Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Septin-9

Gene

Sept9

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential).By similarityCurated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei319GTPBy similarity1
Binding sitei345GTP; via amide nitrogenBy similarity1
Binding sitei480GTP; via amide nitrogen and carbonyl oxygenBy similarity1
Binding sitei495GTPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi285 – 292GTPBy similarity8
Nucleotide bindingi425 – 433GTPBy similarity9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division
LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Septin-9
Alternative name(s):
Eighth septin
Eseptin
Septin-like protein
Short name:
SLP
Gene namesi
Name:Sept9
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi708523 Sept9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi288G → V: Abolishes the GTP binding. 1 Publication1

Chemistry databases

ChEMBLiCHEMBL2176803

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001735371 – 564Septin-9Add BLAST564

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei12PhosphoserineCombined sources1
Modified residuei24PhosphothreonineBy similarity1
Modified residuei31PhosphothreonineBy similarity1
Modified residuei44N6-acetyllysineBy similarity1
Modified residuei64PhosphoserineBy similarity1
Modified residuei67PhosphoserineCombined sources1
Modified residuei71PhosphoserineBy similarity1
Modified residuei125PhosphothreonineBy similarity1
Modified residuei258PhosphotyrosineBy similarity1
Modified residuei307PhosphoserineBy similarity1
Modified residuei312PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PeptideAtlasiQ9QZR6
PRIDEiQ9QZR6

PTM databases

iPTMnetiQ9QZR6
PhosphoSitePlusiQ9QZR6

Expressioni

Tissue specificityi

Expressed in the brain, mainly in the perikarya and processes of astrocytes in the cerebellum, dentate gyrus and corpus callosum (at protein level). In the sciatic nerve, highly expressed in Schwann cells (at protein level). Isoforms are differentially expressed in testes, kidney, liver, heart, spleen and brain. Undetectable in skeletal muscle.3 Publications

Interactioni

Subunit structurei

Septins polymerize into heterooligomeric protein complexes that form filaments, and associate with cellular membranes, actin filaments, and microtubules. GTPase activity is required for filament formation. Interacts with SEPT2, SEPT6, SEPT7, SEPT11 and SEPT14. Interacts with RTKN and ARHGEF18 (By similarity).By similarity

Protein-protein interaction databases

BioGridi249831, 1 interactor
IntActiQ9QZR6, 4 interactors

Structurei

3D structure databases

ProteinModelPortaliQ9QZR6
SMRiQ9QZR6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini275 – 546Septin-type GPROSITE-ProRule annotationAdd BLAST272

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni285 – 292G1 motifPROSITE-ProRule annotation8
Regioni342 – 345G3 motifPROSITE-ProRule annotation4
Regioni424 – 427G4 motifPROSITE-ProRule annotation4

Sequence similaritiesi

Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000233586
HOVERGENiHBG098529
InParanoidiQ9QZR6
KOiK16938
PhylomeDBiQ9QZR6

Family and domain databases

CDDicd01850 CDC_Septin, 1 hit
InterProiView protein in InterPro
IPR030379 G_SEPTIN_dom
IPR027417 P-loop_NTPase
IPR030645 SEPT9
IPR016491 Septin
PANTHERiPTHR18884:SF47 PTHR18884:SF47, 1 hit
PfamiView protein in Pfam
PF00735 Septin, 1 hit
PIRSFiPIRSF006698 Septin, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51719 G_SEPTIN, 1 hit

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9QZR6-1) [UniParc]FASTAAdd to basket
Also known as: SLP-a

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MERDRITALK RSFEVEEIEP PNSTPPRRVQ TPLLRATVAS SSQKFQDLGV
60 70 80 90 100
KNSEPAARLV DTLSQRSPKP SLRRVDLAGA KAPEPMSRRT ELSIDISSKQ
110 120 130 140 150
VESTASTPGP SRFGLKRAEV LGHKTPEPVP RRTEITIVKP QESGLRRVET
160 170 180 190 200
PASKAPEGSA MPVTDAAPKR VEIQVPKPAE APNCPLPPQT LENSEAPMSQ
210 220 230 240 250
LQSRLEPRPP VTEVPYRNQE DSEVAPSCVV DMADNPRDAM LKQAPVSRNE
260 270 280 290 300
KAPVDFGYVG IDSILEQMRR KAMKQGFEFN IMVVGQSGLG KSTLINTLFK
310 320 330 340 350
SKISRKSVQP ISEERIPKTI EIKSITHDIE EKGVRMKLTV IDTPGFGDHI
360 370 380 390 400
NNENCWQPIM KFINDQYEKY LQEEVNINRK KRIPDTRVHC CLYFIPATGH
410 420 430 440 450
SLRPLDIEFM KRLSKVVNIV PVIAKADTLT LEERVYFKQR ITSDLLSNGI
460 470 480 490 500
DVYPQKEFDE AEDRLVNEKF REMIPFAVVG SDHEYQVNGK RILGRKTKWG
510 520 530 540 550
TIEVENTTHC EFAYLRDLLI RTHMQNIKDI TSNIHFEAYR VKRLNEGNSA
560
MANGIEKEPE TQEM
Length:564
Mass (Da):63,792
Last modified:May 1, 2000 - v1
Checksum:iB45160157F986C0C
GO
Isoform 2 (identifier: Q9QZR6-2) [UniParc]FASTAAdd to basket
Also known as: SLP-b

The sequence of this isoform differs from the canonical sequence as follows:
     1-85: Missing.

Show »
Length:479
Mass (Da):54,389
Checksum:i60936B32230625BD
GO
Isoform 3 (identifier: Q9QZR6-3) [UniParc]FASTAAdd to basket
Also known as: E-septin long form

The sequence of this isoform differs from the canonical sequence as follows:
     1-160: Missing.

Show »
Length:404
Mass (Da):46,282
Checksum:i7C81BC3E3F45859F
GO
Isoform 4 (identifier: Q9QZR6-4) [UniParc]FASTAAdd to basket
Also known as: E-septin short form

The sequence of this isoform differs from the canonical sequence as follows:
     1-231: Missing.

Show »
Length:333
Mass (Da):38,524
Checksum:i02941CFB5584A557
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti230V → G in AAF01206 (PubMed:10371165).Curated1
Sequence conflicti460E → ED in AAF01206 (PubMed:10371165).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0123431 – 231Missing in isoform 4. 1 PublicationAdd BLAST231
Alternative sequenceiVSP_0123441 – 160Missing in isoform 3. 1 PublicationAdd BLAST160
Alternative sequenceiVSP_0123451 – 85Missing in isoform 2. 1 PublicationAdd BLAST85

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF180525 mRNA Translation: AAF01206.1
AF180526 mRNA Translation: AAF01207.1
AF170253 mRNA Translation: AAF03376.1
AF173899 mRNA Translation: AAF03391.1
PIRiJC7365
RefSeqiNP_001106969.1, NM_001113497.1
NP_114025.2, NM_031837.2
NP_789826.2, NM_176856.2
UniGeneiRn.91127

Genome annotation databases

GeneIDi83788
KEGGirno:83788

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiSEPT9_RAT
AccessioniPrimary (citable) accession number: Q9QZR6
Secondary accession number(s): Q9QZJ7, Q9QZJ8, Q9QZP9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: May 1, 2000
Last modified: May 23, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health