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Protein

Urotensin-2

Gene

Uts2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Highly potent vasoconstrictor.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hormone

Enzyme and pathway databases

ReactomeiR-MMU-375276. Peptide ligand-binding receptors.
R-MMU-416476. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Urotensin-2
Alternative name(s):
Urotensin II
Short name:
U-II
Short name:
UII
Gene namesi
Name:Uts2
Synonyms:Ucn2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1346329. Uts2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL1163115.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence analysisAdd
BLAST
Propeptidei21 – 10484Sequence analysisPRO_0000036350Add
BLAST
Propeptidei107 – 1093Sequence analysisPRO_0000036351
Peptidei110 – 12314Urotensin-2PRO_0000036352Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi117 ↔ 122By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PaxDbiQ9QZQ3.
PRIDEiQ9QZQ3.

PTM databases

PhosphoSiteiQ9QZQ3.

Expressioni

Tissue specificityi

Brain specific. Predominantly expressed in motoneurons of the brainstem and spinal cord.

Gene expression databases

BgeeiQ9QZQ3.
CleanExiMM_UCN2.
MM_UTS2.
ExpressionAtlasiQ9QZQ3. baseline and differential.
GenevisibleiQ9QZQ3. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000030803.

Chemistry

BindingDBiQ9QZQ3.

Family & Domainsi

Sequence similaritiesi

Belongs to the urotensin-2 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J3M9. Eukaryota.
ENOG410Z3PQ. LUCA.
GeneTreeiENSGT00510000049583.
HOGENOMiHOG000136847.
HOVERGENiHBG065793.
InParanoidiQ9QZQ3.
KOiK05248.
OMAiCPLFSLP.
OrthoDBiEOG7FR7JC.
PhylomeDBiQ9QZQ3.
TreeFamiTF330799.

Family and domain databases

InterProiIPR001483. Urotensin_II.
[Graphical view]
PfamiPF02083. Urotensin_II. 1 hit.
[Graphical view]
PROSITEiPS00984. UROTENSIN_II. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9QZQ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDRVPFCCLL FIGLLNPLLS LPVTDTGERT LQLPVLEEDA LRALEELERM
60 70 80 90 100
ALLQTLRQTM GTEAGESPGE AGPSTETPTP RGSMRKAFAG QNSNTVLSRL
110 120
LARTRKQHKQ HGAAPECFWK YCI
Length:123
Mass (Da):13,625
Last modified:May 1, 2000 - v1
Checksum:iF96486195137F7F4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF172175 mRNA. Translation: AAD55767.1.
CCDSiCCDS18977.1.
RefSeqiNP_036040.1. NM_011910.2.
UniGeneiMm.89984.

Genome annotation databases

EnsembliENSMUST00000030803; ENSMUSP00000030803; ENSMUSG00000028963.
GeneIDi24111.
KEGGimmu:24111.
UCSCiuc008vyd.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF172175 mRNA. Translation: AAD55767.1.
CCDSiCCDS18977.1.
RefSeqiNP_036040.1. NM_011910.2.
UniGeneiMm.89984.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000030803.

Chemistry

BindingDBiQ9QZQ3.
ChEMBLiCHEMBL1163115.

PTM databases

PhosphoSiteiQ9QZQ3.

Proteomic databases

PaxDbiQ9QZQ3.
PRIDEiQ9QZQ3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030803; ENSMUSP00000030803; ENSMUSG00000028963.
GeneIDi24111.
KEGGimmu:24111.
UCSCiuc008vyd.1. mouse.

Organism-specific databases

CTDi10911.
MGIiMGI:1346329. Uts2.

Phylogenomic databases

eggNOGiENOG410J3M9. Eukaryota.
ENOG410Z3PQ. LUCA.
GeneTreeiENSGT00510000049583.
HOGENOMiHOG000136847.
HOVERGENiHBG065793.
InParanoidiQ9QZQ3.
KOiK05248.
OMAiCPLFSLP.
OrthoDBiEOG7FR7JC.
PhylomeDBiQ9QZQ3.
TreeFamiTF330799.

Enzyme and pathway databases

ReactomeiR-MMU-375276. Peptide ligand-binding receptors.
R-MMU-416476. G alpha (q) signalling events.

Miscellaneous databases

NextBioi304135.
PROiQ9QZQ3.
SOURCEiSearch...

Gene expression databases

BgeeiQ9QZQ3.
CleanExiMM_UCN2.
MM_UTS2.
ExpressionAtlasiQ9QZQ3. baseline and differential.
GenevisibleiQ9QZQ3. MM.

Family and domain databases

InterProiIPR001483. Urotensin_II.
[Graphical view]
PfamiPF02083. Urotensin_II. 1 hit.
[Graphical view]
PROSITEiPS00984. UROTENSIN_II. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning, sequence analysis and tissue distribution of the mouse and rat urotensin II precursors."
    Coulouarn Y., Jegou S., Tostivint H., Vaudry H., Lihrmann I.
    FEBS Lett. 457:28-32(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Spinal cord.

Entry informationi

Entry nameiUTS2_MOUSE
AccessioniPrimary (citable) accession number: Q9QZQ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: February 17, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.