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Protein

Phospholipid-transporting ATPase 11C

Gene

Atp11c

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. Required for B cell differentiation past the pro-B cell stage. Seems to mediate phosphatidylserine (PS) flipping in pro-B cells. May be involved in the transport of cholestatic bile acids.3 Publications

Catalytic activityi

ATP + H2O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei409 – 40914-aspartylphosphate intermediateBy similarity
Metal bindingi816 – 8161MagnesiumBy similarity
Metal bindingi820 – 8201MagnesiumBy similarity

GO - Molecular functioni

GO - Biological processi

  • phospholipid translocation Source: UniProtKB
  • positive regulation of B cell differentiation Source: UniProtKB
  • pre-B cell differentiation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid transport, Transport

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi3.6.3.1. 3474.
ReactomeiR-MMU-936837. Ion transport by P-type ATPases.

Names & Taxonomyi

Protein namesi
Recommended name:
Phospholipid-transporting ATPase 11C (EC:3.6.3.1)
Alternative name(s):
ATPase class VI type 11C
P4-ATPase flippase complex alpha subunit ATP11C
Gene namesi
Name:Atp11c
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:1859661. Atp11c.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 8383CytoplasmicSequence analysisAdd
BLAST
Transmembranei84 – 10421HelicalSequence analysisAdd
BLAST
Topological domaini105 – 287183ExtracellularSequence analysisAdd
BLAST
Transmembranei288 – 30821HelicalSequence analysisAdd
BLAST
Topological domaini309 – 34335CytoplasmicSequence analysisAdd
BLAST
Transmembranei344 – 36421HelicalSequence analysisAdd
BLAST
Topological domaini365 – 876512ExtracellularSequence analysisAdd
BLAST
Transmembranei877 – 89721HelicalSequence analysisAdd
BLAST
Topological domaini898 – 9058CytoplasmicSequence analysis
Transmembranei906 – 92621HelicalSequence analysisAdd
BLAST
Topological domaini927 – 95226ExtracellularSequence analysisAdd
BLAST
Transmembranei953 – 97321HelicalSequence analysisAdd
BLAST
Topological domaini974 – 98815CytoplasmicSequence analysisAdd
BLAST
Transmembranei989 – 100921HelicalSequence analysisAdd
BLAST
Topological domaini1010 – 102314ExtracellularSequence analysisAdd
BLAST
Transmembranei1024 – 104421HelicalSequence analysisAdd
BLAST
Topological domaini1045 – 106622CytoplasmicSequence analysisAdd
BLAST
Transmembranei1067 – 108721HelicalSequence analysisAdd
BLAST
Topological domaini1088 – 112942ExtracellularSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Membrane

Pathology & Biotechi

Involvement in diseasei

Mice defective in Atp11c show defective B lymphopoiesis, specifically in mature bone marrow, hyperbilirubinemia linked to mild cholestasis and hepatocellular carcinoma.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11291129Phospholipid-transporting ATPase 11CPRO_0000046374Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei442 – 4421PhosphoserineBy similarity
Modified residuei1105 – 11051PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9QZW0.
MaxQBiQ9QZW0.
PaxDbiQ9QZW0.
PRIDEiQ9QZW0.

PTM databases

iPTMnetiQ9QZW0.
SwissPalmiQ9QZW0.

Expressioni

Gene expression databases

BgeeiQ9QZW0.
CleanExiMM_ATP11C.
ExpressionAtlasiQ9QZW0. baseline and differential.
GenevisibleiQ9QZW0. MM.

Interactioni

Subunit structurei

Component of a P4-ATPase flippase complex which consists of a catalytic alpha subunit and an accessory beta subunit. Interacts with TMEM30A (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000099066.

Structurei

3D structure databases

ProteinModelPortaliQ9QZW0.
SMRiQ9QZW0. Positions 387-699.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili607 – 64337Sequence analysisAdd
BLAST
Coiled coili695 – 72632Sequence analysisAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0206. Eukaryota.
COG0474. LUCA.
GeneTreeiENSGT00770000120474.
HOGENOMiHOG000202528.
HOVERGENiHBG050601.
InParanoidiQ9QZW0.
KOiK01530.
OMAiNDEPWYN.
PhylomeDBiQ9QZW0.

Family and domain databases

Gene3Di2.70.150.10. 2 hits.
3.40.1110.10. 1 hit.
3.40.50.1000. 2 hits.
InterProiIPR030363. ATP11C.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR006539. P-type_ATPase_IV.
IPR032631. P-type_ATPase_N.
IPR001757. P_typ_ATPase.
IPR032630. P_typ_ATPase_c.
[Graphical view]
PANTHERiPTHR24092. PTHR24092. 1 hit.
PTHR24092:SF38. PTHR24092:SF38. 1 hit.
PfamiPF00122. E1-E2_ATPase. 1 hit.
PF16212. PhoLip_ATPase_C. 1 hit.
PF16209. PhoLip_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 3 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01652. ATPase-Plipid. 1 hit.
TIGR01494. ATPase_P-type. 3 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9QZW0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFRRTLNRLC AGEEKRVGTR TVFVGNHPIS GTEPYIAQRF CDNRIVSSKY
60 70 80 90 100
TLWNFLPKNL FEQFRRIANF YFLIIFLVQV TVDTPTSPVT SGLPLFFVIT
110 120 130 140 150
VTAIKQGYED WLRHRADNEV NKSAVYIIEN AKRVRKESEK IKVGDVVEVQ
160 170 180 190 200
ANETFPCDLI LLSSCTTDGT CYVTTASLDG ESNCKTHYAV RDTIALCTAE
210 220 230 240 250
SIDNLRATIE CEQPQPDLYR FVGRISIYSN SIEAVARSLG PENLLLKGAT
260 270 280 290 300
LKNTKKIYGV AVYTGMETKM ALNYQGKSQK CSAVEKSINA FLIVYLFILL
310 320 330 340 350
TKAAVCTTLK YVWQSSPYND EPWYNQKTQK ERETFQVLKM FTDFLSFMVL
360 370 380 390 400
FNFIIPVSMY VTVEMQKFLG SFFISWDKDF FDEEINEGAL VNTSDLNEEL
410 420 430 440 450
GQVDYVFTDK TGTLTENSME FIECCIDGHK YKGTTQEVDG LSQTDGPLAY
460 470 480 490 500
FDKADKNREA LFLRALCLCH TVEMKTNDDV DGPVEGAGFT YISSSPDEIA
510 520 530 540 550
LVKGAKRFGF TFLGNQNGYI RVENQRKEIE EYELLHTLNF DSVRRRMSVI
560 570 580 590 600
VRTQKGDILL FCKGADSSIF PRVHSHQIEL TKDHVERNAM DGYRTLCVAF
610 620 630 640 650
KEIPPDDFER INAQLVEAKM ALQDREEKLE KVFDEIETNM NLIGATAVED
660 670 680 690 700
KLQDQAAETI EALHAAGLKV WVLTGDKMET AKSTCYACRL FQTNTELLEL
710 720 730 740 750
TTKTIEESER KEDRLHELLI EYRKKLLHEF PKSTRSLKKA WTEHQEYGLI
760 770 780 790 800
IDGSTLSLIL NSSQDCSSNN YKSIFLQICM KCTAVLCCRM APLQKAQIVR
810 820 830 840 850
MVKNLKGSPI TLSIGDGAND VSMILESHVG IGIKGKEGRQ AARNSDYSVP
860 870 880 890 900
KFKHLKKLLL VHGHLYYVRI AHLVQYFFYK NLCFILPQFL YQFFCGFSQQ
910 920 930 940 950
PLYDAAYLTM YNICFTSLPI LAYSLLEQHI NIDTLTADPR LYMKITGNAM
960 970 980 990 1000
LQLGPFLHWT FLAAFEGTVF FFGTYFLFQT SSLEDNGKIY GNWTFGTIVF
1010 1020 1030 1040 1050
TVLVFTVTLK LALDTRFWTW INHFVIWGSL AFYVFFSFFW GGIIWPFLKQ
1060 1070 1080 1090 1100
QRMYFVFAQM LCSVSTWLAI ILLIFISLFP EILLIVVKNV RRRSARRNLS
1110 1120
CRRASDSLSA RPSVRPLLLR TFSDESNIL
Length:1,129
Mass (Da):129,240
Last modified:January 9, 2007 - v2
Checksum:iEE82DFD1F0669294
GO
Isoform 2 (identifier: Q9QZW0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     833-835: Missing.
     1097-1129: RNLSCRRASDSLSARPSVRPLLLRTFSDESNIL → NPNLELPMLLSYKHIDRGCS

Show »
Length:1,113
Mass (Da):127,511
Checksum:i30C9A9ABF4963C24
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti786 – 7916LCCRMA → VCCADQ in AAF09445 (PubMed:11015572).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei833 – 8353Missing in isoform 2. 1 PublicationVSP_022222
Alternative sequencei1097 – 112933RNLSC…ESNIL → NPNLELPMLLSYKHIDRGCS in isoform 2. 1 PublicationVSP_022223Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC106087 mRNA. Translation: AAI06088.1.
AF156547 mRNA. Translation: AAF09445.1.
CCDSiCCDS40988.1. [Q9QZW0-1]
RefSeqiNP_001001798.1. NM_001001798.2.
NP_001032952.1. NM_001037863.1. [Q9QZW0-1]
XP_006528153.1. XM_006528090.2. [Q9QZW0-1]
XP_006528154.1. XM_006528091.2. [Q9QZW0-1]
XP_011245917.1. XM_011247615.1. [Q9QZW0-1]
XP_011245918.1. XM_011247616.1. [Q9QZW0-1]
UniGeneiMm.490394.

Genome annotation databases

EnsembliENSMUST00000101527; ENSMUSP00000099066; ENSMUSG00000062949. [Q9QZW0-1]
ENSMUST00000206006; ENSMUSP00000146015; ENSMUSG00000108408. [Q9QZW0-1]
GeneIDi320940.
KEGGimmu:320940.
UCSCiuc009tia.1. mouse. [Q9QZW0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC106087 mRNA. Translation: AAI06088.1.
AF156547 mRNA. Translation: AAF09445.1.
CCDSiCCDS40988.1. [Q9QZW0-1]
RefSeqiNP_001001798.1. NM_001001798.2.
NP_001032952.1. NM_001037863.1. [Q9QZW0-1]
XP_006528153.1. XM_006528090.2. [Q9QZW0-1]
XP_006528154.1. XM_006528091.2. [Q9QZW0-1]
XP_011245917.1. XM_011247615.1. [Q9QZW0-1]
XP_011245918.1. XM_011247616.1. [Q9QZW0-1]
UniGeneiMm.490394.

3D structure databases

ProteinModelPortaliQ9QZW0.
SMRiQ9QZW0. Positions 387-699.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000099066.

PTM databases

iPTMnetiQ9QZW0.
SwissPalmiQ9QZW0.

Proteomic databases

EPDiQ9QZW0.
MaxQBiQ9QZW0.
PaxDbiQ9QZW0.
PRIDEiQ9QZW0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000101527; ENSMUSP00000099066; ENSMUSG00000062949. [Q9QZW0-1]
ENSMUST00000206006; ENSMUSP00000146015; ENSMUSG00000108408. [Q9QZW0-1]
GeneIDi320940.
KEGGimmu:320940.
UCSCiuc009tia.1. mouse. [Q9QZW0-1]

Organism-specific databases

CTDi286410.
MGIiMGI:1859661. Atp11c.

Phylogenomic databases

eggNOGiKOG0206. Eukaryota.
COG0474. LUCA.
GeneTreeiENSGT00770000120474.
HOGENOMiHOG000202528.
HOVERGENiHBG050601.
InParanoidiQ9QZW0.
KOiK01530.
OMAiNDEPWYN.
PhylomeDBiQ9QZW0.

Enzyme and pathway databases

BRENDAi3.6.3.1. 3474.
ReactomeiR-MMU-936837. Ion transport by P-type ATPases.

Miscellaneous databases

ChiTaRSiAtp11c. mouse.
NextBioi397728.
PROiQ9QZW0.
SOURCEiSearch...

Gene expression databases

BgeeiQ9QZW0.
CleanExiMM_ATP11C.
ExpressionAtlasiQ9QZW0. baseline and differential.
GenevisibleiQ9QZW0. MM.

Family and domain databases

Gene3Di2.70.150.10. 2 hits.
3.40.1110.10. 1 hit.
3.40.50.1000. 2 hits.
InterProiIPR030363. ATP11C.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR006539. P-type_ATPase_IV.
IPR032631. P-type_ATPase_N.
IPR001757. P_typ_ATPase.
IPR032630. P_typ_ATPase_c.
[Graphical view]
PANTHERiPTHR24092. PTHR24092. 1 hit.
PTHR24092:SF38. PTHR24092:SF38. 1 hit.
PfamiPF00122. E1-E2_ATPase. 1 hit.
PF16212. PhoLip_ATPase_C. 1 hit.
PF16209. PhoLip_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 3 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01652. ATPase-Plipid. 1 hit.
TIGR01494. ATPase_P-type. 3 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Thyroid.
  2. "Differential expression of putative transbilayer amphipath transporters."
    Halleck M.S., Lawler J.F. Jr., Blackshaw S., Gao L., Nagarajan P., Hacker C., Pyle S., Newman J.T., Nakanishi Y., Ando H., Weinstock D., Williamson P.L., Schlegel R.A.
    Physiol. Genomics 1:139-150(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 767-1129 (ISOFORM 2).
    Strain: C57BL/6J.
    Tissue: Mammary gland.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brown adipose tissue, Kidney, Liver and Spleen.
  4. "The P4-type ATPase ATP11C is essential for B lymphopoiesis in adult bone marrow."
    Siggs O.M., Arnold C.N., Huber C., Pirie E., Xia Y., Lin P., Nemazee D., Beutler B.
    Nat. Immunol. 12:434-440(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  5. Cited for: FUNCTION, INVOLVEMENT IN DEFECTIVE LYMPHOPOIESIS.
  6. "X-linked cholestasis in mouse due to mutations of the P4-ATPase ATP11C."
    Siggs O.M., Schnabl B., Webb B., Beutler B.
    Proc. Natl. Acad. Sci. U.S.A. 108:7890-7895(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INVOLVEMENT IN CHOLESTASIS.

Entry informationi

Entry nameiAT11C_MOUSE
AccessioniPrimary (citable) accession number: Q9QZW0
Secondary accession number(s): Q3KQR4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 30, 2003
Last sequence update: January 9, 2007
Last modified: May 11, 2016
This is version 125 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.