Protein NOV homolog precursor - Rattus norvegicus (Rat)

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Q9QZQ5 (NOV_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 88. History...

Clusters with 100%, 90%, 50% identity |

Documents (1) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Protein NOV homolog
Short name=NovH

Alternative name(s):
CCN family member 3
Nephroblastoma-overexpressed gene protein homolog

Gene names

Name:	Nov
Synonyms:	Ccn3

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	351 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Can act as a growth factor for some cells and binds to a specific receptor that leads to the phosphorylation of a 221 kDa protein.
Subunit structure	Interacts with FBLN1 By similarity.
Subcellular location	Secreted.
Tissue specificity	Ubiquitous.
Sequence similarities	Belongs to the CCN family. Contains 1 CTCK (C-terminal cystine knot-like) domain. Contains 1 IGFBP N-terminal domain. Contains 1 TSP type-1 domain. Contains 1 VWFC domain.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Growth factor
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	regulation of cell growth Inferred from electronic annotation. Source: InterPro regulation of gene expression Inferred from direct assay PubMed 18597638. Source: MGI
Cellular_component	axon Inferred from direct assay PubMed 19286457. Source: RGD dendrite Inferred from direct assay PubMed 19286457. Source: RGD extracellular matrix Inferred from direct assay PubMed 19286457. Source: RGD extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell intracellular membrane-bounded organelle Inferred from electronic annotation. Source: Compara neuronal cell body Inferred from direct assay PubMed 19286457. Source: RGD
Molecular_function	growth factor activity Traceable author statement Ref.1. Source: RGD
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 21

Potential

Chain

22 – 351

330

Protein NOV homolog

PRO_0000014417

Regions

Domain

25 – 99

IGFBP N-terminal

Domain

102 – 168

VWFC

Domain

199 – 244

TSP type-1

Domain

258 – 332

CTCK

Amino acid modifications

Glycosylation

N-linked (GlcNAc...) Potential

Glycosylation

274

N-linked (GlcNAc...) Potential

Disulfide bond

258 ↔ 295

By similarity

Disulfide bond

275 ↔ 309

By similarity

Disulfide bond

286 ↔ 325

By similarity

Disulfide bond

289 ↔ 327

By similarity

Disulfide bond

294 ↔ 331

By similarity

Sequences

Sequence

Length

Mass (Da)

Tools

Q9QZQ5 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 02619707DE7C1BFB
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FASTA

351

38,510

        10         20         30         40         50         60 
MSVFLRKQCL CLGFLLLHLL NQVSATLRCP SRCPSQCPSI SPTCAPGVRS VLDGCSCCPV 

        70         80         90        100        110        120 
CARQRGESCS EMRPCDQSSG LYCDRSADPN NETGICMVPE GDNCVFDGVI YRNGEKFEPN 

       130        140        150        160        170        180 
CQYHCTCRDG QIGCVPRCQL DVLLPGPDCP APKKVAVPGE CCEKWTCGSE EKGTLGGLAL 

       190        200        210        220        230        240 
PAYRPEATVG VELSDSSINC IEQTTEWSAC SKSCGMGLST RVTNRNLQCE MVKQTRLCMV 

       250        260        270        280        290        300 
RPCEQEPGEA TDMKGKKCLR TKKSLKSIHL QFKNCTSLYT YKPRFCGICS DGRCCTPFNT 

       310        320        330        340        350 
KTIQVEFQCL PGQIIKKPVM VIGTCTCHSN CPQNNEAFLQ ELELKTSRGE M

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Nephroblastoma overexpressed gene (NOV) codes for a growth factor that induces protein tyrosine phosphorylation." Liu C., Liu X.J., Crowe P.D., Kelner G.S., Fan J., Barry G., Manu F., Ling N., De Souza E.B., Maki R.A. Gene 238:471-478(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION. Strain: Sprague-Dawley.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Heart.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF171936 mRNA. Translation: AAD49371.1. BC072548 mRNA. Translation: AAH72548.1.
IPI	IPI00215256.
RefSeq	NP_110495.1. NM_030868.2.
UniGene	Rn.162955.
3D structure databases
ProteinModelPortal	Q9QZQ5.
ModBase	Search...
Protein-protein interaction databases
STRING	10116.ENSRNOP00000011904.
Proteomic databases
PaxDb	Q9QZQ5.
PRIDE	Q9QZQ5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000011904; ENSRNOP00000011904; ENSRNOG00000008697.
GeneID	81526.
KEGG	rno:81526.
UCSC	RGD:621553. rat.
Organism-specific databases
CTD	4856.
RGD	621553. Nov.
Phylogenomic databases
eggNOG	NOG72934.
GeneTree	ENSGT00550000074368.
HOGENOM	HOG000231462.
HOVERGEN	HBG000635.
InParanoid	Q9QZQ5.
OMA	CCTPHNT.
OrthoDB	EOG4QZ7M8.
Gene expression databases
Genevestigator	Q9QZQ5.
GermOnline	ENSRNOG00000008697. Rattus norvegicus.
Family and domain databases
InterPro	IPR006208. Cys_knot. IPR006207. Cys_knot_C. IPR000867. IGFBP-like. IPR012395. IGFBP_CNN. IPR017891. Insulin_GF-bd_Cys-rich_CS. IPR000884. Thrombospondin_1_rpt. IPR001007. VWF_C. [Graphical view]
Pfam	PF00007. Cys_knot. 1 hit. PF00219. IGFBP. 1 hit. PF00090. TSP_1. 1 hit. PF00093. VWC. 1 hit. [Graphical view]
PIRSF	PIRSF036495. IGFBP_rP_CNN. 1 hit.
SMART	SM00041. CT. 1 hit. SM00121. IB. 1 hit. SM00209. TSP1. 1 hit. SM00214. VWC. 1 hit. [Graphical view]
SUPFAM	SSF82895. TSP1. 1 hit.
PROSITE	PS01185. CTCK_1. 1 hit. PS01225. CTCK_2. 1 hit. PS00222. IGFBP_N_1. 1 hit. PS51323. IGFBP_N_2. 1 hit. PS50092. TSP1. 1 hit. PS01208. VWFC_1. 1 hit. PS50184. VWFC_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	615061.

Entry information

Entry name

NOV_RAT

Accession

Primary (citable) accession number: Q9QZQ5

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 19, 2002
Last sequence update:	May 1, 2000
Last modified:	April 3, 2013
This is version 88 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents