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Protein

F-box only protein 8

Gene

Fbxo8

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

May promote guanine-nucleotide exchange on an ARF. Promotes the activation of ARF through replacement of GDP with GTP (Potential).Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGuanine-nucleotide releasing factor

Names & Taxonomyi

Protein namesi
Recommended name:
F-box only protein 8
Gene namesi
Name:Fbxo8
Synonyms:Fbx8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1354696. Fbxo8.

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001202191 – 319F-box only protein 8Add BLAST319

Proteomic databases

PaxDbiQ9QZN3.
PRIDEiQ9QZN3.

PTM databases

PhosphoSitePlusiQ9QZN3.

Expressioni

Tissue specificityi

High expression in brain, heart, kidney, liver, lung, skeletal muscle, testis, and day-7 embryos.

Gene expression databases

BgeeiENSMUSG00000038206.
CleanExiMM_FBXO8.
ExpressionAtlasiQ9QZN3. baseline and differential.
GenevisibleiQ9QZN3. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000037544.

Structurei

3D structure databases

ProteinModelPortaliQ9QZN3.
SMRiQ9QZN3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini68 – 111F-boxAdd BLAST44
Domaini146 – 276SEC7Add BLAST131

Phylogenomic databases

eggNOGiKOG0929. Eukaryota.
COG5307. LUCA.
GeneTreeiENSGT00760000119036.
HOGENOMiHOG000006813.
HOVERGENiHBG018990.
InParanoidiQ9QZN3.
KOiK10294.
OMAiLHNFSNQ.
OrthoDBiEOG091G0H7Q.

Family and domain databases

Gene3Di1.10.1000.11. 1 hit.
InterProiView protein in InterPro
IPR036047. F-box-like_dom_sf.
IPR001810. F-box_dom.
IPR023394. Sec7_alpha_orthog.
IPR000904. Sec7_dom.
IPR035999. Sec7_sf.
PfamiView protein in Pfam
PF12937. F-box-like. 1 hit.
PF01369. Sec7. 1 hit.
SMARTiView protein in SMART
SM00222. Sec7. 1 hit.
SUPFAMiSSF48425. SSF48425. 1 hit.
SSF81383. SSF81383. 1 hit.
PROSITEiView protein in PROSITE
PS50181. FBOX. 1 hit.
PS50190. SEC7. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9QZN3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGQGLWRVAR NHHLQQEAYS ETGYLSREQS RRVASSNISH TSHRKQAQGG
60 70 80 90 100
IDIYHLLKAR KSKEQEGFIN LEMLPPELSF TILSYLNATD LCLASCVWQD
110 120 130 140 150
LANDELLWQG LCKSTWGHCS IYNKNPPLGF SFRKLYMQLD EGSLTFNANP
160 170 180 190 200
EEGVSYFMSK GILDDSPKEI AKFIFCTRTL NWKKLRIYLD ERRDVLDDLV
210 220 230 240 250
TLHNFRNQFL PNALREFFRH IHAPEERGEY LETLITKFSH RFCACNPDLM
260 270 280 290 300
RELGLSPDAV YVLCYSLILL SIDLTSPHVK NKMSKREFIR NTRRAAQNIS
310
EDFVGHLYDN IYLIGHVAA
Length:319
Mass (Da):36,970
Last modified:July 27, 2011 - v2
Checksum:iB6A14F089FD83261
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti89T → I in AAF09136 (PubMed:10531037).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF176527 mRNA. Translation: AAF09136.1.
AK029989 mRNA. Translation: BAC26720.1.
AK078111 mRNA. Translation: BAC37130.1.
AK147748 mRNA. Translation: BAE28112.1.
CH466569 Genomic DNA. Translation: EDL28608.1.
CH466569 Genomic DNA. Translation: EDL28609.1.
BC034854 mRNA. Translation: AAH34854.1.
CCDSiCCDS22314.1.
RefSeqiNP_056606.2. NM_015791.3.
UniGeneiMm.251174.

Genome annotation databases

EnsembliENSMUST00000040218; ENSMUSP00000037544; ENSMUSG00000038206.
GeneIDi50753.
KEGGimmu:50753.
UCSCiuc009lsr.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiFBX8_MOUSE
AccessioniPrimary (citable) accession number: Q9QZN3
Secondary accession number(s): Q8JZY7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: July 27, 2011
Last modified: November 22, 2017
This is version 114 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot