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Q9QZQ5

- NOV_RAT

UniProt

Q9QZQ5 - NOV_RAT

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Protein

Protein NOV homolog

Gene

Nov

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Can act as a growth factor for some cells and binds to a specific receptor that leads to the phosphorylation of a 221 kDa protein.

GO - Molecular functioni

  1. growth factor activity Source: RGD

GO - Biological processi

  1. regulation of cell growth Source: InterPro
  2. regulation of gene expression Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Growth factor

Names & Taxonomyi

Protein namesi
Recommended name:
Protein NOV homolog
Short name:
NovH
Alternative name(s):
CCN family member 3
Nephroblastoma-overexpressed gene protein homolog
Gene namesi
Name:Nov
Synonyms:Ccn3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 7

Organism-specific databases

RGDi621553. Nov.

Subcellular locationi

GO - Cellular componenti

  1. axon Source: RGD
  2. dendrite Source: RGD
  3. extracellular matrix Source: RGD
  4. extracellular region Source: UniProtKB-KW
  5. intracellular membrane-bounded organelle Source: Ensembl
  6. neuronal cell body Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence AnalysisAdd
BLAST
Chaini22 – 351330Protein NOV homologPRO_0000014417Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi91 – 911N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi258 ↔ 295By similarity
Glycosylationi274 – 2741N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi275 ↔ 309By similarity
Disulfide bondi286 ↔ 325By similarity
Disulfide bondi289 ↔ 327By similarity
Disulfide bondi294 ↔ 331By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9QZQ5.
PRIDEiQ9QZQ5.

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

GenevestigatoriQ9QZQ5.

Interactioni

Subunit structurei

Interacts with FBLN1.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000011904.

Structurei

3D structure databases

ProteinModelPortaliQ9QZQ5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini25 – 9975IGFBP N-terminalPROSITE-ProRule annotationAdd
BLAST
Domaini102 – 16867VWFCPROSITE-ProRule annotationAdd
BLAST
Domaini199 – 24446TSP type-1PROSITE-ProRule annotationAdd
BLAST
Domaini258 – 33275CTCKPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the CCN family.Curated
Contains 1 CTCK (C-terminal cystine knot-like) domain.PROSITE-ProRule annotation
Contains 1 IGFBP N-terminal domain.PROSITE-ProRule annotation
Contains 1 TSP type-1 domain.PROSITE-ProRule annotation
Contains 1 VWFC domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG72934.
GeneTreeiENSGT00760000119225.
HOGENOMiHOG000231462.
HOVERGENiHBG000635.
InParanoidiQ9QZQ5.
OMAiCCTPHNT.
OrthoDBiEOG7N8ZXB.
PhylomeDBiQ9QZQ5.
TreeFamiTF326070.

Family and domain databases

InterProiIPR006207. Cys_knot_C.
IPR006208. Glyco_hormone_CN.
IPR009030. Growth_fac_rcpt_N_dom.
IPR000867. IGFBP-like.
IPR012395. IGFBP_CNN.
IPR017891. Insulin_GF-bd_Cys-rich_CS.
IPR000884. Thrombospondin_1_rpt.
IPR001007. VWF_C.
[Graphical view]
PfamiPF00007. Cys_knot. 1 hit.
PF00219. IGFBP. 1 hit.
PF00090. TSP_1. 1 hit.
PF00093. VWC. 1 hit.
[Graphical view]
PIRSFiPIRSF036495. IGFBP_rP_CNN. 1 hit.
SMARTiSM00041. CT. 1 hit.
SM00121. IB. 1 hit.
SM00209. TSP1. 1 hit.
SM00214. VWC. 1 hit.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.
SSF82895. SSF82895. 1 hit.
PROSITEiPS01185. CTCK_1. 1 hit.
PS01225. CTCK_2. 1 hit.
PS00222. IGFBP_N_1. 1 hit.
PS51323. IGFBP_N_2. 1 hit.
PS50092. TSP1. 1 hit.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9QZQ5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSVFLRKQCL CLGFLLLHLL NQVSATLRCP SRCPSQCPSI SPTCAPGVRS
60 70 80 90 100
VLDGCSCCPV CARQRGESCS EMRPCDQSSG LYCDRSADPN NETGICMVPE
110 120 130 140 150
GDNCVFDGVI YRNGEKFEPN CQYHCTCRDG QIGCVPRCQL DVLLPGPDCP
160 170 180 190 200
APKKVAVPGE CCEKWTCGSE EKGTLGGLAL PAYRPEATVG VELSDSSINC
210 220 230 240 250
IEQTTEWSAC SKSCGMGLST RVTNRNLQCE MVKQTRLCMV RPCEQEPGEA
260 270 280 290 300
TDMKGKKCLR TKKSLKSIHL QFKNCTSLYT YKPRFCGICS DGRCCTPFNT
310 320 330 340 350
KTIQVEFQCL PGQIIKKPVM VIGTCTCHSN CPQNNEAFLQ ELELKTSRGE

M
Length:351
Mass (Da):38,510
Last modified:May 1, 2000 - v1
Checksum:i02619707DE7C1BFB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF171936 mRNA. Translation: AAD49371.1.
BC072548 mRNA. Translation: AAH72548.1.
RefSeqiNP_110495.1. NM_030868.2.
UniGeneiRn.162955.

Genome annotation databases

EnsembliENSRNOT00000011904; ENSRNOP00000011904; ENSRNOG00000008697.
GeneIDi81526.
KEGGirno:81526.
UCSCiRGD:621553. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF171936 mRNA. Translation: AAD49371.1 .
BC072548 mRNA. Translation: AAH72548.1 .
RefSeqi NP_110495.1. NM_030868.2.
UniGenei Rn.162955.

3D structure databases

ProteinModelPortali Q9QZQ5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000011904.

Proteomic databases

PaxDbi Q9QZQ5.
PRIDEi Q9QZQ5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000011904 ; ENSRNOP00000011904 ; ENSRNOG00000008697 .
GeneIDi 81526.
KEGGi rno:81526.
UCSCi RGD:621553. rat.

Organism-specific databases

CTDi 4856.
RGDi 621553. Nov.

Phylogenomic databases

eggNOGi NOG72934.
GeneTreei ENSGT00760000119225.
HOGENOMi HOG000231462.
HOVERGENi HBG000635.
InParanoidi Q9QZQ5.
OMAi CCTPHNT.
OrthoDBi EOG7N8ZXB.
PhylomeDBi Q9QZQ5.
TreeFami TF326070.

Miscellaneous databases

NextBioi 615061.
PROi Q9QZQ5.

Gene expression databases

Genevestigatori Q9QZQ5.

Family and domain databases

InterProi IPR006207. Cys_knot_C.
IPR006208. Glyco_hormone_CN.
IPR009030. Growth_fac_rcpt_N_dom.
IPR000867. IGFBP-like.
IPR012395. IGFBP_CNN.
IPR017891. Insulin_GF-bd_Cys-rich_CS.
IPR000884. Thrombospondin_1_rpt.
IPR001007. VWF_C.
[Graphical view ]
Pfami PF00007. Cys_knot. 1 hit.
PF00219. IGFBP. 1 hit.
PF00090. TSP_1. 1 hit.
PF00093. VWC. 1 hit.
[Graphical view ]
PIRSFi PIRSF036495. IGFBP_rP_CNN. 1 hit.
SMARTi SM00041. CT. 1 hit.
SM00121. IB. 1 hit.
SM00209. TSP1. 1 hit.
SM00214. VWC. 1 hit.
[Graphical view ]
SUPFAMi SSF57184. SSF57184. 1 hit.
SSF82895. SSF82895. 1 hit.
PROSITEi PS01185. CTCK_1. 1 hit.
PS01225. CTCK_2. 1 hit.
PS00222. IGFBP_N_1. 1 hit.
PS51323. IGFBP_N_2. 1 hit.
PS50092. TSP1. 1 hit.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Nephroblastoma overexpressed gene (NOV) codes for a growth factor that induces protein tyrosine phosphorylation."
    Liu C., Liu X.J., Crowe P.D., Kelner G.S., Fan J., Barry G., Manu F., Ling N., De Souza E.B., Maki R.A.
    Gene 238:471-478(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION.
    Strain: Sprague-Dawley.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Heart.

Entry informationi

Entry nameiNOV_RAT
AccessioniPrimary (citable) accession number: Q9QZQ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: May 1, 2000
Last modified: October 29, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3