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Q9QZS7

- NPHN_MOUSE

UniProt

Q9QZS7 - NPHN_MOUSE

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Protein

Nephrin

Gene

Nphs1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Seems to play a role in the development or function of the kidney glomerular filtration barrier. Regulates glomerular vascular permeability. May anchor the podocyte slit diaphragm to the actin cytoskeleton. Plays a role in skeletal muscle formation through regulation of myoblast fusion.3 Publications

GO - Biological processi

  1. cell adhesion Source: MGI
  2. glomerular basement membrane development Source: Ensembl
  3. glomerular visceral epithelial cell development Source: Ensembl
  4. JNK cascade Source: MGI
  5. MAPK cascade Source: MGI
  6. myoblast fusion Source: UniProtKB
  7. positive regulation of actin filament polymerization Source: MGI
  8. regulation of excretion Source: UniProtKB
  9. skeletal muscle tissue development Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Cell adhesion, Myogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Nephrin
Alternative name(s):
Renal glomerulus-specific cell adhesion receptor
Gene namesi
Name:Nphs1
Synonyms:Nphn
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:1859637. Nphs1.

Subcellular locationi

Cell membrane Curated; Single-pass type I membrane protein Curated
Note: Located at podocyte slit diaphragm between podocyte foot processes.1 Publication

GO - Cellular componenti

  1. cell projection Source: UniProtKB
  2. extracellular vesicular exosome Source: Ensembl
  3. integral component of membrane Source: MGI
  4. integral component of plasma membrane Source: MGI
  5. membrane raft Source: Ensembl
  6. plasma membrane Source: UniProtKB
  7. protein complex Source: Ensembl
  8. slit diaphragm Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Death by postnatal day 2 associated with proteinuria, edema and massive glomerular vascular leak. Kidneys display enlarged Bowman's spaces, dilated tubuli, effacement of podocyte foot processes and an absence of the glomerular epithelial slit diaphragm. Impaired skeletal muscle development characterized by incomplete myoblast fusion.3 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3535Sequence AnalysisAdd
BLAST
Chaini36 – 12561221NephrinPRO_0000015053Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi54 – 541N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi67 ↔ 125PROSITE-ProRule annotation
Disulfide bondi174 ↔ 231PROSITE-ProRule annotation
Disulfide bondi279 ↔ 331PROSITE-ProRule annotation
Glycosylationi370 – 3701N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi375 ↔ 431PROSITE-ProRule annotation
Glycosylationi415 – 4151N-linked (GlcNAc...)Sequence Analysis
Modified residuei446 – 4461PhosphoserineBy similarity
Disulfide bondi479 ↔ 542PROSITE-ProRule annotation
Glycosylationi561 – 5611N-linked (GlcNAc...)Sequence Analysis
Glycosylationi578 – 5781N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi581 ↔ 637PROSITE-ProRule annotation
Glycosylationi591 – 5911N-linked (GlcNAc...)Sequence Analysis
Glycosylationi722 – 7221N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi775 ↔ 830PROSITE-ProRule annotation
Disulfide bondi877 ↔ 934PROSITE-ProRule annotation
Modified residuei1208 – 12081Phosphotyrosine; by FYNBy similarity

Post-translational modificationi

Phosphorylated at Tyr-1208 by FYN, leading to the recruitment and activation of phospholipase C-gamma-1/PLCG1.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ9QZS7.
PRIDEiQ9QZS7.

PTM databases

PhosphoSiteiQ9QZS7.

Expressioni

Tissue specificityi

Expressed in kidney glomeruli. In the embryo, expressed in the mesonephric kidney at E11 with strong expression in cranial tubules with podocyte-like structures. Expression is observed in the podocytes of the developing kidney from E13. High expression is also detected in the developing cerebellum, hindbrain, spinal cord, retina and hypothalamus. Expressed in skeletal muscle during myoblast fusion such as in the adult following acute injury and in the embryo but not detected in uninjured adult skeletal muscle. Isoform 1 and isoform 2 are expressed in the newborn brain and developing cerebellum. Isoform 1 is the predominant isoform in adult kidney.5 Publications

Gene expression databases

BgeeiQ9QZS7.
CleanExiMM_NPHS1.
ExpressionAtlasiQ9QZS7. baseline and differential.
GenevestigatoriQ9QZS7.

Interactioni

Subunit structurei

Interacts with NPHS2 and with CD2AP (via C-terminal domain). Interacts with MAGI1 (via PDZ 2 and 3 domains) forming a tripartite complex with IGSF5/JAM4. Forms a complex with ACTN4, CASK, IQGAP1, MAGI2, SPTAN1 and SPTBN1 (By similarity). Interacts with DDN; the interaction is direct. Self-associates (via the Ig-like domains). Also interacts (via the Ig-like domains) with KIRREL/NEPH1 and KIRREL2; the interaction with KIRREL is dependent on KIRREL glycosylation.By similarity6 Publications

Protein-protein interaction databases

BioGridi207694. 1 interaction.
STRINGi10090.ENSMUSP00000006825.

Structurei

3D structure databases

ProteinModelPortaliQ9QZS7.
SMRiQ9QZS7. Positions 48-1036.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini36 – 10781043ExtracellularSequence AnalysisAdd
BLAST
Topological domaini1100 – 1256157CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei1079 – 109921HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini39 – 144106Ig-like C2-type 1Add
BLAST
Domaini149 – 24799Ig-like C2-type 2Add
BLAST
Domaini256 – 34792Ig-like C2-type 3Add
BLAST
Domaini354 – 44895Ig-like C2-type 4Add
BLAST
Domaini454 – 554101Ig-like C2-type 5Add
BLAST
Domaini558 – 64992Ig-like C2-type 6Add
BLAST
Domaini754 – 84693Ig-like C2-type 7Add
BLAST
Domaini852 – 953102Ig-like C2-type 8Add
BLAST
Domaini957 – 105195Fibronectin type-IIIPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the immunoglobulin superfamily.Curated
Contains 1 fibronectin type-III domain.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG251936.
GeneTreeiENSGT00550000074545.
HOVERGENiHBG031752.
InParanoidiQ9QZS7.
OMAiNVNEGSQ.
OrthoDBiEOG7RBZ7J.
PhylomeDBiQ9QZS7.
TreeFamiTF327139.

Family and domain databases

Gene3Di2.60.40.10. 10 hits.
InterProiIPR013162. CD80_C2-set.
IPR003961. Fibronectin_type3.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF08205. C2-set_2. 5 hits.
PF00041. fn3. 1 hit.
PF07679. I-set. 2 hits.
PF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00060. FN3. 1 hit.
SM00409. IG. 5 hits.
SM00408. IGc2. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 1 hit.
PROSITEiPS50853. FN3. 1 hit.
PS50835. IG_LIKE. 8 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9QZS7-1) [UniParc]FASTAAdd to Basket

Also known as: NephrinA

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGAKEATVRG PGASPVHRTC HLIPLLLAGM LTTGLAQSPV PTSAPRGFWA
60 70 80 90 100
LSENLTVVEG STVKLWCGVR APGSVVQWAK DGLLLGPNPK IPGFPRYSLE
110 120 130 140 150
GDSAKGEFHL LIEACDLSDD AEYECQVGRS ELGPELVSPS VILSILVSPK
160 170 180 190 200
VLQLTPEAGS TVTWVAGQEY VVTCVSGDAK PAPDIIFIQG GRTVEDVSSS
210 220 230 240 250
VNEGSEEKLF FTEAEARVTP QSSDNGQLLV CEGSNPALAT PIKASFTMNI
260 270 280 290 300
LFPPGPPVID WPGLNEGHVR AGENLELPCI ARGGNPPATL QWLKNGKPVS
310 320 330 340 350
IAWGTEHAQA VAHSVLVMTV RPEDHGARLS CQSYNSVSAE TQERSITLQV
360 370 380 390 400
TFPPSAVTIL GSTSQSENKN VTLCCLTKSS RPRVLLRWWL GGRQLLPTDE
410 420 430 440 450
TVMDGLHGGH ISMSNLTLLV KREDNGLSLT CEAFSDAFSK ETFKKSLTLN
460 470 480 490 500
VKYPAQKLWI EGPPEGQSIR TGTRVRLVCL AIGGNPEPSL TWLKDSRPVN
510 520 530 540 550
DPRQSQEPRR VQLGSVEKSG STFSRELVLI IGPPDNLAKF SCKAGQLSAS
560 570 580 590 600
TQLVVQFPPT NLTILANSSA LRPGDALNLT CVSISSNPPV NLSLDKEGER
610 620 630 640 650
LDDVAAKPQS APFKGSAASR SVFLRVSSRD HGHRVTCRAH SEALRETVSS
660 670 680 690 700
FYRLNVLYPP EFLGEQVRAV TVVEQGQALL PVSVSANPAP EAFNWTFRGY
710 720 730 740 750
RLSPAGGPRH RILSGGALQL WNVTRADDGF YQLHCQNSEG TAEALLKLDV
760 770 780 790 800
HYAPTIRALK DPTEVNVGGS VDIVCTVDAN PILPEMFSWE RLGEDEEELN
810 820 830 840 850
LDDMEKMSKG STGRLRIRQA KLSQAGAYQC IVDNGVAPAA RGLVRLVVRF
860 870 880 890 900
APQVDHPTPL TKVAAAGDST SSATLHCRAR GVPNIDFTWT KNGVPLDLQD
910 920 930 940 950
PRYTEHKYHQ GVVHSSLLTI ANVSAAQDYA LFKCTATNAL GSDHTNIQLV
960 970 980 990 1000
SISRPDPPLG LKVVSVSPHS VGLEWKPGFD GGLPQRFQIR YEALESPGFL
1010 1020 1030 1040 1050
YMDVLPAQAT TFTLTGLKPS TRYRIWLLAS NALGDSGLTD KGIQVSITTP
1060 1070 1080 1090 1100
GLDQAPEDTD QPLPTEQPPG PPRLPLLPVL FAVGGLLLLS NASCVGGLLW
1110 1120 1130 1140 1150
RRRLRRLAEE ISEKTEAGSE EDRIRNEYEE SQWTGDRDTR SSTVSTAEVD
1160 1170 1180 1190 1200
PHYYSMRDFS PQLPPTLEEV SYRQAFTGIE DEDMAFPGHL YDEVERVYGP
1210 1220 1230 1240 1250
PGVWGPLYDE VQMDPYDLRW PEVKYEDPRG IYDQVAADMD AGEPGSLPFE

LRGHLV
Length:1,256
Mass (Da):136,336
Last modified:March 8, 2011 - v2
Checksum:i339A670F2AF000A2
GO
Isoform 2 (identifier: Q9QZS7-2) [UniParc]FASTAAdd to Basket

Also known as: NephrinB

The sequence of this isoform differs from the canonical sequence as follows:
     1-33: MGAKEATVRGPGASPVHRTCHLIPLLLAGMLTT → MEKWRAWDPQSIQRRKTAK

Show »
Length:1,242
Mass (Da):135,352
Checksum:i5DA81EAA712A3EBB
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1 – 2424MGAKE…CHLIP → MALGTTLRAS in AAF03368. (PubMed:10504499)CuratedAdd
BLAST
Sequence conflicti6 – 61A → V in AAF91087. (PubMed:10820162)Curated
Sequence conflicti21 – 211H → R in AAF91087. (PubMed:10820162)Curated
Sequence conflicti43 – 431S → P in AAF91085. (PubMed:10820162)Curated
Sequence conflicti43 – 431S → P in AAG17142. (PubMed:12039968)Curated
Sequence conflicti43 – 431S → P in AAK38483. (PubMed:12039968)Curated
Sequence conflicti43 – 431S → P in BAI63574. (PubMed:19887377)Curated
Sequence conflicti63 – 631V → I in AAF03368. (PubMed:10504499)Curated
Sequence conflicti63 – 631V → I in AAF91087. (PubMed:10820162)Curated
Sequence conflicti140 – 1401S → R in AAF03368. (PubMed:10504499)Curated
Sequence conflicti140 – 1401S → R in AAF91087. (PubMed:10820162)Curated
Sequence conflicti145 – 1451I → V in AAF03368. (PubMed:10504499)Curated
Sequence conflicti145 – 1451I → V in AAF91087. (PubMed:10820162)Curated
Sequence conflicti148 – 1481S → P in AAF03368. (PubMed:10504499)Curated
Sequence conflicti148 – 1481S → P in AAF91087. (PubMed:10820162)Curated
Sequence conflicti178 – 1781D → G in AAF03368. (PubMed:10504499)Curated
Sequence conflicti178 – 1781D → G in AAF91087. (PubMed:10820162)Curated
Sequence conflicti763 – 7631T → A in AAF03368. (PubMed:10504499)Curated
Sequence conflicti996 – 9961S → T in AAF03368. (PubMed:10504499)Curated
Sequence conflicti996 – 9961S → T in AAF91087. (PubMed:10820162)Curated
Sequence conflicti1076 – 10761L → Q in AAF03368. (PubMed:10504499)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 3333MGAKE…GMLTT → MEKWRAWDPQSIQRRKTAK in isoform 2. 1 PublicationVSP_040676Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF168466 mRNA. Translation: AAF03368.1.
AF172254
, AF172247, AF172248, AF172249, AF172250, AF172251, AF172252, AF172253 Genomic DNA. Translation: AAF91085.1.
AF172256 mRNA. Translation: AAF91087.1.
AF190638 Genomic DNA. Translation: AAG17142.1.
AF191090 mRNA. Translation: AAK38483.1.
AB513652 mRNA. Translation: BAI63574.1.
AC167970 mRNA. No translation available.
AY183460 Genomic DNA. Translation: AAO22850.1.
CCDSiCCDS39884.1. [Q9QZS7-1]
RefSeqiNP_062332.2. NM_019459.2. [Q9QZS7-1]
XP_006540278.1. XM_006540215.1. [Q9QZS7-2]
UniGeneiMm.437830.

Genome annotation databases

EnsembliENSMUST00000006825; ENSMUSP00000006825; ENSMUSG00000006649. [Q9QZS7-1]
GeneIDi54631.
KEGGimmu:54631.
UCSCiuc009gem.1. mouse. [Q9QZS7-2]
uc009gen.1. mouse. [Q9QZS7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF168466 mRNA. Translation: AAF03368.1 .
AF172254
, AF172247 , AF172248 , AF172249 , AF172250 , AF172251 , AF172252 , AF172253 Genomic DNA. Translation: AAF91085.1 .
AF172256 mRNA. Translation: AAF91087.1 .
AF190638 Genomic DNA. Translation: AAG17142.1 .
AF191090 mRNA. Translation: AAK38483.1 .
AB513652 mRNA. Translation: BAI63574.1 .
AC167970 mRNA. No translation available.
AY183460 Genomic DNA. Translation: AAO22850.1 .
CCDSi CCDS39884.1. [Q9QZS7-1 ]
RefSeqi NP_062332.2. NM_019459.2. [Q9QZS7-1 ]
XP_006540278.1. XM_006540215.1. [Q9QZS7-2 ]
UniGenei Mm.437830.

3D structure databases

ProteinModelPortali Q9QZS7.
SMRi Q9QZS7. Positions 48-1036.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 207694. 1 interaction.
STRINGi 10090.ENSMUSP00000006825.

PTM databases

PhosphoSitei Q9QZS7.

Proteomic databases

PaxDbi Q9QZS7.
PRIDEi Q9QZS7.

Protocols and materials databases

DNASUi 54631.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000006825 ; ENSMUSP00000006825 ; ENSMUSG00000006649 . [Q9QZS7-1 ]
GeneIDi 54631.
KEGGi mmu:54631.
UCSCi uc009gem.1. mouse. [Q9QZS7-2 ]
uc009gen.1. mouse. [Q9QZS7-1 ]

Organism-specific databases

CTDi 4868.
MGIi MGI:1859637. Nphs1.

Phylogenomic databases

eggNOGi NOG251936.
GeneTreei ENSGT00550000074545.
HOVERGENi HBG031752.
InParanoidi Q9QZS7.
OMAi NVNEGSQ.
OrthoDBi EOG7RBZ7J.
PhylomeDBi Q9QZS7.
TreeFami TF327139.

Miscellaneous databases

NextBioi 311448.
PROi Q9QZS7.
SOURCEi Search...

Gene expression databases

Bgeei Q9QZS7.
CleanExi MM_NPHS1.
ExpressionAtlasi Q9QZS7. baseline and differential.
Genevestigatori Q9QZS7.

Family and domain databases

Gene3Di 2.60.40.10. 10 hits.
InterProi IPR013162. CD80_C2-set.
IPR003961. Fibronectin_type3.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
[Graphical view ]
Pfami PF08205. C2-set_2. 5 hits.
PF00041. fn3. 1 hit.
PF07679. I-set. 2 hits.
PF07686. V-set. 1 hit.
[Graphical view ]
SMARTi SM00060. FN3. 1 hit.
SM00409. IG. 5 hits.
SM00408. IGc2. 1 hit.
[Graphical view ]
SUPFAMi SSF49265. SSF49265. 1 hit.
PROSITEi PS50853. FN3. 1 hit.
PS50835. IG_LIKE. 8 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Nephrin localizes to the slit pore of the glomerular epithelial cell."
    Holzman L.B., St John P.L., Kovari I.A., Verma R., Holthoefer H., Abrahamson D.R.
    Kidney Int. 56:1481-1491(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION.
  2. "Primary structure of mouse and rat nephrin cDNA and structure and expression of the mouse gene."
    Putaala H., Sainio K., Sariola H., Tryggvason K.
    J. Am. Soc. Nephrol. 11:991-1001(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
    Tissue: Kidney.
  3. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-494 (ISOFORM 1), FUNCTION, DISRUPTION PHENOTYPE.
    Strain: 129/SvEv and C57BL/6J.
  4. "Ptf1a directly controls expression of immunoglobulin superfamily molecules Nephrin and Neph3 in the developing central nervous system."
    Nishida K., Hoshino M., Kawaguchi Y., Murakami F.
    J. Biol. Chem. 285:373-380(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), SELF-ASSOCIATION, INTERACTION WITH KIRREL2, TISSUE SPECIFICITY.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  6. "Alternatively used promoters and distinct elements direct tissue-specific expression of nephrin."
    Beltcheva O., Kontusaari S., Fetissov S., Putaala H., Kilpelainen P., Hokfelt T., Tryggvason K.
    J. Am. Soc. Nephrol. 14:352-358(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-19 (ISOFORM 2), TISSUE SPECIFICITY, ALTERNATIVE SPLICING.
    Strain: 129/Sv.
  7. "CD2AP localizes to the slit diaphragm and binds to nephrin via a novel C-terminal domain."
    Shih N.Y., Li J., Cotran R., Mundel P., Miner J.H., Shaw A.S.
    Am. J. Pathol. 159:2303-2308(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CD2AP.
  8. "The murine nephrin gene is specifically expressed in kidney, brain and pancreas: inactivation of the gene leads to massive proteinuria and neonatal death."
    Putaala H., Soininen R., Kilpelainen P., Wartiovaara J., Tryggvason K.
    Hum. Mol. Genet. 10:1-8(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.
  9. "Podocin, a raft-associated component of the glomerular slit diaphragm, interacts with CD2AP and nephrin."
    Schwarz K., Simons M., Reiser J., Saleem M.A., Faul C., Kriz W., Shaw A.S., Holzman L.B., Mundel P.
    J. Clin. Invest. 108:1621-1629(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CD2AP AND NPHS2.
  10. "NEPH1 defines a novel family of podocin interacting proteins."
    Sellin L., Huber T.B., Gerke P., Quack I., Pavenstaedt H., Walz G.
    FASEB J. 17:115-117(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH KIRREL1.
    Strain: Swiss Webster.
    Tissue: Brain.
  11. "Homodimerization and heterodimerization of the glomerular podocyte proteins nephrin and NEPH1."
    Gerke P., Huber T.B., Sellin L., Benzing T., Walz G.
    J. Am. Soc. Nephrol. 14:918-926(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: SELF-ASSOCIATION, INTERACTION WITH KIRREL.
  12. "Nuclear relocation of the nephrin and CD2AP-binding protein dendrin promotes apoptosis of podocytes."
    Asanuma K., Campbell K.N., Kim K., Faul C., Mundel P.
    Proc. Natl. Acad. Sci. U.S.A. 104:10134-10139(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH DDN.
  13. "A role for nephrin, a renal protein, in vertebrate skeletal muscle cell fusion."
    Sohn R.L., Huang P., Kawahara G., Mitchell M., Guyon J., Kalluri R., Kunkel L.M., Gussoni E.
    Proc. Natl. Acad. Sci. U.S.A. 106:9274-9279(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiNPHN_MOUSE
AccessioniPrimary (citable) accession number: Q9QZS7
Secondary accession number(s): D2KXA7
, Q811S5, Q925S5, Q9ESC6, Q9ET59, Q9JIX1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: March 8, 2011
Last modified: October 29, 2014
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3