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Protein

PDZ domain-containing protein 2

Gene

Pdzd2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • cell adhesion Source: UniProtKB-KW
  • intracellular signal transduction Source: RGD
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
PDZ domain-containing protein 2
Alternative name(s):
PDZ domain-containing protein 3
Plakophilin-related armadillo repeat protein-interacting PDZ protein
Cleaved into the following chain:
Gene namesi
Name:Pdzd2
Synonyms:Papin, Pdzk3, Pin1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi619958. Pdzd2.

Subcellular locationi

  • Nucleus 1 Publication
  • Cytoplasm By similarity
  • Endoplasmic reticulum 1 Publication
  • Cell junction 1 Publication

  • Note: At cell-cell contacts in lung epithelial cells (PubMed:10896674).

GO - Cellular componenti

  • apical part of cell Source: RGD
  • cell-cell junction Source: UniProtKB
  • cytoplasm Source: UniProtKB
  • endoplasmic reticulum Source: UniProtKB
  • extracellular region Source: UniProtKB
  • neuron projection Source: RGD
  • nucleus Source: UniProtKB
  • postsynaptic density Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasm, Endoplasmic reticulum, Nucleus, Secreted

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi2402 – 241110DLDKLCNGED → I: Loss of proteolytic cleavage.
Mutagenesisi2402 – 24021D → A: Loss of proteolytic cleavage. 1 Publication
Mutagenesisi2404 – 24041D → A: No loss of proteolytic cleavage. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 27662766PDZ domain-containing protein 2PRO_0000058295Add
BLAST
Chaini?2403 – 2766364Processed PDZ domain-containing protein 2PRO_0000302757Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei517 – 5171PhosphoserineCombined sources
Modified residuei891 – 8911PhosphoserineCombined sources
Modified residuei895 – 8951PhosphoserineCombined sources
Modified residuei1767 – 17671PhosphoserineCombined sources

Post-translational modificationi

A secreted form is produced by caspase-mediated proteolytic cleavage.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei2402 – 24032Cleavage; by caspases

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9QZR8.
PRIDEiQ9QZR8.

PTM databases

iPTMnetiQ9QZR8.
PhosphoSiteiQ9QZR8.
SwissPalmiQ9QZR8.

Expressioni

Tissue specificityi

Expressed in the heart, liver, brain, spleen, lung, kidney, testis and skeletal muscle.2 Publications

Interactioni

Subunit structurei

Interacts with SCN10A, CTNND2 and PKP4.2 Publications

Protein-protein interaction databases

IntActiQ9QZR8. 2 interactions.
MINTiMINT-7026539.
STRINGi10116.ENSRNOP00000017937.

Structurei

3D structure databases

ProteinModelPortaliQ9QZR8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini85 – 17793PDZ 1PROSITE-ProRule annotationAdd
BLAST
Domaini334 – 41986PDZ 2PROSITE-ProRule annotationAdd
BLAST
Domaini535 – 62187PDZ 3PROSITE-ProRule annotationAdd
BLAST
Domaini679 – 76486PDZ 4PROSITE-ProRule annotationAdd
BLAST
Domaini2550 – 263485PDZ 5PROSITE-ProRule annotationAdd
BLAST
Domaini2678 – 276386PDZ 6PROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi2271 – 2390120Ser-richAdd
BLAST

Sequence similaritiesi

Contains 6 PDZ (DHR) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3528. Eukaryota.
ENOG4110362. LUCA.
HOGENOMiHOG000115486.
HOVERGENiHBG082116.
InParanoidiQ9QZR8.
PhylomeDBiQ9QZR8.

Family and domain databases

Gene3Di2.30.42.10. 6 hits.
InterProiIPR001478. PDZ.
[Graphical view]
PfamiPF00595. PDZ. 5 hits.
[Graphical view]
SMARTiSM00228. PDZ. 6 hits.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 6 hits.
PROSITEiPS50106. PDZ. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9QZR8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPITQDNALL HLPLLYEWLQ NSLREGGDSP EQRLCQAAIQ KLQEYIQLNL
60 70 80 90 100
AVDESTVPPD HSPPEMEICT VYLTKQLGDT ETVGLSFGNI PVFGDYGEKR
110 120 130 140 150
RGGKKRKTHQ GPVLDVGCIW VTELRKNSPA GKSGKVRLRD EILSLNGQLM
160 170 180 190 200
VGVDVTGASY LAEQCWNGGF IYLIMLRRFK QKAHVTYNGN SGNSSEPGET
210 220 230 240 250
PTLELGDQTS KKGKRTRKFG VISRPSISKT PEDSKSSSGC DTADDPNSEL
260 270 280 290 300
ENGADPELGN GHAFELENGP HSLKDVAGPH LERSEADSEV ELRVPKTEAP
310 320 330 340 350
LSDSNDKRRF SKTGKTDFQS SDCLAREEVG RIWKMELLKE SDGLGIQVSG
360 370 380 390 400
GRGSKRSPHA IVVTQVKEGG AAHRDGRLSL GDELLVINGH LLVGLSHEEA
410 420 430 440 450
VAILRSATGM VQLVVASKMP GSEESQDVGS SEESKGNLES PKQGNCKTKL
460 470 480 490 500
KSRLSGGVHR LESVEEYNEL MVRNGDPRIR MLEVSRDGRK HSLPQLLDST
510 520 530 540 550
GTSQEYHIVK KSTRSLSTTH VESPWRLIRP SVISIIGLYK EKGKGLGFSI
560 570 580 590 600
AGGRDCIRGQ MGIFVKTIFP NGSAAEDGRL KEGDEILDVN GIPIKGLTFQ
610 620 630 640 650
EAIHTFKQIR SGLFVLTVRT KLLSPSLTPC STPTHMSRSS SPSFNTNSGG
660 670 680 690 700
TPAGGGQEEG GSSSLGRKAP GPKDRIVMEV TLNKEPRVGL GIGACCLALE
710 720 730 740 750
NSPPGIYIHS LAPGSVAKME SNLSRGDQIL EVNSVNVRHA ALSKVHAILS
760 770 780 790 800
KCPPGPVRLV IGRHPNPKVS EQEMDEVIAR STYQESREAN SSPGLGTPLK
810 820 830 840 850
SPSLAKKDSL LSESELSQYF VHDGQGSLSD FVVAGSEDED HPGSGYETSE
860 870 880 890 900
DGSLLPVPSA HKARANSLVT LGSQRTSGLL HKQVTVARQA SLPGSPQVLR
910 920 930 940 950
NPLLRQRRVR CYDSNGGSDD EDFDGEGDCI SLPGVLPGPG KPLVEDDTRP
960 970 980 990 1000
ALTTSSKSID VNKQEERLQK PLVSKACSVP LLGSSLDSEH SILNGAGGTP
1010 1020 1030 1040 1050
PKVASLPGSG ETPKNGPRGS GRKEMSGSRS SPKLEYRVPT DTQSPRSPEN
1060 1070 1080 1090 1100
HTSPPQKSEN LVSRHKPVAR ISPHYKRSDA EEAPGGTANG PCAQDLKVQA
1110 1120 1130 1140 1150
SPVKDPVTSR QPGGTAEKEL RGNPTPGDSS VPTNCGPAST PCHPNIGLPT
1160 1170 1180 1190 1200
ENPQGAAPEC GPHPGTGWDG SSEHLCSPGK SREVHPDSSE TPTVAEQVHQ
1210 1220 1230 1240 1250
PESLSQPVSP RTSEPESQGI SKMKPPSQRC VSPREKASTP PDSSRAWAAP
1260 1270 1280 1290 1300
GDSSPSTRRI AVPMSTGAAP ATAIPQASLV SQERSRGLSG PSKGLGTKEL
1310 1320 1330 1340 1350
CIPKSLKDGA LLEDTAPASG KMSHASSPSG PVATERTLSG SPENPVTDID
1360 1370 1380 1390 1400
NFIEEASEAR LSQSPQKADC RAHGDTFESQ PPGGAGSSSS HHAQMVRSDQ
1410 1420 1430 1440 1450
TSSPRKTGGT GSPPPQQWAL QPSVLDSIHP DKHLAVNKTF LNNYSRNFSN
1460 1470 1480 1490 1500
FHEDSISLSG PGGSSEPSPS SMYGNAEDSS SDPESLAEDP GAAARNNWSP
1510 1520 1530 1540 1550
PLSPESSPKE GSSESEDERI EICSTDGCPG TPVTAPPPTQ VALCPVLPVQ
1560 1570 1580 1590 1600
QRAVCKPVGD ICERACFVPG ASRTSIPDSS QPFSFLDVSS EEPETWASIN
1610 1620 1630 1640 1650
ASQNHMPVCT EGIMDVTSTS SNMGDSQSSQ MTRHCRNAPF VLGNPDMVND
1660 1670 1680 1690 1700
LGRDLLDEGA PKEGAAAASV MRSVFALGAE GPKNGEAVLA DLHIAERGNL
1710 1720 1730 1740 1750
EDLLQKPKTI SRRPILTWFK EINKDSQGSH LRSTSEKEQS SMLALGPGSK
1760 1770 1780 1790 1800
ANMVNTGHRK GVTVPKSPPS RQKSQENKDL PPKSPVETLG NCQKPKCSPK
1810 1820 1830 1840 1850
LKRLNSKGKA SPEVPVAIST KGSRNDHRKT LPSPQASHKM FSKAVSHRLH
1860 1870 1880 1890 1900
IADQEEPKNT AGDTPKPPQC VPESKPPQAA LGSLRTSASD TSIRTFTSPL
1910 1920 1930 1940 1950
TSPKLLPEQG ANSRFHMAVY LESDTSCPTT SRSPRSGPEG KAPHANSGSA
1960 1970 1980 1990 2000
SPPASRASLA LAGIRQSKQF TPGRADLLVS EATQPQGICE KGAEKKVSDP
2010 2020 2030 2040 2050
PQRTNQLKIV EISSERVPKN ACGDRPPESD RKGGFLTQNN CQEKSAIRLR
2060 2070 2080 2090 2100
QSEESSPEHT PFPPSQASQV EREIRWSFSM AKPATSSSSS LQLPAKLPES
2110 2120 2130 2140 2150
FQGKSSQMPA SVGVPKNGVP IGLAGEESPY FTPRPATRTY SMPAQFSSHF
2160 2170 2180 2190 2200
GREGPSPHSP SHSPQDPQVP AMGGKLSEKT AKGVTNGQGV YSVKPLLETS
2210 2220 2230 2240 2250
KNLSPVDGRD VSADPETSCL IPDKVKVTRR QYCCEQSWPH ESTSFFSVKQ
2260 2270 2280 2290 2300
RIKSFENLAN SDRPTAKCAT SPFLSVSSKP PINRRSSGSI PSGSPSDMTS
2310 2320 2330 2340 2350
RSLRRSLSSC SESQSEASSL LPQMTKSPSS MTLTVSRQNP PDTSNKGPSP
2360 2370 2380 2390 2400
DPKKSLVPVG IPTSTVSPAS PSKRNKSSVR HAQPSPVSRS KLQERRTLSM
2410 2420 2430 2440 2450
PDLDKLCNGE DDSASPGAVL FKTQLEITPR RSKGSQATSP AGSPARGHAD
2460 2470 2480 2490 2500
FNGSTFLSCP MNGGTRAYTK GNSPPASEPA IATGSREEGE SVWATPSGKS
2510 2520 2530 2540 2550
WSVSLDRLLA SVGNQQRLQG ILSLVGSKSP ILTLIQEAKA QSETKEDICF
2560 2570 2580 2590 2600
IVLNKKEGSG LGFSVAGGAD VEPKSVMVHR VFSQGVASQE GTVSRGDFLL
2610 2620 2630 2640 2650
SVNGTSLAGL AHSEVTKVLH QAELHKHALM IIKKGNDQPG PSFKQEPPSA
2660 2670 2680 2690 2700
NGKGPFPRRT LPLEPGAGRN GAAHDALCVE VLKTSAGLGL SLDGGKSSVS
2710 2720 2730 2740 2750
GEGPLVIKRV YKGGAAERAG TIEAGDEILA INGKPLVGLV HFDAWNIMKS
2760
VPEGPVQLVI RKHRDS
Length:2,766
Mass (Da):293,890
Last modified:May 1, 2000 - v1
Checksum:i1DC34DF7B4A6D1DD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF169411 mRNA. Translation: AAD55940.1.
RefSeqiNP_075229.1. NM_022940.1.
UniGeneiRn.48728.

Genome annotation databases

GeneIDi65034.
KEGGirno:65034.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF169411 mRNA. Translation: AAD55940.1.
RefSeqiNP_075229.1. NM_022940.1.
UniGeneiRn.48728.

3D structure databases

ProteinModelPortaliQ9QZR8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9QZR8. 2 interactions.
MINTiMINT-7026539.
STRINGi10116.ENSRNOP00000017937.

PTM databases

iPTMnetiQ9QZR8.
PhosphoSiteiQ9QZR8.
SwissPalmiQ9QZR8.

Proteomic databases

PaxDbiQ9QZR8.
PRIDEiQ9QZR8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi65034.
KEGGirno:65034.

Organism-specific databases

CTDi23037.
RGDi619958. Pdzd2.

Phylogenomic databases

eggNOGiKOG3528. Eukaryota.
ENOG4110362. LUCA.
HOGENOMiHOG000115486.
HOVERGENiHBG082116.
InParanoidiQ9QZR8.
PhylomeDBiQ9QZR8.

Miscellaneous databases

PROiQ9QZR8.

Family and domain databases

Gene3Di2.30.42.10. 6 hits.
InterProiIPR001478. PDZ.
[Graphical view]
PfamiPF00595. PDZ. 5 hits.
[Graphical view]
SMARTiSM00228. PDZ. 6 hits.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 6 hits.
PROSITEiPS50106. PDZ. 6 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPDZD2_RAT
AccessioniPrimary (citable) accession number: Q9QZR8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: May 1, 2000
Last modified: June 8, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.