Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q9QZZ6 (DERM_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 100. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Dermatopontin
Alternative name(s):
Early quiescence protein 1
Short name=EQ-1
Tyrosine-rich acidic matrix protein
Short name=TRAMP
Gene names
Name:Dpt
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length201 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Seems to mediate adhesion by cell surface integrin binding. May serve as a communication link between the dermal fibroblast cell surface and its extracellular matrix environment. Enhances TGFB1 activity By similarity. Inhibits cell proliferation. Accelerates collagen fibril formation, and stabilizes collagen fibrils against low-temperature dissociation. Ref.1 Ref.4

Subunit structure

Interacts with TGFB1, DCN and collagen By similarity.

Subcellular location

Secretedextracellular spaceextracellular matrix By similarity.

Induction

Induced by cell quiescence. Ref.1

Post-translational modification

Sulfated on tyrosine residue(s) By similarity.

Disruption phenotype

Mice have reduced skin elasticity, a decrease in skin-thickness, and lower collagen content in the skin. Ref.4

Sequence similarities

Belongs to the dermatopontin family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818 By similarity
Chain19 – 201183Dermatopontin
PRO_0000007369

Regions

Repeat26 – 79541-1
Repeat70 – 7562-1
Repeat80 – 135561-2
Repeat125 – 13062-2
Repeat181 – 18662-3
Region19 – 1861682 X 53-55 AA tandem repeats
Region70 – 1861173 X 6 AA tandem repeats of D-R-[EQ]-W-[NQK]-[FY]

Amino acid modifications

Modified residue191Pyrrolidone carboxylic acid By similarity
Modified residue231Sulfotyrosine Potential
Modified residue1621Sulfotyrosine Potential
Modified residue1641Sulfotyrosine Potential
Modified residue1671Sulfotyrosine Potential
Modified residue1941Sulfotyrosine Potential
Disulfide bond50 ↔ 77 By similarity
Disulfide bond90 ↔ 132Or C-90 with C-133 By similarity
Disulfide bond106 ↔ 133Or C-106 with C-132 By similarity
Disulfide bond139 ↔ 196 By similarity
Disulfide bond143 ↔ 189 Potential

Experimental info

Sequence conflict641S → T in BAB31905. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q9QZZ6 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: DA64550025B9C98E

FASTA20123,995
        10         20         30         40         50         60 
MDLTLLWVLL PLVTTAWGQY GGYGYPYQQY QDYGDDGWVN LNRQGFSYQC PHGQVVVAVR 

        70         80         90        100        110        120 
SIFSKKEGSD RQWNYACMPT PQSLGEPTEC WWEEINRAGM EWYQKCSNNG LVAGFQSRYF 

       130        140        150        160        170        180 
ESVLDREWQF YCCRYSKRCP YSCWMTTEYP SHYGEDMDMI SYDYDFYMRG ATTTFSAVER 

       190        200 
DRQWKFIMCR MTDYDCEFEN V 

« Hide

References

« Hide 'large scale' references
[1]"Cloning of murine early quiescence-1 gene: the murine counterpart of dermatopontin gene can induce and be induced by cell quiescence."
Tzen C.-Y., Huang Y.-W.
Exp. Cell Res. 294:30-38(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INDUCTION.
Strain: BALB/c.
Tissue: Mesenchymal stem cell.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Ovary and Uterus.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Salivary gland.
[4]"Targeted disruption of dermatopontin causes abnormal collagen fibrillogenesis."
Takeda U., Utani A., Wu J., Adachi E., Koseki H., Taniguchi M., Matsumoto T., Ohashi T., Sato M., Shinkai H.
J. Invest. Dermatol. 119:678-683(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, DISRUPTION PHENOTYPE.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF143374 mRNA. Translation: AAD54221.1.
AK019890 mRNA. Translation: BAB31905.1.
BC046420 mRNA. Translation: AAH46420.1.
CCDSCCDS15437.1.
RefSeqNP_062733.1. NM_019759.2.
UniGeneMm.28935.

3D structure databases

ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ9QZZ6.

Proteomic databases

PaxDbQ9QZZ6.
PRIDEQ9QZZ6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000027861; ENSMUSP00000027861; ENSMUSG00000026574.
GeneID56429.
KEGGmmu:56429.
UCSCuc007diq.1. mouse.

Organism-specific databases

CTD1805.
MGIMGI:1928392. Dpt.

Phylogenomic databases

eggNOGNOG39338.
GeneTreeENSGT00390000010760.
HOGENOMHOG000013186.
HOVERGENHBG005473.
InParanoidQ9QZZ6.
OMAIMCRMTD.
OrthoDBEOG75J0PB.
PhylomeDBQ9QZZ6.
TreeFamTF328602.

Gene expression databases

BgeeQ9QZZ6.
CleanExMM_DPT.
GenevestigatorQ9QZZ6.

Family and domain databases

InterProIPR026645. Dermatopontin_fam.
[Graphical view]
PANTHERPTHR15040. PTHR15040. 1 hit.
ProtoNetSearch...

Other

NextBio312598.
PROQ9QZZ6.
SOURCESearch...

Entry information

Entry nameDERM_MOUSE
AccessionPrimary (citable) accession number: Q9QZZ6
Secondary accession number(s): Q9D2B6
Entry history
Integrated into UniProtKB/Swiss-Prot: July 11, 2001
Last sequence update: May 1, 2000
Last modified: July 9, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot