYQC
60 70 80 90 100
PHGQVVVAVR SIFSKKEGSD RQWNYACMPT PQSLGEPTEC WWEEINRAGM
110 120 130 140 150
EWYQKCSNNG LVAGFQSRYF ESVLDREWQF YCCRYSKRCP YSCWMTTEYP
160 170 180 190 200
SHYGEDMDMI SYDYDFYMRG ATTTFSAVER DRQWKFIMCR MTDYDCEFEN

V
Length:201
Mass (Da):23,995
Last modified:May 1, 2000 - v1
Checksum:iDA64550025B9C98E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti64S → T in BAB31905 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF143374 mRNA Translation: AAD54221.1
AK019890 mRNA Translation: BAB31905.1
BC046420 mRNA Translation: AAH46420.1
CCDSiCCDS15437.1
RefSeqiNP_062733.1, NM_019759.2
UniGeneiMm.28935

Genome annotation databases

EnsembliENSMUST00000027861; ENSMUSP00000027861; ENSMUSG00000026574
GeneIDi56429
KEGGimmu:56429
UCSCiuc007diq.1 mouse

Similar proteinsi

Entry informationi

Entry nameiDERM_MOUSE
AccessioniPrimary (citable) accession number: Q9QZZ6
Secondary accession number(s): Q9D2B6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2001
Last sequence update: May 1, 2000
Last modified: May 23, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health