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Q9QZW9

- MNX1_MOUSE

UniProt

Q9QZW9 - MNX1_MOUSE

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Protein
Motor neuron and pancreas homeobox protein 1
Gene
Mnx1, Hlxb9
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Putative transcription factor involved in pancreas development and function.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi241 – 30060Homeobox
Add
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro
  2. sequence-specific DNA binding transcription factor activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. cell morphogenesis involved in neuron differentiation Source: MGI
  2. central nervous system neuron differentiation Source: MGI
  3. diaphragm development Source: MGI
  4. dorsal/ventral neural tube patterning Source: MGI
  5. endocrine pancreas development Source: MGI
  6. motor neuron axon guidance Source: MGI
  7. nerve development Source: MGI
  8. neuron differentiation Source: MGI
  9. neuron migration Source: MGI
  10. neuron projection morphogenesis Source: MGI
  11. pancreas development Source: MGI
  12. post-embryonic development Source: MGI
  13. respiratory system development Source: MGI
  14. spinal cord motor neuron cell fate specification Source: MGI
  15. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Motor neuron and pancreas homeobox protein 1
Alternative name(s):
Homeobox protein HB9
Gene namesi
Name:Mnx1
Synonyms:Hlxb9
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 5

Organism-specific databases

MGIiMGI:109160. Mnx1.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 404404Motor neuron and pancreas homeobox protein 1
PRO_0000048906Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine By similarity

Keywords - PTMi

Acetylation

Proteomic databases

PRIDEiQ9QZW9.

PTM databases

PhosphoSiteiQ9QZW9.

Expressioni

Gene expression databases

BgeeiQ9QZW9.
CleanExiMM_MNX1.
GenevestigatoriQ9QZW9.

Structurei

3D structure databases

ProteinModelPortaliQ9QZW9.
SMRiQ9QZW9. Positions 239-300.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi40 – 5011Poly-Gly
Add
BLAST
Compositional biasi99 – 1057Poly-Gly
Compositional biasi121 – 13414Poly-Ala
Add
BLAST
Compositional biasi168 – 1769Poly-Ala
Compositional biasi315 – 32410Poly-Gly

Sequence similaritiesi

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG322049.
GeneTreeiENSGT00750000117598.
HOGENOMiHOG000234345.
HOVERGENiHBG051910.
InParanoidiQ9QZW9.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9QZW9-1 [UniParc]FASTAAdd to Basket

« Hide

MEKSKNFRID ALLAVDPPRA ASTQSAPLAL VTSLATTVSG PGRGGSGGGG    50
TSSGASRSCS PASSEATAAP GDRLRAESPS PPRLLAAHCA LLPKPGFLGA 100
GGGGGAAGGP GTPHHHAHPG AAAAAAAAAA AAAAGGLALG LHPGGAQGGA 150
GLPAQAALYG HPVYSYSAAA AAAALAGQHP ALSYSYPQVQ GAHPAHPADP 200
IKLGASTFQL DQWLRASTAG MILPKMPDFS CEAQSNLLGK CRRPRTAFTS 250
QQLLELEHQF KLNKYLSRPK RFEVATSLML TETQVKIWFQ NRRMKWKRSK 300
KAKEQAAQEA EKQKGGGGGT GKGGSEEKTE EELMGPPVSG DKASGRRLRD 350
LRDSDPDEDE DDEEEDNFPY SNGAGAHAAS SDCSSEDDSP PPRLGGPGHQ 400
PLPQ 404
Length:404
Mass (Da):41,331
Last modified:July 27, 2011 - v2
Checksum:i1D2B56CD645DB50A
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti232 – 2321E → Q in AAD49613. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF153046 mRNA. Translation: AAD49613.1.
AC164700 Genomic DNA. No translation available.
CCDSiCCDS19150.1.
UniGeneiMm.103760.

Genome annotation databases

EnsembliENSMUST00000001608; ENSMUSP00000001608; ENSMUSG00000001566.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF153046 mRNA. Translation: AAD49613.1 .
AC164700 Genomic DNA. No translation available.
CCDSi CCDS19150.1.
UniGenei Mm.103760.

3D structure databases

ProteinModelPortali Q9QZW9.
SMRi Q9QZW9. Positions 239-300.
ModBasei Search...

PTM databases

PhosphoSitei Q9QZW9.

Proteomic databases

PRIDEi Q9QZW9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000001608 ; ENSMUSP00000001608 ; ENSMUSG00000001566 .

Organism-specific databases

MGIi MGI:109160. Mnx1.

Phylogenomic databases

eggNOGi NOG322049.
GeneTreei ENSGT00750000117598.
HOGENOMi HOG000234345.
HOVERGENi HBG051910.
InParanoidi Q9QZW9.

Miscellaneous databases

PROi Q9QZW9.
SOURCEi Search...

Gene expression databases

Bgeei Q9QZW9.
CleanExi MM_MNX1.
Genevestigatori Q9QZW9.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
InterProi IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
[Graphical view ]
PRINTSi PR00024. HOMEOBOX.
SMARTi SM00389. HOX. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Pancreas dorsal lobe agenesis and abnormal islets of Langerhans in Hlxb9-deficient mice."
    Harrison K.A., Thaler J., Pfaff S.L., Gu H., Kehrl J.H.
    Nat. Genet. 23:71-75(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Swiss Webster / NIH.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.

Entry informationi

Entry nameiMNX1_MOUSE
AccessioniPrimary (citable) accession number: Q9QZW9
Secondary accession number(s): E9QPC0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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