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Protein

Phospholipid-metabolizing enzyme A-C1

Gene

Hrasls

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Exhibits calcium-independent phospholipase activity towards phosphatidylcholine (PC) and phosphatidylethanolamine (PE). Also shows acyltransferase activities, transferring an acyl group of PCs to the amino group of PEs and the hydroxyl group of lyso PCs.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei30By similarity1
Active sitei119Acyl-thioester intermediateBy similarity1

GO - Molecular functioni

  • phospholipase activity Source: MGI
  • transferase activity Source: UniProtKB-KW

GO - Biological processi

  • ether lipid metabolic process Source: MGI
  • lipid catabolic process Source: UniProtKB-KW
  • peroxisome organization Source: MGI
  • Ras protein signal transduction Source: MGI
  • regulation of cell growth Source: MGI

Keywordsi

Molecular functionHydrolase, Transferase
Biological processLipid degradation, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Phospholipid-metabolizing enzyme A-C1 (EC:2.3.1.-, EC:3.1.1.-)
Alternative name(s):
HRAS-like suppressor 1
Short name:
HRSL1
Gene namesi
Name:Hrasls
Synonyms:Hrasrs
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1351473 Hrasls

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 139CytoplasmicSequence analysisAdd BLAST139
Transmembranei140 – 163HelicalSequence analysisAdd BLAST24
Topological domaini164 – 167LumenalSequence analysis4

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001524821 – 167Phospholipid-metabolizing enzyme A-C1Add BLAST167

Proteomic databases

PaxDbiQ9QZU4
PRIDEiQ9QZU4

PTM databases

iPTMnetiQ9QZU4
PhosphoSitePlusiQ9QZU4

Expressioni

Tissue specificityi

Expressed in skeletal muscle, heart, brain and bone marrow.

Gene expression databases

CleanExiMM_HRASLS

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000087257

Structurei

3D structure databases

ProteinModelPortaliQ9QZU4
SMRiQ9QZU4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the H-rev107 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IWFR Eukaryota
ENOG4111G30 LUCA
HOGENOMiHOG000293227
HOVERGENiHBG028837
InParanoidiQ9QZU4
PhylomeDBiQ9QZU4
TreeFamiTF330836

Family and domain databases

InterProiView protein in InterPro
IPR007053 LRAT-like_dom
PfamiView protein in Pfam
PF04970 LRAT, 1 hit

Sequencei

Sequence statusi: Complete.

Q9QZU4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVNDCFSLT YPHNPHPGDL IEVFRPCYQH WALYLGDGYV INIAPIDGIR
60 70 80 90 100
SSFTSAKSVF STKALVKMQL LKDVVGNDTY RINNKYDTTY PPLPVEEVIQ
110 120 130 140 150
RSEFPIGQEV AYDLLVNNCE HFVTLLRYGE GVSEQANRAI GTIGLVAAGI
160
DIFTFLGLFP KRQRTKY
Length:167
Mass (Da):18,810
Last modified:May 1, 2000 - v1
Checksum:i619C43691DCC86C8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti105P → A in BAB23348 (PubMed:10542256).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF163095 mRNA Translation: AAF13304.1
AB510982 mRNA Translation: BAI63211.1
AK004528 mRNA Translation: BAB23348.1
AK039471 mRNA Translation: BAC30361.1
AC154448 Genomic DNA No translation available.
CH466521 Genomic DNA Translation: EDK97707.1
CH466521 Genomic DNA Translation: EDK97708.1
BC048482 mRNA Translation: AAH48482.1
CCDSiCCDS28094.1
RefSeqiNP_038779.2, NM_013751.5
XP_006522267.1, XM_006522204.1
XP_017172511.1, XM_017317022.1
UniGeneiMm.103650

Genome annotation databases

GeneIDi27281
UCSCiuc007yvw.1 mouse

Similar proteinsi

Entry informationi

Entry nameiHRSL1_MOUSE
AccessioniPrimary (citable) accession number: Q9QZU4
Secondary accession number(s): Q5D099, Q9D0S3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: May 1, 2000
Last modified: February 28, 2018
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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