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Q9QZZ4

- MYO15_MOUSE

UniProt

Q9QZZ4 - MYO15_MOUSE

Protein

Unconventional myosin-XV

Gene

Myo15a

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 131 (01 Oct 2014)
      Sequence version 2 (04 Dec 2007)
      Previous versions | rss
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    Functioni

    Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments By similarity. Required for the arrangement of stereocilia in mature hair bundles.By similarity2 Publications

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi1299 – 13068ATPSequence Analysis

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. motor activity Source: InterPro
    3. protein binding Source: UniProtKB

    GO - Biological processi

    1. inner ear morphogenesis Source: MGI
    2. locomotory behavior Source: MGI
    3. sensory perception of sound Source: MGI

    Keywords - Molecular functioni

    Motor protein, Myosin

    Keywords - Biological processi

    Hearing

    Keywords - Ligandi

    Actin-binding, ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Unconventional myosin-XV
    Alternative name(s):
    Unconventional myosin-15
    Gene namesi
    Name:Myo15a
    Synonyms:Myo15
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:1261811. Myo15.

    Subcellular locationi

    Cell projectionstereocilium 1 Publication. Cytoplasmcytoskeleton 1 Publication
    Note: Localizes to stereocilium tips in cochlear and vestibular hair cells.

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-KW
    2. myosin complex Source: UniProtKB-KW
    3. stereocilium Source: MGI
    4. stereocilium bundle Source: MGI

    Keywords - Cellular componenti

    Cell projection, Cytoplasm, Cytoskeleton

    Pathology & Biotechi

    Involvement in diseasei

    Defects in Myo15a are the cause of shaker-2 (sh-2), a condition causing deafness, circling behavior, head tossing and hyperactivity. Auditory hair cells of affected animals have very short stereocilia and a long actin-containing protrusion at their basal end.

    Keywords - Diseasei

    Deafness, Disease mutation

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 35113511Unconventional myosin-XVPRO_0000123475Add
    BLAST

    Proteomic databases

    PaxDbiQ9QZZ4.
    PRIDEiQ9QZZ4.

    PTM databases

    PhosphoSiteiQ9QZZ4.

    Expressioni

    Tissue specificityi

    In the developing inner ear, expressed in cochlea and vestibular apparatus. Expression appears to be restricted to cochlear neurosensory cells and upper epithelial layer of macula saccula. Also expressed in macula utriculi and cristae ampullaris of the semicircular canals. In adult cochlear hair cells, highest expression in stereocilia and apical body.1 Publication

    Gene expression databases

    BgeeiQ9QZZ4.
    CleanExiMM_MYO15.
    GenevestigatoriQ9QZZ4.

    Interactioni

    Subunit structurei

    Interacts with the third PDZ domain of WHRN which is necessary for localization of WHRN to stereocilium tips. Interacts with FASLG By similarity. Interacts with EPS8.By similarity2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Dfnb31Q80VW55EBI-4281382,EBI-7417603

    Protein-protein interaction databases

    BioGridi201662. 2 interactions.
    IntActiQ9QZZ4. 3 interactions.
    MINTiMINT-1895306.
    STRINGi10090.ENSMUSP00000071777.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9QZZ4.
    SMRiQ9QZZ4. Positions 1206-1978, 2028-2269, 2666-2937, 3046-3424.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1206 – 1883678Myosin motorAdd
    BLAST
    Domaini1886 – 190823IQ 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini1909 – 193830IQ 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini2049 – 2195147MyTH4 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini2848 – 293487SH3PROSITE-ProRule annotationAdd
    BLAST
    Domaini3031 – 3185155MyTH4 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini3190 – 3511322FERMPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1776 – 17838Actin-bindingSequence Analysis
    Regioni1872 – 2013142Neck or regulatory domainAdd
    BLAST
    Regioni2014 – 35111498TailAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili1307 – 133428Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Contains 1 FERM domain.PROSITE-ProRule annotation
    Contains 2 IQ domains.PROSITE-ProRule annotation
    Contains 1 myosin motor domain.Curated
    Contains 2 MyTH4 domains.PROSITE-ProRule annotation
    Contains 1 SH3 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil, Repeat, SH3 domain

    Phylogenomic databases

    eggNOGiCOG5022.
    GeneTreeiENSGT00750000117344.
    HOVERGENiHBG052554.
    InParanoidiQ9QZZ4.
    KOiK10361.
    OMAiPSQNMLE.
    OrthoDBiEOG7XPZ4Q.
    PhylomeDBiQ9QZZ4.
    TreeFamiTF316834.

    Family and domain databases

    InterProiIPR019749. Band_41_domain.
    IPR019748. FERM_central.
    IPR000299. FERM_domain.
    IPR000048. IQ_motif_EF-hand-BS.
    IPR001609. Myosin_head_motor_dom.
    IPR000857. MyTH4_dom.
    IPR027417. P-loop_NTPase.
    IPR011511. SH3_2.
    IPR001452. SH3_domain.
    [Graphical view]
    PfamiPF00612. IQ. 2 hits.
    PF00063. Myosin_head. 1 hit.
    PF00784. MyTH4. 2 hits.
    PF07653. SH3_2. 1 hit.
    [Graphical view]
    PRINTSiPR00193. MYOSINHEAVY.
    SMARTiSM00295. B41. 1 hit.
    SM00015. IQ. 3 hits.
    SM00242. MYSc. 1 hit.
    SM00139. MyTH4. 2 hits.
    SM00326. SH3. 1 hit.
    [Graphical view]
    SUPFAMiSSF47031. SSF47031. 1 hit.
    SSF50044. SSF50044. 1 hit.
    SSF52540. SSF52540. 1 hit.
    PROSITEiPS50057. FERM_3. 1 hit.
    PS50096. IQ. 2 hits.
    PS51456. MYOSIN_MOTOR. 1 hit.
    PS51016. MYTH4. 2 hits.
    PS50002. SH3. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9QZZ4-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MADEEKKAKK GKKGKKAPEP EKPKRSLKGT SRLFMGFRDR TPKISKKGQF     50
    RSASAFFWGL HTGPQKTKRK KKARTVLKST SKLMTQMRVG KKKRAMKGKK 100
    PSFMVIRFPG RRGYGRLRPR AQSLSKASTA INWLTKKFLL KKAEESGSEQ 150
    ATVDAWLQRS SSRVGSRKLP FPSGAEILRH GGRLRRFPRS HSIYSSGEPV 200
    GFLPFEDEAP FRHAGSRKSL YGLEGFQDLG EYYDYHREGD DYYDQQSLYH 250
    YEEQEPYLAE FGGYSPAWPP YDDYGYPPGD PYNYYHPDYY GDTLYPGYAY 300
    GYGYGYDDFE PPYAPPSGYS SPYSYHDSFE SEAYPYSYYL DPYATHHMPY 350
    PPYDFPYDTP YDIPYFDPYG VPYAEGVYGG GAEAIYPPGM PYVYPEEPAF 400
    MYPWVPPPIM SPHNPYAHPM DDIAELEEPE ETGEERQSTS FRLPSAAFFE 450
    QQGMDKPARS KLSLIRKFRL FPRPQVKLFG KEKLEVPLPP SLDIPLPLGD 500
    AEGEEEEEEM PPVPTMPYTH PYWSFLTPRQ RNLQRALSAF GARQGLGFGP 550
    EFGHPTPRPA TSLARFLKKT LSEKKPIPRL RGSQKARGGR PPVREAAYKR 600
    FGYKLAGMDP DRPNTPIVLR RSQPQARNNN NSHGPPSPRP APRALTHWSA 650
    LISPPMPAPS PSPASPLTPP FSPTFSRPPR LASPYGSLRQ HPPPWAAPAH 700
    VPFPPQANWW GFAEPPGTSP EVAPDLLAFP VPRPSFRASR SRSRRAAYGF 750
    PSPSLIGSRR RPHLPSPQPS LRSLPGQGYH SPLGPLSPQL SLRRGPFQPP 800
    FPPPPRRPQS LREAFSLRRA SGRLGPPRSP VLGSPRPPSP PPLLKHGPRH 850
    RSLNLPSRLP RTWRRLSEPP TRAVKPWVHR AYPPPPSAGP WGASTGALEQ 900
    QENQREAEDS ETPWTVPPLA PSWDVDMPPT QRPPSPWPEG IGSLRGFSRP 950
    PPVPENPLLE HTSPSCEPQS EDRVSNLTGI FLGQHHDPGP GQLTKSADPS 1000
    LEKPEEVVTL GDPQPPAEPE ALNPTPPNKN VVSERKVLRL SASYPLVTCK 1050
    QARATWPQWH RWKTVSRTPA PLAPTRAPGP LLKAGEQPRA EPGRFAVVMP 1100
    QVRGVSSFRP KGPAPVQPPE HPDQDPEQGP APQACSLRWP RLWPPTDAHC 1150
    LWSRIRTYSS QSHLRGHGGD CHKSLWKKTR PQSWQNKMHS IRNLPSMRSR 1200
    EQHREDGVED MTQLEDLQET TVLANLKTRF ERNLIYTYIG SILVSVNPYR 1250
    MFAIYGPEQV QQYSGRALGE NPPHLFAIAN LAFAKMLDAK QNQCVIISGE 1300
    SGSGKTEATK LILRCLAAMN QRRDVMQQIK ILEATPLLEA FGNAKTVRND 1350
    NSSRFGKFVE IFLEGGVICG AITSQYLLEK SRIVFQAKNE RNYHIFYELL 1400
    AGLPAQLRQA FSLQEAETYY YLNQGGNCEI AGKSDADDFR RLLAAMEVLG 1450
    FTSEDQDSIF RILASILHLG NVYFEKHETD AQEVASVVSA REIQAVAELL 1500
    QVSPEGLQKA ITFKVTETIR EKIFTPLTVE SAVDARDAIA KVLYALLFGW 1550
    LITRVNALVS PKQDTLSIAI LDIYGFEDLS FNSFEQLCIN YANENLQYLF 1600
    NKIVFQEEQE EYIREQMDWR EIAFADNQPC INLISLKPYG ILRILDDQCC 1650
    FPQATDHTFL QKCHYHHGAN PLYSKPKMPL PEFTIKHYAG KVTYQVHKFL 1700
    DKNHDQVRQD VLDLFVHSRT RVVAHLFSSH AAQTAPPRLG KSSSITRLYK 1750
    AHTVAAKFQQ SLLDLVEKME RCNPLFVRCL KPNHKKEPGL FEPDVMMAQL 1800
    RYSGVLETVR IRKEGFPVRL PFQVFIDRYR CLVALKLNVP ADGDMCVSLL 1850
    SRLCTVTPDM YRVGISKLFL KEHLHQLLES MRERVQNRAA LTLQRYLRGF 1900
    FIQRHFRSLR RKIILLQSRA RGFLARQRYQ QMRQSLLKFR SLVHTYVNRR 1950
    RYLKLRAEQR RRAQEAWLRE QEELSKREVV PVRHLEVPAE VAGLLQAAAG 2000
    LKLSSGPRVA VVRAPRLQAE PCVTLPLDIN NYPMAKFIRC HFKEPSFGML 2050
    TVPLKMPLTR LPVEHHAEAI SVFKLILRFM GDPHLHGTQE MILGNYIVHQ 2100
    GLVEPALRDE ILAQLANQVW RNPNAYNSKR GWLLLAACLS GFAPSPHLDK 2150
    FLLKFVSDYG QNGFQAVCQH RLLQAMGSGA ARTFPPTQLE WTAIQEKASM 2200
    ALDVSCFNGD QFSCPVHTWS TGEAVAGDIL KHRGLADGWR GWTVAMKNGV 2250
    QWAELAGHDY VLDLVSDLEL LRDFPRQKSY FIVGAEGPLA GRGDTRGVFG 2300
    NCWDSDEDTP TRPQPQDHVA KMPDLDGYCS HKEDGTNGET EAQRWTSNRQ 2350
    AVDSIGESTV PPRELDGYLD SLFDPVLACG DADLEKPTAI AYRMKGGGQP 2400
    GGGGGSTSED TSRRPPEPKL KPIPGLDAST LALQQAFIHR QAVLLAREMT 2450
    LQALALQQQP LSATSRPQLP ERPLAPEARP KTVVGTGPPA KPVLVRPTPQ 2500
    SWAPGSVAKA PKIPSKPVAV PILAQDWTAP ESISASPELV RYSTLNSEHF 2550
    PQPTQQIRSI IKQYKQPPWA GHPEARRTDG GKVFRRPPDP HEEALMILKG 2600
    QKTQLAVVPG TQVSREAVAM VKPVTSAPRP CMGPTPVQPS RSLEPPEDPV 2650
    QTQLHRLVNP NFYGYQDIPW RIFLRKEVFY PKDNYSHPVQ LDLLFRQILH 2700
    DTFSEACLRI SEDERLQMKA LFAQNQLDTQ RPLVTESVKR AAISMARDSW 2750
    EIYFSRLFPA MGSVGTGVQI LAVSHTGIKL LQMVKGSKEA SRRLRVLCAY 2800
    SFADILFVTM PSQNMLEFNL SNEKLILFSA RAQQVKTLVD TFILELKKDS 2850
    DYVVAVRNFL SEDPELLSFH KGDIIHLQSL EPTRVGYSAG CVVRKKLVYL 2900
    EELRRRGPDF GWRFGAVHGR VGRFPSELVQ PAAAPDFLQL PAEPGRGRAA 2950
    AVAAAVASAA AAQEVGRRRE GPPVRARSAD SGEDSIALPP STMLEFAQKY 3000
    FRDPRRRPRD GLKLKSKEDR ESKTLEDVLC FTKVPIQESL IELSDSNLNK 3050
    MAVDMFVAVM RFMGDAPLKG QSELDVLCTL LKLCGDHEVM RDECYCQIVK 3100
    QITDNSSPKQ DSCQRGWRLL YIMAAYYSCS EVFYPYLIRF LQHVSWTPGL 3150
    PFQGIAKACE QNLQKTLRFG GRLEFPSNME LRAMLAGRSS KRQLFLLPGG 3200
    LERHLKIKTC TVALDVIEGL CTEMALTRPE AFDEYVIFVV TNRGQHVCPL 3250
    SCRAYILDVA SEMEQVDGGY TLWFRRVLWD QPLKFENELY VTMHYNQVLP 3300
    DYLKGLFSSV PARQPTEQQL QQVSKLASLQ HRAKDHFYLP SVREVQEYIP 3350
    AQLYHTTAGD TWLNLVSQHR QQTQALSPHQ ARAQFLGLLS AFPLFGSSFF 3400
    FIQSCSNVLV PAPCILAVNH NGLNFLSTKT HELIVKIPLK EIQSTWTQQP 3450
    TANSSYPYVE ISLGDVAAQR TMQLQLEQGL ELCRVVAVHV ESMLSAREER 3500
    LTLPPSEITL L 3511
    Length:3,511
    Mass (Da):395,622
    Last modified:December 4, 2007 - v2
    Checksum:iB66F3E06F4B5983E
    GO
    Isoform 2 (identifier: Q9QZZ4-2) [UniParc]FASTAAdd to Basket

    Also known as: 1a

    The sequence of this isoform differs from the canonical sequence as follows:
         1955-1972: Missing.

    Show »
    Length:3,493
    Mass (Da):393,314
    Checksum:i3079F6C54FBA524B
    GO
    Isoform 3 (identifier: Q9QZZ4-3) [UniParc]FASTAAdd to Basket

    Also known as: 2a

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1187: Missing.
         1955-1972: Missing.

    Show »
    Length:2,306
    Mass (Da):260,047
    Checksum:iE0CE013113707EC8
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti1141 – 11411R → C in AAF05904. (PubMed:10552926)Curated
    Sequence conflicti1141 – 11411R → C in AAP88402. (PubMed:14610277)Curated
    Sequence conflicti1330 – 13312Missing in AAC40124. (PubMed:9603735)Curated
    Sequence conflicti1579 – 15791L → R in BAA36582. (PubMed:9703981)Curated
    Sequence conflicti2077 – 20771L → M in AAC40124. (PubMed:9603735)Curated
    Sequence conflicti2139 – 21391L → P in AAC40124. (PubMed:9603735)Curated
    Sequence conflicti2953 – 29531A → V in AAF05904. (PubMed:10552926)Curated
    Sequence conflicti2953 – 29531A → V in AAP88402. (PubMed:14610277)Curated
    Sequence conflicti2953 – 29531A → V in AAP88403. (PubMed:14610277)Curated
    Sequence conflicti3195 – 31951F → S in AAF05904. (PubMed:10552926)Curated
    Sequence conflicti3195 – 31951F → S in AAP88402. (PubMed:14610277)Curated
    Sequence conflicti3195 – 31951F → S in AAP88403. (PubMed:14610277)Curated
    Sequence conflicti3449 – 34491Q → K in AAF05904. (PubMed:10552926)Curated
    Sequence conflicti3449 – 34491Q → K in AAP88402. (PubMed:14610277)Curated
    Sequence conflicti3449 – 34491Q → K in AAP88403. (PubMed:14610277)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti1779 – 17791C → Y in sh-2. 2 Publications

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 11871187Missing in isoform 3. 1 PublicationVSP_029944Add
    BLAST
    Alternative sequencei1955 – 197218Missing in isoform 2 and isoform 3. 1 PublicationVSP_029945Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF144095 mRNA. Translation: AAF05904.1.
    AY331132 mRNA. Translation: AAP88402.1.
    AY331133 mRNA. Translation: AAP88403.1.
    AL596090, AL596386 Genomic DNA. Translation: CAI24082.2.
    AL596090, AL596386 Genomic DNA. Translation: CAM14761.1.
    AL596090, AL596386 Genomic DNA. Translation: CAM14762.1.
    AL596386, AL596090 Genomic DNA. Translation: CAI35347.1.
    AL596386, AL596090 Genomic DNA. Translation: CAM21169.1.
    AL596386, AL596090 Genomic DNA. Translation: CAM21170.1.
    AF053130 mRNA. Translation: AAC40124.1.
    AB014510 mRNA. Translation: BAA36582.1.
    CCDSiCCDS24792.1. [Q9QZZ4-1]
    CCDS24793.1. [Q9QZZ4-3]
    CCDS48811.1. [Q9QZZ4-2]
    PIRiA59295.
    T42386.
    RefSeqiNP_001096641.1. NM_001103171.1. [Q9QZZ4-2]
    NP_034992.2. NM_010862.2. [Q9QZZ4-1]
    NP_874357.2. NM_182698.2. [Q9QZZ4-3]
    XP_006532490.1. XM_006532427.1. [Q9QZZ4-1]
    XP_006532491.1. XM_006532428.1. [Q9QZZ4-2]
    UniGeneiMm.89960.

    Genome annotation databases

    EnsembliENSMUST00000071880; ENSMUSP00000071777; ENSMUSG00000042678. [Q9QZZ4-1]
    ENSMUST00000081823; ENSMUSP00000080507; ENSMUSG00000042678. [Q9QZZ4-3]
    ENSMUST00000094135; ENSMUSP00000091686; ENSMUSG00000042678. [Q9QZZ4-2]
    GeneIDi17910.
    KEGGimmu:17910.
    UCSCiuc007jfz.1. mouse. [Q9QZZ4-1]
    uc007jga.1. mouse. [Q9QZZ4-3]
    uc007jgb.2. mouse. [Q9QZZ4-2]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF144095 mRNA. Translation: AAF05904.1 .
    AY331132 mRNA. Translation: AAP88402.1 .
    AY331133 mRNA. Translation: AAP88403.1 .
    AL596090 , AL596386 Genomic DNA. Translation: CAI24082.2 .
    AL596090 , AL596386 Genomic DNA. Translation: CAM14761.1 .
    AL596090 , AL596386 Genomic DNA. Translation: CAM14762.1 .
    AL596386 , AL596090 Genomic DNA. Translation: CAI35347.1 .
    AL596386 , AL596090 Genomic DNA. Translation: CAM21169.1 .
    AL596386 , AL596090 Genomic DNA. Translation: CAM21170.1 .
    AF053130 mRNA. Translation: AAC40124.1 .
    AB014510 mRNA. Translation: BAA36582.1 .
    CCDSi CCDS24792.1. [Q9QZZ4-1 ]
    CCDS24793.1. [Q9QZZ4-3 ]
    CCDS48811.1. [Q9QZZ4-2 ]
    PIRi A59295.
    T42386.
    RefSeqi NP_001096641.1. NM_001103171.1. [Q9QZZ4-2 ]
    NP_034992.2. NM_010862.2. [Q9QZZ4-1 ]
    NP_874357.2. NM_182698.2. [Q9QZZ4-3 ]
    XP_006532490.1. XM_006532427.1. [Q9QZZ4-1 ]
    XP_006532491.1. XM_006532428.1. [Q9QZZ4-2 ]
    UniGenei Mm.89960.

    3D structure databases

    ProteinModelPortali Q9QZZ4.
    SMRi Q9QZZ4. Positions 1206-1978, 2028-2269, 2666-2937, 3046-3424.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 201662. 2 interactions.
    IntActi Q9QZZ4. 3 interactions.
    MINTi MINT-1895306.
    STRINGi 10090.ENSMUSP00000071777.

    PTM databases

    PhosphoSitei Q9QZZ4.

    Proteomic databases

    PaxDbi Q9QZZ4.
    PRIDEi Q9QZZ4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000071880 ; ENSMUSP00000071777 ; ENSMUSG00000042678 . [Q9QZZ4-1 ]
    ENSMUST00000081823 ; ENSMUSP00000080507 ; ENSMUSG00000042678 . [Q9QZZ4-3 ]
    ENSMUST00000094135 ; ENSMUSP00000091686 ; ENSMUSG00000042678 . [Q9QZZ4-2 ]
    GeneIDi 17910.
    KEGGi mmu:17910.
    UCSCi uc007jfz.1. mouse. [Q9QZZ4-1 ]
    uc007jga.1. mouse. [Q9QZZ4-3 ]
    uc007jgb.2. mouse. [Q9QZZ4-2 ]

    Organism-specific databases

    CTDi 17910.
    MGIi MGI:1261811. Myo15.

    Phylogenomic databases

    eggNOGi COG5022.
    GeneTreei ENSGT00750000117344.
    HOVERGENi HBG052554.
    InParanoidi Q9QZZ4.
    KOi K10361.
    OMAi PSQNMLE.
    OrthoDBi EOG7XPZ4Q.
    PhylomeDBi Q9QZZ4.
    TreeFami TF316834.

    Miscellaneous databases

    NextBioi 292745.
    PROi Q9QZZ4.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9QZZ4.
    CleanExi MM_MYO15.
    Genevestigatori Q9QZZ4.

    Family and domain databases

    InterProi IPR019749. Band_41_domain.
    IPR019748. FERM_central.
    IPR000299. FERM_domain.
    IPR000048. IQ_motif_EF-hand-BS.
    IPR001609. Myosin_head_motor_dom.
    IPR000857. MyTH4_dom.
    IPR027417. P-loop_NTPase.
    IPR011511. SH3_2.
    IPR001452. SH3_domain.
    [Graphical view ]
    Pfami PF00612. IQ. 2 hits.
    PF00063. Myosin_head. 1 hit.
    PF00784. MyTH4. 2 hits.
    PF07653. SH3_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00193. MYOSINHEAVY.
    SMARTi SM00295. B41. 1 hit.
    SM00015. IQ. 3 hits.
    SM00242. MYSc. 1 hit.
    SM00139. MyTH4. 2 hits.
    SM00326. SH3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47031. SSF47031. 1 hit.
    SSF50044. SSF50044. 1 hit.
    SSF52540. SSF52540. 1 hit.
    PROSITEi PS50057. FERM_3. 1 hit.
    PS50096. IQ. 2 hits.
    PS51456. MYOSIN_MOTOR. 1 hit.
    PS51016. MYTH4. 2 hits.
    PS50002. SH3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of the human and mouse unconventional myosin XV genes responsible for hereditary deafness DFNB3 and shaker 2."
      Liang Y., Wang A., Belyantseva I.A., Anderson D.W., Probst F.J., Barber T.D., Miller W., Touchman J.W., Jin L., Sullivan S.L., Sellers J.R., Camper S.A., Lloyd R.V., Kachar B., Friedman T.B., Fridell R.A.
      Genomics 61:243-258(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
    2. "Myosin XVa localizes to the tips of inner ear sensory cell stereocilia and is essential for staircase formation of the hair bundle."
      Belyantseva I.A., Boger E.T., Friedman T.B.
      Proc. Natl. Acad. Sci. U.S.A. 100:13958-13963(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 3), FUNCTION, SUBCELLULAR LOCATION.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    4. Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1168-2970 (ISOFORM 1), VARIANT SH-2 TYR-1779.
      Tissue: Embryo.
    5. Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1237-1823, VARIANT SH-2 TYR-1779.
      Strain: C57BL/6.
    6. "Myosin-XVa is required for tip localization of whirlin and differential elongation of hair-cell stereocilia."
      Belyantseva I.A., Boger E.T., Naz S., Frolenkov G.I., Sellers J.R., Ahmed Z.M., Griffith A.J., Friedman T.B.
      Nat. Cell Biol. 7:148-156(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH WHRN.
    7. "Regulation of stereocilia length by myosin XVa and whirlin depends on the actin-regulatory protein Eps8."
      Manor U., Disanza A., Grati M., Andrade L., Lin H., Di Fiore P.P., Scita G., Kachar B.
      Curr. Biol. 21:167-172(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH EPS8.

    Entry informationi

    Entry nameiMYO15_MOUSE
    AccessioniPrimary (citable) accession number: Q9QZZ4
    Secondary accession number(s): A2A637
    , A2A638, O70395, Q5SX93, Q7TMR5, Q7TMR6, Q9QWL6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 21, 2001
    Last sequence update: December 4, 2007
    Last modified: October 1, 2014
    This is version 131 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Caution

    Represents an unconventional myosin. This protein should not be confused with the conventional myosin-15 (MYH15).Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3