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Q9QZW9

- MNX1_MOUSE

UniProt

Q9QZW9 - MNX1_MOUSE

Protein

Motor neuron and pancreas homeobox protein 1

Gene

Mnx1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Putative transcription factor involved in pancreas development and function.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi241 – 30060HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: InterPro
    2. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. cell morphogenesis involved in neuron differentiation Source: MGI
    2. central nervous system neuron differentiation Source: MGI
    3. diaphragm development Source: MGI
    4. dorsal/ventral neural tube patterning Source: MGI
    5. endocrine pancreas development Source: MGI
    6. motor neuron axon guidance Source: MGI
    7. nerve development Source: MGI
    8. neuron differentiation Source: MGI
    9. neuron migration Source: MGI
    10. neuron projection morphogenesis Source: MGI
    11. pancreas development Source: MGI
    12. post-embryonic development Source: MGI
    13. respiratory system development Source: MGI
    14. spinal cord motor neuron cell fate specification Source: MGI
    15. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Motor neuron and pancreas homeobox protein 1
    Alternative name(s):
    Homeobox protein HB9
    Gene namesi
    Name:Mnx1
    Synonyms:Hlxb9
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 5

    Organism-specific databases

    MGIiMGI:109160. Mnx1.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: MGI

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 404404Motor neuron and pancreas homeobox protein 1PRO_0000048906Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PRIDEiQ9QZW9.

    PTM databases

    PhosphoSiteiQ9QZW9.

    Expressioni

    Gene expression databases

    BgeeiQ9QZW9.
    CleanExiMM_MNX1.
    GenevestigatoriQ9QZW9.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9QZW9.
    SMRiQ9QZW9. Positions 239-300.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi40 – 5011Poly-GlyAdd
    BLAST
    Compositional biasi99 – 1057Poly-Gly
    Compositional biasi121 – 13414Poly-AlaAdd
    BLAST
    Compositional biasi168 – 1769Poly-Ala
    Compositional biasi315 – 32410Poly-Gly

    Sequence similaritiesi

    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG322049.
    GeneTreeiENSGT00750000117598.
    HOGENOMiHOG000234345.
    HOVERGENiHBG051910.
    InParanoidiQ9QZW9.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    [Graphical view]
    PRINTSiPR00024. HOMEOBOX.
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9QZW9-1 [UniParc]FASTAAdd to Basket

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    MEKSKNFRID ALLAVDPPRA ASTQSAPLAL VTSLATTVSG PGRGGSGGGG    50
    TSSGASRSCS PASSEATAAP GDRLRAESPS PPRLLAAHCA LLPKPGFLGA 100
    GGGGGAAGGP GTPHHHAHPG AAAAAAAAAA AAAAGGLALG LHPGGAQGGA 150
    GLPAQAALYG HPVYSYSAAA AAAALAGQHP ALSYSYPQVQ GAHPAHPADP 200
    IKLGASTFQL DQWLRASTAG MILPKMPDFS CEAQSNLLGK CRRPRTAFTS 250
    QQLLELEHQF KLNKYLSRPK RFEVATSLML TETQVKIWFQ NRRMKWKRSK 300
    KAKEQAAQEA EKQKGGGGGT GKGGSEEKTE EELMGPPVSG DKASGRRLRD 350
    LRDSDPDEDE DDEEEDNFPY SNGAGAHAAS SDCSSEDDSP PPRLGGPGHQ 400
    PLPQ 404
    Length:404
    Mass (Da):41,331
    Last modified:July 27, 2011 - v2
    Checksum:i1D2B56CD645DB50A
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti232 – 2321E → Q in AAD49613. (PubMed:10471502)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF153046 mRNA. Translation: AAD49613.1.
    AC164700 Genomic DNA. No translation available.
    CCDSiCCDS19150.1.
    UniGeneiMm.103760.

    Genome annotation databases

    EnsembliENSMUST00000001608; ENSMUSP00000001608; ENSMUSG00000001566.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF153046 mRNA. Translation: AAD49613.1 .
    AC164700 Genomic DNA. No translation available.
    CCDSi CCDS19150.1.
    UniGenei Mm.103760.

    3D structure databases

    ProteinModelPortali Q9QZW9.
    SMRi Q9QZW9. Positions 239-300.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q9QZW9.

    Proteomic databases

    PRIDEi Q9QZW9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000001608 ; ENSMUSP00000001608 ; ENSMUSG00000001566 .

    Organism-specific databases

    MGIi MGI:109160. Mnx1.

    Phylogenomic databases

    eggNOGi NOG322049.
    GeneTreei ENSGT00750000117598.
    HOGENOMi HOG000234345.
    HOVERGENi HBG051910.
    InParanoidi Q9QZW9.

    Miscellaneous databases

    PROi Q9QZW9.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9QZW9.
    CleanExi MM_MNX1.
    Genevestigatori Q9QZW9.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    [Graphical view ]
    PRINTSi PR00024. HOMEOBOX.
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Pancreas dorsal lobe agenesis and abnormal islets of Langerhans in Hlxb9-deficient mice."
      Harrison K.A., Thaler J., Pfaff S.L., Gu H., Kehrl J.H.
      Nat. Genet. 23:71-75(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Swiss Webster / NIH.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.

    Entry informationi

    Entry nameiMNX1_MOUSE
    AccessioniPrimary (citable) accession number: Q9QZW9
    Secondary accession number(s): E9QPC0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 15, 2004
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 105 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3