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Protein

Gamma-butyrobetaine dioxygenase

Gene

Bbox1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the formation of L-carnitine from gamma-butyrobetaine.

Catalytic activityi

4-trimethylammoniobutanoate + 2-oxoglutarate + O2 = 3-hydroxy-4-trimethylammoniobutanoate + succinate + CO2.

Cofactori

Protein has several cofactor binding sites:
  • Fe2+By similarityNote: Binds 1 Fe2+ ion per subunit.By similarity
  • L-ascorbate

Pathwayi: carnitine biosynthesis

This protein is involved in the pathway carnitine biosynthesis, which is part of Amine and polyamine biosynthesis.
View all proteins of this organism that are known to be involved in the pathway carnitine biosynthesis and in Amine and polyamine biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi38ZincBy similarity1
Metal bindingi40ZincBy similarity1
Metal bindingi43ZincBy similarity1
Metal bindingi82ZincBy similarity1
Metal bindingi202Iron; catalyticBy similarity1
Metal bindingi204Iron; catalyticBy similarity1
Metal bindingi347Iron; catalyticBy similarity1

GO - Molecular functioni

  • gamma-butyrobetaine dioxygenase activity Source: UniProtKB
  • identical protein binding Source: RGD
  • iron ion binding Source: InterPro
  • zinc ion binding Source: UniProtKB

GO - Biological processi

  • carnitine biosynthetic process Source: UniProtKB

Keywordsi

Molecular functionDioxygenase, Oxidoreductase
Biological processCarnitine biosynthesis
LigandIron, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-14431
BRENDAi1.14.11.1 5301
SABIO-RKiQ9QZU7
UniPathwayiUPA00118

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-butyrobetaine dioxygenase (EC:1.14.11.1)
Alternative name(s):
Gamma-butyrobetaine hydroxylase
Short name:
Gamma-BBH
Gamma-butyrobetaine,2-oxoglutarate dioxygenase
Gene namesi
Name:Bbox1
Synonyms:Bbh
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi619756 Bbox1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002070871 – 387Gamma-butyrobetaine dioxygenaseAdd BLAST387

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei351PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9QZU7
PRIDEiQ9QZU7

PTM databases

iPTMnetiQ9QZU7
PhosphoSitePlusiQ9QZU7

Expressioni

Tissue specificityi

Expressed in the liver and in some extend in the testis and the epididymis.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000006197

Structurei

3D structure databases

ProteinModelPortaliQ9QZU7
SMRiQ9QZU7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the gamma-BBH/TMLD family.Curated

Phylogenomic databases

eggNOGiKOG3888 Eukaryota
COG2175 LUCA
HOGENOMiHOG000231427
HOVERGENiHBG031125
InParanoidiQ9QZU7
KOiK00471
PhylomeDBiQ9QZU7
TreeFamiTF313805

Family and domain databases

Gene3Di3.30.2020.30, 1 hit
InterProiView protein in InterPro
IPR012775 GBBH
IPR038492 GBBH-like_N_sf
IPR010376 GBH-like_N
IPR003819 TauD/TfdA-like
PfamiView protein in Pfam
PF06155 DUF971, 1 hit
PF02668 TauD, 1 hit
TIGRFAMsiTIGR02409 carnitine_bodg, 1 hit

Sequencei

Sequence statusi: Complete.

Q9QZU7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHCAILKAEA VDGARLMQIF WHDGAESLYP AVWLRDNCQC SDCYLHSAKA
60 70 80 90 100
RKLLLEALDV NIRMDDLTFD QKKVYITWPN GHYSEFEANW LKKRCFSQEA
110 120 130 140 150
RAGLQGELFL PECQYWGSEL QLPTLNFEDV LNDDDHAYKW LSSLKKVGIV
160 170 180 190 200
RLTGAADKRG EIIKLGKRIG FLYLTFYGHT WQVQDKIDAN NVAYTTGKLS
210 220 230 240 250
FHTDYPALHH PPGVQLLHCI KQTVTGGDSE IVDGFNVCQK LKEKNPQAFS
260 270 280 290 300
ILSSTFVDFT DIGVDYCDFS VQSKHKIIEL DDKGQVVRIN FNNATRDTVF
310 320 330 340 350
DVPIERVQPF YAALKEFVDL MNSKEYKYTF KMNPGDVITF DNWRLLHGRR
360 370 380
SYEAGTEISR HLEGAYADWD VVMSRLRILR QRVMNGN
Length:387
Mass (Da):44,546
Last modified:May 1, 2000 - v1
Checksum:i357804BFB35BF274
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF160958 mRNA Translation: AAD53264.1
RefSeqiNP_072151.1, NM_022629.1
XP_017447515.1, XM_017592026.1
UniGeneiRn.16333

Genome annotation databases

GeneIDi64564
KEGGirno:64564
UCSCiRGD:619756 rat

Similar proteinsi

Entry informationi

Entry nameiBODG_RAT
AccessioniPrimary (citable) accession number: Q9QZU7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2002
Last sequence update: May 1, 2000
Last modified: March 28, 2018
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health