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Protein

Dermatopontin

Gene

Dpt

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Seems to mediate adhesion by cell surface integrin binding. May serve as a communication link between the dermal fibroblast cell surface and its extracellular matrix environment. Enhances TGFB1 activity (By similarity). Inhibits cell proliferation. Accelerates collagen fibril formation, and stabilizes collagen fibrils against low-temperature dissociation.By similarity2 Publications

GO - Biological processi

  • cell adhesion Source: UniProtKB-KW
  • collagen fibril organization Source: MGI
  • negative regulation of cell proliferation Source: MGI
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Dermatopontin
Alternative name(s):
Early quiescence protein 1
Short name:
EQ-1
Tyrosine-rich acidic matrix protein
Short name:
TRAMP
Gene namesi
Name:Dpt
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1928392. Dpt.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Disruption phenotypei

Mice have reduced skin elasticity, a decrease in skin-thickness, and lower collagen content in the skin.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18By similarityAdd BLAST18
ChainiPRO_000000736919 – 201DermatopontinAdd BLAST183

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei19Pyrrolidone carboxylic acidBy similarity1
Modified residuei23SulfotyrosineSequence analysis1
Disulfide bondi50 ↔ 77By similarity
Disulfide bondi90 ↔ 132Or C-90 with C-133By similarity
Disulfide bondi106 ↔ 133Or C-106 with C-132By similarity
Disulfide bondi139 ↔ 196By similarity
Disulfide bondi143 ↔ 189Sequence analysis
Modified residuei162SulfotyrosineSequence analysis1
Modified residuei164SulfotyrosineSequence analysis1
Modified residuei167SulfotyrosineSequence analysis1
Modified residuei194SulfotyrosineSequence analysis1

Post-translational modificationi

Sulfated on tyrosine residue(s).By similarity

Keywords - PTMi

Disulfide bond, Pyrrolidone carboxylic acid, Sulfation

Proteomic databases

MaxQBiQ9QZZ6.
PaxDbiQ9QZZ6.
PRIDEiQ9QZZ6.

PTM databases

PhosphoSitePlusiQ9QZZ6.

Expressioni

Inductioni

Induced by cell quiescence.1 Publication

Gene expression databases

BgeeiENSMUSG00000026574.
CleanExiMM_DPT.
GenevisibleiQ9QZZ6. MM.

Interactioni

Subunit structurei

Interacts with TGFB1, DCN and collagen.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027861.

Structurei

3D structure databases

ProteinModelPortaliQ9QZZ6.
SMRiQ9QZZ6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati26 – 791-1Add BLAST54
Repeati70 – 752-16
Repeati80 – 1351-2Add BLAST56
Repeati125 – 1302-26
Repeati181 – 1862-36

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni19 – 1862 X 53-55 AA tandem repeatsAdd BLAST168
Regioni70 – 1863 X 6 AA tandem repeats of D-R-[EQ]-W-[NQK]-[FY]Add BLAST117

Sequence similaritiesi

Belongs to the dermatopontin family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IGCN. Eukaryota.
ENOG4111HSK. LUCA.
GeneTreeiENSGT00390000010760.
HOGENOMiHOG000013186.
HOVERGENiHBG005473.
InParanoidiQ9QZZ6.
OMAiRRCPYSC.
OrthoDBiEOG091G0L6V.
PhylomeDBiQ9QZZ6.
TreeFamiTF328602.

Family and domain databases

InterProiIPR026645. Dermatopontin_fam.
[Graphical view]
PANTHERiPTHR15040. PTHR15040. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9QZZ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLTLLWVLL PLVTTAWGQY GGYGYPYQQY QDYGDDGWVN LNRQGFSYQC
60 70 80 90 100
PHGQVVVAVR SIFSKKEGSD RQWNYACMPT PQSLGEPTEC WWEEINRAGM
110 120 130 140 150
EWYQKCSNNG LVAGFQSRYF ESVLDREWQF YCCRYSKRCP YSCWMTTEYP
160 170 180 190 200
SHYGEDMDMI SYDYDFYMRG ATTTFSAVER DRQWKFIMCR MTDYDCEFEN

V
Length:201
Mass (Da):23,995
Last modified:May 1, 2000 - v1
Checksum:iDA64550025B9C98E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti64S → T in BAB31905 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF143374 mRNA. Translation: AAD54221.1.
AK019890 mRNA. Translation: BAB31905.1.
BC046420 mRNA. Translation: AAH46420.1.
CCDSiCCDS15437.1.
RefSeqiNP_062733.1. NM_019759.2.
UniGeneiMm.28935.

Genome annotation databases

EnsembliENSMUST00000027861; ENSMUSP00000027861; ENSMUSG00000026574.
GeneIDi56429.
KEGGimmu:56429.
UCSCiuc007diq.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF143374 mRNA. Translation: AAD54221.1.
AK019890 mRNA. Translation: BAB31905.1.
BC046420 mRNA. Translation: AAH46420.1.
CCDSiCCDS15437.1.
RefSeqiNP_062733.1. NM_019759.2.
UniGeneiMm.28935.

3D structure databases

ProteinModelPortaliQ9QZZ6.
SMRiQ9QZZ6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027861.

PTM databases

PhosphoSitePlusiQ9QZZ6.

Proteomic databases

MaxQBiQ9QZZ6.
PaxDbiQ9QZZ6.
PRIDEiQ9QZZ6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000027861; ENSMUSP00000027861; ENSMUSG00000026574.
GeneIDi56429.
KEGGimmu:56429.
UCSCiuc007diq.1. mouse.

Organism-specific databases

CTDi1805.
MGIiMGI:1928392. Dpt.

Phylogenomic databases

eggNOGiENOG410IGCN. Eukaryota.
ENOG4111HSK. LUCA.
GeneTreeiENSGT00390000010760.
HOGENOMiHOG000013186.
HOVERGENiHBG005473.
InParanoidiQ9QZZ6.
OMAiRRCPYSC.
OrthoDBiEOG091G0L6V.
PhylomeDBiQ9QZZ6.
TreeFamiTF328602.

Miscellaneous databases

PROiQ9QZZ6.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026574.
CleanExiMM_DPT.
GenevisibleiQ9QZZ6. MM.

Family and domain databases

InterProiIPR026645. Dermatopontin_fam.
[Graphical view]
PANTHERiPTHR15040. PTHR15040. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiDERM_MOUSE
AccessioniPrimary (citable) accession number: Q9QZZ6
Secondary accession number(s): Q9D2B6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2001
Last sequence update: May 1, 2000
Last modified: November 2, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.