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Q9QZU9

- UB2L6_MOUSE

UniProt

Q9QZU9 - UB2L6_MOUSE

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Protein
Ubiquitin/ISG15-conjugating enzyme E2 L6
Gene
Ube2l6, Ubce8
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalyzes the covalent attachment of ubiquitin or ISG15 to other proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Promotes ubiquitination and subsequent proteasomal degradation of FLT3 By similarity.

Catalytic activityi

ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei86 – 861Glycyl thioester intermediate By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. ISG15 ligase activity Source: MGI
  3. protein binding Source: MGI
  4. small conjugating protein ligase activity Source: MGI

GO - Biological processi

  1. ISG15-protein conjugation Source: MGI
  2. modification-dependent protein catabolic process Source: MGI
  3. protein ubiquitination Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Ubl conjugation pathway

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_198533. ISG15 antiviral mechanism.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin/ISG15-conjugating enzyme E2 L6 (EC:6.3.2.19)
Alternative name(s):
UbcM8
Ubiquitin carrier protein L6
Ubiquitin-protein ligase L6
Gene namesi
Name:Ube2l6
Synonyms:Ubce8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:1914500. Ube2l6.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 153153Ubiquitin/ISG15-conjugating enzyme E2 L6
PRO_0000082479Add
BLAST

Post-translational modificationi

ISGylated By similarity.

Keywords - PTMi

Ubl conjugation

Proteomic databases

PaxDbiQ9QZU9.
PRIDEiQ9QZU9.

PTM databases

PhosphoSiteiQ9QZU9.

Expressioni

Gene expression databases

ArrayExpressiQ9QZU9.
BgeeiQ9QZU9.
CleanExiMM_UBE2L6.
GenevestigatoriQ9QZU9.

Interactioni

Subunit structurei

Interacts with RNF19A, RNF19B and RNF144B. Interacts with FLT3 (tyrosine phosphorylated) By similarity.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000107264.

Structurei

3D structure databases

ProteinModelPortaliQ9QZU9.
SMRiQ9QZU9. Positions 3-152.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG5078.
GeneTreeiENSGT00740000115416.
HOGENOMiHOG000233455.
HOVERGENiHBG063308.
KOiK04553.
OMAiPEKPPYN.
OrthoDBiEOG7GXPD8.
TreeFamiTF313043.

Family and domain databases

Gene3Di3.10.110.10. 1 hit.
InterProiIPR000608. UBQ-conjugat_E2.
IPR023313. UBQ-conjugating_AS.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view]
PfamiPF00179. UQ_con. 1 hit.
[Graphical view]
SUPFAMiSSF54495. SSF54495. 1 hit.
PROSITEiPS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9QZU9-1 [UniParc]FASTAAdd to Basket

« Hide

MMASKRVAKE LESLSKELPP YLRQLSSDDA NVLVWHMLLL PDQLPYGLKA    50
FQVRIDFPRE YPFKPPTLRF TTKIYHPNVR EDGLVCLPLI SNENWKPYTK 100
PYQVLEALNV LVSKPNLEEP VRLELADLLT QNPEMFRKKA EEFTLKFGVD 150
RPS 153
Length:153
Mass (Da):17,841
Last modified:May 26, 2009 - v3
Checksum:i71EEFF050CDE57F1
GO

Sequence cautioni

The sequence AAD55978.1 differs from that shown. Reason: Erroneous initiation.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti29 – 291D → Y in AAD55978. 1 Publication
Sequence conflicti63 – 631F → L in AAH08238. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF159230 mRNA. Translation: AAD55978.1. Different initiation.
AK010942 mRNA. Translation: BAB27282.1.
AK013452 mRNA. Translation: BAB28861.1.
AK152010 mRNA. Translation: BAE30873.1.
AK152113 mRNA. Translation: BAE30957.1.
AK168695 mRNA. Translation: BAE40539.1.
AK171629 mRNA. Translation: BAE42574.1.
CH466519 Genomic DNA. Translation: EDL27303.1.
BC008238 mRNA. Translation: AAH08238.1.
CCDSiCCDS16194.2.
RefSeqiNP_064333.2. NM_019949.2.
UniGeneiMm.38261.

Genome annotation databases

EnsembliENSMUST00000102642; ENSMUSP00000099702; ENSMUSG00000027078.
GeneIDi56791.
KEGGimmu:56791.
UCSCiuc012byn.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF159230 mRNA. Translation: AAD55978.1 . Different initiation.
AK010942 mRNA. Translation: BAB27282.1 .
AK013452 mRNA. Translation: BAB28861.1 .
AK152010 mRNA. Translation: BAE30873.1 .
AK152113 mRNA. Translation: BAE30957.1 .
AK168695 mRNA. Translation: BAE40539.1 .
AK171629 mRNA. Translation: BAE42574.1 .
CH466519 Genomic DNA. Translation: EDL27303.1 .
BC008238 mRNA. Translation: AAH08238.1 .
CCDSi CCDS16194.2.
RefSeqi NP_064333.2. NM_019949.2.
UniGenei Mm.38261.

3D structure databases

ProteinModelPortali Q9QZU9.
SMRi Q9QZU9. Positions 3-152.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000107264.

PTM databases

PhosphoSitei Q9QZU9.

Proteomic databases

PaxDbi Q9QZU9.
PRIDEi Q9QZU9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000102642 ; ENSMUSP00000099702 ; ENSMUSG00000027078 .
GeneIDi 56791.
KEGGi mmu:56791.
UCSCi uc012byn.1. mouse.

Organism-specific databases

CTDi 9246.
MGIi MGI:1914500. Ube2l6.

Phylogenomic databases

eggNOGi COG5078.
GeneTreei ENSGT00740000115416.
HOGENOMi HOG000233455.
HOVERGENi HBG063308.
KOi K04553.
OMAi PEKPPYN.
OrthoDBi EOG7GXPD8.
TreeFami TF313043.

Enzyme and pathway databases

UniPathwayi UPA00143 .
Reactomei REACT_198533. ISG15 antiviral mechanism.

Miscellaneous databases

ChiTaRSi UBE2L6. mouse.
NextBioi 313332.
PROi Q9QZU9.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9QZU9.
Bgeei Q9QZU9.
CleanExi MM_UBE2L6.
Genevestigatori Q9QZU9.

Family and domain databases

Gene3Di 3.10.110.10. 1 hit.
InterProi IPR000608. UBQ-conjugat_E2.
IPR023313. UBQ-conjugating_AS.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view ]
Pfami PF00179. UQ_con. 1 hit.
[Graphical view ]
SUPFAMi SSF54495. SSF54495. 1 hit.
PROSITEi PS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Progression from mammary hyperplasia to adenocarcinoma in MMTV-FGF8b transgenic mice is associated with altered expression of CD63, IGFBP7/mac25, alpha-synuclein, and UbcM8."
    Cook G., Lawshe A., MacArthur C.A.
    Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and NOD.
    Tissue: Bone marrow, Embryo and Embryonic liver.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiUB2L6_MOUSE
AccessioniPrimary (citable) accession number: Q9QZU9
Secondary accession number(s): Q3U8R0, Q922F1, Q9CQN0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: May 26, 2009
Last modified: September 3, 2014
This is version 112 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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