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Protein

Urotensin-2

Gene

Uts2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Highly potent vasoconstrictor.By similarity

GO - Biological processi

  • negative regulation of blood pressure Source: RGD
  • negative regulation of glomerular filtration Source: RGD
  • negative regulation of heart rate Source: RGD
  • negative regulation of insulin secretion Source: RGD
  • negative regulation of renal sodium excretion Source: RGD
  • negative regulation of urine volume Source: RGD
  • positive regulation of angiogenesis Source: RGD
  • positive regulation of blood pressure Source: RGD
  • positive regulation of cell differentiation Source: RGD
  • positive regulation of circadian sleep/wake cycle, REM sleep Source: RGD
  • positive regulation of circadian sleep/wake cycle, wakefulness Source: RGD
  • positive regulation of collagen biosynthetic process Source: RGD
  • positive regulation of cytosolic calcium ion concentration Source: RGD
  • positive regulation of fibroblast migration Source: RGD
  • positive regulation of fibroblast proliferation Source: RGD
  • positive regulation of heart rate Source: RGD
  • positive regulation of synaptic transmission, cholinergic Source: RGD
  • positive regulation of vasodilation Source: RGD
  • response to drug Source: RGD
  • response to hypoxia Source: RGD
  • response to testosterone Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Hormone

Enzyme and pathway databases

ReactomeiR-RNO-375276. Peptide ligand-binding receptors.
R-RNO-416476. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Urotensin-2
Alternative name(s):
Urotensin II
Short name:
U-II
Short name:
UII
Gene namesi
Name:Uts2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi3930. Uts2.

Subcellular locationi

GO - Cellular componenti

  • cell Source: GOC
  • extracellular space Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL1163103.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence analysisAdd
BLAST
Propeptidei21 – 10484Sequence analysisPRO_0000036355Add
BLAST
Peptidei110 – 12314Urotensin-2PRO_0000036356Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi117 ↔ 122By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PaxDbiQ9QZQ4.

Expressioni

Tissue specificityi

Brain specific.

Gene expression databases

GenevisibleiQ9QZQ4. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000024798.

Chemistry

BindingDBiQ9QZQ4.

Family & Domainsi

Sequence similaritiesi

Belongs to the urotensin-2 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J3M9. Eukaryota.
ENOG410Z3PQ. LUCA.
GeneTreeiENSGT00510000049583.
HOGENOMiHOG000136847.
HOVERGENiHBG065793.
InParanoidiQ9QZQ4.
KOiK05248.
OMAiCPLFSLP.
OrthoDBiEOG7FR7JC.
PhylomeDBiQ9QZQ4.
TreeFamiTF330799.

Family and domain databases

InterProiIPR001483. Urotensin_II.
[Graphical view]
PfamiPF02083. Urotensin_II. 1 hit.
[Graphical view]
PROSITEiPS00984. UROTENSIN_II. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9QZQ4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDRVPFCCLL FVGLLNPLLS FPVTDTGEMS LQLPVLEENA LRALEELERT
60 70 80 90 100
ALLQTLRQTV GTEAEGSLGQ ADPSAETPTP RGSLRKALTG QDSNTVLSRL
110 120
LARTRKQRKQ HGTAPECFWK YCI
Length:123
Mass (Da):13,614
Last modified:May 1, 2000 - v1
Checksum:iE4F1A8EE124AF1EA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF172174 mRNA. Translation: AAD55766.1.
RefSeqiNP_062033.1. NM_019160.2.
UniGeneiRn.48886.

Genome annotation databases

EnsembliENSRNOT00000024798; ENSRNOP00000024798; ENSRNOG00000018393.
GeneIDi29180.
KEGGirno:29180.
UCSCiRGD:3930. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF172174 mRNA. Translation: AAD55766.1.
RefSeqiNP_062033.1. NM_019160.2.
UniGeneiRn.48886.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000024798.

Chemistry

BindingDBiQ9QZQ4.
ChEMBLiCHEMBL1163103.

Proteomic databases

PaxDbiQ9QZQ4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000024798; ENSRNOP00000024798; ENSRNOG00000018393.
GeneIDi29180.
KEGGirno:29180.
UCSCiRGD:3930. rat.

Organism-specific databases

CTDi10911.
RGDi3930. Uts2.

Phylogenomic databases

eggNOGiENOG410J3M9. Eukaryota.
ENOG410Z3PQ. LUCA.
GeneTreeiENSGT00510000049583.
HOGENOMiHOG000136847.
HOVERGENiHBG065793.
InParanoidiQ9QZQ4.
KOiK05248.
OMAiCPLFSLP.
OrthoDBiEOG7FR7JC.
PhylomeDBiQ9QZQ4.
TreeFamiTF330799.

Enzyme and pathway databases

ReactomeiR-RNO-375276. Peptide ligand-binding receptors.
R-RNO-416476. G alpha (q) signalling events.

Miscellaneous databases

PROiQ9QZQ4.

Gene expression databases

GenevisibleiQ9QZQ4. RN.

Family and domain databases

InterProiIPR001483. Urotensin_II.
[Graphical view]
PfamiPF02083. Urotensin_II. 1 hit.
[Graphical view]
PROSITEiPS00984. UROTENSIN_II. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning, sequence analysis and tissue distribution of the mouse and rat urotensin II precursors."
    Coulouarn Y., Jegou S., Tostivint H., Vaudry H., Lihrmann I.
    FEBS Lett. 457:28-32(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Spinal cord.

Entry informationi

Entry nameiUTS2_RAT
AccessioniPrimary (citable) accession number: Q9QZQ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: July 6, 2016
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.