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Protein

F-box only protein 8

Gene

Fbxo8

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

May promote guanine-nucleotide exchange on an ARF. Promotes the activation of ARF through replacement of GDP with GTP (Potential).Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Guanine-nucleotide releasing factor

Names & Taxonomyi

Protein namesi
Recommended name:
F-box only protein 8
Gene namesi
Name:Fbxo8
Synonyms:Fbx8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1354696. Fbxo8.

Subcellular locationi

GO - Cellular componenti

  • ubiquitin ligase complex Source: MGI
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 319319F-box only protein 8PRO_0000120219Add
BLAST

Proteomic databases

PaxDbiQ9QZN3.
PRIDEiQ9QZN3.

PTM databases

PhosphoSiteiQ9QZN3.

Expressioni

Tissue specificityi

High expression in brain, heart, kidney, liver, lung, skeletal muscle, testis, and day-7 embryos.

Gene expression databases

BgeeiENSMUSG00000038206.
CleanExiMM_FBXO8.
ExpressionAtlasiQ9QZN3. baseline and differential.
GenevisibleiQ9QZN3. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000037544.

Structurei

3D structure databases

ProteinModelPortaliQ9QZN3.
SMRiQ9QZN3. Positions 146-311.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini68 – 11144F-boxPROSITE-ProRule annotationAdd
BLAST
Domaini146 – 276131SEC7PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 F-box domain.PROSITE-ProRule annotation
Contains 1 SEC7 domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0929. Eukaryota.
COG5307. LUCA.
GeneTreeiENSGT00760000119036.
HOGENOMiHOG000006813.
HOVERGENiHBG018990.
InParanoidiQ9QZN3.
KOiK10294.
OMAiLHNFSNQ.
OrthoDBiEOG091G0H7Q.

Family and domain databases

Gene3Di1.10.1000.11. 1 hit.
InterProiIPR001810. F-box_dom.
IPR023394. Sec7_alpha_orthog.
IPR000904. Sec7_dom.
[Graphical view]
PfamiPF12937. F-box-like. 1 hit.
PF01369. Sec7. 1 hit.
[Graphical view]
SMARTiSM00222. Sec7. 1 hit.
[Graphical view]
SUPFAMiSSF48425. SSF48425. 1 hit.
SSF81383. SSF81383. 1 hit.
PROSITEiPS50181. FBOX. 1 hit.
PS50190. SEC7. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9QZN3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGQGLWRVAR NHHLQQEAYS ETGYLSREQS RRVASSNISH TSHRKQAQGG
60 70 80 90 100
IDIYHLLKAR KSKEQEGFIN LEMLPPELSF TILSYLNATD LCLASCVWQD
110 120 130 140 150
LANDELLWQG LCKSTWGHCS IYNKNPPLGF SFRKLYMQLD EGSLTFNANP
160 170 180 190 200
EEGVSYFMSK GILDDSPKEI AKFIFCTRTL NWKKLRIYLD ERRDVLDDLV
210 220 230 240 250
TLHNFRNQFL PNALREFFRH IHAPEERGEY LETLITKFSH RFCACNPDLM
260 270 280 290 300
RELGLSPDAV YVLCYSLILL SIDLTSPHVK NKMSKREFIR NTRRAAQNIS
310
EDFVGHLYDN IYLIGHVAA
Length:319
Mass (Da):36,970
Last modified:July 27, 2011 - v2
Checksum:iB6A14F089FD83261
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti89 – 891T → I in AAF09136 (PubMed:10531037).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF176527 mRNA. Translation: AAF09136.1.
AK029989 mRNA. Translation: BAC26720.1.
AK078111 mRNA. Translation: BAC37130.1.
AK147748 mRNA. Translation: BAE28112.1.
CH466569 Genomic DNA. Translation: EDL28608.1.
CH466569 Genomic DNA. Translation: EDL28609.1.
BC034854 mRNA. Translation: AAH34854.1.
CCDSiCCDS22314.1.
RefSeqiNP_056606.2. NM_015791.3.
UniGeneiMm.251174.

Genome annotation databases

EnsembliENSMUST00000040218; ENSMUSP00000037544; ENSMUSG00000038206.
GeneIDi50753.
KEGGimmu:50753.
UCSCiuc009lsr.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF176527 mRNA. Translation: AAF09136.1.
AK029989 mRNA. Translation: BAC26720.1.
AK078111 mRNA. Translation: BAC37130.1.
AK147748 mRNA. Translation: BAE28112.1.
CH466569 Genomic DNA. Translation: EDL28608.1.
CH466569 Genomic DNA. Translation: EDL28609.1.
BC034854 mRNA. Translation: AAH34854.1.
CCDSiCCDS22314.1.
RefSeqiNP_056606.2. NM_015791.3.
UniGeneiMm.251174.

3D structure databases

ProteinModelPortaliQ9QZN3.
SMRiQ9QZN3. Positions 146-311.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000037544.

PTM databases

PhosphoSiteiQ9QZN3.

Proteomic databases

PaxDbiQ9QZN3.
PRIDEiQ9QZN3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000040218; ENSMUSP00000037544; ENSMUSG00000038206.
GeneIDi50753.
KEGGimmu:50753.
UCSCiuc009lsr.1. mouse.

Organism-specific databases

CTDi26269.
MGIiMGI:1354696. Fbxo8.

Phylogenomic databases

eggNOGiKOG0929. Eukaryota.
COG5307. LUCA.
GeneTreeiENSGT00760000119036.
HOGENOMiHOG000006813.
HOVERGENiHBG018990.
InParanoidiQ9QZN3.
KOiK10294.
OMAiLHNFSNQ.
OrthoDBiEOG091G0H7Q.

Miscellaneous databases

ChiTaRSiFbxo8. mouse.
PROiQ9QZN3.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000038206.
CleanExiMM_FBXO8.
ExpressionAtlasiQ9QZN3. baseline and differential.
GenevisibleiQ9QZN3. MM.

Family and domain databases

Gene3Di1.10.1000.11. 1 hit.
InterProiIPR001810. F-box_dom.
IPR023394. Sec7_alpha_orthog.
IPR000904. Sec7_dom.
[Graphical view]
PfamiPF12937. F-box-like. 1 hit.
PF01369. Sec7. 1 hit.
[Graphical view]
SMARTiSM00222. Sec7. 1 hit.
[Graphical view]
SUPFAMiSSF48425. SSF48425. 1 hit.
SSF81383. SSF81383. 1 hit.
PROSITEiPS50181. FBOX. 1 hit.
PS50190. SEC7. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFBX8_MOUSE
AccessioniPrimary (citable) accession number: Q9QZN3
Secondary accession number(s): Q8JZY7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: July 27, 2011
Last modified: September 7, 2016
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.