Motor neuron and pancreas homeobox protein 1

Contribute

Send feedback

Read comments (?) or add your own

Q9QZW9 (MNX1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 94. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

text xml rdf/xml gff fasta

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Motor neuron and pancreas homeobox protein 1

Alternative name(s):
Homeobox protein HB9

Gene names

Name:	Mnx1
Synonyms:	Hlxb9

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	404 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Putative transcription factor involved in pancreas development and function.
Subcellular location	Nucleus By similarity.
Sequence similarities	Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Homeobox
Ligand	DNA-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	diaphragm development Inferred from mutant phenotype PubMed 10482234. Source: MGI dorsal/ventral neural tube patterning Inferred from direct assay PubMed 18590716. Source: MGI endocrine pancreas development Inferred from mutant phenotype PubMed 10471501. Source: MGI motor neuron axon guidance Inferred from mutant phenotype PubMed 10482234. Source: MGI nerve development Inferred from mutant phenotype PubMed 11395002. Source: MGI neuron migration Inferred from mutant phenotype PubMed 10482234. Source: MGI post-embryonic development Inferred from mutant phenotype PubMed 10482234. Source: MGI spinal cord motor neuron cell fate specification Inferred from mutant phenotype PubMed 10482234. Source: MGI transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from direct assay PubMed 17042795. Source: MGI
Molecular_function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 404

404

Motor neuron and pancreas homeobox protein 1

PRO_0000048906

Regions

DNA binding

241 – 300

Homeobox

Compositional bias

40 – 50

Poly-Gly

Compositional bias

99 – 105

Poly-Gly

Compositional bias

121 – 134

Poly-Ala

Compositional bias

168 – 176

Poly-Ala

Compositional bias

315 – 324

Poly-Gly

Experimental info

Sequence conflict

232

E → Q in AAD49613. Ref.1

Sequences

Sequence

Length

Mass (Da)

Tools

Q9QZW9 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: 1D2B56CD645DB50A
Show »

FASTA

404

41,331

        10         20         30         40         50         60 
MEKSKNFRID ALLAVDPPRA ASTQSAPLAL VTSLATTVSG PGRGGSGGGG TSSGASRSCS 

        70         80         90        100        110        120 
PASSEATAAP GDRLRAESPS PPRLLAAHCA LLPKPGFLGA GGGGGAAGGP GTPHHHAHPG 

       130        140        150        160        170        180 
AAAAAAAAAA AAAAGGLALG LHPGGAQGGA GLPAQAALYG HPVYSYSAAA AAAALAGQHP 

       190        200        210        220        230        240 
ALSYSYPQVQ GAHPAHPADP IKLGASTFQL DQWLRASTAG MILPKMPDFS CEAQSNLLGK 

       250        260        270        280        290        300 
CRRPRTAFTS QQLLELEHQF KLNKYLSRPK RFEVATSLML TETQVKIWFQ NRRMKWKRSK 

       310        320        330        340        350        360 
KAKEQAAQEA EKQKGGGGGT GKGGSEEKTE EELMGPPVSG DKASGRRLRD LRDSDPDEDE 

       370        380        390        400 
DDEEEDNFPY SNGAGAHAAS SDCSSEDDSP PPRLGGPGHQ PLPQ

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Pancreas dorsal lobe agenesis and abnormal islets of Langerhans in Hlxb9-deficient mice." Harrison K.A., Thaler J., Pfaff S.L., Gu H., Kehrl J.H. Nat. Genet. 23:71-75(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Swiss Webster / NIH.
[2]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF153046 mRNA. Translation: AAD49613.1. AC164700 Genomic DNA. No translation available.
IPI	IPI00138194.
UniGene	Mm.103760.
3D structure databases
ProteinModelPortal	Q9QZW9.
SMR	Q9QZW9. Positions 243-300.
ModBase	Search...
PTM databases
PhosphoSite	Q9QZW9.
Proteomic databases
PRIDE	Q9QZW9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000001608; ENSMUSP00000001608; ENSMUSG00000001566.
Organism-specific databases
MGI	MGI:109160. Mnx1.
Phylogenomic databases
eggNOG	NOG322049.
GeneTree	ENSGT00660000095141.
HOGENOM	HOG000234345.
HOVERGEN	HBG051910.
InParanoid	Q9QZW9.
Gene expression databases
ArrayExpress	Q9QZW9.
Bgee	Q9QZW9.
CleanEx	MM_MNX1.
Genevestigator	Q9QZW9.
GermOnline	ENSMUSG00000001566. Mus musculus.
Family and domain databases
Gene3D	1.10.10.60. 1 hit.
InterPro	IPR017970. Homeobox_CS. IPR020479. Homeobox_metazoa. IPR001356. Homeodomain. IPR009057. Homeodomain-like. [Graphical view]
Pfam	PF00046. Homeobox. 1 hit. [Graphical view]
PRINTS	PR00024. HOMEOBOX.
SMART	SM00389. HOX. 1 hit. [Graphical view]
SUPFAM	SSF46689. Homeodomain_like. 1 hit.
PROSITE	PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
SOURCE	Search...

Entry information

Entry name

MNX1_MOUSE

Accession

Primary (citable) accession number: Q9QZW9
Secondary accession number(s): E9QPC0

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 15, 2004
Last sequence update:	July 27, 2011
Last modified:	May 1, 2013
This is version 94 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents