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Protein

Keratin-associated protein 15-1

Gene

Krtap15-1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.Curated

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin-associated protein 15-1
Alternative name(s):
Keratin-associated protein 15
Pubertal mammary gland-specific protein 2
Gene namesi
Name:Krtap15-1By similarity
Synonyms:Krtap15Imported, Pmg2Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:1347350. Krtap15.

Subcellular locationi

GO - Cellular componenti

  1. intermediate filament Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Keratin

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 150150Keratin-associated protein 15-1PRO_0000271177Add
BLAST

Proteomic databases

PRIDEiQ9QZU5.

PTM databases

PhosphoSiteiQ9QZU5.

Expressioni

Tissue specificityi

Expressed at high levels in skin and at lower levels in the developing mammary gland.1 Publication

Developmental stagei

In skin, expression starts shortly after birth and reaches a first maximum at 9 days. A second peak of expression is observed at 3.5 weeks, then levels decline and remain low in the adult. In the developing mammary gland, expression is detected exclusively at the onset of puberty.1 Publication

Gene expression databases

CleanExiMM_KRTAP15.
ExpressionAtlasiQ9QZU5. baseline and differential.
GenevestigatoriQ9QZU5.

Interactioni

Subunit structurei

Interacts with hair keratins.Curated

Family & Domainsi

Sequence similaritiesi

Belongs to the PMG family.Sequence Analysis

Phylogenomic databases

GeneTreeiENSGT00390000012339.
HOVERGENiHBG052275.
InParanoidiQ9QZU5.
PhylomeDBiQ9QZU5.

Family and domain databases

InterProiIPR007951. KRTAP_PMG.
[Graphical view]
PANTHERiPTHR19051. PTHR19051. 1 hit.
PfamiPF05287. PMG. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9QZU5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSYTCNSGNY SSQSFGGFLR QPVSTYNSFY PTSNVVYSPK NFQLGSSFYN
60 70 80 90 100
GQQETFSEPL EGHLPCVGSA SFHTSCFRPK QYFSSPCQGG FTGSFGYGNT
110 120 130 140 150
GFGAFGFGSS GIRSQGCGSN FYRPGYFSSK SIQSSYYQPG YSSGFCGSNF
Length:150
Mass (Da):16,242
Last modified:May 1, 2000 - v1
Checksum:i60A1E3A5F6F04BDA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF162800 Genomic DNA. Translation: AAD47277.1.
AK132534 mRNA. Translation: BAE21225.1.
BC116219 mRNA. Translation: AAI16220.1.
RefSeqiNP_038741.1. NM_013713.1.
UniGeneiMm.86430.

Genome annotation databases

EnsembliENSMUST00000187823; ENSMUSP00000140888; ENSMUSG00000022931.
GeneIDi26560.
KEGGimmu:26560.
UCSCiuc007zvg.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF162800 Genomic DNA. Translation: AAD47277.1.
AK132534 mRNA. Translation: BAE21225.1.
BC116219 mRNA. Translation: AAI16220.1.
RefSeqiNP_038741.1. NM_013713.1.
UniGeneiMm.86430.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiQ9QZU5.

Proteomic databases

PRIDEiQ9QZU5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000187823; ENSMUSP00000140888; ENSMUSG00000022931.
GeneIDi26560.
KEGGimmu:26560.
UCSCiuc007zvg.1. mouse.

Organism-specific databases

CTDi26560.
MGIiMGI:1347350. Krtap15.

Phylogenomic databases

GeneTreeiENSGT00390000012339.
HOVERGENiHBG052275.
InParanoidiQ9QZU5.
PhylomeDBiQ9QZU5.

Miscellaneous databases

NextBioi304623.
PROiQ9QZU5.
SOURCEiSearch...

Gene expression databases

CleanExiMM_KRTAP15.
ExpressionAtlasiQ9QZU5. baseline and differential.
GenevestigatoriQ9QZU5.

Family and domain databases

InterProiIPR007951. KRTAP_PMG.
[Graphical view]
PANTHERiPTHR19051. PTHR19051. 1 hit.
PfamiPF05287. PMG. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Pmg-1 and pmg-2 constitute a novel family of KAP genes differentially expressed during skin and mammary gland development."
    Kuhn F., Lassing C., Range A., Mueller M., Hunziker T., Ziemiecki A., Andres A.-C.
    Mech. Dev. 86:193-196(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6JImported.
    Tissue: SkinImported.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiKR151_MOUSE
AccessioniPrimary (citable) accession number: Q9QZU5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: May 1, 2000
Last modified: January 7, 2015
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.