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Protein

Neuronal PAS domain-containing protein 3

Gene

Npas3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a broad role in neurogenesis. May control regulatory pathways relevant to schizophrenia and to psychotic illness.1 Publication

GO - Molecular functioni

GO - Biological processi

  • developmental process Source: GO_Central
  • locomotory behavior Source: MGI
  • maternal behavior Source: MGI
  • positive regulation of transcription, DNA-templated Source: UniProtKB
  • regulation of transcription from RNA polymerase II promoter Source: GO_Central
  • startle response Source: MGI
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Neuronal PAS domain-containing protein 3
Short name:
Neuronal PAS3
Alternative name(s):
Basic-helix-loop-helix-PAS protein MOP6
Member of PAS protein 6
Gene namesi
Name:Npas3
Synonyms:Mop6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1351610. Npas3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 925925Neuronal PAS domain-containing protein 3PRO_0000127409Add
BLAST

Proteomic databases

MaxQBiQ9QZQ0.
PaxDbiQ9QZQ0.
PRIDEiQ9QZQ0.

PTM databases

iPTMnetiQ9QZQ0.
PhosphoSiteiQ9QZQ0.

Expressioni

Tissue specificityi

Detected exclusively in adult brain in inhibitory interneurons.

Developmental stagei

Expression detected between 9.5 and 11.5 dpc in the developing neural tube. Was also expressed throughout the neuroepithelium of the developing central nervous system between 10. 5 and 12.5 dpc at 14.5 dpc, the expression became restricted to the neopallial layer of the cortex. At 12.5 dpc, expression was evident in nonneural tissues such as the developing dermis and mesenchyme surrounding the otic and nasal placodes. Expression was also detected in the developing cardiac valves, limb and developing kidney.

Gene expression databases

CleanExiMM_NPAS3.

Interactioni

Subunit structurei

Efficient DNA binding requires dimerization with another bHLH protein.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000098975.

Structurei

3D structure databases

ProteinModelPortaliQ9QZQ0.
SMRiQ9QZQ0. Positions 59-442.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini58 – 11154bHLHPROSITE-ProRule annotationAdd
BLAST
Domaini152 – 22271PAS 1PROSITE-ProRule annotationAdd
BLAST
Domaini324 – 39471PAS 2PROSITE-ProRule annotationAdd
BLAST
Domaini398 – 44144PACAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi236 – 2449Poly-Ser
Compositional biasi706 – 7094Poly-Gly
Compositional biasi760 – 77112Poly-GlyAdd
BLAST

Sequence similaritiesi

Contains 1 bHLH (basic helix-loop-helix) domain.PROSITE-ProRule annotation
Contains 2 PAS (PER-ARNT-SIM) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3558. Eukaryota.
ENOG410YK57. LUCA.
HOGENOMiHOG000113836.
HOVERGENiHBG052656.
InParanoidiQ9QZQ0.
PhylomeDBiQ9QZQ0.

Family and domain databases

InterProiIPR011598. bHLH_dom.
IPR000014. PAS.
IPR013767. PAS_fold.
IPR013655. PAS_fold_3.
[Graphical view]
PfamiPF00989. PAS. 1 hit.
PF08447. PAS_3. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
SM00091. PAS. 2 hits.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
SSF55785. SSF55785. 2 hits.
PROSITEiPS50888. BHLH. 1 hit.
PS50112. PAS. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9QZQ0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGRAGAAANG TPQNVQGITS YQQRITAQHP LPNQSECRKI YRYDGIYCES
60 70 80 90 100
TYQNLQALRK EKSRDAARSR RGKENFEFYE LAKLLPLPAA ITSQLDKASI
110 120 130 140 150
IRLTISYLKM RDFANQGDPP WNLRMEGPPP NTSVKGAQRR RSPSALAIEV
160 170 180 190 200
FEAHLGSHIL QSLDGFVFAL NQEGKFLYIS ETVSIYLGLS QVELTGSSVF
210 220 230 240 250
DYVHPGDHVE MAEQLGMKLP PGRGLLSQGT TEDAASSASS SSQSETPEPV
260 270 280 290 300
ETTSPSLLTT DNTLERSFFI RMKSTLTKRG VHIKSSGYKV IHITGRLRLR
310 320 330 340 350
VPLSHGRTVP SQIMGLVVVA HALPPPTINE VRIDCHMFVT RVNMDLNIIY
360 370 380 390 400
CENRISDYMD LTPVDIVGKR CYHFIHAEDV EGIRHSHLDL LNKGQCVTKY
410 420 430 440 450
YRWMQKNGGY IWIQSSATIA INAKNANEKN IIWVNYLLSN PEYKDTPMDI
460 470 480 490 500
AQLPHLPEKA SESSETSDSE SDSKDTSGIT EDNENSKSDE KGNQSENSED
510 520 530 540 550
PEPDRKKSGS ACDNDMNCND DGHSSSNPDS RDSDDSFEHS DFEHPKAAED
560 570 580 590 600
GFGALGPMQI KVERYVESEA DLRLQPCESL TSDSAKDSDS ANEAGAQASS
610 620 630 640 650
KHQKRKRRRK RQKGGSASRR RLSSASSPGL DAGLVEPPRL LSSPHSASVL
660 670 680 690 700
KIKTEIAEPI NFDNESSIWN YPPNREISRN ESPYSMTKPP TSEHFPSPQG
710 720 730 740 750
QGGSIGGGGA LHVAIPDSVL TPPGADGTAG RKTQFSGTAP VPSDPLSPPL
760 770 780 790 800
SASPRDKHPG GGAGSGGGGP GASNSLLYTG DLEALQRLQA GNVVLPLVHR
810 820 830 840 850
VTGTLAATST AAQRVYTTGT IRYAPAEVTL AMQGNLLPNA HAVNFVDVNS
860 870 880 890 900
PGFGLDPKTP MEMLYHHVHR LNMSGPFGGA VSAASLTQMP GGNVFTTAEG
910 920
LFSTLPFPVY SNGIHAAQTL ERKED
Length:925
Mass (Da):100,458
Last modified:May 1, 2000 - v1
Checksum:iB6B07C9B6755B938
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti141 – 1411R → L in AAG35181 (Ref. 2) Curated
Sequence conflicti156 – 1561G → E in AAG35181 (Ref. 2) Curated
Sequence conflicti166 – 1661F → L in AAG35181 (Ref. 2) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF173871 mRNA. Translation: AAF14283.1.
AF168769 mRNA. Translation: AAG35181.1.
CCDSiCCDS25907.1.
UniGeneiMm.247044.
Mm.466545.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF173871 mRNA. Translation: AAF14283.1.
AF168769 mRNA. Translation: AAG35181.1.
CCDSiCCDS25907.1.
UniGeneiMm.247044.
Mm.466545.

3D structure databases

ProteinModelPortaliQ9QZQ0.
SMRiQ9QZQ0. Positions 59-442.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000098975.

PTM databases

iPTMnetiQ9QZQ0.
PhosphoSiteiQ9QZQ0.

Proteomic databases

MaxQBiQ9QZQ0.
PaxDbiQ9QZQ0.
PRIDEiQ9QZQ0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:1351610. Npas3.

Phylogenomic databases

eggNOGiKOG3558. Eukaryota.
ENOG410YK57. LUCA.
HOGENOMiHOG000113836.
HOVERGENiHBG052656.
InParanoidiQ9QZQ0.
PhylomeDBiQ9QZQ0.

Miscellaneous databases

ChiTaRSiNpas3. mouse.
PROiQ9QZQ0.
SOURCEiSearch...

Gene expression databases

CleanExiMM_NPAS3.

Family and domain databases

InterProiIPR011598. bHLH_dom.
IPR000014. PAS.
IPR013767. PAS_fold.
IPR013655. PAS_fold_3.
[Graphical view]
PfamiPF00989. PAS. 1 hit.
PF08447. PAS_3. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
SM00091. PAS. 2 hits.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
SSF55785. SSF55785. 2 hits.
PROSITEiPS50888. BHLH. 1 hit.
PS50112. PAS. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of Npas3, a novel basic helix-loop-helix PAS gene expressed in the developing mouse nervous system."
    Brunskill E.W., Witte D.P., Shreiner A.B., Potter S.S.
    Mech. Dev. 88:237-241(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Cloning and chromosomal localization of MOP6."
    Thomas R.S., Bradfield C.A.
    Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 141-280.
  3. "Behavioral and regulatory abnormalities in mice deficient in the NPAS1 and NPAS3 transcription factors."
    Erbel-Sieler C., Dudley C., Zhou Y., Wu X., Estill S.J., Han T., Diaz-Arrastia R., Brunskill E.W., Potter S.S., McKnight S.L.
    Proc. Natl. Acad. Sci. U.S.A. 101:13648-13653(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.

Entry informationi

Entry nameiNPAS3_MOUSE
AccessioniPrimary (citable) accession number: Q9QZQ0
Secondary accession number(s): Q9EQP4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: May 1, 2000
Last modified: July 6, 2016
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.