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Protein

Phospholipid-metabolizing enzyme A-C1

Gene

Hrasls

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Exhibits calcium-independent phospholipase activity towards phosphatidylcholine (PC) and phosphatidylethanolamine (PE). Also shows acyltransferase activities, transferring an acyl group of PCs to the amino group of PEs and the hydroxyl group of lyso PCs.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei30 – 301By similarity
Active sitei119 – 1191Acyl-thioester intermediateBy similarity

GO - Molecular functioni

  • phospholipase activity Source: MGI
  • transferase activity Source: UniProtKB-KW

GO - Biological processi

  • ether lipid metabolic process Source: MGI
  • lipid catabolic process Source: UniProtKB-KW
  • peroxisome organization Source: MGI
  • Ras protein signal transduction Source: MGI
  • regulation of cell growth Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transferase

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Phospholipid-metabolizing enzyme A-C1 (EC:2.3.1.-, EC:3.1.1.-)
Alternative name(s):
HRAS-like suppressor 1
Short name:
HRSL1
Gene namesi
Name:Hrasls
Synonyms:Hrasrs
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1351473. Hrasls.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 139139CytoplasmicSequence analysisAdd
BLAST
Transmembranei140 – 16324HelicalSequence analysisAdd
BLAST
Topological domaini164 – 1674LumenalSequence analysis

GO - Cellular componenti

  • cytoplasm Source: MGI
  • integral component of membrane Source: UniProtKB-KW
  • nuclear envelope lumen Source: MGI
  • peroxisome Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 167167Phospholipid-metabolizing enzyme A-C1PRO_0000152482Add
BLAST

Proteomic databases

PaxDbiQ9QZU4.
PRIDEiQ9QZU4.

PTM databases

PhosphoSiteiQ9QZU4.

Expressioni

Tissue specificityi

Expressed in skeletal muscle, heart, brain and bone marrow.

Gene expression databases

BgeeiENSMUSG00000022525.
CleanExiMM_HRASLS.

Structurei

3D structure databases

ProteinModelPortaliQ9QZU4.
SMRiQ9QZU4. Positions 15-129.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the H-rev107 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IWFR. Eukaryota.
ENOG4111G30. LUCA.
HOGENOMiHOG000293227.
HOVERGENiHBG028837.
InParanoidiQ9QZU4.
PhylomeDBiQ9QZU4.
TreeFamiTF330836.

Family and domain databases

InterProiIPR007053. LRAT-like_dom.
[Graphical view]
PfamiPF04970. LRAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9QZU4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVNDCFSLT YPHNPHPGDL IEVFRPCYQH WALYLGDGYV INIAPIDGIR
60 70 80 90 100
SSFTSAKSVF STKALVKMQL LKDVVGNDTY RINNKYDTTY PPLPVEEVIQ
110 120 130 140 150
RSEFPIGQEV AYDLLVNNCE HFVTLLRYGE GVSEQANRAI GTIGLVAAGI
160
DIFTFLGLFP KRQRTKY
Length:167
Mass (Da):18,810
Last modified:May 1, 2000 - v1
Checksum:i619C43691DCC86C8
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti105 – 1051P → A in BAB23348 (PubMed:10542256).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF163095 mRNA. Translation: AAF13304.1.
AB510982 mRNA. Translation: BAI63211.1.
AK004528 mRNA. Translation: BAB23348.1.
AK039471 mRNA. Translation: BAC30361.1.
AC154448 Genomic DNA. No translation available.
CH466521 Genomic DNA. Translation: EDK97707.1.
CH466521 Genomic DNA. Translation: EDK97708.1.
BC048482 mRNA. Translation: AAH48482.1.
CCDSiCCDS28094.1.
RefSeqiNP_038779.2. NM_013751.5.
XP_006522267.1. XM_006522204.1.
UniGeneiMm.103650.

Genome annotation databases

GeneIDi27281.
KEGGimmu:27281.
UCSCiuc007yvw.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF163095 mRNA. Translation: AAF13304.1.
AB510982 mRNA. Translation: BAI63211.1.
AK004528 mRNA. Translation: BAB23348.1.
AK039471 mRNA. Translation: BAC30361.1.
AC154448 Genomic DNA. No translation available.
CH466521 Genomic DNA. Translation: EDK97707.1.
CH466521 Genomic DNA. Translation: EDK97708.1.
BC048482 mRNA. Translation: AAH48482.1.
CCDSiCCDS28094.1.
RefSeqiNP_038779.2. NM_013751.5.
XP_006522267.1. XM_006522204.1.
UniGeneiMm.103650.

3D structure databases

ProteinModelPortaliQ9QZU4.
SMRiQ9QZU4. Positions 15-129.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiQ9QZU4.

Proteomic databases

PaxDbiQ9QZU4.
PRIDEiQ9QZU4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi27281.
KEGGimmu:27281.
UCSCiuc007yvw.1. mouse.

Organism-specific databases

CTDi57110.
MGIiMGI:1351473. Hrasls.

Phylogenomic databases

eggNOGiENOG410IWFR. Eukaryota.
ENOG4111G30. LUCA.
HOGENOMiHOG000293227.
HOVERGENiHBG028837.
InParanoidiQ9QZU4.
PhylomeDBiQ9QZU4.
TreeFamiTF330836.

Miscellaneous databases

ChiTaRSiHrasls. mouse.
PROiQ9QZU4.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022525.
CleanExiMM_HRASLS.

Family and domain databases

InterProiIPR007053. LRAT-like_dom.
[Graphical view]
PfamiPF04970. LRAT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHRSL1_MOUSE
AccessioniPrimary (citable) accession number: Q9QZU4
Secondary accession number(s): Q5D099, Q9D0S3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: May 1, 2000
Last modified: September 7, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.