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Protein

F-box only protein 16

Gene

Fbxo16

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation.

Keywords - Biological processi

Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
F-box only protein 16
Gene namesi
Name:Fbxo16
Synonyms:Fbx16
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1354706. Fbxo16.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 334334F-box only protein 16PRO_0000119897Add
BLAST

Proteomic databases

PaxDbiQ9QZM9.
PRIDEiQ9QZM9.

PTM databases

iPTMnetiQ9QZM9.
PhosphoSiteiQ9QZM9.

Expressioni

Gene expression databases

BgeeiENSMUSG00000034532.
CleanExiMM_FBXO16.
ExpressionAtlasiQ9QZM9. baseline and differential.
GenevisibleiQ9QZM9. MM.

Interactioni

Subunit structurei

Part of a SCF (SKP1-cullin-F-box) protein ligase complex.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000130805.

Structurei

3D structure databases

ProteinModelPortaliQ9QZM9.
SMRiQ9QZM9. Positions 82-161.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini86 – 13247F-boxPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 F-box domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0274. Eukaryota.
ENOG410XRWX. LUCA.
GeneTreeiENSGT00530000063689.
HOGENOMiHOG000110666.
HOVERGENiHBG051567.
InParanoidiQ9QZM9.
KOiK10299.
OMAiKRHEMTP.
OrthoDBiEOG091G018T.
PhylomeDBiQ9QZM9.
TreeFamiTF328656.

Family and domain databases

InterProiIPR001810. F-box_dom.
[Graphical view]
PfamiPF12937. F-box-like. 1 hit.
[Graphical view]
SMARTiSM00256. FBOX. 1 hit.
[Graphical view]
SUPFAMiSSF81383. SSF81383. 1 hit.
PROSITEiPS50181. FBOX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9QZM9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMAFAPPKSI DGPKMQTKMS TWTPLNHQLL NDQVFEERRA LLGKWFDKWT
60 70 80 90 100
DSQRRRILTG LLERCSLSQQ KFCCRKLQEK IPAEALDFTT KLPRVLSVYI
110 120 130 140 150
FSFLDPRSLC RCAQVSWYWK SLAELDQLWM LKCLRFNWYI SFSPTPFEQG
160 170 180 190 200
VWKKHYIQMV RELHVTKPKT PPKDEFTTAD VQPIPGNSPD EKQSPSLAFR
210 220 230 240 250
SSSSLRKKNN PGEKELPPWR SSDKHPTDII RFNYLDNCDP ELFRLGRRKR
260 270 280 290 300
SEVTPDFKRQ LRDKKNKLQD RARLRKAQSL ISLSSPPKVP VRLAWPLHLP
310 320 330
VAPSDREAAT EALLEHLQKH PGLQSPSPRL QSQS
Length:334
Mass (Da):38,987
Last modified:May 1, 2000 - v1
Checksum:iE5826DA24FE3684B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti102 – 1021S → F in BAC36580 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF176531 mRNA. Translation: AAF09140.1.
AK077043 mRNA. Translation: BAC36580.1.
AK164657 mRNA. Translation: BAE37863.1.
CCDSiCCDS36956.1.
RefSeqiNP_056610.1. NM_015795.1.
UniGeneiMm.65308.

Genome annotation databases

EnsembliENSMUST00000169656; ENSMUSP00000130805; ENSMUSG00000034532.
GeneIDi50759.
KEGGimmu:50759.
UCSCiuc007ujd.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF176531 mRNA. Translation: AAF09140.1.
AK077043 mRNA. Translation: BAC36580.1.
AK164657 mRNA. Translation: BAE37863.1.
CCDSiCCDS36956.1.
RefSeqiNP_056610.1. NM_015795.1.
UniGeneiMm.65308.

3D structure databases

ProteinModelPortaliQ9QZM9.
SMRiQ9QZM9. Positions 82-161.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000130805.

PTM databases

iPTMnetiQ9QZM9.
PhosphoSiteiQ9QZM9.

Proteomic databases

PaxDbiQ9QZM9.
PRIDEiQ9QZM9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000169656; ENSMUSP00000130805; ENSMUSG00000034532.
GeneIDi50759.
KEGGimmu:50759.
UCSCiuc007ujd.1. mouse.

Organism-specific databases

CTDi157574.
MGIiMGI:1354706. Fbxo16.

Phylogenomic databases

eggNOGiKOG0274. Eukaryota.
ENOG410XRWX. LUCA.
GeneTreeiENSGT00530000063689.
HOGENOMiHOG000110666.
HOVERGENiHBG051567.
InParanoidiQ9QZM9.
KOiK10299.
OMAiKRHEMTP.
OrthoDBiEOG091G018T.
PhylomeDBiQ9QZM9.
TreeFamiTF328656.

Miscellaneous databases

PROiQ9QZM9.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000034532.
CleanExiMM_FBXO16.
ExpressionAtlasiQ9QZM9. baseline and differential.
GenevisibleiQ9QZM9. MM.

Family and domain databases

InterProiIPR001810. F-box_dom.
[Graphical view]
PfamiPF12937. F-box-like. 1 hit.
[Graphical view]
SMARTiSM00256. FBOX. 1 hit.
[Graphical view]
SUPFAMiSSF81383. SSF81383. 1 hit.
PROSITEiPS50181. FBOX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFBX16_MOUSE
AccessioniPrimary (citable) accession number: Q9QZM9
Secondary accession number(s): Q3TP74, Q8C5V6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 9, 2003
Last sequence update: May 1, 2000
Last modified: September 7, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.