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Q9QZR6

- SEPT9_RAT

UniProt

Q9QZR6 - SEPT9_RAT

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Protein

Septin-9

Gene

Sept9

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential).By similarityCurated

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei319 – 3191GTPBy similarity
Binding sitei345 – 3451GTP; via amide nitrogenBy similarity
Binding sitei480 – 4801GTP; via amide nitrogen and carbonyl oxygenBy similarity
Binding sitei495 – 4951GTPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi285 – 2928GTPBy similarity
Nucleotide bindingi425 – 4339GTPBy similarity

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-KW

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Septin-9
Alternative name(s):
Eighth septin
Eseptin
Septin-like protein
Short name:
SLP
Gene namesi
Name:Sept9
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi708523. Sept9.

Subcellular locationi

Cytoplasmcytoskeleton 2 Publications
Note: In embryonic fibroblasts, associated with actin stress fibers. No apparent co-distribution with microtubules, but some colocalization with vimentin filaments in the perinuclear region.

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. cytoskeleton Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi288 – 2881G → V: Abolishes the GTP binding. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 564564Septin-9PRO_0000173537Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei12 – 121PhosphoserineBy similarity
Modified residuei24 – 241PhosphothreonineBy similarity
Modified residuei44 – 441N6-acetyllysineBy similarity
Modified residuei64 – 641PhosphoserineBy similarity
Modified residuei67 – 671Phosphoserine1 Publication
Modified residuei125 – 1251PhosphothreonineBy similarity
Modified residuei258 – 2581PhosphotyrosineBy similarity
Modified residuei307 – 3071PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ9QZR6.
PRIDEiQ9QZR6.

PTM databases

PhosphoSiteiQ9QZR6.

Expressioni

Tissue specificityi

Expressed in the brain, mainly in the perikarya and processes of astrocytes in the cerebellum, dentate gyrus and corpus callosum (at protein level). In the sciatic nerve, highly expressed in Schwann cells (at protein level). Isoforms are differentially expressed in testes, kidney, liver, heart, spleen and brain. Undetectable in skeletal muscle.3 Publications

Gene expression databases

GenevestigatoriQ9QZR6.

Interactioni

Subunit structurei

Septins polymerize into heterooligomeric protein complexes that form filaments, and associate with cellular membranes, actin filaments, and microtubules. GTPase activity is required for filament formation. Interacts with SEPT2, SEPT6, SEPT7, SEPT11 and SEPT14. Interacts with RTKN and ARHGEF18 (By similarity).By similarity

Protein-protein interaction databases

BioGridi249831. 1 interaction.
IntActiQ9QZR6. 4 interactions.
MINTiMINT-4567142.
STRINGi10116.ENSRNOP00000010365.

Structurei

3D structure databases

ProteinModelPortaliQ9QZR6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini275 – 546272Septin-type GAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG5019.
HOGENOMiHOG000233586.
HOVERGENiHBG098529.
InParanoidiQ9QZR6.
KOiK16938.
PhylomeDBiQ9QZR6.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR000038. Cell_div_GTP-bd.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR18884. PTHR18884. 1 hit.
PfamiPF00735. Septin. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51719. G_SEPTIN. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9QZR6-1) [UniParc]FASTAAdd to Basket

Also known as: SLP-a

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MERDRITALK RSFEVEEIEP PNSTPPRRVQ TPLLRATVAS SSQKFQDLGV
60 70 80 90 100
KNSEPAARLV DTLSQRSPKP SLRRVDLAGA KAPEPMSRRT ELSIDISSKQ
110 120 130 140 150
VESTASTPGP SRFGLKRAEV LGHKTPEPVP RRTEITIVKP QESGLRRVET
160 170 180 190 200
PASKAPEGSA MPVTDAAPKR VEIQVPKPAE APNCPLPPQT LENSEAPMSQ
210 220 230 240 250
LQSRLEPRPP VTEVPYRNQE DSEVAPSCVV DMADNPRDAM LKQAPVSRNE
260 270 280 290 300
KAPVDFGYVG IDSILEQMRR KAMKQGFEFN IMVVGQSGLG KSTLINTLFK
310 320 330 340 350
SKISRKSVQP ISEERIPKTI EIKSITHDIE EKGVRMKLTV IDTPGFGDHI
360 370 380 390 400
NNENCWQPIM KFINDQYEKY LQEEVNINRK KRIPDTRVHC CLYFIPATGH
410 420 430 440 450
SLRPLDIEFM KRLSKVVNIV PVIAKADTLT LEERVYFKQR ITSDLLSNGI
460 470 480 490 500
DVYPQKEFDE AEDRLVNEKF REMIPFAVVG SDHEYQVNGK RILGRKTKWG
510 520 530 540 550
TIEVENTTHC EFAYLRDLLI RTHMQNIKDI TSNIHFEAYR VKRLNEGNSA
560
MANGIEKEPE TQEM
Length:564
Mass (Da):63,792
Last modified:May 1, 2000 - v1
Checksum:iB45160157F986C0C
GO
Isoform 2 (identifier: Q9QZR6-2) [UniParc]FASTAAdd to Basket

Also known as: SLP-b

The sequence of this isoform differs from the canonical sequence as follows:
     1-85: Missing.

Show »
Length:479
Mass (Da):54,389
Checksum:i60936B32230625BD
GO
Isoform 3 (identifier: Q9QZR6-3) [UniParc]FASTAAdd to Basket

Also known as: E-septin long form

The sequence of this isoform differs from the canonical sequence as follows:
     1-160: Missing.

Show »
Length:404
Mass (Da):46,282
Checksum:i7C81BC3E3F45859F
GO
Isoform 4 (identifier: Q9QZR6-4) [UniParc]FASTAAdd to Basket

Also known as: E-septin short form

The sequence of this isoform differs from the canonical sequence as follows:
     1-231: Missing.

Show »
Length:333
Mass (Da):38,524
Checksum:i02941CFB5584A557
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti230 – 2301V → G in AAF01206. (PubMed:10371165)Curated
Sequence conflicti460 – 4601E → ED in AAF01206. (PubMed:10371165)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 231231Missing in isoform 4. 1 PublicationVSP_012343Add
BLAST
Alternative sequencei1 – 160160Missing in isoform 3. 1 PublicationVSP_012344Add
BLAST
Alternative sequencei1 – 8585Missing in isoform 2. 1 PublicationVSP_012345Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF180525 mRNA. Translation: AAF01206.1.
AF180526 mRNA. Translation: AAF01207.1.
AF170253 mRNA. Translation: AAF03376.1.
AF173899 mRNA. Translation: AAF03391.1.
PIRiJC7365.
RefSeqiNP_001106969.1. NM_001113497.1.
NP_114025.2. NM_031837.2.
NP_789826.2. NM_176856.2.
UniGeneiRn.91127.

Genome annotation databases

GeneIDi83788.
KEGGirno:83788.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF180525 mRNA. Translation: AAF01206.1 .
AF180526 mRNA. Translation: AAF01207.1 .
AF170253 mRNA. Translation: AAF03376.1 .
AF173899 mRNA. Translation: AAF03391.1 .
PIRi JC7365.
RefSeqi NP_001106969.1. NM_001113497.1.
NP_114025.2. NM_031837.2.
NP_789826.2. NM_176856.2.
UniGenei Rn.91127.

3D structure databases

ProteinModelPortali Q9QZR6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 249831. 1 interaction.
IntActi Q9QZR6. 4 interactions.
MINTi MINT-4567142.
STRINGi 10116.ENSRNOP00000010365.

Chemistry

ChEMBLi CHEMBL2176803.

PTM databases

PhosphoSitei Q9QZR6.

Proteomic databases

PaxDbi Q9QZR6.
PRIDEi Q9QZR6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 83788.
KEGGi rno:83788.

Organism-specific databases

CTDi 10801.
RGDi 708523. Sept9.

Phylogenomic databases

eggNOGi COG5019.
HOGENOMi HOG000233586.
HOVERGENi HBG098529.
InParanoidi Q9QZR6.
KOi K16938.
PhylomeDBi Q9QZR6.

Miscellaneous databases

NextBioi 616359.

Gene expression databases

Genevestigatori Q9QZR6.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR000038. Cell_div_GTP-bd.
IPR027417. P-loop_NTPase.
[Graphical view ]
PANTHERi PTHR18884. PTHR18884. 1 hit.
Pfami PF00735. Septin. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS51719. G_SEPTIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a novel alternatively spliced septin."
    Fung E.T., Scheller R.H.
    FEBS Lett. 451:203-208(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3 AND 4), TISSUE SPECIFICITY, ALTERNATIVE SPLICING, MUTAGENESIS OF GLY-288.
    Tissue: Brain.
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), SUBCELLULAR LOCATION, TISSUE SPECIFICITY, ALTERNATIVE SPLICING.
    Tissue: Mesangial cell.
  3. Lubec G., Kang S.U.
    Submitted (JUL-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 292-300, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: Sprague-Dawley.
    Tissue: Brain.
  4. "Biochemical and cell biological analyses of a mammalian septin complex, Sept7/9b/11."
    Nagata K., Asano T., Nozawa Y., Inagaki M.
    J. Biol. Chem. 279:55895-55904(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, INTERACTION WITH SEPT7.
  5. "Quantitative phosphoproteomics of vasopressin-sensitive renal cells: regulation of aquaporin-2 phosphorylation at two sites."
    Hoffert J.D., Pisitkun T., Wang G., Shen R.-F., Knepper M.A.
    Proc. Natl. Acad. Sci. U.S.A. 103:7159-7164(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-67, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. "SEPT9 sequence alternations causing hereditary neuralgic amyotrophy are associated with altered interactions with SEPT4/SEPT11 and resistance to Rho/Rhotekin-signaling."
    Sudo K., Ito H., Iwamoto I., Morishita R., Asano T., Nagata K.
    Hum. Mutat. 28:1005-1013(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  7. "Characterization of a SEPT9 interacting protein, SEPT14, a novel testis-specific septin."
    Peterson E.A., Kalikin L.M., Steels J.D., Estey M.P., Trimble W.S., Petty E.M.
    Mamm. Genome 18:796-807(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SEPT14.

Entry informationi

Entry nameiSEPT9_RAT
AccessioniPrimary (citable) accession number: Q9QZR6
Secondary accession number(s): Q9QZJ7, Q9QZJ8, Q9QZP9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: May 1, 2000
Last modified: October 29, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3