Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein NOV homolog

Gene

Nov

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Can act as a growth factor for some cells and binds to a specific receptor that leads to the phosphorylation of a 221 kDa protein.

GO - Molecular functioni

  • growth factor activity Source: RGD
  • heparin binding Source: GO_Central
  • integrin binding Source: GO_Central

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Growth factor

Names & Taxonomyi

Protein namesi
Recommended name:
Protein NOV homolog
Short name:
NovH
Alternative name(s):
CCN family member 3
Nephroblastoma-overexpressed gene protein homolog
Gene namesi
Name:Nov
Synonyms:Ccn3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi621553. Nov.

Subcellular locationi

GO - Cellular componenti

  • axon Source: RGD
  • dendrite Source: RGD
  • extracellular matrix Source: RGD
  • intracellular membrane-bounded organelle Source: Ensembl
  • neuronal cell body Source: RGD
  • proteinaceous extracellular matrix Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence AnalysisAdd
BLAST
Chaini22 – 351330Protein NOV homologPRO_0000014417Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi91 – 911N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi258 ↔ 295By similarity
Glycosylationi274 – 2741N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi275 ↔ 309By similarity
Disulfide bondi286 ↔ 325By similarity
Disulfide bondi289 ↔ 327By similarity
Disulfide bondi294 ↔ 331By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9QZQ5.
PRIDEiQ9QZQ5.

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

GenevisibleiQ9QZQ5. RN.

Interactioni

Subunit structurei

Interacts with FBLN1.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000011904.

Structurei

3D structure databases

ProteinModelPortaliQ9QZQ5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini25 – 9975IGFBP N-terminalPROSITE-ProRule annotationAdd
BLAST
Domaini102 – 16867VWFCPROSITE-ProRule annotationAdd
BLAST
Domaini199 – 24446TSP type-1PROSITE-ProRule annotationAdd
BLAST
Domaini258 – 33275CTCKPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the CCN family.Curated
Contains 1 CTCK (C-terminal cystine knot-like) domain.PROSITE-ProRule annotation
Contains 1 IGFBP N-terminal domain.PROSITE-ProRule annotation
Contains 1 TSP type-1 domain.PROSITE-ProRule annotation
Contains 1 VWFC domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG72934.
GeneTreeiENSGT00760000119225.
HOGENOMiHOG000231462.
HOVERGENiHBG000635.
InParanoidiQ9QZQ5.
OMAiQCEMVKQ.
OrthoDBiEOG7N8ZXB.
PhylomeDBiQ9QZQ5.
TreeFamiTF326070.

Family and domain databases

InterProiIPR006207. Cys_knot_C.
IPR006208. Glyco_hormone_CN.
IPR009030. Growth_fac_rcpt_N_dom.
IPR000867. IGFBP-like.
IPR012395. IGFBP_CNN.
IPR017891. Insulin_GF-bd_Cys-rich_CS.
IPR000884. Thrombospondin_1_rpt.
IPR001007. VWF_C.
[Graphical view]
PfamiPF00007. Cys_knot. 1 hit.
PF00219. IGFBP. 1 hit.
PF00090. TSP_1. 1 hit.
PF00093. VWC. 1 hit.
[Graphical view]
PIRSFiPIRSF036495. IGFBP_rP_CNN. 1 hit.
SMARTiSM00041. CT. 1 hit.
SM00121. IB. 1 hit.
SM00209. TSP1. 1 hit.
SM00214. VWC. 1 hit.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.
SSF82895. SSF82895. 1 hit.
PROSITEiPS01185. CTCK_1. 1 hit.
PS01225. CTCK_2. 1 hit.
PS00222. IGFBP_N_1. 1 hit.
PS51323. IGFBP_N_2. 1 hit.
PS50092. TSP1. 1 hit.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9QZQ5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVFLRKQCL CLGFLLLHLL NQVSATLRCP SRCPSQCPSI SPTCAPGVRS
60 70 80 90 100
VLDGCSCCPV CARQRGESCS EMRPCDQSSG LYCDRSADPN NETGICMVPE
110 120 130 140 150
GDNCVFDGVI YRNGEKFEPN CQYHCTCRDG QIGCVPRCQL DVLLPGPDCP
160 170 180 190 200
APKKVAVPGE CCEKWTCGSE EKGTLGGLAL PAYRPEATVG VELSDSSINC
210 220 230 240 250
IEQTTEWSAC SKSCGMGLST RVTNRNLQCE MVKQTRLCMV RPCEQEPGEA
260 270 280 290 300
TDMKGKKCLR TKKSLKSIHL QFKNCTSLYT YKPRFCGICS DGRCCTPFNT
310 320 330 340 350
KTIQVEFQCL PGQIIKKPVM VIGTCTCHSN CPQNNEAFLQ ELELKTSRGE

M
Length:351
Mass (Da):38,510
Last modified:May 1, 2000 - v1
Checksum:i02619707DE7C1BFB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF171936 mRNA. Translation: AAD49371.1.
BC072548 mRNA. Translation: AAH72548.1.
RefSeqiNP_110495.1. NM_030868.2.
UniGeneiRn.162955.

Genome annotation databases

EnsembliENSRNOT00000011904; ENSRNOP00000011904; ENSRNOG00000008697.
GeneIDi81526.
KEGGirno:81526.
UCSCiRGD:621553. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF171936 mRNA. Translation: AAD49371.1.
BC072548 mRNA. Translation: AAH72548.1.
RefSeqiNP_110495.1. NM_030868.2.
UniGeneiRn.162955.

3D structure databases

ProteinModelPortaliQ9QZQ5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000011904.

Proteomic databases

PaxDbiQ9QZQ5.
PRIDEiQ9QZQ5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000011904; ENSRNOP00000011904; ENSRNOG00000008697.
GeneIDi81526.
KEGGirno:81526.
UCSCiRGD:621553. rat.

Organism-specific databases

CTDi4856.
RGDi621553. Nov.

Phylogenomic databases

eggNOGiNOG72934.
GeneTreeiENSGT00760000119225.
HOGENOMiHOG000231462.
HOVERGENiHBG000635.
InParanoidiQ9QZQ5.
OMAiQCEMVKQ.
OrthoDBiEOG7N8ZXB.
PhylomeDBiQ9QZQ5.
TreeFamiTF326070.

Miscellaneous databases

NextBioi615061.
PROiQ9QZQ5.

Gene expression databases

GenevisibleiQ9QZQ5. RN.

Family and domain databases

InterProiIPR006207. Cys_knot_C.
IPR006208. Glyco_hormone_CN.
IPR009030. Growth_fac_rcpt_N_dom.
IPR000867. IGFBP-like.
IPR012395. IGFBP_CNN.
IPR017891. Insulin_GF-bd_Cys-rich_CS.
IPR000884. Thrombospondin_1_rpt.
IPR001007. VWF_C.
[Graphical view]
PfamiPF00007. Cys_knot. 1 hit.
PF00219. IGFBP. 1 hit.
PF00090. TSP_1. 1 hit.
PF00093. VWC. 1 hit.
[Graphical view]
PIRSFiPIRSF036495. IGFBP_rP_CNN. 1 hit.
SMARTiSM00041. CT. 1 hit.
SM00121. IB. 1 hit.
SM00209. TSP1. 1 hit.
SM00214. VWC. 1 hit.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.
SSF82895. SSF82895. 1 hit.
PROSITEiPS01185. CTCK_1. 1 hit.
PS01225. CTCK_2. 1 hit.
PS00222. IGFBP_N_1. 1 hit.
PS51323. IGFBP_N_2. 1 hit.
PS50092. TSP1. 1 hit.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Nephroblastoma overexpressed gene (NOV) codes for a growth factor that induces protein tyrosine phosphorylation."
    Liu C., Liu X.J., Crowe P.D., Kelner G.S., Fan J., Barry G., Manu F., Ling N., De Souza E.B., Maki R.A.
    Gene 238:471-478(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION.
    Strain: Sprague-Dawley.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Heart.

Entry informationi

Entry nameiNOV_RAT
AccessioniPrimary (citable) accession number: Q9QZQ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: May 1, 2000
Last modified: July 22, 2015
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.