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Protein

Gem-associated protein 2

Gene

Gemin2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

mRNA processing, mRNA splicing

Enzyme and pathway databases

ReactomeiR-RNO-191859. snRNP Assembly.

Names & Taxonomyi

Protein namesi
Recommended name:
Gem-associated protein 2
Short name:
Gemin-2
Alternative name(s):
Component of gems 2
Survival of motor neuron protein-interacting protein 1
Short name:
SMN-interacting protein 1
Gene namesi
Name:Gemin2
Synonyms:Sip1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 6

Organism-specific databases

RGDi620842. Gemin2.

Subcellular locationi

  • Nucleusgem By similarity
  • Cytoplasm By similarity

  • Note: Localized in subnuclear structures next to coiled bodies, called gems, which are highly enriched in spliceosomal snRNPs. Also found in the cytoplasm (By similarity).By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 269269Gem-associated protein 2PRO_0000087457Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei70 – 701PhosphoserineBy similarity
Modified residuei155 – 1551PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9QZP1.

PTM databases

iPTMnetiQ9QZP1.
PhosphoSiteiQ9QZP1.

Expressioni

Gene expression databases

GenevisibleiQ9QZP1. RN.

Interactioni

Subunit structurei

Part of the core SMN complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8 and STRAP/UNRIP. Part of the SMN-Sm complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8, STRAP/UNRIP and the Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG. Interacts directly with GEMIN5 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000006137.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi90 – 956Poly-Gln

Sequence similaritiesi

Belongs to the gemin-2 family.Curated

Phylogenomic databases

eggNOGiENOG410IJ8K. Eukaryota.
ENOG410YM8D. LUCA.
GeneTreeiENSGT00390000013814.
HOGENOMiHOG000008019.
HOVERGENiHBG051719.
InParanoidiQ9QZP1.
KOiK13130.
OMAiNHWKSQQ.
OrthoDBiEOG7XH6RF.
PhylomeDBiQ9QZP1.
TreeFamiTF105864.

Family and domain databases

InterProiIPR017364. GEMIN2.
[Graphical view]
PIRSFiPIRSF038038. SMN_Gemin2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9QZP1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAWVPAESAV EELMPRLLPV EPCDLTEGFD PSVPPRTPQE YLRRVQIEAA
60 70 80 90 100
QCPDVVVAQI DPKKLKRKQS VNVSLSGCHP APEGYSPTLQ WQQQQVIQFS
110 120 130 140 150
SVRQSVHKHR NHWKSQQLDS NVTMPKSEDE EGWKKFCLGE RLCAEGATGP
160 170 180 190 200
STDESPGIDY VQVGFPPLLS IVSRMNQATI TSVLEYLSNW FGERDFTPEL
210 220 230 240 250
GRWFYALLAC LEKPLLPEAH SLIRQLARRC SEVRLLVGSK DDERVPALNL
260
LICLVSRYFD QRDLADEPS
Length:269
Mass (Da):30,441
Last modified:May 1, 2000 - v1
Checksum:iE03AB9DBFCCC7EE3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF176072 mRNA. Translation: AAD53287.1.
BC098662 mRNA. Translation: AAH98662.1.
RefSeqiNP_445841.1. NM_053389.1.
UniGeneiRn.34143.

Genome annotation databases

EnsembliENSRNOT00000006137; ENSRNOP00000006137; ENSRNOG00000004360.
GeneIDi84404.
KEGGirno:84404.
UCSCiRGD:620842. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF176072 mRNA. Translation: AAD53287.1.
BC098662 mRNA. Translation: AAH98662.1.
RefSeqiNP_445841.1. NM_053389.1.
UniGeneiRn.34143.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000006137.

PTM databases

iPTMnetiQ9QZP1.
PhosphoSiteiQ9QZP1.

Proteomic databases

PaxDbiQ9QZP1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000006137; ENSRNOP00000006137; ENSRNOG00000004360.
GeneIDi84404.
KEGGirno:84404.
UCSCiRGD:620842. rat.

Organism-specific databases

CTDi8487.
RGDi620842. Gemin2.

Phylogenomic databases

eggNOGiENOG410IJ8K. Eukaryota.
ENOG410YM8D. LUCA.
GeneTreeiENSGT00390000013814.
HOGENOMiHOG000008019.
HOVERGENiHBG051719.
InParanoidiQ9QZP1.
KOiK13130.
OMAiNHWKSQQ.
OrthoDBiEOG7XH6RF.
PhylomeDBiQ9QZP1.
TreeFamiTF105864.

Enzyme and pathway databases

ReactomeiR-RNO-191859. snRNP Assembly.

Miscellaneous databases

PROiQ9QZP1.

Gene expression databases

GenevisibleiQ9QZP1. RN.

Family and domain databases

InterProiIPR017364. GEMIN2.
[Graphical view]
PIRSFiPIRSF038038. SMN_Gemin2. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "SMN interacting protein-1 expression pattern in rat."
    Kallenbach S., La Bella V., Cisterni C., Pettmann B.
    Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Thymus.

Entry informationi

Entry nameiGEMI2_RAT
AccessioniPrimary (citable) accession number: Q9QZP1
Secondary accession number(s): Q4G084
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: June 8, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.