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Protein

CUB and zona pellucida-like domain-containing protein 1

Gene

Cuzd1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

CUZD1 antiserum inhibits cell attachment and proliferation of ovarian cancer cells so may play a role in these processes. May play a role in trypsin activation in pancreatic acinar cells. May also play a role in the uterus during late pregnancy (By similarity).By similarity

GO - Biological processi

  • female pregnancy Source: UniProtKB
  • hormone-mediated signaling pathway Source: RGD
  • trypsinogen activation Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
CUB and zona pellucida-like domain-containing protein 1
Short name:
CUB and ZP domain-containing protein 1
Alternative name(s):
Estrogen-regulated protein 1
Uterus/ovary-specific protein 44
Gene namesi
Name:Cuzd1Imported
Synonyms:Erg1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi619771. Cuzd1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini20 – 568549ExtracellularSequence analysisAdd
BLAST
Transmembranei569 – 58921HelicalSequence analysisAdd
BLAST
Topological domaini590 – 60718CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB
  • transport vesicle membrane Source: UniProtKB-SubCell
  • zymogen granule membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence analysisAdd
BLAST
Chaini20 – 607588CUB and zona pellucida-like domain-containing protein 1Sequence analysisPRO_0000233333Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi22 – 221N-linked (GlcNAc...)Sequence analysis
Disulfide bondi32 ↔ 58PROSITE-ProRule annotation
Glycosylationi67 – 671N-linked (GlcNAc...)Sequence analysis
Disulfide bondi85 ↔ 107PROSITE-ProRule annotation
Disulfide bondi154 ↔ 180PROSITE-ProRule annotation
Glycosylationi195 – 1951N-linked (GlcNAc...)Sequence analysis
Disulfide bondi207 ↔ 229PROSITE-ProRule annotation
Glycosylationi419 – 4191N-linked (GlcNAc...)Sequence analysis
Disulfide bondi442 ↔ 498PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9QZT0.
PRIDEiQ9QZT0.

PTM databases

PhosphoSiteiQ9QZT0.

Expressioni

Tissue specificityi

Expressed predominantly in epithelium of uterus and oviduct.2 Publications

Developmental stagei

In uterus, strongly expressed at proestrus, declines at estrus and disappears at diestrus. In oviduct, strongly expressed at both proestrus and estrus but declines significantly at diestrus. In uterus, highly expressed on day 1 of pregnancy but declines dramatically on day 2 and is not detected between days 3 and 7. In oviduct, highly expressed on days 1 and 2 of pregnancy but declines significantly on days 3 and 4.1 Publication

Inductioni

By estrogen, tamoxifen and growth hormone. Repressed by progesterone and by the antiestrogen ICI 182780.2 Publications

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000045430.

Structurei

3D structure databases

ProteinModelPortaliQ9QZT0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini32 – 146115CUB 1PROSITE-ProRule annotationAdd
BLAST
Domaini154 – 265112CUB 2PROSITE-ProRule annotationAdd
BLAST
Domaini276 – 519244ZPPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 CUB domains.PROSITE-ProRule annotation
Contains 1 ZP domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHBC. Eukaryota.
ENOG410XQVR. LUCA.
HOGENOMiHOG000060083.
HOVERGENiHBG081378.
InParanoidiQ9QZT0.
PhylomeDBiQ9QZT0.

Family and domain databases

Gene3Di2.60.120.290. 2 hits.
InterProiIPR000859. CUB_dom.
IPR001507. ZP_dom.
[Graphical view]
PfamiPF00431. CUB. 2 hits.
PF00100. Zona_pellucida. 1 hit.
[Graphical view]
PRINTSiPR00023. ZPELLUCIDA.
SMARTiSM00042. CUB. 2 hits.
SM00241. ZP. 1 hit.
[Graphical view]
SUPFAMiSSF49854. SSF49854. 2 hits.
PROSITEiPS01180. CUB. 2 hits.
PS51034. ZP_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9QZT0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEVTGRLFIW AILAVSCRAQ LNSTAAEGRP RCTASLGGAN LGETHKALIL
60 70 80 90 100
NLNADENCTW TIERPENRSI RIIFSHIQLD PDSRCENESI KVFDGRSTSG
110 120 130 140 150
PLLGEACSKN DFVPVFESSA NSLTFQIVTD WTRVQRSVFI FYYFFSSGTT
160 170 180 190 200
IPNCGGYLQT LEGSFSSPNY PRPHPELAYC VWHIQVEKGY KINLNFTELF
210 220 230 240 250
LEMDEYCRFD FIAVYDGPST TSGLLKQVCG RGTPTFESSS DAMTVVLSTD
260 270 280 290 300
YANSYRGFFA SYASTYVQEV NTHSLSCASD KMRVIISKSY LQSLNYHESN
310 320 330 340 350
LQLNDPTCRP SVSNVVEFSI PLHECGTIKK IEDHTISYTN IITFTQSPES
360 370 380 390 400
AVITRKRHLQ IVVTCEMEYN STVEILYITE DDVIQNQSVL GKYNTSMALY
410 420 430 440 450
ESGSFENLIQ ESPYYVDLNQ TLFVQATLHT SDPSLVVFLD TCRASPTSDF
460 470 480 490 500
ASPTYDLISS GCSRDETCEV YPLFGHYGRF QFNAFKFLRH LSSVYLKCKI
510 520 530 540 550
LICDTSDHTS RCNQGCVSRR KRDIPSYKWK TDSVIGPIRL KRDRLVNGDS
560 570 580 590 600
GLLPQTHEAE ISKQPLSHLH LFSFMVLALN VVIVVTATVR HFLNRWKDHG

YQKLQVY
Length:607
Mass (Da):68,640
Last modified:May 2, 2006 - v2
Checksum:i68B59BCD31322012
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti35 – 351S → M in AAD55939 (PubMed:10542259).Curated
Sequence conflicti273 – 2731H → T in AAH90345 (PubMed:15489334).Curated
Sequence conflicti469 – 4691E → K in AAH90345 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF167170 mRNA. Translation: AAD55939.1.
AF022147 mRNA. Translation: AAB71895.1.
BC090345 mRNA. Translation: AAH90345.1.
RefSeqiNP_446457.1. NM_054005.1.
UniGeneiRn.10825.

Genome annotation databases

GeneIDi117179.
KEGGirno:117179.
UCSCiRGD:619771. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF167170 mRNA. Translation: AAD55939.1.
AF022147 mRNA. Translation: AAB71895.1.
BC090345 mRNA. Translation: AAH90345.1.
RefSeqiNP_446457.1. NM_054005.1.
UniGeneiRn.10825.

3D structure databases

ProteinModelPortaliQ9QZT0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000045430.

PTM databases

PhosphoSiteiQ9QZT0.

Proteomic databases

PaxDbiQ9QZT0.
PRIDEiQ9QZT0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi117179.
KEGGirno:117179.
UCSCiRGD:619771. rat.

Organism-specific databases

CTDi50624.
RGDi619771. Cuzd1.

Phylogenomic databases

eggNOGiENOG410IHBC. Eukaryota.
ENOG410XQVR. LUCA.
HOGENOMiHOG000060083.
HOVERGENiHBG081378.
InParanoidiQ9QZT0.
PhylomeDBiQ9QZT0.

Miscellaneous databases

NextBioi620030.
PROiQ9QZT0.

Family and domain databases

Gene3Di2.60.120.290. 2 hits.
InterProiIPR000859. CUB_dom.
IPR001507. ZP_dom.
[Graphical view]
PfamiPF00431. CUB. 2 hits.
PF00100. Zona_pellucida. 1 hit.
[Graphical view]
PRINTSiPR00023. ZPELLUCIDA.
SMARTiSM00042. CUB. 2 hits.
SM00241. ZP. 1 hit.
[Graphical view]
SUPFAMiSSF49854. SSF49854. 2 hits.
PROSITEiPS01180. CUB. 2 hits.
PS51034. ZP_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and uterus/oviduct-specific expression of a novel estrogen-regulated gene (ERG1)."
    Chen D., Xu X., Zhu L.-J., Angervo M., Li Q., Bagchi M.K., Bagchi I.C.
    J. Biol. Chem. 274:32215-32224(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, INDUCTION.
    Strain: Sprague-DawleyImported.
    Tissue: Uterus1 Publication.
  2. "Induction of UO-44 gene expression by tamoxifen in the rat uterus and ovary."
    Huynh H., Ng C.Y., Lim K.B., Ong C.K., Ong C.S., Tran E., Nguyen T.T.T., Chan T.W.M.G.
    Endocrinology 142:2985-2995(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, INDUCTION.
    Strain: Sprague-DawleyImported.
    Tissue: UterusImported.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2-607.
    Tissue: Ovary.

Entry informationi

Entry nameiCUZD1_RAT
AccessioniPrimary (citable) accession number: Q9QZT0
Secondary accession number(s): O35360, Q5D000
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: May 2, 2006
Last modified: November 11, 2015
This is version 87 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.