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Protein

PR domain zinc finger protein 4

Gene

Prdm4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May function as a transcription factor involved in cell differentiation.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri586 – 608C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri614 – 636C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri642 – 664C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri670 – 692C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri698 – 720C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri726 – 747C2H2-type 6; degeneratePROSITE-ProRule annotationAdd BLAST22

GO - Molecular functioni

GO - Biological processi

  • cellular response to growth factor stimulus Source: RGD
  • cellular response to nutrient Source: RGD
  • negative regulation of cell growth Source: RGD
  • negative regulation of gene expression Source: ParkinsonsUK-UCL
  • regulation of neural precursor cell proliferation Source: ParkinsonsUK-UCL
  • regulation of stem cell differentiation Source: ParkinsonsUK-UCL
  • regulation of transcription, DNA-templated Source: UniProtKB-KW
  • transcription by RNA polymerase II Source: InterPro

Keywordsi

Molecular functionDNA-binding, Methyltransferase, Transferase
Biological processTranscription, Transcription regulation
LigandMetal-binding, S-adenosyl-L-methionine, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
PR domain zinc finger protein 4 (EC:2.1.1.-)
Alternative name(s):
PR domain-containing protein 4
Gene namesi
Name:Prdm4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi619929 Prdm4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002307931 – 798PR domain zinc finger protein 4Add BLAST798

Proteomic databases

PaxDbiQ9QZP2
PRIDEiQ9QZP2

Interactioni

GO - Molecular functioni

  • death receptor binding Source: RGD
  • histone methyltransferase binding Source: InterPro

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000006886

Structurei

3D structure databases

ProteinModelPortaliQ9QZP2
SMRiQ9QZP2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini408 – 525SETPROSITE-ProRule annotationAdd BLAST118

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi15 – 20Poly-Ser6
Compositional biasi89 – 94Poly-Pro6
Compositional biasi753 – 756Poly-Ser4

Sequence similaritiesi

Belongs to the class V-like SAM-binding methyltransferase superfamily.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri586 – 608C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri614 – 636C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri642 – 664C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri670 – 692C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri698 – 720C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri726 – 747C2H2-type 6; degeneratePROSITE-ProRule annotationAdd BLAST22

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
KOG2461 Eukaryota
COG5048 LUCA
HOGENOMiHOG000060213
HOVERGENiHBG053672
InParanoidiQ9QZP2
KOiK12463
PhylomeDBiQ9QZP2

Family and domain databases

InterProiView protein in InterPro
IPR017124 PRDM4
IPR001214 SET_dom
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PIRSFiPIRSF037161 PRDM4, 1 hit
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 7 hits
SUPFAMiSSF57667 SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS50280 SET, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 5 hits
PS50157 ZINC_FINGER_C2H2_2, 6 hits

Sequencei

Sequence statusi: Complete.

Q9QZP2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNDMNLSPVG MEQLSSSSVS NALPVSGSHL GLAASPSHSA IPAPGLPVAI
60 70 80 90 100
PNLGPSLSSL PSALSLMLPM GIGDRGVMCG LPERNYTLPP PPYPHLESSY
110 120 130 140 150
FRTILPGILS YLADRPPPQY IHPNSINVDG NTALSITNNP SALDPYQANG
160 170 180 190 200
NVGLELGIVS IDSRSVNTHG AQSLHPNDGH EVALDTTITM ENVSRVTSPI
210 220 230 240 250
STDGMAEELT MDGVTGEHSQ IPNGSRSHEP LSVDSVSNNL TADTVGHGGV
260 270 280 290 300
IPIHGNGLEL PVVMETDHIA NRVNGISDSV LSDSIHTVAM STNSVSVALS
310 320 330 340 350
TSHNFASLES VSLQEVGLSL EPVAVSSITQ EVAMGTGHVD VSSDSLSFVP
360 370 380 390 400
SSLQMEDSNS NKENMATLFT IWCTLCDRAY PSDCPDHGPV TFVPDTPIES
410 420 430 440 450
RARLSLPKQL VLRQSIVGTD VGVWTAETIP VRTCFGPLIG QQSHSMEVAE
460 470 480 490 500
WTDKAVSHVW KIYHNGVLEF CIITTDENEC NWMMFVRKAR NREEQNLVAY
510 520 530 540 550
PHDGKIYFCT SQDIPPENEL LFYYSRDYAQ QIGVPEHPDV HLCNCGKECS
560 570 580 590 600
SYSEFKAHLT SHIHNHLPSQ GHSSSHGPSH SKERKWKCSM CPQAFISPSK
610 620 630 640 650
LHVHFMGHMG MKPHKCDFCS KAFSDPSNLR THLKIHTGQK NYRCTLCDKS
660 670 680 690 700
FTQKAHLESH MVIHTGEKNL KCDYCDKLFM RRQDLKQHVL IHTQERQIKC
710 720 730 740 750
PKCDKLFLRT NHLKKHLNSH EGRRDYVCEK CTKAYLTKYH LTRHLKACKE
760 770 780 790
PASSSSAQDD EDEDGDSGED GLPGSMTTEG CRMSSAVYSA DESLSAHK
Length:798
Mass (Da):87,392
Last modified:May 1, 2000 - v1
Checksum:i7E409426E6B56F90
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF176023 mRNA Translation: AAD52971.1
RefSeqiNP_579846.1, NM_133312.1
UniGeneiRn.162921

Genome annotation databases

GeneIDi170820
KEGGirno:170820
UCSCiRGD:619929 rat

Similar proteinsi

Entry informationi

Entry nameiPRDM4_RAT
AccessioniPrimary (citable) accession number: Q9QZP2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: May 1, 2000
Last modified: June 20, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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