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Protein

Sodium/potassium/calcium exchanger 1

Gene

Slc24a1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Critical component of the visual transduction cascade, controlling the calcium concentration of outer segments during light and darkness. Light causes a rapid lowering of cytosolic free calcium in the outer segment of both retinal rod and cone photoreceptors and the light-induced lowering of calcium is caused by extrusion via this protein which plays a key role in the process of light adaptation. Transports 1 Ca2+ and 1 K+ in exchange for 4 Na+.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Antiport, Calcium transport, Ion transport, Sensory transduction, Symport, Transport, Vision

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/potassium/calcium exchanger 1
Alternative name(s):
Na(+)/K(+)/Ca(2+)-exchange protein 1
Retinal rod Na-Ca+K exchanger
Solute carrier family 24 member 1
Gene namesi
Name:Slc24a1
Synonyms:Nckx1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi620080. Slc24a1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 419ExtracellularSequence analysisAdd BLAST419
Transmembranei420 – 440HelicalSequence analysisAdd BLAST21
Topological domaini441 – 464CytoplasmicSequence analysisAdd BLAST24
Transmembranei465 – 485HelicalSequence analysisAdd BLAST21
Topological domaini486 – 491ExtracellularSequence analysis6
Transmembranei492 – 512HelicalSequence analysisAdd BLAST21
Topological domaini513 – 519CytoplasmicSequence analysis7
Transmembranei520 – 544HelicalSequence analysisAdd BLAST25
Topological domaini545 – 552ExtracellularSequence analysis8
Transmembranei553 – 569HelicalSequence analysisAdd BLAST17
Topological domaini570 – 989CytoplasmicSequence analysisAdd BLAST420
Transmembranei990 – 1010HelicalSequence analysisAdd BLAST21
Topological domaini1011 – 1017ExtracellularSequence analysis7
Transmembranei1018 – 1038HelicalSequence analysisAdd BLAST21
Topological domaini1039 – 1053CytoplasmicSequence analysisAdd BLAST15
Transmembranei1054 – 1074HelicalSequence analysisAdd BLAST21
Topological domaini1075 – 1092ExtracellularSequence analysisAdd BLAST18
Transmembranei1093 – 1113HelicalSequence analysisAdd BLAST21
Topological domaini1114 – 1121CytoplasmicSequence analysis8
Transmembranei1122 – 1142HelicalSequence analysisAdd BLAST21
Topological domaini1143 – 1150ExtracellularSequence analysis8
Transmembranei1151 – 1171HelicalSequence analysisAdd BLAST21
Topological domaini1172 – 1181CytoplasmicSequence analysis10

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002233041 – 1181Sodium/potassium/calcium exchanger 1Add BLAST1181
Signal peptidei1 – ?Not cleavedBy similarity

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi271N-linked (GlcNAc...)Sequence analysis1
Modified residuei625PhosphoserineSequence analysis1
Modified residuei690PhosphothreonineBy similarity1

Post-translational modificationi

The uncleaved signal sequence is required for efficient membrane targeting and proper membrane integration and topology.By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ9QZM6.
PRIDEiQ9QZM6.

Expressioni

Tissue specificityi

Highly expressed in the eye.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000051962.

Structurei

3D structure databases

ProteinModelPortaliQ9QZM6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati461 – 501Alpha-1Add BLAST41
Repeati730 – 7411Add BLAST12
Repeati742 – 7542Add BLAST13
Repeati755 – 7663Add BLAST12
Repeati767 – 7784Add BLAST12
Repeati779 – 7915Add BLAST13
Repeati792 – 8046Add BLAST13
Repeati805 – 8177Add BLAST13
Repeati818 – 8308Add BLAST13
Repeati831 – 8439Add BLAST13
Repeati844 – 85610Add BLAST13
Repeati857 – 86911Add BLAST13
Repeati870 – 88112Add BLAST12
Repeati882 – 89313Add BLAST12
Repeati894 – 90514Add BLAST12
Repeati1061 – 1092Alpha-2Add BLAST32

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni730 – 90514 X approximate tandem repeatsAdd BLAST176

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi952 – 974Poly-GluAdd BLAST23

Sequence similaritiesi

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1307. Eukaryota.
ENOG410Y9YY. LUCA.
HOGENOMiHOG000231933.
HOVERGENiHBG104097.
InParanoidiQ9QZM6.
KOiK13749.
PhylomeDBiQ9QZM6.

Family and domain databases

InterProiIPR004481. K/Na/Ca-exchanger.
IPR004837. NaCa_Exmemb.
IPR004817. SLC24A1.
[Graphical view]
PANTHERiPTHR10846. PTHR10846. 4 hits.
PfamiPF01699. Na_Ca_ex. 2 hits.
[Graphical view]
TIGRFAMsiTIGR00927. 2A1904. 1 hit.
TIGR00367. TIGR00367. 1 hit.

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9QZM6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGKLIRMGTQ ERRLLRPKRL HWSRLLFFLG MLIIGSTYQH LRRPQNPPSM
60 70 80 90 100
WTKVSSQQPI KLAIRDLPND EITVTDKDPP EASSEVEGEM LAPQDTVIIG
110 120 130 140 150
EAAPSIAMED TPNPPITTKI TPTSLKNNYS PTTAGTRRQK ENIPPTPSRA
160 170 180 190 200
PSHFISTSGR QRVKSYTPKP RGGRKSSSPT HTREEGRMHT PSPAGAPRTI
210 220 230 240 250
SPTSTEKDSE TTATYRMLEP RSERTAGKTS LKRMVPNTRT FLTREVETDL
260 270 280 290 300
VTSPSLVGKN TLGSPRRGER NSSTTPLRAV LQPTPATSEE QVTASIRMGS
310 320 330 340 350
TPATTEGSTA AQRIGNPLSG TSTPAVRIAS VTDREKRPST AHGTLVTPQV
360 370 380 390 400
KAVLTTQVHR CVVVKPAPAV PMTPSPSMTA ILFPEAPTSG PSALPPGWPN
410 420 430 440 450
LHPKAEYPPD LFSVEDRRQG WVVLHIFGMT YVFVALAIVC DEYFVPALGV
460 470 480 490 500
ITDKLQISED VAGATFMAAG GSAPELFTSL IGVFISHSNV GIGTIVGSAV
510 520 530 540 550
FNILFVIGTC ALFSREILNL TWWPLFRDVS FYILDLSMLI VFFLDSLIAW
560 570 580 590 600
WESLLLLLAY ALYVFTMKWN KQIERWVKEQ LSRRPVAKVM ALGDLSKPSD
610 620 630 640 650
GAIEENEQQD NKKLKLPSVL TRGSSSASLH NSIIRSTIYH LMLHSLDPLG
660 670 680 690 700
EARPSKDKQE SLNQEARVLP QTKAESSSDE EEPAELPAVT VTPAPAPEDK
710 720 730 740 750
GDQEEDPGCQ EDVDEAEHRG DMTGEEGERE TEAEGKKDEE GETEAERKED
760 770 780 790 800
GQEEETETKG KEKQEGETES EGKDEQEGET EAEGKEADHE GETEAEGKEV
810 820 830 840 850
EHEGETEAEG TEDEQEGETE AEGKEVEQEG ETEAEGKEVE HEVETEAERK
860 870 880 890 900
ETNHEGETEA EGKEADHEGE TEAEGNVEHQ GETEAEGKVE HEGETEAGEK
910 920 930 940 950
DEHEGQSETQ ADDTEVKDGE GEAEANAEDQ CETAQGEKGA DGGGGSDGGD
960 970 980 990 1000
SEEEEDEEDE EEEEEEEEEE EEEESEEPLS LEWPESRQKQ AIYLFLLPIV
1010 1020 1030 1040 1050
FPLWLTIPDV RRQEARKFFV ITFLGSIIWI AMFSYLMVWW AHQVGETIGI
1060 1070 1080 1090 1100
SEEIMGLTIL AAGTSIPDLI TSVIVARKGL GDMAVSSSVG SNIFDITVGL
1110 1120 1130 1140 1150
PVPWLLFSLI NALQPIPVSS NGLFCAIVLL FLMLLFVIFS IASCKWRMNK
1160 1170 1180
ILGFTMFLLY FVFLVISVML EDRIISCPVS V
Length:1,181
Mass (Da):129,981
Last modified:May 1, 2000 - v1
Checksum:iB063C1C1193696AE
GO
Isoform 2 (identifier: Q9QZM6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     598-710: Missing.

Show »
Length:1,068
Mass (Da):117,757
Checksum:i860796B1423E167B
GO
Isoform 3 (identifier: Q9QZM6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     616-710: Missing.

Show »
Length:1,086
Mass (Da):119,782
Checksum:i43790F23B8664175
GO
Isoform 4 (identifier: Q9QZM6-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     652-679: Missing.

Show »
Length:1,153
Mass (Da):126,899
Checksum:i93DD50700AC53DCB
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_006161598 – 710Missing in isoform 2. CuratedAdd BLAST113
Alternative sequenceiVSP_006162616 – 710Missing in isoform 3. CuratedAdd BLAST95
Alternative sequenceiVSP_006163652 – 679Missing in isoform 4. CuratedAdd BLAST28

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF176688 mRNA. Translation: AAD53121.1.
U49235 mRNA. Translation: AAB37753.1.
RefSeqiNP_064475.1. NM_020090.1. [Q9QZM6-1]
XP_017451362.1. XM_017595873.1. [Q9QZM6-1]
UniGeneiRn.205732.

Genome annotation databases

GeneIDi56814.
KEGGirno:56814.
UCSCiRGD:620080. rat. [Q9QZM6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF176688 mRNA. Translation: AAD53121.1.
U49235 mRNA. Translation: AAB37753.1.
RefSeqiNP_064475.1. NM_020090.1. [Q9QZM6-1]
XP_017451362.1. XM_017595873.1. [Q9QZM6-1]
UniGeneiRn.205732.

3D structure databases

ProteinModelPortaliQ9QZM6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000051962.

Proteomic databases

PaxDbiQ9QZM6.
PRIDEiQ9QZM6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi56814.
KEGGirno:56814.
UCSCiRGD:620080. rat. [Q9QZM6-1]

Organism-specific databases

CTDi9187.
RGDi620080. Slc24a1.

Phylogenomic databases

eggNOGiKOG1307. Eukaryota.
ENOG410Y9YY. LUCA.
HOGENOMiHOG000231933.
HOVERGENiHBG104097.
InParanoidiQ9QZM6.
KOiK13749.
PhylomeDBiQ9QZM6.

Miscellaneous databases

PROiQ9QZM6.

Family and domain databases

InterProiIPR004481. K/Na/Ca-exchanger.
IPR004837. NaCa_Exmemb.
IPR004817. SLC24A1.
[Graphical view]
PANTHERiPTHR10846. PTHR10846. 4 hits.
PfamiPF01699. Na_Ca_ex. 2 hits.
[Graphical view]
TIGRFAMsiTIGR00927. 2A1904. 1 hit.
TIGR00367. TIGR00367. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNCKX1_RAT
AccessioniPrimary (citable) accession number: Q9QZM6
Secondary accession number(s): Q62932
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 13, 2001
Last sequence update: May 1, 2000
Last modified: November 30, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.