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Protein

Phospholipid-transporting ATPase 11C

Gene

Atp11c

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. Required for B cell differentiation past the pro-B cell stage. Seems to mediate phosphatidylserine (PS) flipping in pro-B cells. May be involved in the transport of cholestatic bile acids.3 Publications

Catalytic activityi

ATP + H2O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei4094-aspartylphosphate intermediateBy similarity1
Metal bindingi816MagnesiumBy similarity1
Metal bindingi820MagnesiumBy similarity1

GO - Molecular functioni

GO - Biological processi

  • phospholipid translocation Source: UniProtKB
  • positive regulation of B cell differentiation Source: UniProtKB
  • pre-B cell differentiation Source: UniProtKB

Keywordsi

Molecular functionHydrolase
Biological processLipid transport, Transport
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi3.6.3.1 3474
ReactomeiR-MMU-936837 Ion transport by P-type ATPases

Names & Taxonomyi

Protein namesi
Recommended name:
Phospholipid-transporting ATPase 11C (EC:3.6.3.1)
Alternative name(s):
ATPase class VI type 11C
P4-ATPase flippase complex alpha subunit ATP11C
Gene namesi
Name:Atp11c
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:1859661 Atp11c

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 83CytoplasmicSequence analysisAdd BLAST83
Transmembranei84 – 104HelicalSequence analysisAdd BLAST21
Topological domaini105 – 287ExtracellularSequence analysisAdd BLAST183
Transmembranei288 – 308HelicalSequence analysisAdd BLAST21
Topological domaini309 – 343CytoplasmicSequence analysisAdd BLAST35
Transmembranei344 – 364HelicalSequence analysisAdd BLAST21
Topological domaini365 – 876ExtracellularSequence analysisAdd BLAST512
Transmembranei877 – 897HelicalSequence analysisAdd BLAST21
Topological domaini898 – 905CytoplasmicSequence analysis8
Transmembranei906 – 926HelicalSequence analysisAdd BLAST21
Topological domaini927 – 952ExtracellularSequence analysisAdd BLAST26
Transmembranei953 – 973HelicalSequence analysisAdd BLAST21
Topological domaini974 – 988CytoplasmicSequence analysisAdd BLAST15
Transmembranei989 – 1009HelicalSequence analysisAdd BLAST21
Topological domaini1010 – 1023ExtracellularSequence analysisAdd BLAST14
Transmembranei1024 – 1044HelicalSequence analysisAdd BLAST21
Topological domaini1045 – 1066CytoplasmicSequence analysisAdd BLAST22
Transmembranei1067 – 1087HelicalSequence analysisAdd BLAST21
Topological domaini1088 – 1129ExtracellularSequence analysisAdd BLAST42

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Membrane

Pathology & Biotechi

Involvement in diseasei

Mice defective in Atp11c show defective B lymphopoiesis, specifically in mature bone marrow, hyperbilirubinemia linked to mild cholestasis and hepatocellular carcinoma.2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000463741 – 1129Phospholipid-transporting ATPase 11CAdd BLAST1129

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei442PhosphoserineBy similarity1
Modified residuei1105PhosphoserineBy similarity1
Modified residuei1113PhosphoserineBy similarity1
Modified residuei1123PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9QZW0
PRIDEiQ9QZW0

PTM databases

iPTMnetiQ9QZW0
PhosphoSitePlusiQ9QZW0
SwissPalmiQ9QZW0

Expressioni

Gene expression databases

BgeeiENSMUSG00000062949
CleanExiMM_ATP11C
ExpressionAtlasiQ9QZW0 baseline and differential
GenevisibleiQ9QZW0 MM

Interactioni

Subunit structurei

Component of a P4-ATPase flippase complex which consists of a catalytic alpha subunit and an accessory beta subunit. Interacts with TMEM30A (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000099066

Structurei

3D structure databases

ProteinModelPortaliQ9QZW0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili607 – 643Sequence analysisAdd BLAST37
Coiled coili695 – 726Sequence analysisAdd BLAST32

Sequence similaritiesi

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0206 Eukaryota
COG0474 LUCA
GeneTreeiENSGT00910000144008
HOGENOMiHOG000202528
HOVERGENiHBG050601
InParanoidiQ9QZW0
KOiK01530
OMAiVLKMFTD
OrthoDBiEOG091G03B1
PhylomeDBiQ9QZW0

Family and domain databases

Gene3Di3.40.1110.10, 1 hit
3.40.50.1000, 1 hit
InterProiView protein in InterPro
IPR030363 ATP11C
IPR023299 ATPase_P-typ_cyto_dom_N
IPR018303 ATPase_P-typ_P_site
IPR023298 ATPase_P-typ_TM_dom_sf
IPR008250 ATPase_P-typ_transduc_dom_A_sf
IPR036412 HAD-like_sf
IPR023214 HAD_sf
IPR006539 P-type_ATPase_IV
IPR032631 P-type_ATPase_N
IPR001757 P_typ_ATPase
IPR032630 P_typ_ATPase_c
PANTHERiPTHR24092 PTHR24092, 1 hit
PTHR24092:SF38 PTHR24092:SF38, 1 hit
PfamiView protein in Pfam
PF16212 PhoLip_ATPase_C, 1 hit
PF16209 PhoLip_ATPase_N, 1 hit
SUPFAMiSSF56784 SSF56784, 3 hits
SSF81653 SSF81653, 2 hits
SSF81660 SSF81660, 1 hit
SSF81665 SSF81665, 3 hits
TIGRFAMsiTIGR01652 ATPase-Plipid, 1 hit
TIGR01494 ATPase_P-type, 3 hits
PROSITEiView protein in PROSITE
PS00154 ATPASE_E1_E2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9QZW0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFRRTLNRLC AGEEKRVGTR TVFVGNHPIS GTEPYIAQRF CDNRIVSSKY
60 70 80 90 100
TLWNFLPKNL FEQFRRIANF YFLIIFLVQV TVDTPTSPVT SGLPLFFVIT
110 120 130 140 150
VTAIKQGYED WLRHRADNEV NKSAVYIIEN AKRVRKESEK IKVGDVVEVQ
160 170 180 190 200
ANETFPCDLI LLSSCTTDGT CYVTTASLDG ESNCKTHYAV RDTIALCTAE
210 220 230 240 250
SIDNLRATIE CEQPQPDLYR FVGRISIYSN SIEAVARSLG PENLLLKGAT
260 270 280 290 300
LKNTKKIYGV AVYTGMETKM ALNYQGKSQK CSAVEKSINA FLIVYLFILL
310 320 330 340 350
TKAAVCTTLK YVWQSSPYND EPWYNQKTQK ERETFQVLKM FTDFLSFMVL
360 370 380 390 400
FNFIIPVSMY VTVEMQKFLG SFFISWDKDF FDEEINEGAL VNTSDLNEEL
410 420 430 440 450
GQVDYVFTDK TGTLTENSME FIECCIDGHK YKGTTQEVDG LSQTDGPLAY
460 470 480 490 500
FDKADKNREA LFLRALCLCH TVEMKTNDDV DGPVEGAGFT YISSSPDEIA
510 520 530 540 550
LVKGAKRFGF TFLGNQNGYI RVENQRKEIE EYELLHTLNF DSVRRRMSVI
560 570 580 590 600
VRTQKGDILL FCKGADSSIF PRVHSHQIEL TKDHVERNAM DGYRTLCVAF
610 620 630 640 650
KEIPPDDFER INAQLVEAKM ALQDREEKLE KVFDEIETNM NLIGATAVED
660 670 680 690 700
KLQDQAAETI EALHAAGLKV WVLTGDKMET AKSTCYACRL FQTNTELLEL
710 720 730 740 750
TTKTIEESER KEDRLHELLI EYRKKLLHEF PKSTRSLKKA WTEHQEYGLI
760 770 780 790 800
IDGSTLSLIL NSSQDCSSNN YKSIFLQICM KCTAVLCCRM APLQKAQIVR
810 820 830 840 850
MVKNLKGSPI TLSIGDGAND VSMILESHVG IGIKGKEGRQ AARNSDYSVP
860 870 880 890 900
KFKHLKKLLL VHGHLYYVRI AHLVQYFFYK NLCFILPQFL YQFFCGFSQQ
910 920 930 940 950
PLYDAAYLTM YNICFTSLPI LAYSLLEQHI NIDTLTADPR LYMKITGNAM
960 970 980 990 1000
LQLGPFLHWT FLAAFEGTVF FFGTYFLFQT SSLEDNGKIY GNWTFGTIVF
1010 1020 1030 1040 1050
TVLVFTVTLK LALDTRFWTW INHFVIWGSL AFYVFFSFFW GGIIWPFLKQ
1060 1070 1080 1090 1100
QRMYFVFAQM LCSVSTWLAI ILLIFISLFP EILLIVVKNV RRRSARRNLS
1110 1120
CRRASDSLSA RPSVRPLLLR TFSDESNIL
Length:1,129
Mass (Da):129,240
Last modified:January 9, 2007 - v2
Checksum:iEE82DFD1F0669294
GO
Isoform 2 (identifier: Q9QZW0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     833-835: Missing.
     1097-1129: RNLSCRRASDSLSARPSVRPLLLRTFSDESNIL → NPNLELPMLLSYKHIDRGCS

Show »
Length:1,113
Mass (Da):127,511
Checksum:i30C9A9ABF4963C24
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti786 – 791LCCRMA → VCCADQ in AAF09445 (PubMed:11015572).Curated6

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_022222833 – 835Missing in isoform 2. 1 Publication3
Alternative sequenceiVSP_0222231097 – 1129RNLSC…ESNIL → NPNLELPMLLSYKHIDRGCS in isoform 2. 1 PublicationAdd BLAST33

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC106087 mRNA Translation: AAI06088.1
AF156547 mRNA Translation: AAF09445.1
CCDSiCCDS40988.1 [Q9QZW0-1]
RefSeqiNP_001032952.1, NM_001037863.1 [Q9QZW0-1]
XP_006528153.1, XM_006528090.3 [Q9QZW0-1]
XP_006528154.1, XM_006528091.3 [Q9QZW0-1]
XP_011245917.1, XM_011247615.2 [Q9QZW0-1]
XP_011245918.1, XM_011247616.1 [Q9QZW0-1]
UniGeneiMm.490394

Genome annotation databases

EnsembliENSMUST00000101527; ENSMUSP00000099066; ENSMUSG00000062949 [Q9QZW0-1]
ENSMUST00000206006; ENSMUSP00000146015; ENSMUSG00000108408 [Q9QZW0-1]
GeneIDi320940
KEGGimmu:320940
UCSCiuc009tia.1 mouse [Q9QZW0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiAT11C_MOUSE
AccessioniPrimary (citable) accession number: Q9QZW0
Secondary accession number(s): Q3KQR4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 30, 2003
Last sequence update: January 9, 2007
Last modified: March 28, 2018
This is version 141 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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