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Q9QZU5

- KR151_MOUSE

UniProt

Q9QZU5 - KR151_MOUSE

Protein

Keratin-associated protein 15-1

Gene

Krtap15-1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.Curated

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Keratin-associated protein 15-1
    Alternative name(s):
    Keratin-associated protein 15
    Pubertal mammary gland-specific protein 2
    Gene namesi
    Name:Krtap15-1By similarity
    Synonyms:Krtap15Imported, Pmg2Imported
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:1347350. Krtap15.

    Subcellular locationi

    GO - Cellular componenti

    1. intermediate filament Source: UniProtKB-KW

    Keywords - Cellular componenti

    Keratin

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 150150Keratin-associated protein 15-1PRO_0000271177Add
    BLAST

    Proteomic databases

    PRIDEiQ9QZU5.

    PTM databases

    PhosphoSiteiQ9QZU5.

    Expressioni

    Tissue specificityi

    Expressed at high levels in skin and at lower levels in the developing mammary gland.1 Publication

    Developmental stagei

    In skin, expression starts shortly after birth and reaches a first maximum at 9 days. A second peak of expression is observed at 3.5 weeks, then levels decline and remain low in the adult. In the developing mammary gland, expression is detected exclusively at the onset of puberty.1 Publication

    Gene expression databases

    CleanExiMM_KRTAP15.
    GenevestigatoriQ9QZU5.

    Interactioni

    Subunit structurei

    Interacts with hair keratins.Curated

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PMG family.Sequence Analysis

    Phylogenomic databases

    HOVERGENiHBG052275.
    PhylomeDBiQ9QZU5.

    Family and domain databases

    InterProiIPR007951. KRTAP_PMG.
    [Graphical view]
    PANTHERiPTHR19051. PTHR19051. 1 hit.
    PfamiPF05287. PMG. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9QZU5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSYTCNSGNY SSQSFGGFLR QPVSTYNSFY PTSNVVYSPK NFQLGSSFYN    50
    GQQETFSEPL EGHLPCVGSA SFHTSCFRPK QYFSSPCQGG FTGSFGYGNT 100
    GFGAFGFGSS GIRSQGCGSN FYRPGYFSSK SIQSSYYQPG YSSGFCGSNF 150
    Length:150
    Mass (Da):16,242
    Last modified:May 1, 2000 - v1
    Checksum:i60A1E3A5F6F04BDA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF162800 Genomic DNA. Translation: AAD47277.1.
    AK132534 mRNA. Translation: BAE21225.1.
    BC116219 mRNA. Translation: AAI16220.1.
    RefSeqiNP_038741.1. NM_013713.1.
    UniGeneiMm.86430.

    Genome annotation databases

    GeneIDi26560.
    KEGGimmu:26560.
    UCSCiuc007zvg.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF162800 Genomic DNA. Translation: AAD47277.1 .
    AK132534 mRNA. Translation: BAE21225.1 .
    BC116219 mRNA. Translation: AAI16220.1 .
    RefSeqi NP_038741.1. NM_013713.1.
    UniGenei Mm.86430.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q9QZU5.

    Proteomic databases

    PRIDEi Q9QZU5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 26560.
    KEGGi mmu:26560.
    UCSCi uc007zvg.1. mouse.

    Organism-specific databases

    CTDi 26560.
    MGIi MGI:1347350. Krtap15.

    Phylogenomic databases

    HOVERGENi HBG052275.
    PhylomeDBi Q9QZU5.

    Miscellaneous databases

    NextBioi 304623.
    PROi Q9QZU5.
    SOURCEi Search...

    Gene expression databases

    CleanExi MM_KRTAP15.
    Genevestigatori Q9QZU5.

    Family and domain databases

    InterProi IPR007951. KRTAP_PMG.
    [Graphical view ]
    PANTHERi PTHR19051. PTHR19051. 1 hit.
    Pfami PF05287. PMG. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Pmg-1 and pmg-2 constitute a novel family of KAP genes differentially expressed during skin and mammary gland development."
      Kuhn F., Lassing C., Range A., Mueller M., Hunziker T., Ziemiecki A., Andres A.-C.
      Mech. Dev. 86:193-196(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6JImported.
      Tissue: SkinImported.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiKR151_MOUSE
    AccessioniPrimary (citable) accession number: Q9QZU5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 9, 2007
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 49 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3