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Q9QZS7

- NPHN_MOUSE

UniProt

Q9QZS7 - NPHN_MOUSE

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Protein

Nephrin

Gene
Nphs1, Nphn
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Seems to play a role in the development or function of the kidney glomerular filtration barrier. Regulates glomerular vascular permeability. May anchor the podocyte slit diaphragm to the actin cytoskeleton. Plays a role in skeletal muscle formation through regulation of myoblast fusion.3 Publications

GO - Molecular functioni

  1. protein binding Source: MGI

GO - Biological processi

  1. cell adhesion Source: MGI
  2. glomerular basement membrane development Source: Ensembl
  3. glomerular visceral epithelial cell development Source: Ensembl
  4. JNK cascade Source: MGI
  5. MAPK cascade Source: MGI
  6. myoblast fusion Source: UniProtKB
  7. positive regulation of actin filament polymerization Source: MGI
  8. regulation of excretion Source: UniProtKB
  9. skeletal muscle tissue development Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Cell adhesion, Myogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Nephrin
Alternative name(s):
Renal glomerulus-specific cell adhesion receptor
Gene namesi
Name:Nphs1
Synonyms:Nphn
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:1859637. Nphs1.

Subcellular locationi

Cell membrane; Single-pass type I membrane protein Reviewed prediction
Note: Located at podocyte slit diaphragm between podocyte foot processes.1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini36 – 10781043Extracellular Reviewed predictionAdd
BLAST
Transmembranei1079 – 109921Helical; Reviewed predictionAdd
BLAST
Topological domaini1100 – 1256157Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. cell projection Source: UniProtKB
  2. integral component of membrane Source: MGI
  3. integral component of plasma membrane Source: MGI
  4. membrane raft Source: Ensembl
  5. plasma membrane Source: UniProtKB
  6. protein complex Source: Ensembl
  7. slit diaphragm Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Death by postnatal day 2 associated with proteinuria, edema and massive glomerular vascular leak. Kidneys display enlarged Bowman's spaces, dilated tubuli, effacement of podocyte foot processes and an absence of the glomerular epithelial slit diaphragm. Impaired skeletal muscle development characterized by incomplete myoblast fusion.3 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3535 Reviewed predictionAdd
BLAST
Chaini36 – 12561221NephrinPRO_0000015053Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi54 – 541N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi67 ↔ 125 By similarity
Disulfide bondi174 ↔ 231 By similarity
Disulfide bondi279 ↔ 331 By similarity
Glycosylationi370 – 3701N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi375 ↔ 431 By similarity
Glycosylationi415 – 4151N-linked (GlcNAc...) Reviewed prediction
Modified residuei446 – 4461Phosphoserine By similarity
Disulfide bondi479 ↔ 542 By similarity
Glycosylationi561 – 5611N-linked (GlcNAc...) Reviewed prediction
Glycosylationi578 – 5781N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi581 ↔ 637 By similarity
Glycosylationi591 – 5911N-linked (GlcNAc...) Reviewed prediction
Glycosylationi722 – 7221N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi775 ↔ 830 By similarity
Disulfide bondi877 ↔ 934 By similarity
Modified residuei1208 – 12081Phosphotyrosine; by FYN By similarity

Post-translational modificationi

Phosphorylated at Tyr-1208 by FYN, leading to the recruitment and activation of phospholipase C-gamma-1/PLCG1 By similarity.

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ9QZS7.
PRIDEiQ9QZS7.

PTM databases

PhosphoSiteiQ9QZS7.

Expressioni

Tissue specificityi

Expressed in kidney glomeruli. In the embryo, expressed in the mesonephric kidney at E11 with strong expression in cranial tubules with podocyte-like structures. Expression is observed in the podocytes of the developing kidney from E13. High expression is also detected in the developing cerebellum, hindbrain, spinal cord, retina and hypothalamus. Expressed in skeletal muscle during myoblast fusion such as in the adult following acute injury and in the embryo but not detected in uninjured adult skeletal muscle. Isoform 1 and isoform 2 are expressed in the newborn brain and developing cerebellum. Isoform 1 is the predominant isoform in adult kidney.5 Publications

Gene expression databases

ArrayExpressiQ9QZS7.
BgeeiQ9QZS7.
CleanExiMM_NPHS1.
GenevestigatoriQ9QZS7.

Interactioni

Subunit structurei

Interacts with NPHS2 and with CD2AP (via C-terminal domain). Interacts with MAGI1 (via PDZ 2 and 3 domains) forming a tripartite complex with IGSF5/JAM4. Forms a complex with ACTN4, CASK, IQGAP1, MAGI2, SPTAN1 and SPTBN1 By similarity. Interacts with DDN; the interaction is direct. Self-associates (via the Ig-like domains). Also interacts (via the Ig-like domains) with KIRREL/NEPH1 and KIRREL2; the interaction with KIRREL is dependent on KIRREL glycosylation.6 Publications

Protein-protein interaction databases

BioGridi207694. 1 interaction.
STRINGi10090.ENSMUSP00000006825.

Structurei

3D structure databases

ProteinModelPortaliQ9QZS7.
SMRiQ9QZS7. Positions 47-1036.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini39 – 144106Ig-like C2-type 1Add
BLAST
Domaini149 – 24799Ig-like C2-type 2Add
BLAST
Domaini256 – 34792Ig-like C2-type 3Add
BLAST
Domaini354 – 44895Ig-like C2-type 4Add
BLAST
Domaini454 – 554101Ig-like C2-type 5Add
BLAST
Domaini558 – 64992Ig-like C2-type 6Add
BLAST
Domaini754 – 84693Ig-like C2-type 7Add
BLAST
Domaini852 – 953102Ig-like C2-type 8Add
BLAST
Domaini957 – 105195Fibronectin type-IIIAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG251936.
GeneTreeiENSGT00550000074545.
HOVERGENiHBG031752.
InParanoidiQ9ET59.
OMAiNVNEGSQ.
OrthoDBiEOG7RBZ7J.
PhylomeDBiQ9QZS7.
TreeFamiTF327139.

Family and domain databases

Gene3Di2.60.40.10. 10 hits.
InterProiIPR013162. CD80_C2-set.
IPR003961. Fibronectin_type3.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF08205. C2-set_2. 5 hits.
PF00041. fn3. 1 hit.
PF07679. I-set. 2 hits.
PF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00060. FN3. 1 hit.
SM00409. IG. 5 hits.
SM00408. IGc2. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 1 hit.
PROSITEiPS50853. FN3. 1 hit.
PS50835. IG_LIKE. 8 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9QZS7-1) [UniParc]FASTAAdd to Basket

Also known as: NephrinA

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MGAKEATVRG PGASPVHRTC HLIPLLLAGM LTTGLAQSPV PTSAPRGFWA     50
LSENLTVVEG STVKLWCGVR APGSVVQWAK DGLLLGPNPK IPGFPRYSLE 100
GDSAKGEFHL LIEACDLSDD AEYECQVGRS ELGPELVSPS VILSILVSPK 150
VLQLTPEAGS TVTWVAGQEY VVTCVSGDAK PAPDIIFIQG GRTVEDVSSS 200
VNEGSEEKLF FTEAEARVTP QSSDNGQLLV CEGSNPALAT PIKASFTMNI 250
LFPPGPPVID WPGLNEGHVR AGENLELPCI ARGGNPPATL QWLKNGKPVS 300
IAWGTEHAQA VAHSVLVMTV RPEDHGARLS CQSYNSVSAE TQERSITLQV 350
TFPPSAVTIL GSTSQSENKN VTLCCLTKSS RPRVLLRWWL GGRQLLPTDE 400
TVMDGLHGGH ISMSNLTLLV KREDNGLSLT CEAFSDAFSK ETFKKSLTLN 450
VKYPAQKLWI EGPPEGQSIR TGTRVRLVCL AIGGNPEPSL TWLKDSRPVN 500
DPRQSQEPRR VQLGSVEKSG STFSRELVLI IGPPDNLAKF SCKAGQLSAS 550
TQLVVQFPPT NLTILANSSA LRPGDALNLT CVSISSNPPV NLSLDKEGER 600
LDDVAAKPQS APFKGSAASR SVFLRVSSRD HGHRVTCRAH SEALRETVSS 650
FYRLNVLYPP EFLGEQVRAV TVVEQGQALL PVSVSANPAP EAFNWTFRGY 700
RLSPAGGPRH RILSGGALQL WNVTRADDGF YQLHCQNSEG TAEALLKLDV 750
HYAPTIRALK DPTEVNVGGS VDIVCTVDAN PILPEMFSWE RLGEDEEELN 800
LDDMEKMSKG STGRLRIRQA KLSQAGAYQC IVDNGVAPAA RGLVRLVVRF 850
APQVDHPTPL TKVAAAGDST SSATLHCRAR GVPNIDFTWT KNGVPLDLQD 900
PRYTEHKYHQ GVVHSSLLTI ANVSAAQDYA LFKCTATNAL GSDHTNIQLV 950
SISRPDPPLG LKVVSVSPHS VGLEWKPGFD GGLPQRFQIR YEALESPGFL 1000
YMDVLPAQAT TFTLTGLKPS TRYRIWLLAS NALGDSGLTD KGIQVSITTP 1050
GLDQAPEDTD QPLPTEQPPG PPRLPLLPVL FAVGGLLLLS NASCVGGLLW 1100
RRRLRRLAEE ISEKTEAGSE EDRIRNEYEE SQWTGDRDTR SSTVSTAEVD 1150
PHYYSMRDFS PQLPPTLEEV SYRQAFTGIE DEDMAFPGHL YDEVERVYGP 1200
PGVWGPLYDE VQMDPYDLRW PEVKYEDPRG IYDQVAADMD AGEPGSLPFE 1250
LRGHLV 1256
Length:1,256
Mass (Da):136,336
Last modified:March 8, 2011 - v2
Checksum:i339A670F2AF000A2
GO
Isoform 2 (identifier: Q9QZS7-2) [UniParc]FASTAAdd to Basket

Also known as: NephrinB

The sequence of this isoform differs from the canonical sequence as follows:
     1-33: MGAKEATVRGPGASPVHRTCHLIPLLLAGMLTT → MEKWRAWDPQSIQRRKTAK

Show »
Length:1,242
Mass (Da):135,352
Checksum:i5DA81EAA712A3EBB
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 3333MGAKE…GMLTT → MEKWRAWDPQSIQRRKTAK in isoform 2. VSP_040676Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1 – 2424MGAKE…CHLIP → MALGTTLRAS in AAF03368. 1 PublicationAdd
BLAST
Sequence conflicti6 – 61A → V in AAF91087. 1 Publication
Sequence conflicti21 – 211H → R in AAF91087. 1 Publication
Sequence conflicti43 – 431S → P in AAF91085. 1 Publication
Sequence conflicti43 – 431S → P in AAG17142. 1 Publication
Sequence conflicti43 – 431S → P in AAK38483. 1 Publication
Sequence conflicti43 – 431S → P in BAI63574. 1 Publication
Sequence conflicti63 – 631V → I in AAF03368. 1 Publication
Sequence conflicti63 – 631V → I in AAF91087. 1 Publication
Sequence conflicti140 – 1401S → R in AAF03368. 1 Publication
Sequence conflicti140 – 1401S → R in AAF91087. 1 Publication
Sequence conflicti145 – 1451I → V in AAF03368. 1 Publication
Sequence conflicti145 – 1451I → V in AAF91087. 1 Publication
Sequence conflicti148 – 1481S → P in AAF03368. 1 Publication
Sequence conflicti148 – 1481S → P in AAF91087. 1 Publication
Sequence conflicti178 – 1781D → G in AAF03368. 1 Publication
Sequence conflicti178 – 1781D → G in AAF91087. 1 Publication
Sequence conflicti763 – 7631T → A in AAF03368. 1 Publication
Sequence conflicti996 – 9961S → T in AAF03368. 1 Publication
Sequence conflicti996 – 9961S → T in AAF91087. 1 Publication
Sequence conflicti1076 – 10761L → Q in AAF03368. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF168466 mRNA. Translation: AAF03368.1.
AF172254
, AF172247, AF172248, AF172249, AF172250, AF172251, AF172252, AF172253 Genomic DNA. Translation: AAF91085.1.
AF172256 mRNA. Translation: AAF91087.1.
AF190638 Genomic DNA. Translation: AAG17142.1.
AF191090 mRNA. Translation: AAK38483.1.
AB513652 mRNA. Translation: BAI63574.1.
AC167970 mRNA. No translation available.
AY183460 Genomic DNA. Translation: AAO22850.1.
CCDSiCCDS39884.1. [Q9QZS7-1]
RefSeqiNP_062332.2. NM_019459.2. [Q9QZS7-1]
XP_006540278.1. XM_006540215.1. [Q9QZS7-2]
UniGeneiMm.437830.

Genome annotation databases

EnsembliENSMUST00000006825; ENSMUSP00000006825; ENSMUSG00000006649. [Q9QZS7-1]
GeneIDi54631.
KEGGimmu:54631.
UCSCiuc009gem.1. mouse. [Q9QZS7-2]
uc009gen.1. mouse. [Q9QZS7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF168466 mRNA. Translation: AAF03368.1 .
AF172254
, AF172247 , AF172248 , AF172249 , AF172250 , AF172251 , AF172252 , AF172253 Genomic DNA. Translation: AAF91085.1 .
AF172256 mRNA. Translation: AAF91087.1 .
AF190638 Genomic DNA. Translation: AAG17142.1 .
AF191090 mRNA. Translation: AAK38483.1 .
AB513652 mRNA. Translation: BAI63574.1 .
AC167970 mRNA. No translation available.
AY183460 Genomic DNA. Translation: AAO22850.1 .
CCDSi CCDS39884.1. [Q9QZS7-1 ]
RefSeqi NP_062332.2. NM_019459.2. [Q9QZS7-1 ]
XP_006540278.1. XM_006540215.1. [Q9QZS7-2 ]
UniGenei Mm.437830.

3D structure databases

ProteinModelPortali Q9QZS7.
SMRi Q9QZS7. Positions 47-1036.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 207694. 1 interaction.
STRINGi 10090.ENSMUSP00000006825.

PTM databases

PhosphoSitei Q9QZS7.

Proteomic databases

PaxDbi Q9QZS7.
PRIDEi Q9QZS7.

Protocols and materials databases

DNASUi 54631.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000006825 ; ENSMUSP00000006825 ; ENSMUSG00000006649 . [Q9QZS7-1 ]
GeneIDi 54631.
KEGGi mmu:54631.
UCSCi uc009gem.1. mouse. [Q9QZS7-2 ]
uc009gen.1. mouse. [Q9QZS7-1 ]

Organism-specific databases

CTDi 4868.
MGIi MGI:1859637. Nphs1.

Phylogenomic databases

eggNOGi NOG251936.
GeneTreei ENSGT00550000074545.
HOVERGENi HBG031752.
InParanoidi Q9ET59.
OMAi NVNEGSQ.
OrthoDBi EOG7RBZ7J.
PhylomeDBi Q9QZS7.
TreeFami TF327139.

Miscellaneous databases

NextBioi 311448.
PROi Q9QZS7.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9QZS7.
Bgeei Q9QZS7.
CleanExi MM_NPHS1.
Genevestigatori Q9QZS7.

Family and domain databases

Gene3Di 2.60.40.10. 10 hits.
InterProi IPR013162. CD80_C2-set.
IPR003961. Fibronectin_type3.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
[Graphical view ]
Pfami PF08205. C2-set_2. 5 hits.
PF00041. fn3. 1 hit.
PF07679. I-set. 2 hits.
PF07686. V-set. 1 hit.
[Graphical view ]
SMARTi SM00060. FN3. 1 hit.
SM00409. IG. 5 hits.
SM00408. IGc2. 1 hit.
[Graphical view ]
SUPFAMi SSF49265. SSF49265. 1 hit.
PROSITEi PS50853. FN3. 1 hit.
PS50835. IG_LIKE. 8 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Nephrin localizes to the slit pore of the glomerular epithelial cell."
    Holzman L.B., St John P.L., Kovari I.A., Verma R., Holthoefer H., Abrahamson D.R.
    Kidney Int. 56:1481-1491(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION.
  2. "Primary structure of mouse and rat nephrin cDNA and structure and expression of the mouse gene."
    Putaala H., Sainio K., Sariola H., Tryggvason K.
    J. Am. Soc. Nephrol. 11:991-1001(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
    Tissue: Kidney.
  3. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-494 (ISOFORM 1), FUNCTION, DISRUPTION PHENOTYPE.
    Strain: 129/SvEv and C57BL/6J.
  4. "Ptf1a directly controls expression of immunoglobulin superfamily molecules Nephrin and Neph3 in the developing central nervous system."
    Nishida K., Hoshino M., Kawaguchi Y., Murakami F.
    J. Biol. Chem. 285:373-380(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), SELF-ASSOCIATION, INTERACTION WITH KIRREL2, TISSUE SPECIFICITY.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  6. "Alternatively used promoters and distinct elements direct tissue-specific expression of nephrin."
    Beltcheva O., Kontusaari S., Fetissov S., Putaala H., Kilpelainen P., Hokfelt T., Tryggvason K.
    J. Am. Soc. Nephrol. 14:352-358(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-19 (ISOFORM 2), TISSUE SPECIFICITY, ALTERNATIVE SPLICING.
    Strain: 129/Sv.
  7. "CD2AP localizes to the slit diaphragm and binds to nephrin via a novel C-terminal domain."
    Shih N.Y., Li J., Cotran R., Mundel P., Miner J.H., Shaw A.S.
    Am. J. Pathol. 159:2303-2308(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CD2AP.
  8. "The murine nephrin gene is specifically expressed in kidney, brain and pancreas: inactivation of the gene leads to massive proteinuria and neonatal death."
    Putaala H., Soininen R., Kilpelainen P., Wartiovaara J., Tryggvason K.
    Hum. Mol. Genet. 10:1-8(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.
  9. "Podocin, a raft-associated component of the glomerular slit diaphragm, interacts with CD2AP and nephrin."
    Schwarz K., Simons M., Reiser J., Saleem M.A., Faul C., Kriz W., Shaw A.S., Holzman L.B., Mundel P.
    J. Clin. Invest. 108:1621-1629(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CD2AP AND NPHS2.
  10. "NEPH1 defines a novel family of podocin interacting proteins."
    Sellin L., Huber T.B., Gerke P., Quack I., Pavenstaedt H., Walz G.
    FASEB J. 17:115-117(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH KIRREL1.
    Strain: Swiss Webster.
    Tissue: Brain.
  11. "Homodimerization and heterodimerization of the glomerular podocyte proteins nephrin and NEPH1."
    Gerke P., Huber T.B., Sellin L., Benzing T., Walz G.
    J. Am. Soc. Nephrol. 14:918-926(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: SELF-ASSOCIATION, INTERACTION WITH KIRREL.
  12. "Nuclear relocation of the nephrin and CD2AP-binding protein dendrin promotes apoptosis of podocytes."
    Asanuma K., Campbell K.N., Kim K., Faul C., Mundel P.
    Proc. Natl. Acad. Sci. U.S.A. 104:10134-10139(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH DDN.
  13. "A role for nephrin, a renal protein, in vertebrate skeletal muscle cell fusion."
    Sohn R.L., Huang P., Kawahara G., Mitchell M., Guyon J., Kalluri R., Kunkel L.M., Gussoni E.
    Proc. Natl. Acad. Sci. U.S.A. 106:9274-9279(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiNPHN_MOUSE
AccessioniPrimary (citable) accession number: Q9QZS7
Secondary accession number(s): D2KXA7
, Q811S5, Q925S5, Q9ESC6, Q9ET59, Q9JIX1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: March 8, 2011
Last modified: September 3, 2014
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi