Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Motor neuron and pancreas homeobox protein 1

Gene

Mnx1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Putative transcription factor involved in pancreas development and function.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi241 – 30060HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro

GO - Biological processi

  1. cell morphogenesis involved in neuron differentiation Source: MGI
  2. central nervous system neuron differentiation Source: MGI
  3. diaphragm development Source: MGI
  4. dorsal/ventral neural tube patterning Source: MGI
  5. endocrine pancreas development Source: MGI
  6. motor neuron axon guidance Source: MGI
  7. nerve development Source: MGI
  8. neuron differentiation Source: MGI
  9. neuron migration Source: MGI
  10. neuron projection morphogenesis Source: MGI
  11. pancreas development Source: MGI
  12. post-embryonic development Source: MGI
  13. regulation of transcription, DNA-templated Source: UniProtKB-KW
  14. respiratory system development Source: MGI
  15. spinal cord motor neuron cell fate specification Source: MGI
  16. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Motor neuron and pancreas homeobox protein 1
Alternative name(s):
Homeobox protein HB9
Gene namesi
Name:Mnx1
Synonyms:Hlxb9
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 5

Organism-specific databases

MGIiMGI:109160. Mnx1.

Subcellular locationi

Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  1. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 404404Motor neuron and pancreas homeobox protein 1PRO_0000048906Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ9QZW9.
PRIDEiQ9QZW9.

PTM databases

PhosphoSiteiQ9QZW9.

Expressioni

Gene expression databases

BgeeiQ9QZW9.
CleanExiMM_MNX1.
ExpressionAtlasiQ9QZW9. differential.
GenevestigatoriQ9QZW9.

Structurei

3D structure databases

ProteinModelPortaliQ9QZW9.
SMRiQ9QZW9. Positions 239-300.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi40 – 5011Poly-GlyAdd
BLAST
Compositional biasi99 – 1057Poly-Gly
Compositional biasi121 – 13414Poly-AlaAdd
BLAST
Compositional biasi168 – 1769Poly-Ala
Compositional biasi315 – 32410Poly-Gly

Sequence similaritiesi

Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG322049.
GeneTreeiENSGT00780000121835.
HOGENOMiHOG000234345.
HOVERGENiHBG051910.
InParanoidiQ9QZW9.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9QZW9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKSKNFRID ALLAVDPPRA ASTQSAPLAL VTSLATTVSG PGRGGSGGGG
60 70 80 90 100
TSSGASRSCS PASSEATAAP GDRLRAESPS PPRLLAAHCA LLPKPGFLGA
110 120 130 140 150
GGGGGAAGGP GTPHHHAHPG AAAAAAAAAA AAAAGGLALG LHPGGAQGGA
160 170 180 190 200
GLPAQAALYG HPVYSYSAAA AAAALAGQHP ALSYSYPQVQ GAHPAHPADP
210 220 230 240 250
IKLGASTFQL DQWLRASTAG MILPKMPDFS CEAQSNLLGK CRRPRTAFTS
260 270 280 290 300
QQLLELEHQF KLNKYLSRPK RFEVATSLML TETQVKIWFQ NRRMKWKRSK
310 320 330 340 350
KAKEQAAQEA EKQKGGGGGT GKGGSEEKTE EELMGPPVSG DKASGRRLRD
360 370 380 390 400
LRDSDPDEDE DDEEEDNFPY SNGAGAHAAS SDCSSEDDSP PPRLGGPGHQ

PLPQ
Length:404
Mass (Da):41,331
Last modified:July 27, 2011 - v2
Checksum:i1D2B56CD645DB50A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti232 – 2321E → Q in AAD49613 (PubMed:10471502).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF153046 mRNA. Translation: AAD49613.1.
AC164700 Genomic DNA. No translation available.
CCDSiCCDS19150.1.
UniGeneiMm.103760.

Genome annotation databases

EnsembliENSMUST00000001608; ENSMUSP00000001608; ENSMUSG00000001566.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF153046 mRNA. Translation: AAD49613.1.
AC164700 Genomic DNA. No translation available.
CCDSiCCDS19150.1.
UniGeneiMm.103760.

3D structure databases

ProteinModelPortaliQ9QZW9.
SMRiQ9QZW9. Positions 239-300.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiQ9QZW9.

Proteomic databases

MaxQBiQ9QZW9.
PRIDEiQ9QZW9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000001608; ENSMUSP00000001608; ENSMUSG00000001566.

Organism-specific databases

MGIiMGI:109160. Mnx1.

Phylogenomic databases

eggNOGiNOG322049.
GeneTreeiENSGT00780000121835.
HOGENOMiHOG000234345.
HOVERGENiHBG051910.
InParanoidiQ9QZW9.

Miscellaneous databases

PROiQ9QZW9.
SOURCEiSearch...

Gene expression databases

BgeeiQ9QZW9.
CleanExiMM_MNX1.
ExpressionAtlasiQ9QZW9. differential.
GenevestigatoriQ9QZW9.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Pancreas dorsal lobe agenesis and abnormal islets of Langerhans in Hlxb9-deficient mice."
    Harrison K.A., Thaler J., Pfaff S.L., Gu H., Kehrl J.H.
    Nat. Genet. 23:71-75(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Swiss Webster / NIH.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.

Entry informationi

Entry nameiMNX1_MOUSE
AccessioniPrimary (citable) accession number: Q9QZW9
Secondary accession number(s): E9QPC0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: July 27, 2011
Last modified: March 4, 2015
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.