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Q9QZQ5

- NOV_RAT

UniProt

Q9QZQ5 - NOV_RAT

Protein

Protein NOV homolog

Gene

Nov

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Can act as a growth factor for some cells and binds to a specific receptor that leads to the phosphorylation of a 221 kDa protein.

    GO - Molecular functioni

    1. growth factor activity Source: RGD

    GO - Biological processi

    1. regulation of cell growth Source: InterPro
    2. regulation of gene expression Source: MGI

    Keywords - Molecular functioni

    Growth factor

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein NOV homolog
    Short name:
    NovH
    Alternative name(s):
    CCN family member 3
    Nephroblastoma-overexpressed gene protein homolog
    Gene namesi
    Name:Nov
    Synonyms:Ccn3
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 7

    Organism-specific databases

    RGDi621553. Nov.

    Subcellular locationi

    GO - Cellular componenti

    1. axon Source: RGD
    2. dendrite Source: RGD
    3. extracellular matrix Source: RGD
    4. extracellular region Source: UniProtKB-SubCell
    5. intracellular membrane-bounded organelle Source: Ensembl
    6. neuronal cell body Source: RGD

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Chaini22 – 351330Protein NOV homologPRO_0000014417Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi91 – 911N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi258 ↔ 295By similarity
    Glycosylationi274 – 2741N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi275 ↔ 309By similarity
    Disulfide bondi286 ↔ 325By similarity
    Disulfide bondi289 ↔ 327By similarity
    Disulfide bondi294 ↔ 331By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ9QZQ5.
    PRIDEiQ9QZQ5.

    Expressioni

    Tissue specificityi

    Ubiquitous.

    Gene expression databases

    GenevestigatoriQ9QZQ5.

    Interactioni

    Subunit structurei

    Interacts with FBLN1.By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000011904.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9QZQ5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini25 – 9975IGFBP N-terminalPROSITE-ProRule annotationAdd
    BLAST
    Domaini102 – 16867VWFCPROSITE-ProRule annotationAdd
    BLAST
    Domaini199 – 24446TSP type-1PROSITE-ProRule annotationAdd
    BLAST
    Domaini258 – 33275CTCKPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the CCN family.Curated
    Contains 1 CTCK (C-terminal cystine knot-like) domain.PROSITE-ProRule annotation
    Contains 1 IGFBP N-terminal domain.PROSITE-ProRule annotation
    Contains 1 TSP type-1 domain.PROSITE-ProRule annotation
    Contains 1 VWFC domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG72934.
    GeneTreeiENSGT00750000117442.
    HOGENOMiHOG000231462.
    HOVERGENiHBG000635.
    InParanoidiQ9QZQ5.
    OMAiCCTPHNT.
    OrthoDBiEOG7N8ZXB.
    PhylomeDBiQ9QZQ5.
    TreeFamiTF326070.

    Family and domain databases

    InterProiIPR006207. Cys_knot_C.
    IPR006208. Glyco_hormone_CN.
    IPR009030. Growth_fac_rcpt_N_dom.
    IPR000867. IGFBP-like.
    IPR012395. IGFBP_CNN.
    IPR017891. Insulin_GF-bd_Cys-rich_CS.
    IPR000884. Thrombospondin_1_rpt.
    IPR001007. VWF_C.
    [Graphical view]
    PfamiPF00007. Cys_knot. 1 hit.
    PF00219. IGFBP. 1 hit.
    PF00090. TSP_1. 1 hit.
    PF00093. VWC. 1 hit.
    [Graphical view]
    PIRSFiPIRSF036495. IGFBP_rP_CNN. 1 hit.
    SMARTiSM00041. CT. 1 hit.
    SM00121. IB. 1 hit.
    SM00209. TSP1. 1 hit.
    SM00214. VWC. 1 hit.
    [Graphical view]
    SUPFAMiSSF57184. SSF57184. 1 hit.
    SSF82895. SSF82895. 1 hit.
    PROSITEiPS01185. CTCK_1. 1 hit.
    PS01225. CTCK_2. 1 hit.
    PS00222. IGFBP_N_1. 1 hit.
    PS51323. IGFBP_N_2. 1 hit.
    PS50092. TSP1. 1 hit.
    PS01208. VWFC_1. 1 hit.
    PS50184. VWFC_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9QZQ5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSVFLRKQCL CLGFLLLHLL NQVSATLRCP SRCPSQCPSI SPTCAPGVRS    50
    VLDGCSCCPV CARQRGESCS EMRPCDQSSG LYCDRSADPN NETGICMVPE 100
    GDNCVFDGVI YRNGEKFEPN CQYHCTCRDG QIGCVPRCQL DVLLPGPDCP 150
    APKKVAVPGE CCEKWTCGSE EKGTLGGLAL PAYRPEATVG VELSDSSINC 200
    IEQTTEWSAC SKSCGMGLST RVTNRNLQCE MVKQTRLCMV RPCEQEPGEA 250
    TDMKGKKCLR TKKSLKSIHL QFKNCTSLYT YKPRFCGICS DGRCCTPFNT 300
    KTIQVEFQCL PGQIIKKPVM VIGTCTCHSN CPQNNEAFLQ ELELKTSRGE 350
    M 351
    Length:351
    Mass (Da):38,510
    Last modified:May 1, 2000 - v1
    Checksum:i02619707DE7C1BFB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF171936 mRNA. Translation: AAD49371.1.
    BC072548 mRNA. Translation: AAH72548.1.
    RefSeqiNP_110495.1. NM_030868.2.
    UniGeneiRn.162955.

    Genome annotation databases

    EnsembliENSRNOT00000011904; ENSRNOP00000011904; ENSRNOG00000008697.
    GeneIDi81526.
    KEGGirno:81526.
    UCSCiRGD:621553. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF171936 mRNA. Translation: AAD49371.1 .
    BC072548 mRNA. Translation: AAH72548.1 .
    RefSeqi NP_110495.1. NM_030868.2.
    UniGenei Rn.162955.

    3D structure databases

    ProteinModelPortali Q9QZQ5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000011904.

    Proteomic databases

    PaxDbi Q9QZQ5.
    PRIDEi Q9QZQ5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000011904 ; ENSRNOP00000011904 ; ENSRNOG00000008697 .
    GeneIDi 81526.
    KEGGi rno:81526.
    UCSCi RGD:621553. rat.

    Organism-specific databases

    CTDi 4856.
    RGDi 621553. Nov.

    Phylogenomic databases

    eggNOGi NOG72934.
    GeneTreei ENSGT00750000117442.
    HOGENOMi HOG000231462.
    HOVERGENi HBG000635.
    InParanoidi Q9QZQ5.
    OMAi CCTPHNT.
    OrthoDBi EOG7N8ZXB.
    PhylomeDBi Q9QZQ5.
    TreeFami TF326070.

    Miscellaneous databases

    NextBioi 615061.
    PROi Q9QZQ5.

    Gene expression databases

    Genevestigatori Q9QZQ5.

    Family and domain databases

    InterProi IPR006207. Cys_knot_C.
    IPR006208. Glyco_hormone_CN.
    IPR009030. Growth_fac_rcpt_N_dom.
    IPR000867. IGFBP-like.
    IPR012395. IGFBP_CNN.
    IPR017891. Insulin_GF-bd_Cys-rich_CS.
    IPR000884. Thrombospondin_1_rpt.
    IPR001007. VWF_C.
    [Graphical view ]
    Pfami PF00007. Cys_knot. 1 hit.
    PF00219. IGFBP. 1 hit.
    PF00090. TSP_1. 1 hit.
    PF00093. VWC. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF036495. IGFBP_rP_CNN. 1 hit.
    SMARTi SM00041. CT. 1 hit.
    SM00121. IB. 1 hit.
    SM00209. TSP1. 1 hit.
    SM00214. VWC. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57184. SSF57184. 1 hit.
    SSF82895. SSF82895. 1 hit.
    PROSITEi PS01185. CTCK_1. 1 hit.
    PS01225. CTCK_2. 1 hit.
    PS00222. IGFBP_N_1. 1 hit.
    PS51323. IGFBP_N_2. 1 hit.
    PS50092. TSP1. 1 hit.
    PS01208. VWFC_1. 1 hit.
    PS50184. VWFC_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Nephroblastoma overexpressed gene (NOV) codes for a growth factor that induces protein tyrosine phosphorylation."
      Liu C., Liu X.J., Crowe P.D., Kelner G.S., Fan J., Barry G., Manu F., Ling N., De Souza E.B., Maki R.A.
      Gene 238:471-478(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION.
      Strain: Sprague-Dawley.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Heart.

    Entry informationi

    Entry nameiNOV_RAT
    AccessioniPrimary (citable) accession number: Q9QZQ5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 19, 2002
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 95 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3