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Q9QZW9 (MNX1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 104. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Motor neuron and pancreas homeobox protein 1
Alternative name(s):
Homeobox protein HB9
Gene names
Name:Mnx1
Synonyms:Hlxb9
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length404 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Putative transcription factor involved in pancreas development and function.

Subcellular location

Nucleus By similarity.

Sequence similarities

Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   DomainHomeobox
   LigandDNA-binding
   PTMAcetylation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell morphogenesis involved in neuron differentiation

Inferred from mutant phenotype PubMed 10482234. Source: MGI

central nervous system neuron differentiation

Inferred from mutant phenotype PubMed 10482234. Source: MGI

diaphragm development

Inferred from mutant phenotype PubMed 10482234. Source: MGI

dorsal/ventral neural tube patterning

Inferred from direct assay PubMed 18590716. Source: MGI

endocrine pancreas development

Inferred from mutant phenotype PubMed 10471501. Source: MGI

motor neuron axon guidance

Inferred from mutant phenotype PubMed 10482234. Source: MGI

nerve development

Inferred from mutant phenotype PubMed 11395002. Source: MGI

neuron differentiation

Inferred from mutant phenotype PubMed 11395002. Source: MGI

neuron migration

Inferred from mutant phenotype PubMed 10482234. Source: MGI

neuron projection morphogenesis

Inferred from mutant phenotype PubMed 10482234. Source: MGI

pancreas development

Inferred from mutant phenotype PubMed 10471501. Source: MGI

post-embryonic development

Inferred from mutant phenotype PubMed 10482234. Source: MGI

respiratory system development

Inferred from mutant phenotype PubMed 10482234. Source: MGI

spinal cord motor neuron cell fate specification

Inferred from mutant phenotype PubMed 10482234. Source: MGI

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from direct assay PubMed 17042795PubMed 23610558. Source: MGI

   Molecular_functionsequence-specific DNA binding

Inferred from electronic annotation. Source: InterPro

sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 404404Motor neuron and pancreas homeobox protein 1
PRO_0000048906

Regions

DNA binding241 – 30060Homeobox
Compositional bias40 – 5011Poly-Gly
Compositional bias99 – 1057Poly-Gly
Compositional bias121 – 13414Poly-Ala
Compositional bias168 – 1769Poly-Ala
Compositional bias315 – 32410Poly-Gly

Amino acid modifications

Modified residue11N-acetylmethionine By similarity

Experimental info

Sequence conflict2321E → Q in AAD49613. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q9QZW9 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: 1D2B56CD645DB50A

FASTA40441,331
        10         20         30         40         50         60 
MEKSKNFRID ALLAVDPPRA ASTQSAPLAL VTSLATTVSG PGRGGSGGGG TSSGASRSCS 

        70         80         90        100        110        120 
PASSEATAAP GDRLRAESPS PPRLLAAHCA LLPKPGFLGA GGGGGAAGGP GTPHHHAHPG 

       130        140        150        160        170        180 
AAAAAAAAAA AAAAGGLALG LHPGGAQGGA GLPAQAALYG HPVYSYSAAA AAAALAGQHP 

       190        200        210        220        230        240 
ALSYSYPQVQ GAHPAHPADP IKLGASTFQL DQWLRASTAG MILPKMPDFS CEAQSNLLGK 

       250        260        270        280        290        300 
CRRPRTAFTS QQLLELEHQF KLNKYLSRPK RFEVATSLML TETQVKIWFQ NRRMKWKRSK 

       310        320        330        340        350        360 
KAKEQAAQEA EKQKGGGGGT GKGGSEEKTE EELMGPPVSG DKASGRRLRD LRDSDPDEDE 

       370        380        390        400 
DDEEEDNFPY SNGAGAHAAS SDCSSEDDSP PPRLGGPGHQ PLPQ 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF153046 mRNA. Translation: AAD49613.1.
AC164700 Genomic DNA. No translation available.
CCDSCCDS19150.1.
UniGeneMm.103760.

3D structure databases

ProteinModelPortalQ9QZW9.
SMRQ9QZW9. Positions 239-300.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ9QZW9.

Proteomic databases

PRIDEQ9QZW9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000001608; ENSMUSP00000001608; ENSMUSG00000001566.

Organism-specific databases

MGIMGI:109160. Mnx1.

Phylogenomic databases

eggNOGNOG322049.
GeneTreeENSGT00750000117598.
HOGENOMHOG000234345.
HOVERGENHBG051910.
InParanoidQ9QZW9.

Gene expression databases

BgeeQ9QZW9.
CleanExMM_MNX1.
GenevestigatorQ9QZW9.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
InterProIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSPR00024. HOMEOBOX.
SMARTSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROQ9QZW9.
SOURCESearch...

Entry information

Entry nameMNX1_MOUSE
AccessionPrimary (citable) accession number: Q9QZW9
Secondary accession number(s): E9QPC0
Entry history
Integrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot