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Protein

F-box/LRR-repeat protein 17

Gene

Fbxl17

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.By similarity

Keywords - Biological processi

Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
F-box/LRR-repeat protein 17
Alternative name(s):
F-box and leucine-rich repeat protein 17
F-box only protein 13
Gene namesi
Name:Fbxl17
Synonyms:Fbl17, Fbx13, Fbxo13
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1354704. Fbxl17.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 701701F-box/LRR-repeat protein 17PRO_0000119866Add
BLAST

Proteomic databases

EPDiQ9QZN1.
MaxQBiQ9QZN1.
PaxDbiQ9QZN1.
PeptideAtlasiQ9QZN1.
PRIDEiQ9QZN1.

PTM databases

iPTMnetiQ9QZN1.
PhosphoSiteiQ9QZN1.

Expressioni

Gene expression databases

BgeeiQ9QZN1.
CleanExiMM_FBXL17.
ExpressionAtlasiQ9QZN1. baseline and differential.
GenevisibleiQ9QZN1. MM.

Interactioni

Subunit structurei

Interacts with SKP1 and CUL1.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000024761.

Structurei

3D structure databases

ProteinModelPortaliQ9QZN1.
SMRiQ9QZN1. Positions 322-585.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini318 – 36548F-boxPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi25 – 284Poly-Arg
Compositional biasi84 – 896Poly-Pro
Compositional biasi93 – 15058Ala-richAdd
BLAST
Compositional biasi181 – 326146Pro-richAdd
BLAST
Compositional biasi217 – 23519Gly-richAdd
BLAST

Sequence similaritiesi

Contains 1 F-box domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1947. Eukaryota.
ENOG410XQ54. LUCA.
GeneTreeiENSGT00760000119059.
HOGENOMiHOG000169154.
HOVERGENiHBG107935.
InParanoidiQ9QZN1.
KOiK10283.
OMAiWSINDRC.
OrthoDBiEOG7DNNW7.
PhylomeDBiQ9QZN1.
TreeFamiTF332421.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR001810. F-box_dom.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR006553. Leu-rich_rpt_Cys-con_subtyp.
[Graphical view]
PfamiPF12937. F-box-like. 1 hit.
PF13516. LRR_6. 1 hit.
[Graphical view]
SMARTiSM00256. FBOX. 1 hit.
SM00367. LRR_CC. 11 hits.
[Graphical view]
SUPFAMiSSF81383. SSF81383. 1 hit.
PROSITEiPS50181. FBOX. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9QZN1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGHLLSKEPR NRPSQKRPRC CSWCRRRRPL LRLPRRALAK ASPQPAAPRS
60 70 80 90 100
RDCFFRGPCM LCFIVHSPGA PASAGLEEEP PLSPPPPPPR DGAYAAVSSQ
110 120 130 140 150
HLARRYAALA AEDCAAAARR FLLSSAAAAA AAASSPASCC KELGLAAAAA
160 170 180 190 200
WEQQGRSLFL AGVGPVRFLG PLAAVQLFRA PPAPPPQAEP ATALEMVCKR
210 220 230 240 250
KGAGVPACTP CKQPRCGCGG CGGGGGGGGG PAGGGASPPR PPDAGCCQAP
260 270 280 290 300
EQPPPPLCPA PASPASECAP IVAAAGDTVR AGGTAPSSAQ QQPESGDADC
310 320 330 340 350
QEPPENPCDC HREPPPEIPD INQLPPSILL KIFSNLSLNE RCLSASLVCK
360 370 380 390 400
YWRDLCLDFQ FWKQLDLSSR QQVTDELLEK IASRSQNIIE INISDCRSLS
410 420 430 440 450
DSGVCVLAFK CPGLLRYTAY RCKQLSDTSI IAVASHCPLL QKVHVGNQDK
460 470 480 490 500
LTDEGLKQLG SRCRELKDIH FGQCYKISDE GMIVIAKSCL KLQRIYMQEN
510 520 530 540 550
KLVTDQSVKA FAEHCPELQY VGFMGCSVTS KGVIHLTKLR NLSSLDLRHI
560 570 580 590 600
TELDNETVME IVKRCKNLSS LNLCLNWIIN DRCVEVIAKE GQNLKELYLV
610 620 630 640 650
SCKITDYALI AIGRYSVTIE TVDVGWCKEI TDQGATLIAQ SSKSLRYLGL
660 670 680 690 700
MRCDKVNELT VEQLVQQYPH ITFSTVLQDC KRTLERAYQM GWTPNMSAAT

S
Length:701
Mass (Da):75,683
Last modified:May 5, 2009 - v3
Checksum:i314208800D0063CC
GO
Isoform 2 (identifier: Q9QZN1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-474: Missing.
     475-502: YKISDEGMIVIAKSCLKLQRIYMQENKL → MDPFGFVLLDKEGMKYEKTQTKKPGKAK

Show »
Length:227
Mass (Da):25,656
Checksum:iF89A42FD2FDDB962
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 474474Missing in isoform 2. 1 PublicationVSP_009477Add
BLAST
Alternative sequencei475 – 50228YKISD…QENKL → MDPFGFVLLDKEGMKYEKTQ TKKPGKAK in isoform 2. 1 PublicationVSP_009478Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH466537 Genomic DNA. Translation: EDL38277.1.
BC058120 mRNA. Translation: AAH58120.1.
BC138330 mRNA. Translation: AAI38331.1.
BC138331 mRNA. Translation: AAI38332.1.
AF176529 mRNA. Translation: AAF09138.1.
AK004419 mRNA. Translation: BAC25082.1.
CCDSiCCDS50162.1. [Q9QZN1-1]
RefSeqiNP_056609.1. NM_015794.1. [Q9QZN1-1]
UniGeneiMm.136366.

Genome annotation databases

EnsembliENSMUST00000024761; ENSMUSP00000024761; ENSMUSG00000023965. [Q9QZN1-1]
GeneIDi50758.
KEGGimmu:50758.
UCSCiuc008dfj.2. mouse. [Q9QZN1-2]
uc008dfl.2. mouse. [Q9QZN1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH466537 Genomic DNA. Translation: EDL38277.1.
BC058120 mRNA. Translation: AAH58120.1.
BC138330 mRNA. Translation: AAI38331.1.
BC138331 mRNA. Translation: AAI38332.1.
AF176529 mRNA. Translation: AAF09138.1.
AK004419 mRNA. Translation: BAC25082.1.
CCDSiCCDS50162.1. [Q9QZN1-1]
RefSeqiNP_056609.1. NM_015794.1. [Q9QZN1-1]
UniGeneiMm.136366.

3D structure databases

ProteinModelPortaliQ9QZN1.
SMRiQ9QZN1. Positions 322-585.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000024761.

PTM databases

iPTMnetiQ9QZN1.
PhosphoSiteiQ9QZN1.

Proteomic databases

EPDiQ9QZN1.
MaxQBiQ9QZN1.
PaxDbiQ9QZN1.
PeptideAtlasiQ9QZN1.
PRIDEiQ9QZN1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000024761; ENSMUSP00000024761; ENSMUSG00000023965. [Q9QZN1-1]
GeneIDi50758.
KEGGimmu:50758.
UCSCiuc008dfj.2. mouse. [Q9QZN1-2]
uc008dfl.2. mouse. [Q9QZN1-1]

Organism-specific databases

CTDi64839.
MGIiMGI:1354704. Fbxl17.

Phylogenomic databases

eggNOGiKOG1947. Eukaryota.
ENOG410XQ54. LUCA.
GeneTreeiENSGT00760000119059.
HOGENOMiHOG000169154.
HOVERGENiHBG107935.
InParanoidiQ9QZN1.
KOiK10283.
OMAiWSINDRC.
OrthoDBiEOG7DNNW7.
PhylomeDBiQ9QZN1.
TreeFamiTF332421.

Miscellaneous databases

ChiTaRSiFbxl17. mouse.
PROiQ9QZN1.
SOURCEiSearch...

Gene expression databases

BgeeiQ9QZN1.
CleanExiMM_FBXL17.
ExpressionAtlasiQ9QZN1. baseline and differential.
GenevisibleiQ9QZN1. MM.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR001810. F-box_dom.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR006553. Leu-rich_rpt_Cys-con_subtyp.
[Graphical view]
PfamiPF12937. F-box-like. 1 hit.
PF13516. LRR_6. 1 hit.
[Graphical view]
SMARTiSM00256. FBOX. 1 hit.
SM00367. LRR_CC. 11 hits.
[Graphical view]
SUPFAMiSSF81383. SSF81383. 1 hit.
PROSITEiPS50181. FBOX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: C57BL/6J.
    Tissue: Brain.
  3. Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 240-674 (ISOFORM 1).
  4. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 568-701 (ISOFORMS 1/2).
    Strain: C57BL/6J.

Entry informationi

Entry nameiFXL17_MOUSE
AccessioniPrimary (citable) accession number: Q9QZN1
Secondary accession number(s): B2RRC1, Q8BTC3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2004
Last sequence update: May 5, 2009
Last modified: July 6, 2016
This is version 121 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.