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Q9QZQ5 (NOV_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein NOV homolog

Short name=NovH
Alternative name(s):
CCN family member 3
Nephroblastoma-overexpressed gene protein homolog
Gene names
Name:Nov
Synonyms:Ccn3
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length351 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Can act as a growth factor for some cells and binds to a specific receptor that leads to the phosphorylation of a 221 kDa protein.

Subunit structure

Interacts with FBLN1 By similarity.

Subcellular location

Secreted.

Tissue specificity

Ubiquitous.

Sequence similarities

Belongs to the CCN family.

Contains 1 CTCK (C-terminal cystine knot-like) domain.

Contains 1 IGFBP N-terminal domain.

Contains 1 TSP type-1 domain.

Contains 1 VWFC domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Potential
Chain22 – 351330Protein NOV homolog
PRO_0000014417

Regions

Domain25 – 9975IGFBP N-terminal
Domain102 – 16867VWFC
Domain199 – 24446TSP type-1
Domain258 – 33275CTCK

Amino acid modifications

Glycosylation911N-linked (GlcNAc...) Potential
Glycosylation2741N-linked (GlcNAc...) Potential
Disulfide bond258 ↔ 295 By similarity
Disulfide bond275 ↔ 309 By similarity
Disulfide bond286 ↔ 325 By similarity
Disulfide bond289 ↔ 327 By similarity
Disulfide bond294 ↔ 331 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9QZQ5 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 02619707DE7C1BFB

FASTA35138,510
        10         20         30         40         50         60 
MSVFLRKQCL CLGFLLLHLL NQVSATLRCP SRCPSQCPSI SPTCAPGVRS VLDGCSCCPV 

        70         80         90        100        110        120 
CARQRGESCS EMRPCDQSSG LYCDRSADPN NETGICMVPE GDNCVFDGVI YRNGEKFEPN 

       130        140        150        160        170        180 
CQYHCTCRDG QIGCVPRCQL DVLLPGPDCP APKKVAVPGE CCEKWTCGSE EKGTLGGLAL 

       190        200        210        220        230        240 
PAYRPEATVG VELSDSSINC IEQTTEWSAC SKSCGMGLST RVTNRNLQCE MVKQTRLCMV 

       250        260        270        280        290        300 
RPCEQEPGEA TDMKGKKCLR TKKSLKSIHL QFKNCTSLYT YKPRFCGICS DGRCCTPFNT 

       310        320        330        340        350 
KTIQVEFQCL PGQIIKKPVM VIGTCTCHSN CPQNNEAFLQ ELELKTSRGE M 

« Hide

References

« Hide 'large scale' references
[1]"Nephroblastoma overexpressed gene (NOV) codes for a growth factor that induces protein tyrosine phosphorylation."
Liu C., Liu X.J., Crowe P.D., Kelner G.S., Fan J., Barry G., Manu F., Ling N., De Souza E.B., Maki R.A.
Gene 238:471-478(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION.
Strain: Sprague-Dawley.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Heart.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF171936 mRNA. Translation: AAD49371.1.
BC072548 mRNA. Translation: AAH72548.1.
RefSeqNP_110495.1. NM_030868.2.
UniGeneRn.162955.

3D structure databases

ProteinModelPortalQ9QZQ5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000011904.

Proteomic databases

PaxDbQ9QZQ5.
PRIDEQ9QZQ5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000011904; ENSRNOP00000011904; ENSRNOG00000008697.
GeneID81526.
KEGGrno:81526.
UCSCRGD:621553. rat.

Organism-specific databases

CTD4856.
RGD621553. Nov.

Phylogenomic databases

eggNOGNOG72934.
GeneTreeENSGT00750000117442.
HOGENOMHOG000231462.
HOVERGENHBG000635.
InParanoidQ9QZQ5.
OMACCTPHNT.
OrthoDBEOG7N8ZXB.
PhylomeDBQ9QZQ5.
TreeFamTF326070.

Gene expression databases

GenevestigatorQ9QZQ5.

Family and domain databases

InterProIPR006207. Cys_knot_C.
IPR006208. Glyco_hormone_CN.
IPR009030. Growth_fac_rcpt_N_dom.
IPR000867. IGFBP-like.
IPR012395. IGFBP_CNN.
IPR017891. Insulin_GF-bd_Cys-rich_CS.
IPR000884. Thrombospondin_1_rpt.
IPR001007. VWF_C.
[Graphical view]
PfamPF00007. Cys_knot. 1 hit.
PF00219. IGFBP. 1 hit.
PF00090. TSP_1. 1 hit.
PF00093. VWC. 1 hit.
[Graphical view]
PIRSFPIRSF036495. IGFBP_rP_CNN. 1 hit.
SMARTSM00041. CT. 1 hit.
SM00121. IB. 1 hit.
SM00209. TSP1. 1 hit.
SM00214. VWC. 1 hit.
[Graphical view]
SUPFAMSSF57184. SSF57184. 1 hit.
SSF82895. SSF82895. 1 hit.
PROSITEPS01185. CTCK_1. 1 hit.
PS01225. CTCK_2. 1 hit.
PS00222. IGFBP_N_1. 1 hit.
PS51323. IGFBP_N_2. 1 hit.
PS50092. TSP1. 1 hit.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio615061.
PROQ9QZQ5.

Entry information

Entry nameNOV_RAT
AccessionPrimary (citable) accession number: Q9QZQ5
Entry history
Integrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: May 1, 2000
Last modified: April 16, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families