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Protein

Unconventional myosin-XV

Gene

Myo15a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity). Required for the arrangement of stereocilia in mature hair bundles.By similarity2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi1299 – 1306ATPSequence analysis8

GO - Molecular functioni

GO - Biological processi

  • inner ear morphogenesis Source: MGI
  • locomotory behavior Source: MGI
  • sensory perception of sound Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Motor protein, Myosin

Keywords - Biological processi

Hearing

Keywords - Ligandi

Actin-binding, ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Unconventional myosin-XV
Alternative name(s):
Unconventional myosin-15
Gene namesi
Name:Myo15a
Synonyms:Myo15
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1261811. Myo15.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-KW
  • extracellular exosome Source: MGI
  • myosin complex Source: UniProtKB-KW
  • stereocilium Source: MGI
  • stereocilium bundle Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton

Pathology & Biotechi

Involvement in diseasei

Defects in Myo15a are the cause of shaker-2 (sh-2), a condition causing deafness, circling behavior, head tossing and hyperactivity. Auditory hair cells of affected animals have very short stereocilia and a long actin-containing protrusion at their basal end.

Keywords - Diseasei

Deafness, Disease mutation

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001234751 – 3511Unconventional myosin-XVAdd BLAST3511

Proteomic databases

PaxDbiQ9QZZ4.
PRIDEiQ9QZZ4.

PTM databases

iPTMnetiQ9QZZ4.
PhosphoSitePlusiQ9QZZ4.

Expressioni

Tissue specificityi

In the developing inner ear, expressed in cochlea and vestibular apparatus. Expression appears to be restricted to cochlear neurosensory cells and upper epithelial layer of macula saccula. Also expressed in macula utriculi and cristae ampullaris of the semicircular canals. In adult cochlear hair cells, highest expression in stereocilia and apical body.1 Publication

Gene expression databases

BgeeiENSMUSG00000042678.
CleanExiMM_MYO15.
ExpressionAtlasiQ9QZZ4. baseline and differential.
GenevisibleiQ9QZZ4. MM.

Interactioni

Subunit structurei

Interacts with the third PDZ domain of WHRN which is necessary for localization of WHRN to stereocilium tips. Interacts with FASLG (By similarity). Interacts with EPS8.By similarity2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Dfnb31Q80VW55EBI-4281382,EBI-7417603

Protein-protein interaction databases

BioGridi201662. 2 interactors.
IntActiQ9QZZ4. 3 interactors.
MINTiMINT-1895306.
STRINGi10090.ENSMUSP00000071777.

Structurei

3D structure databases

ProteinModelPortaliQ9QZZ4.
SMRiQ9QZZ4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1206 – 1883Myosin motorAdd BLAST678
Domaini1886 – 1908IQ 1PROSITE-ProRule annotationAdd BLAST23
Domaini1909 – 1938IQ 2PROSITE-ProRule annotationAdd BLAST30
Domaini2049 – 2195MyTH4 1PROSITE-ProRule annotationAdd BLAST147
Domaini2848 – 2934SH3PROSITE-ProRule annotationAdd BLAST87
Domaini3031 – 3185MyTH4 2PROSITE-ProRule annotationAdd BLAST155
Domaini3190 – 3511FERMPROSITE-ProRule annotationAdd BLAST322

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1776 – 1783Actin-bindingSequence analysis8
Regioni1872 – 2013Neck or regulatory domainAdd BLAST142
Regioni2014 – 3511TailAdd BLAST1498

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1307 – 1334Sequence analysisAdd BLAST28

Sequence similaritiesi

Contains 1 FERM domain.PROSITE-ProRule annotation
Contains 2 IQ domains.PROSITE-ProRule annotation
Contains 1 myosin motor domain.Curated
Contains 2 MyTH4 domains.PROSITE-ProRule annotation
Contains 1 SH3 domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat, SH3 domain

Phylogenomic databases

eggNOGiKOG4229. Eukaryota.
COG5022. LUCA.
GeneTreeiENSGT00840000129687.
HOVERGENiHBG052554.
InParanoidiQ9QZZ4.
KOiK10361.
OMAiPSQNMLE.
OrthoDBiEOG091G006G.
PhylomeDBiQ9QZZ4.
TreeFamiTF316834.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR019748. FERM_central.
IPR000299. FERM_domain.
IPR000048. IQ_motif_EF-hand-BS.
IPR001609. Myosin_head_motor_dom.
IPR000857. MyTH4_dom.
IPR027417. P-loop_NTPase.
IPR011993. PH_dom-like.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00373. FERM_M. 1 hit.
PF00612. IQ. 2 hits.
PF00063. Myosin_head. 1 hit.
PF00784. MyTH4. 2 hits.
PF07653. SH3_2. 1 hit.
[Graphical view]
PRINTSiPR00193. MYOSINHEAVY.
SMARTiSM00015. IQ. 3 hits.
SM00242. MYSc. 1 hit.
SM00139. MyTH4. 2 hits.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF47031. SSF47031. 1 hit.
SSF50044. SSF50044. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS50057. FERM_3. 1 hit.
PS50096. IQ. 2 hits.
PS51456. MYOSIN_MOTOR. 1 hit.
PS51016. MYTH4. 2 hits.
PS50002. SH3. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9QZZ4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MADEEKKAKK GKKGKKAPEP EKPKRSLKGT SRLFMGFRDR TPKISKKGQF
60 70 80 90 100
RSASAFFWGL HTGPQKTKRK KKARTVLKST SKLMTQMRVG KKKRAMKGKK
110 120 130 140 150
PSFMVIRFPG RRGYGRLRPR AQSLSKASTA INWLTKKFLL KKAEESGSEQ
160 170 180 190 200
ATVDAWLQRS SSRVGSRKLP FPSGAEILRH GGRLRRFPRS HSIYSSGEPV
210 220 230 240 250
GFLPFEDEAP FRHAGSRKSL YGLEGFQDLG EYYDYHREGD DYYDQQSLYH
260 270 280 290 300
YEEQEPYLAE FGGYSPAWPP YDDYGYPPGD PYNYYHPDYY GDTLYPGYAY
310 320 330 340 350
GYGYGYDDFE PPYAPPSGYS SPYSYHDSFE SEAYPYSYYL DPYATHHMPY
360 370 380 390 400
PPYDFPYDTP YDIPYFDPYG VPYAEGVYGG GAEAIYPPGM PYVYPEEPAF
410 420 430 440 450
MYPWVPPPIM SPHNPYAHPM DDIAELEEPE ETGEERQSTS FRLPSAAFFE
460 470 480 490 500
QQGMDKPARS KLSLIRKFRL FPRPQVKLFG KEKLEVPLPP SLDIPLPLGD
510 520 530 540 550
AEGEEEEEEM PPVPTMPYTH PYWSFLTPRQ RNLQRALSAF GARQGLGFGP
560 570 580 590 600
EFGHPTPRPA TSLARFLKKT LSEKKPIPRL RGSQKARGGR PPVREAAYKR
610 620 630 640 650
FGYKLAGMDP DRPNTPIVLR RSQPQARNNN NSHGPPSPRP APRALTHWSA
660 670 680 690 700
LISPPMPAPS PSPASPLTPP FSPTFSRPPR LASPYGSLRQ HPPPWAAPAH
710 720 730 740 750
VPFPPQANWW GFAEPPGTSP EVAPDLLAFP VPRPSFRASR SRSRRAAYGF
760 770 780 790 800
PSPSLIGSRR RPHLPSPQPS LRSLPGQGYH SPLGPLSPQL SLRRGPFQPP
810 820 830 840 850
FPPPPRRPQS LREAFSLRRA SGRLGPPRSP VLGSPRPPSP PPLLKHGPRH
860 870 880 890 900
RSLNLPSRLP RTWRRLSEPP TRAVKPWVHR AYPPPPSAGP WGASTGALEQ
910 920 930 940 950
QENQREAEDS ETPWTVPPLA PSWDVDMPPT QRPPSPWPEG IGSLRGFSRP
960 970 980 990 1000
PPVPENPLLE HTSPSCEPQS EDRVSNLTGI FLGQHHDPGP GQLTKSADPS
1010 1020 1030 1040 1050
LEKPEEVVTL GDPQPPAEPE ALNPTPPNKN VVSERKVLRL SASYPLVTCK
1060 1070 1080 1090 1100
QARATWPQWH RWKTVSRTPA PLAPTRAPGP LLKAGEQPRA EPGRFAVVMP
1110 1120 1130 1140 1150
QVRGVSSFRP KGPAPVQPPE HPDQDPEQGP APQACSLRWP RLWPPTDAHC
1160 1170 1180 1190 1200
LWSRIRTYSS QSHLRGHGGD CHKSLWKKTR PQSWQNKMHS IRNLPSMRSR
1210 1220 1230 1240 1250
EQHREDGVED MTQLEDLQET TVLANLKTRF ERNLIYTYIG SILVSVNPYR
1260 1270 1280 1290 1300
MFAIYGPEQV QQYSGRALGE NPPHLFAIAN LAFAKMLDAK QNQCVIISGE
1310 1320 1330 1340 1350
SGSGKTEATK LILRCLAAMN QRRDVMQQIK ILEATPLLEA FGNAKTVRND
1360 1370 1380 1390 1400
NSSRFGKFVE IFLEGGVICG AITSQYLLEK SRIVFQAKNE RNYHIFYELL
1410 1420 1430 1440 1450
AGLPAQLRQA FSLQEAETYY YLNQGGNCEI AGKSDADDFR RLLAAMEVLG
1460 1470 1480 1490 1500
FTSEDQDSIF RILASILHLG NVYFEKHETD AQEVASVVSA REIQAVAELL
1510 1520 1530 1540 1550
QVSPEGLQKA ITFKVTETIR EKIFTPLTVE SAVDARDAIA KVLYALLFGW
1560 1570 1580 1590 1600
LITRVNALVS PKQDTLSIAI LDIYGFEDLS FNSFEQLCIN YANENLQYLF
1610 1620 1630 1640 1650
NKIVFQEEQE EYIREQMDWR EIAFADNQPC INLISLKPYG ILRILDDQCC
1660 1670 1680 1690 1700
FPQATDHTFL QKCHYHHGAN PLYSKPKMPL PEFTIKHYAG KVTYQVHKFL
1710 1720 1730 1740 1750
DKNHDQVRQD VLDLFVHSRT RVVAHLFSSH AAQTAPPRLG KSSSITRLYK
1760 1770 1780 1790 1800
AHTVAAKFQQ SLLDLVEKME RCNPLFVRCL KPNHKKEPGL FEPDVMMAQL
1810 1820 1830 1840 1850
RYSGVLETVR IRKEGFPVRL PFQVFIDRYR CLVALKLNVP ADGDMCVSLL
1860 1870 1880 1890 1900
SRLCTVTPDM YRVGISKLFL KEHLHQLLES MRERVQNRAA LTLQRYLRGF
1910 1920 1930 1940 1950
FIQRHFRSLR RKIILLQSRA RGFLARQRYQ QMRQSLLKFR SLVHTYVNRR
1960 1970 1980 1990 2000
RYLKLRAEQR RRAQEAWLRE QEELSKREVV PVRHLEVPAE VAGLLQAAAG
2010 2020 2030 2040 2050
LKLSSGPRVA VVRAPRLQAE PCVTLPLDIN NYPMAKFIRC HFKEPSFGML
2060 2070 2080 2090 2100
TVPLKMPLTR LPVEHHAEAI SVFKLILRFM GDPHLHGTQE MILGNYIVHQ
2110 2120 2130 2140 2150
GLVEPALRDE ILAQLANQVW RNPNAYNSKR GWLLLAACLS GFAPSPHLDK
2160 2170 2180 2190 2200
FLLKFVSDYG QNGFQAVCQH RLLQAMGSGA ARTFPPTQLE WTAIQEKASM
2210 2220 2230 2240 2250
ALDVSCFNGD QFSCPVHTWS TGEAVAGDIL KHRGLADGWR GWTVAMKNGV
2260 2270 2280 2290 2300
QWAELAGHDY VLDLVSDLEL LRDFPRQKSY FIVGAEGPLA GRGDTRGVFG
2310 2320 2330 2340 2350
NCWDSDEDTP TRPQPQDHVA KMPDLDGYCS HKEDGTNGET EAQRWTSNRQ
2360 2370 2380 2390 2400
AVDSIGESTV PPRELDGYLD SLFDPVLACG DADLEKPTAI AYRMKGGGQP
2410 2420 2430 2440 2450
GGGGGSTSED TSRRPPEPKL KPIPGLDAST LALQQAFIHR QAVLLAREMT
2460 2470 2480 2490 2500
LQALALQQQP LSATSRPQLP ERPLAPEARP KTVVGTGPPA KPVLVRPTPQ
2510 2520 2530 2540 2550
SWAPGSVAKA PKIPSKPVAV PILAQDWTAP ESISASPELV RYSTLNSEHF
2560 2570 2580 2590 2600
PQPTQQIRSI IKQYKQPPWA GHPEARRTDG GKVFRRPPDP HEEALMILKG
2610 2620 2630 2640 2650
QKTQLAVVPG TQVSREAVAM VKPVTSAPRP CMGPTPVQPS RSLEPPEDPV
2660 2670 2680 2690 2700
QTQLHRLVNP NFYGYQDIPW RIFLRKEVFY PKDNYSHPVQ LDLLFRQILH
2710 2720 2730 2740 2750
DTFSEACLRI SEDERLQMKA LFAQNQLDTQ RPLVTESVKR AAISMARDSW
2760 2770 2780 2790 2800
EIYFSRLFPA MGSVGTGVQI LAVSHTGIKL LQMVKGSKEA SRRLRVLCAY
2810 2820 2830 2840 2850
SFADILFVTM PSQNMLEFNL SNEKLILFSA RAQQVKTLVD TFILELKKDS
2860 2870 2880 2890 2900
DYVVAVRNFL SEDPELLSFH KGDIIHLQSL EPTRVGYSAG CVVRKKLVYL
2910 2920 2930 2940 2950
EELRRRGPDF GWRFGAVHGR VGRFPSELVQ PAAAPDFLQL PAEPGRGRAA
2960 2970 2980 2990 3000
AVAAAVASAA AAQEVGRRRE GPPVRARSAD SGEDSIALPP STMLEFAQKY
3010 3020 3030 3040 3050
FRDPRRRPRD GLKLKSKEDR ESKTLEDVLC FTKVPIQESL IELSDSNLNK
3060 3070 3080 3090 3100
MAVDMFVAVM RFMGDAPLKG QSELDVLCTL LKLCGDHEVM RDECYCQIVK
3110 3120 3130 3140 3150
QITDNSSPKQ DSCQRGWRLL YIMAAYYSCS EVFYPYLIRF LQHVSWTPGL
3160 3170 3180 3190 3200
PFQGIAKACE QNLQKTLRFG GRLEFPSNME LRAMLAGRSS KRQLFLLPGG
3210 3220 3230 3240 3250
LERHLKIKTC TVALDVIEGL CTEMALTRPE AFDEYVIFVV TNRGQHVCPL
3260 3270 3280 3290 3300
SCRAYILDVA SEMEQVDGGY TLWFRRVLWD QPLKFENELY VTMHYNQVLP
3310 3320 3330 3340 3350
DYLKGLFSSV PARQPTEQQL QQVSKLASLQ HRAKDHFYLP SVREVQEYIP
3360 3370 3380 3390 3400
AQLYHTTAGD TWLNLVSQHR QQTQALSPHQ ARAQFLGLLS AFPLFGSSFF
3410 3420 3430 3440 3450
FIQSCSNVLV PAPCILAVNH NGLNFLSTKT HELIVKIPLK EIQSTWTQQP
3460 3470 3480 3490 3500
TANSSYPYVE ISLGDVAAQR TMQLQLEQGL ELCRVVAVHV ESMLSAREER
3510
LTLPPSEITL L
Length:3,511
Mass (Da):395,622
Last modified:December 4, 2007 - v2
Checksum:iB66F3E06F4B5983E
GO
Isoform 2 (identifier: Q9QZZ4-2) [UniParc]FASTAAdd to basket
Also known as: 1a

The sequence of this isoform differs from the canonical sequence as follows:
     1955-1972: Missing.

Show »
Length:3,493
Mass (Da):393,314
Checksum:i3079F6C54FBA524B
GO
Isoform 3 (identifier: Q9QZZ4-3) [UniParc]FASTAAdd to basket
Also known as: 2a

The sequence of this isoform differs from the canonical sequence as follows:
     1-1187: Missing.
     1955-1972: Missing.

Show »
Length:2,306
Mass (Da):260,047
Checksum:iE0CE013113707EC8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1141R → C in AAF05904 (PubMed:10552926).Curated1
Sequence conflicti1141R → C in AAP88402 (PubMed:14610277).Curated1
Sequence conflicti1330 – 1331Missing in AAC40124 (PubMed:9603735).Curated2
Sequence conflicti1579L → R in BAA36582 (PubMed:9703981).Curated1
Sequence conflicti2077L → M in AAC40124 (PubMed:9603735).Curated1
Sequence conflicti2139L → P in AAC40124 (PubMed:9603735).Curated1
Sequence conflicti2953A → V in AAF05904 (PubMed:10552926).Curated1
Sequence conflicti2953A → V in AAP88402 (PubMed:14610277).Curated1
Sequence conflicti2953A → V in AAP88403 (PubMed:14610277).Curated1
Sequence conflicti3195F → S in AAF05904 (PubMed:10552926).Curated1
Sequence conflicti3195F → S in AAP88402 (PubMed:14610277).Curated1
Sequence conflicti3195F → S in AAP88403 (PubMed:14610277).Curated1
Sequence conflicti3449Q → K in AAF05904 (PubMed:10552926).Curated1
Sequence conflicti3449Q → K in AAP88402 (PubMed:14610277).Curated1
Sequence conflicti3449Q → K in AAP88403 (PubMed:14610277).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti1779C → Y in sh-2. 2 Publications1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0299441 – 1187Missing in isoform 3. 1 PublicationAdd BLAST1187
Alternative sequenceiVSP_0299451955 – 1972Missing in isoform 2 and isoform 3. 1 PublicationAdd BLAST18

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF144095 mRNA. Translation: AAF05904.1.
AY331132 mRNA. Translation: AAP88402.1.
AY331133 mRNA. Translation: AAP88403.1.
AL596090, AL596386 Genomic DNA. Translation: CAI24082.2.
AL596090, AL596386 Genomic DNA. Translation: CAM14761.1.
AL596090, AL596386 Genomic DNA. Translation: CAM14762.1.
AL596386, AL596090 Genomic DNA. Translation: CAI35347.1.
AL596386, AL596090 Genomic DNA. Translation: CAM21169.1.
AL596386, AL596090 Genomic DNA. Translation: CAM21170.1.
AF053130 mRNA. Translation: AAC40124.1.
AB014510 mRNA. Translation: BAA36582.1.
CCDSiCCDS24792.1. [Q9QZZ4-1]
CCDS24793.1. [Q9QZZ4-3]
CCDS48811.1. [Q9QZZ4-2]
PIRiA59295.
T42386.
RefSeqiNP_001096641.1. NM_001103171.1. [Q9QZZ4-2]
NP_034992.2. NM_010862.2. [Q9QZZ4-1]
NP_874357.2. NM_182698.2. [Q9QZZ4-3]
XP_017169821.1. XM_017314332.1. [Q9QZZ4-1]
XP_017169822.1. XM_017314333.1. [Q9QZZ4-2]
UniGeneiMm.89960.

Genome annotation databases

EnsembliENSMUST00000071880; ENSMUSP00000071777; ENSMUSG00000042678. [Q9QZZ4-1]
ENSMUST00000081823; ENSMUSP00000080507; ENSMUSG00000042678. [Q9QZZ4-3]
ENSMUST00000094135; ENSMUSP00000091686; ENSMUSG00000042678. [Q9QZZ4-2]
GeneIDi17910.
KEGGimmu:17910.
UCSCiuc007jfz.1. mouse. [Q9QZZ4-1]
uc007jga.1. mouse. [Q9QZZ4-3]
uc007jgb.2. mouse. [Q9QZZ4-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF144095 mRNA. Translation: AAF05904.1.
AY331132 mRNA. Translation: AAP88402.1.
AY331133 mRNA. Translation: AAP88403.1.
AL596090, AL596386 Genomic DNA. Translation: CAI24082.2.
AL596090, AL596386 Genomic DNA. Translation: CAM14761.1.
AL596090, AL596386 Genomic DNA. Translation: CAM14762.1.
AL596386, AL596090 Genomic DNA. Translation: CAI35347.1.
AL596386, AL596090 Genomic DNA. Translation: CAM21169.1.
AL596386, AL596090 Genomic DNA. Translation: CAM21170.1.
AF053130 mRNA. Translation: AAC40124.1.
AB014510 mRNA. Translation: BAA36582.1.
CCDSiCCDS24792.1. [Q9QZZ4-1]
CCDS24793.1. [Q9QZZ4-3]
CCDS48811.1. [Q9QZZ4-2]
PIRiA59295.
T42386.
RefSeqiNP_001096641.1. NM_001103171.1. [Q9QZZ4-2]
NP_034992.2. NM_010862.2. [Q9QZZ4-1]
NP_874357.2. NM_182698.2. [Q9QZZ4-3]
XP_017169821.1. XM_017314332.1. [Q9QZZ4-1]
XP_017169822.1. XM_017314333.1. [Q9QZZ4-2]
UniGeneiMm.89960.

3D structure databases

ProteinModelPortaliQ9QZZ4.
SMRiQ9QZZ4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi201662. 2 interactors.
IntActiQ9QZZ4. 3 interactors.
MINTiMINT-1895306.
STRINGi10090.ENSMUSP00000071777.

PTM databases

iPTMnetiQ9QZZ4.
PhosphoSitePlusiQ9QZZ4.

Proteomic databases

PaxDbiQ9QZZ4.
PRIDEiQ9QZZ4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000071880; ENSMUSP00000071777; ENSMUSG00000042678. [Q9QZZ4-1]
ENSMUST00000081823; ENSMUSP00000080507; ENSMUSG00000042678. [Q9QZZ4-3]
ENSMUST00000094135; ENSMUSP00000091686; ENSMUSG00000042678. [Q9QZZ4-2]
GeneIDi17910.
KEGGimmu:17910.
UCSCiuc007jfz.1. mouse. [Q9QZZ4-1]
uc007jga.1. mouse. [Q9QZZ4-3]
uc007jgb.2. mouse. [Q9QZZ4-2]

Organism-specific databases

CTDi17910.
MGIiMGI:1261811. Myo15.

Phylogenomic databases

eggNOGiKOG4229. Eukaryota.
COG5022. LUCA.
GeneTreeiENSGT00840000129687.
HOVERGENiHBG052554.
InParanoidiQ9QZZ4.
KOiK10361.
OMAiPSQNMLE.
OrthoDBiEOG091G006G.
PhylomeDBiQ9QZZ4.
TreeFamiTF316834.

Miscellaneous databases

PROiQ9QZZ4.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000042678.
CleanExiMM_MYO15.
ExpressionAtlasiQ9QZZ4. baseline and differential.
GenevisibleiQ9QZZ4. MM.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR019748. FERM_central.
IPR000299. FERM_domain.
IPR000048. IQ_motif_EF-hand-BS.
IPR001609. Myosin_head_motor_dom.
IPR000857. MyTH4_dom.
IPR027417. P-loop_NTPase.
IPR011993. PH_dom-like.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00373. FERM_M. 1 hit.
PF00612. IQ. 2 hits.
PF00063. Myosin_head. 1 hit.
PF00784. MyTH4. 2 hits.
PF07653. SH3_2. 1 hit.
[Graphical view]
PRINTSiPR00193. MYOSINHEAVY.
SMARTiSM00015. IQ. 3 hits.
SM00242. MYSc. 1 hit.
SM00139. MyTH4. 2 hits.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF47031. SSF47031. 1 hit.
SSF50044. SSF50044. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS50057. FERM_3. 1 hit.
PS50096. IQ. 2 hits.
PS51456. MYOSIN_MOTOR. 1 hit.
PS51016. MYTH4. 2 hits.
PS50002. SH3. 1 hit.
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Entry informationi

Entry nameiMYO15_MOUSE
AccessioniPrimary (citable) accession number: Q9QZZ4
Secondary accession number(s): A2A637
, A2A638, O70395, Q5SX93, Q7TMR5, Q7TMR6, Q9QWL6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: December 4, 2007
Last modified: November 30, 2016
This is version 150 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

Represents an unconventional myosin. This protein should not be confused with the conventional myosin-15 (MYH15).Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.